Immunology for University Students
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Immunology for University Students
Resources and Material for Lecturers and Students - Immunology (University level)
Curated by Alfredo Corell
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Autoinflammatory vs. Autoimmune: What is the Difference?

Autoinflammatory vs. Autoimmune: What is the Difference? | Immunology for University Students | Scoop.it
Autoinflammatory vs. autoimmune: The periodic fever syndromes fall into the autoinflammatory disease category.
Alfredo Corell's insight:

Sometimes the differences between autoinflammatory and Autoimmune pathologies are not so obvious.


This blog post summarizes this 2 groupos of pathologies with an excelent list of reference links.

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New comic book explains to children about Primary Immunodeficiency

New comic book explains to children about Primary Immunodeficiency | Immunology for University Students | Scoop.it
New comic book explains to children about Primary Immunodeficiency
News-Medical.net
Explaining the effects and lifestyle impact of PID to a child can be very challenging for families, especially during times of anxiety and stress around diagnosis.
Alfredo Corell's insight:

the book will cost 14,45 USD


link to the book shop: http://shop.medikidz.com/products/medikidz-explain-primary-immunodeficiency

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Can antibiotics cause autoimmunity?

Can antibiotics cause autoimmunity? | Immunology for University Students | Scoop.it
A certain class of antibiotics prompts cells to produce low levels of novel self proteins that could trigger an autoimmune disease, research suggests.
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Link to the PNAS journal: http://www.pnas.org/content/early/2014/03/26/1402670111 


Significance

Many genetic disorders, including Duchenne muscular dystrophy and cystic fibrosis, are caused by a defective protein resulting from a premature termination codon (PTC) in the mutant gene. Aminoglycosides have been proposed as therapies for these disorders because they increase the frequency of translational read-through of PTCs, permitting expression of full-length protein. We consider the possibility that this approach may prompt an autoimmune response to HLA-presented epitopes encoded downstream of the PTC or other stop codons. We demonstrate that gentamicin induces immunologically relevant levels of an epitope derived from PTC read-through. Furthermore, we identify multiple HLA class I-binding peptides derived from read-through of conventional stop codons in gentamicin-treated cells. These results substantiate the possibility of immune autoreactivity from read-through therapies.

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Immunology Part 1- hypersensitivity states...

Immunology Part 1- hypersensitivity states... | Immunology for University Students | Scoop.it
Immunology as a branch of biomedical science, covers various aspects of immune system in organisms.It covers physiological functions of immune system in states of diseases and health. This video on...
Alfredo Corell's insight:

Not too worked videos (at least in eddition) introducing hypersensitivity states 3 and 4.

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Allergy, Asthma and Immunology

Allergy, Asthma and Immunology | Immunology for University Students | Scoop.it
"A blog about allergy, asthma & immunology" (I'm looking at http://t.co/n7OsWY6IYd "Allergy, Asthma and Immunology")
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Trastornos debidos a inmunodeficiencia - MSD

Trastornos debidos a inmunodeficiencia - MSD | Immunology for University Students | Scoop.it

Los trastornos debidos a inmunodeficiencia son un grupo de enfermedades diversas en las que el sistema inmunitario no funciona de forma adecuada, y en consecuencia las infecciones son más frecuentes, recurren con más frecuencia, por lo general son graves y duran más de lo habitual.

Alfredo Corell's insight:

Manual Merck: Trastrornos debidos a Inmunodeficiencia. Explicaciones sencillas, para nivel de Inmunología General

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Immune System: Diseases, Disorders & Function - a very "basics" post

Immune System: Diseases, Disorders & Function - a very "basics" post | Immunology for University Students | Scoop.it
The job of the immune system is to protect against disease.
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The pathogenesis of systemic lupus erythematosus—an update-Current Opinion in Immunology -

The pathogenesis of systemic lupus erythematosus—an update-Current Opinion in Immunology - | Immunology for University Students | Scoop.it

The pathogenesis of systemic lupus erythematosus—an update

Jinyoung Choi1, *,Sang Taek Kim1, *,Joe Craft1, 2,

1 Department of Internal Medicine (Rheumatology), Yale School of Medicine, New Haven, CT 06520, United States2 Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, United States

http://dx.doi.org/10.1016/j.coi.2012.10.004,

 

Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE. Recent advances in basic and clinical biology have shed new light on disease mechanisms in lupus, with this review discussing the recent studies that offer valuable insights into disease-specific therapeutic targets.

 

The pathogenesis of systemic lupus erythematosus—an update [Current Opinion in Immunology—an update] http://t.co/gKMERgRK...

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Gilbert C FAURE's comment, August 17, 2013 11:26 AM
november 2012, a synthetic review of uptodate hypothesis
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Extreme Orange Allergy Nearly Kills Toddler in First Recorded Case

Extreme Orange Allergy Nearly Kills Toddler in First Recorded Case | Immunology for University Students | Scoop.it

Fruits like oranges don’t commonly cause allergic reactions, and even when they do, the symptoms are usually mild and involve irritation and itching of the mouth.No need to give up your morning glass of OJ, though.

Alfredo Corell's insight:

A 2-year-old girl in Pennsylvania nearly died recently after she suffered an unusually severe allergic reaction to eating an orange, her doctors reported.

The toddler picked up the orange in a supermarket, and within a few minutes of eating it, she developed a reaction that required a prompt trip to the emergency room, and later a helicopter ride to an intensive care unit at the Children's Hospital of Philadelphia.


other review at LiveScience: http://www.livescience.com/48636-this-girl-nearly-died-from-orange-allergy.html 

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First Tests of Ebola Vaccine Appear at Least a Month Away - Bloomberg

First Tests of Ebola Vaccine Appear at Least a Month Away - Bloomberg | Immunology for University Students | Scoop.it
Bloomberg First Tests of Ebola Vaccine Appear at Least a Month Away Bloomberg It would be risky to perform initial safety trials of a Ebola vaccine in Africa where patients may be far from a good hospital that can provide modern medical care should...
Alfredo Corell's insight:

There is no cure for Ebola. The virus has killed 1,069 of 1,975 people afflicted in the four West African nations as of Aug. 11, the WHO said yesterday.

The disease is normally treated by keeping patients hydrated, replacing lost blood and using antibiotics to fight opportunistic infections. The hope is that a patient’s immune system will eventually fight off the virus’s aggressive attack.

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Severe combined immunodeficiency

Andras Fazakas Severe combined immunodeficiency - A deadly combination of defects of T & B lymphocytes + Natural killer cells Its a primary immunodeficiency ...
Alfredo Corell's insight:

a really clear, understandable and visual presentation on Severe combined immunodeficiency.


Strongly Recommended for university students.

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USMLE Animated Immunology - Phagocytosis & Chronic Granulomatous Disease

Free USMLE step 1 & basic medical science videos, animated! By http://www.stepnrun.com, Dr A.Elawad continues with Immunology, presenting phagocytosis, intra...
Alfredo Corell's insight:

Good video animation about phagocytosis and CGD

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Schnitzler's syndrome: diagnosis, treatment, and follow-up - Simon - 2013 - Allergy - Wiley Online Library

Schnitzler's syndrome: diagnosis, treatment, and follow-up - Simon - 2013 - Allergy - Wiley Online Library | Immunology for University Students | Scoop.it
Schnitzler's syndrome: diagnosis, treatment, and follow-up. Free full text. http://t.co/JhGu4prIDC
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Inmunodeficiencias primarias

Inmunodeficiencias primarias | Immunology for University Students | Scoop.it
1. INMUNODEFICIENCIAS PRIMARIAS 1.1. GENERALIDADES. 1.1.1. TIPOS DE INMUNODEFICIENCIAS. 1.1.2. EPIDEMIOLOGÍA DE LAS INMUNODEFICIENCIAS PRIMARIAS. 1.2. DÉFICIT DE LINFOCITOS B. 1.2.1. DATOS CLÍNICOS...
Alfredo Corell's insight:

Buena ficha de Epidemiología Molecular

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Mechanisms of peripheral tolerance to allergens

Mechanisms of peripheral tolerance to allergens | Immunology for University Students | Scoop.it
Mechanisms of peripheral tolerance to allergensO. U. Soyer1,2,3,M. Akdis2,3,J. Ring3,4,H. Behrendt3,5,R. Crameri2,R. Lauener3,6,C. A. Akdis2,3,*

Article first published online: 18 DEC 2012

DOI: 10.1111/all.12085

Alfredo Corell's insight:

The immune system is regulated to protect the host from exaggerated stimulatory signals establishing a state of tolerance in healthy individuals. The disequilibrium in immune regulatory vs effector mechanisms results in allergic or autoimmune disorders in genetically predisposed subjects under certain environmental conditions. As demonstrated in allergen-specific immunotherapy and in the healthy immune response to high-dose allergen exposure models in humans, T regulatory cells are essential in the suppression of Th2-mediated inflammation, maintenance of immune tolerance, induction of the two suppressive cytokines interleukin-10 and transforming growth factor-β, inhibition of allergen-specific IgE, and enhancement of IgG4 and IgA. Also, suppression of dendritic cells, mast cells, and eosinophils contributes to the construction of peripheral tolerance to allergens. This review focuses on mechanisms of peripheral tolerance to allergens with special emphasis on recent developments in the area of immune regulation.

 

Link to the pdf file:

http://onlinelibrary.wiley.com/doi/10.1111/all.12085/pdf

 

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My collection of Educational Immunopathology and Immunology images and videos is growing. Suggestions wellcomed

My collection of Educational Immunopathology and Immunology images and videos is growing. Suggestions wellcomed | Immunology for University Students | Scoop.it
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