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Immunology for University Students
Resources and Material for Lecturers and Students - Immunology (University level)
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Meta-analysisProbiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis

Meta-analysisProbiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis | Immunology for University Students | Scoop.it
Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: system... http://t.co/gP1CfCGOp0
Alfredo Corell's insight:

Conclusions We found no evidence to support a protective association between perinatal use of probiotics and doctor diagnosed asthma or childhood wheeze. Randomised controlled trials to date have not yielded sufficient evidence to recommend probiotics for the primary prevention of these disorders. Extended follow-up of existing trials, along with further clinical and basic research, are needed to accurately define the role of probiotics in the prevention of childhood asthma.
Read more at http://ivancevichmd.blogspot.com/2014/02/probiotic-supplementation-during.html#vCTo9712tLuWOjig.99

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High prevalence of anaphylaxis in patients with systemic mastocytosis – A single-center experience

High prevalence of anaphylaxis in patients with systemic mastocytosis – A single-center experience | Immunology for University Students | Scoop.it
Background

Systemic mastocytosis (SM) is a clonal mast cells disorder characterized by the proliferation, accumulation and activation of mast cells in extra-cutaneous tissues. The clinical picture is heterogeneous and may range from asymptomatic to potentially fatal anaphylactic reactions due to excessive mast cell mediator release.

Objective

The aim of this study was to investigate the prevalence and trigger factors of anaphylactic reactions among adult SM patients. We also explored the clinical spectrum of mast cell mediator-related symptoms in SM patients.

Alfredo Corell's insight:

Anaphylaxis is more prevalent in SM patients, predominantly in atopic SM patients. Hymenoptera venom-induced or idiopathic anaphylaxis were the most frequent elicitors. Our findings implicate that all mastocytosis patients with anaphylaxis should undergo detailed allergological assessment before considering treatment and preventive measures.

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Schnitzler's syndrome: diagnosis, treatment, and follow-up - Simon - 2013 - Allergy - Wiley Online Library

Schnitzler's syndrome: diagnosis, treatment, and follow-up - Simon - 2013 - Allergy - Wiley Online Library | Immunology for University Students | Scoop.it
Schnitzler's syndrome: diagnosis, treatment, and follow-up. Free full text. http://t.co/JhGu4prIDC
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Immunology Part 1- hypersensitivity states...

Immunology Part 1- hypersensitivity states... | Immunology for University Students | Scoop.it
Immunology as a branch of biomedical science, covers various aspects of immune system in organisms.It covers physiological functions of immune system in states of diseases and health. This video on...
Alfredo Corell's insight:

Not too worked videos (at least in eddition) introducing hypersensitivity states 3 and 4.

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Allergy, Asthma and Immunology

Allergy, Asthma and Immunology | Immunology for University Students | Scoop.it
"A blog about allergy, asthma & immunology" (I'm looking at http://t.co/n7OsWY6IYd "Allergy, Asthma and Immunology")
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Mechanisms of peripheral tolerance to allergens

Mechanisms of peripheral tolerance to allergens | Immunology for University Students | Scoop.it
Mechanisms of peripheral tolerance to allergensO. U. Soyer1,2,3,M. Akdis2,3,J. Ring3,4,H. Behrendt3,5,R. Crameri2,R. Lauener3,6,C. A. Akdis2,3,*

Article first published online: 18 DEC 2012

DOI: 10.1111/all.12085

Alfredo Corell's insight:

The immune system is regulated to protect the host from exaggerated stimulatory signals establishing a state of tolerance in healthy individuals. The disequilibrium in immune regulatory vs effector mechanisms results in allergic or autoimmune disorders in genetically predisposed subjects under certain environmental conditions. As demonstrated in allergen-specific immunotherapy and in the healthy immune response to high-dose allergen exposure models in humans, T regulatory cells are essential in the suppression of Th2-mediated inflammation, maintenance of immune tolerance, induction of the two suppressive cytokines interleukin-10 and transforming growth factor-β, inhibition of allergen-specific IgE, and enhancement of IgG4 and IgA. Also, suppression of dendritic cells, mast cells, and eosinophils contributes to the construction of peripheral tolerance to allergens. This review focuses on mechanisms of peripheral tolerance to allergens with special emphasis on recent developments in the area of immune regulation.

 

Link to the pdf file:

http://onlinelibrary.wiley.com/doi/10.1111/all.12085/pdf

 

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