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Immunology for University Students
Resources and Material for Lecturers and Students - Immunology (University level)
Curated by Alfredo Corell
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gut CD4 T cells can switch to CD8 cytotoxic. Nat Immunol 20 january 2013

gut CD4 T cells can switch to CD8 cytotoxic. Nat Immunol 20 january 2013 | Immunology for University Students | Scoop.it

CD4+ and CD8+ T cells are considered distinct functional lymphocyte subsets. Cheroutre and Mucida and their colleagues show that mature gut-associated CD4+ T cells lose ThPOK expression and reactivate CD8 cytolytic effector programs.

Alfredo Corell's insight:

Nature Immunology 20 january 2013

 

Article by Mucida et al: http://www.nature.com/doifinder/10.1038/ni.2523

 

Article by Reis et al:http://www.nature.com/doifinder/10.1038/ni.2518

 

A summary of the findings at:

http://www.sciencedaily.com/releases/2013/01/130120145844.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fimmune_system+%28ScienceDaily%3A+Health+%26+Medicine+News+--+Immune+System%29&goback=.gde_2370476_member_206469340

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T cell tolerance and immunity to commensal bacteria- Current Opinion in Immunology -

T cell tolerance and immunity to commensal bacteria- Current Opinion in Immunology - | Immunology for University Students | Scoop.it

T cell tolerance and immunity to commensal bacteria

Katherine M Nutsch,Chyi-Song Hsieh

Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110, United States

http://dx.doi.org/10.1016/j.coi.2012.04.009,

 

Highlights

► Tolerance is required to commensal bacteria and depends on regulatory T cells. ► Regulatory T cells specific to commensal bacteria are generated from naïve T cells in the periphery. ► Bacterial products can facilitate Treg cell function via the induction of IL-10, an immunosuppressive cytokine. ► Specific commensal bacterial species induce inflammatory or tolerogenic T cell responses in the gut.

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Natural killer cells help to tolerate fetus during pregnacy by regulating inflammatory TH17 cells at the maternal-fetal interface

Natural killer cells help to tolerate fetus during pregnacy by regulating inflammatory TH17 cells at the maternal-fetal interface | Immunology for University Students | Scoop.it
Alfredo Corell's insight:
Binqing Fua,Xianchang Lib,c,Rui Suna,Xianhong Tongd,Bin Lingd,Zhigang Tiana,1, andHaiming Weia,1

 

Natural killer (NK) cells accumulate at the maternal–fetal interface in large numbers, but their exact roles in successful pregnancy remain poorly defined. Here, we provide evidence that TH17 cells and local inflammation can occur at the maternal–fetal interface during natural allogenic pregnancies. We found that decidual NK cells promote immune tolerance and successful pregnancy by dampening inflammatory TH17 cells via IFN-γ secreted by the CD56brightCD27+ NK subset. This NK-cell–mediated regulatory response is lost in patients who experience recurrent spontaneous abortions, which results in a prominent TH17 response and extensive local inflammation. This local inflammatory response further affects the regulatory function of NK cells, leading to the eventual loss of maternal-fetal tolerance. Thus, our data identify NK cells as key regulatory cells at the maternal–fetal interface by suppressing TH17-mediated local inflammation.

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