Immunology for University Students
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Immunology for University Students
Resources and Material for Lecturers and Students - Immunology (University level)
Curated by Alfredo Corell
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Desarrollan un chip que recrea cómo actua el bazo

Desarrollan un chip que recrea cómo actua el bazo | Immunology for University Students | Scoop.it
Investigadores del Centro de Investigación en Salud Internacional de Barcelona (CRESIB) y del Instituto de Bioingeniería de Cataluña (IBEC) han desarrollado por primera vez un modelo funcional de un bazo integrado en un chip que es capaz de actuar como este órgano filtrando los glóbulos rojos de la sangre.
Alfredo Corell's insight:

En concreto, lo han conseguido recreando a microescala las propiedades físicas y las fuerzas hidrodinámicas de la unidad funcional de la pulpa roja del bazo y, según los autores, este dispositivo podría servir para detectar posibles fármacos contra la malaria y otras enfermedades hematológicas.

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Video rewind: 'Bubble Boy' 30 years later

Video rewind: 'Bubble Boy' 30 years later | Immunology for University Students | Scoop.it
David Vetter, aka "Bubble Boy," was born in 1971 with a rare hereditary disorder called severe combined immunodeficiency (SCID). He could not be exposed to any germs or he would die.
Alfredo Corell's insight:

We should not forget the scientific and medical errors done in the past. 

David literally lived in a bubble his whole life

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Identificado un nuevo mecanismo inmunológico clave para el desarrollo de vacunas

Identificado un nuevo mecanismo inmunológico clave para el desarrollo de vacunas | Immunology for University Students | Scoop.it

Científicos del Instituto Hospital del Mar de Investigaciones Médicas han descrito un nuevo subtipo de células linfoides innatas esenciales para la producción de anticuerpos, un hallazgo que puede desembocar en el desarrollo de vacunas más eficaces contra las bacterias encapsuladas.

Alfredo Corell's insight:

Estas células linfoides innatas son la primera línea de defensa inmunológica de las superficies del cuerpo más expuestas a bacterias, como el intestino o la piel


Referencia bibliográfica:

Giuliana Magri, Michio Miyajima, Sabrina Bascones, Arthur Mortha, Irene Puga, Linda Cassis, Carolina M. Barra, Laura Comerma, Aleksey Chudnovskiy, Maurizio Gentile, David Llige, Montserrat Cols, Sergi Serrano, Juan Ignacio Aróstegui, Manel Juan, Jordi Yagüe, Miriam Merad, Sidonia Fagarasan & Andrea Cerutti. "Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells". Nature Immunology. DOI: 10.1038/ni.2830.


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Immense Immunology Insight

Immense Immunology Insight | Immunology for University Students | Scoop.it
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A lot of drawings, quests, facts, tests, mnemonics... about immunology

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Severe combined immunodeficiency

Andras Fazakas Severe combined immunodeficiency - A deadly combination of defects of T & B lymphocytes + Natural killer cells Its a primary immunodeficiency ...
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a really clear, understandable and visual presentation on Severe combined immunodeficiency.


Strongly Recommended for university students.

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Obtienen nanocápsulas con actividad antitumoral en líneas celulares de cáncer de mama

Obtienen nanocápsulas con actividad antitumoral en líneas celulares de cáncer de mama | Immunology for University Students | Scoop.it
SINC, Servicio de Información y Noticias Científicas, plataforma multimedia de comunicación científica (Obtienen nanocápsulas con actividad antitumoral en líneas celulares de cáncer de mama http://t.co/AZYAuzAGh4)...
Alfredo Corell's insight:

Enlace al artículo científico:

http://pubs.acs.org/doi/abs/10.1021/bm401103t 

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Teaching the Relevance of Evolution to Understanding Immune Recognition

Teaching the Relevance of Evolution to Understanding Immune Recognition | Immunology for University Students | Scoop.it

This is a crucial step to understand the vast diversity of Immune specific receptors.

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Neil Greenspan Website http://www.case.edu/med/pathology/faculty/greenspan.html ;

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INMUNOMEDIA 3.0 en la Aventura del Saber

En este video se muestra le entrevista que me han hecho en la Aventura del Saber y que se ha emitido el 5 de febrero de 2014

Alfredo Corell's insight:

Enlace al programa completo en rtve: http://www.rtve.es/alacarta/videos/la-aventura-del-saber/aventura-del-saber-05-02-14/2377592/ 


Enlace al videoclip de la entrevista en rtve a la carta: http://www.rtve.es/alacarta/videos/la-aventura-del-saber/aventura-del-saber-alfredo-corell/2374403/

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Nuria Parra Macías's curator insight, February 8, 2014 3:24 AM

Inmunomedia 3.0: una pica en Flandes en innovación docente. El ejemplo de flipped classroom de la facultad de Medicina de la universidad de Valladolid.

Nuria Parra Macías's comment, February 9, 2014 4:06 PM
A ti por la iniciativa :-)
Alfredo Corell's comment, February 12, 2014 3:20 PM
Cualquier tipo de difusión entre personal docente afin es bienvenida, así que gracias de corazón!!1
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Primary Immunodeficiency Symptoms | Primary Immunodeficiency Diagnosis

Primary Immunodeficiency Symptoms | Primary Immunodeficiency Diagnosis | Immunology for University Students | Scoop.it
Learn about different aspects of primary immunodeficiency, including primary immune deficiency symptoms.
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A simple page for University students

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ExRNA: Decoding messages between cells

ExRNA: Decoding messages between cells | Immunology for University Students | Scoop.it
ExRNA: Decoding messages between cells
Medical Xpress
This video is not supported by your browser at this time. ExRNA's Role as Biomarker and Beyond. Like its cousin DNA, RNA can exist in a near-infinite ...
Alfredo Corell's insight:

Extracellular RNA could communicate between cells in a manner not suspected until now. A cancer cell could send an ex-RNA to a healthy one and the opossite, by ex-RNA we could probably treat some tumours.

Exciting new field!!!!!


Explicative YouTube video: http://www.youtube.com/watch?v=bfMg3RhxNm8#t=13 

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SECONDARY LYMPHOID ORGANS, Art Anderson's Immunology Lecture Notes

SECONDARY LYMPHOID ORGANS, Art Anderson's Immunology Lecture Notes | Immunology for University Students | Scoop.it
This page describes secondary (peripheral) lymphatic organs, and is part of Art Anderson's immunology 522 lecture for the Foundation for Advanced Education in the Sciences (FAES) at NIH. Click on
Alfredo Corell's insight:

With artistic drawings of the secondary organs!!!

 

a must visit!

Secondary lymphatic Tissues control the quality of immune responses. Differences among the various lymphatic tissues significantly affect the form of immunity and relate to how antigens are acquired by these organs. Lymph nodes are filters of lymph, the spleen is a filter of blood and mucosal associated lymphatic tissues acquire antigens by transcytosis to lymphoid tissue from the "external" environment across specialized follicle-associated epithelial cells.

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The Quest for an HIV-1 Vaccine — Moving Forward — NEJM

The Quest for an HIV-1 Vaccine — Moving Forward — NEJM | Immunology for University Students | Scoop.it

Perspective from The New England Journal of Medicine — The Quest for an HIV-1 Vaccine — Moving Forward 

Dan H. Barouch, M.D., Ph.D.

N Engl J Med 2013; 369:2073-2076

November 28, 2013DOI: 10.1056/NEJMp1312711

Alfredo Corell's insight:

Testing only four HIV-1 vaccine concepts for clinical efficacy over the past three decades is insufficient given the scope of the global HIV-1 epidemic. We clearly need more “shots on goal.” We should therefore accelerate the advancement of a diverse series of novel and promising HIV-1 vaccine candidates into clinical efficacy trials over the next several years.

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Taking probiotics during pregnancy has no effect on asthma rate amoung infants - Meta-analysis

Taking probiotics during pregnancy has no effect on asthma rate amoung infants - Meta-analysis | Immunology for University Students | Scoop.it
AbstractObjective To evaluate the association of probiotic supplementation during pregnancy or infancy with childhood asthma and wheeze.Design Systematic review and meta-analysis of randomised controlled trials.Data sources Medline, Embase, and...
Alfredo Corell's insight:

BMJ. 2013 Dec 4;347:f6471. doi: 10.1136/bmj.f6471.Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis.Azad MB, Coneys JG, Kozyrskyj AL, Field CJ, Ramsey CD, Becker AB, Friesen C, Abou-Setta AM, Zarychanski R.

 

 

 

Conclusions We found no evidence to support a protective association between perinatal use of probiotics and doctor diagnosed asthma or childhood wheeze. Randomised controlled trials to date have not yielded sufficient evidence to recommend probiotics for the primary prevention of these disorders. Extended follow-up of existing trials, along with further clinical and basic research, are needed to accurately define the role of probiotics in the prevention of childhood asthma.

 

Press news:http://www.news-medical.net/news/20131209/Taking-probiotics-during-pregnancy-has-no-effect-on-asthma-rate-amoung-infants.aspx ;

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Immune System Strongly Tied to Children's Brain Development

Immune System Strongly Tied to Children's Brain Development | Immunology for University Students | Scoop.it

A young child’s immune system appears to have a significant effect on his or her brain development, according to a new study from the University of Virginia School of Medicine (UVA).

Alfredo Corell's insight:

“What is of the most interest and of a great novelty is the fact that [inflammation-fighting cytokines] have positive correlation with cognitive function. My lab published results showing that these IL-4 cytokines are required for proper brain function in mice, and this work from Dr. Petri’s lab completely independently shows similar correlation in humans.”


Link to the BMC publication http://www.biomedcentral.com/1471-2431/14/50/abstract 

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Intestinal epithelial cells: regulators of barrier function and immune homeostasis

Intestinal epithelial cells: regulators of barrier function and immune homeostasis | Immunology for University Students | Scoop.it
Nature Reviews Immunology 14, 141 (2014).
doi:10.1038/nri3608
Authors: Lance W.
Alfredo Corell's insight:

The abundance of innate and adaptive immune cells that reside together with trillions of beneficial commensal microorganisms in the mammalian gastrointestinal tract requires barrier and regulatory mechanisms that conserve host–microbial interactions and tissue homeostasis. This homeostasis depends on the diverse functions of intestinal epithelial cells (IECs), which include the physical segregation of commensal bacteria and the integration of microbial signals. Hence, IECs are crucial mediators of intestinal homeostasis that enable the establishment of an immunological environment permissive to colonization by commensal bacteria. In this Review, we provide a comprehensive overview of how IECs maintain host–commensal microbial relationships and immune cell homeostasis in the intestine.


Free download with registration: http://www.nature.com/nri/journal/v14/n3/pdf/nri3608.pdf 

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The weak link: adult immunisations

The weak link: adult immunisations | Immunology for University Students | Scoop.it
Adults account for 95 percent of individuals who die from vaccine-preventable diseases (The weak link: adult immunisations. Adults account for 95% of individuals who die from vaccine-preventable diseases.
Alfredo Corell's insight:

Adults account for 95 percent of individuals who die from vaccine-preventable diseases. Yet vaccination rates among adults remain “very low”. The latest feature film from Chain of Protection discusses the importance and need for adult immunisation in the fight against preventable infectious diseases.

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Immunology in the skin (and psoriasis) - a new video by Nature Immunology

Immunology in the skin (and psoriasis) - a new video by Nature Immunology | Immunology for University Students | Scoop.it
The skin is the body's main barrier against physical insults and microbial pathogens. Diverse and functionally specialized subsets of immune cells in the ski...
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a remarkable video about skin immune system and pathogenesis in the particular case of psoriasis.

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El movimiento antivacunas amenaza la salud mundial

El movimiento antivacunas amenaza la salud mundial | Immunology for University Students | Scoop.it
Las vacunas son uno de los pilares básicos entre los que se asienta la medicina científica y la sanidad actuales.  Y aunque desde nuestra visión occidental marcada por el ideal de progreso y supera...
Alfredo Corell's insight:

Estamos llegando a límites insospechados. El movimiento anti-vacunas que últimamente está creciendo (por poner un ejemplo están llegando ya a Valencia las llamadas "small-pox parties") puede poner en jaque el sistema sanitario de muchos países.

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Meta-analysisProbiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis

Meta-analysisProbiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis | Immunology for University Students | Scoop.it
Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: system... http://t.co/gP1CfCGOp0
Alfredo Corell's insight:

Conclusions We found no evidence to support a protective association between perinatal use of probiotics and doctor diagnosed asthma or childhood wheeze. Randomised controlled trials to date have not yielded sufficient evidence to recommend probiotics for the primary prevention of these disorders. Extended follow-up of existing trials, along with further clinical and basic research, are needed to accurately define the role of probiotics in the prevention of childhood asthma.
Read more at http://ivancevichmd.blogspot.com/2014/02/probiotic-supplementation-during.html#vCTo9712tLuWOjig.99

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Innate immunity: The inside story on complement activation

Innate immunity: The inside story on complement activation | Immunology for University Students | Scoop.it

NATURE REVIEWS IMMUNOLOGY | RESEARCH HIGHLIGHT

INNATE IMMUNITY

The inside story on complement activation

Nature Reviews Immunology 1461 (2014)
 
doi:10.1038/nri3603
Alfredo Corell's insight:

The evolutionarily ancient complement system might have started life as an intracellular activation pathway rather than as a liver-derived serum effector cascade. 

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Autoimmunity (self immunity) USMLE video animation

This immunology video explains autoimmunity and the effect of autoimmune symptoms in human body. For more information, log on to- http://shomusbiology.weebly...
Alfredo Corell's insight:

a simple and accesible video for Immunology university students

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#Immunology - MHC I and II Processing - YouTube

https://www.facebook.com/ArmandoHasudungan
Alfredo Corell's insight:

Another handwritten mini-lecture by Armando Hasudungan


for class II processing: http://www.youtube.com/watch?v=TMnkihN6zVM&feature=youtu.be&a 

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T cell functions. Immunology Lecture 10 (five Video parts)

This is the concluding lecture about the T cells. Function of T helper 1, and 2, cytotoxic T cells, NK cells and T regulator cells (T17) are discussed.
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Another video-series by Mobeen Syed

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Libro de las enfermedades alérgicas de la Fundación BBVA

Libro de las enfermedades alérgicas de la Fundación BBVA | Immunology for University Students | Scoop.it

Libro publicado en 2012 con el patrocinio de la SEAIC

Alfredo Corell's insight:

dirigido por

JOSE MANUEL ZUBELDIA

Mª LUISA BAEZA

IGNACIO JAÚREGUI

CARLOS J. SENENT

escrito por más de 50 alergólogos de prestigio.

 

Descarga el libro en pdf: http://www.alergiafbbva.es/alergia.pdf ;

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Subcutaneous immunoglobulin therapy at home - Nursing Times

Subcutaneous immunoglobulin therapy at home - Nursing Times | Immunology for University Students | Scoop.it

Subcutaneous immunoglobulin therapy at home
Nursing Times
... home, rather than with intravenous immunoglobulin (IVIg) therapy in hospital.

Alfredo Corell's insight:
5 KEY POINTSImmuno-globulins are antibodies prepared from plasma that help keep the body free from infectionBefore the introduction of antibiotics, patients diagnosed with antibody deficiency died prematurely from acute respiratory infectionsSubcutaneous immuno-globulin (SCIg) therapy reduces patients’ susceptibility to recurrent acute and chronic respiratory infectionsManaging their own treatment gives patients greater control over their condition and promotes concordanceDelivering SCIg therapy at home saves the NHS money and is popular with patients
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