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Immunology for University Students
Resources and Material for Lecturers and Students - Immunology (University level)
Curated by Alfredo Corell
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Primary Immunodeficiency Symptoms | Primary Immunodeficiency Diagnosis

Primary Immunodeficiency Symptoms | Primary Immunodeficiency Diagnosis | Immunology for University Students | Scoop.it
Learn about different aspects of primary immunodeficiency, including primary immune deficiency symptoms.
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A simple page for University students

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ExRNA: Decoding messages between cells

ExRNA: Decoding messages between cells | Immunology for University Students | Scoop.it
ExRNA: Decoding messages between cells
Medical Xpress
This video is not supported by your browser at this time. ExRNA's Role as Biomarker and Beyond. Like its cousin DNA, RNA can exist in a near-infinite ...
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Extracellular RNA could communicate between cells in a manner not suspected until now. A cancer cell could send an ex-RNA to a healthy one and the opossite, by ex-RNA we could probably treat some tumours.

Exciting new field!!!!!


Explicative YouTube video: http://www.youtube.com/watch?v=bfMg3RhxNm8#t=13 

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SECONDARY LYMPHOID ORGANS, Art Anderson's Immunology Lecture Notes

SECONDARY LYMPHOID ORGANS, Art Anderson's Immunology Lecture Notes | Immunology for University Students | Scoop.it
This page describes secondary (peripheral) lymphatic organs, and is part of Art Anderson's immunology 522 lecture for the Foundation for Advanced Education in the Sciences (FAES) at NIH. Click on
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With artistic drawings of the secondary organs!!!

 

a must visit!

Secondary lymphatic Tissues control the quality of immune responses. Differences among the various lymphatic tissues significantly affect the form of immunity and relate to how antigens are acquired by these organs. Lymph nodes are filters of lymph, the spleen is a filter of blood and mucosal associated lymphatic tissues acquire antigens by transcytosis to lymphoid tissue from the "external" environment across specialized follicle-associated epithelial cells.

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The Quest for an HIV-1 Vaccine — Moving Forward — NEJM

The Quest for an HIV-1 Vaccine — Moving Forward — NEJM | Immunology for University Students | Scoop.it

Perspective from The New England Journal of Medicine — The Quest for an HIV-1 Vaccine — Moving Forward 

Dan H. Barouch, M.D., Ph.D.

N Engl J Med 2013; 369:2073-2076

November 28, 2013DOI: 10.1056/NEJMp1312711

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Testing only four HIV-1 vaccine concepts for clinical efficacy over the past three decades is insufficient given the scope of the global HIV-1 epidemic. We clearly need more “shots on goal.” We should therefore accelerate the advancement of a diverse series of novel and promising HIV-1 vaccine candidates into clinical efficacy trials over the next several years.

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Taking probiotics during pregnancy has no effect on asthma rate amoung infants - Meta-analysis

Taking probiotics during pregnancy has no effect on asthma rate amoung infants - Meta-analysis | Immunology for University Students | Scoop.it
AbstractObjective To evaluate the association of probiotic supplementation during pregnancy or infancy with childhood asthma and wheeze.Design Systematic review and meta-analysis of randomised controlled trials.Data sources Medline, Embase, and...
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BMJ. 2013 Dec 4;347:f6471. doi: 10.1136/bmj.f6471.Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis.Azad MB, Coneys JG, Kozyrskyj AL, Field CJ, Ramsey CD, Becker AB, Friesen C, Abou-Setta AM, Zarychanski R.

 

 

 

Conclusions We found no evidence to support a protective association between perinatal use of probiotics and doctor diagnosed asthma or childhood wheeze. Randomised controlled trials to date have not yielded sufficient evidence to recommend probiotics for the primary prevention of these disorders. Extended follow-up of existing trials, along with further clinical and basic research, are needed to accurately define the role of probiotics in the prevention of childhood asthma.

 

Press news:http://www.news-medical.net/news/20131209/Taking-probiotics-during-pregnancy-has-no-effect-on-asthma-rate-amoung-infants.aspx ;

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Un proyecto del área de Inmunología de la UVA, Premio Consejo Social de Innovación Educativa

Un proyecto del área de Inmunología de la UVA, Premio Consejo Social de Innovación Educativa | Immunology for University Students | Scoop.it
El 12 de diciembre se entregan los galardones en el Palacio de Congresos Conde Ansúrez de Valladolid .
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Immune-suppressing cells explain newborn infection vulnerability

Immune-suppressing cells explain newborn infection vulnerability | Immunology for University Students | Scoop.it
Cells that allow good bacteria to safely colonize the intestines of newborns may cause immune suppression, explaining why they are vulnerable to infection, researchers say.
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The researchers note that the process of CD71+ immune suppression is vital for the intestines to build up healthy bacterial colonization, and this is more important than the threat of neonatal infection.

However, they emphasize that further research is warranted in order to create new strategies for the protection of newborn infants against infection while still allowing the CD71+ cells to assist in developing healthy intestines.

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High prevalence of anaphylaxis in patients with systemic mastocytosis – A single-center experience

High prevalence of anaphylaxis in patients with systemic mastocytosis – A single-center experience | Immunology for University Students | Scoop.it
Background

Systemic mastocytosis (SM) is a clonal mast cells disorder characterized by the proliferation, accumulation and activation of mast cells in extra-cutaneous tissues. The clinical picture is heterogeneous and may range from asymptomatic to potentially fatal anaphylactic reactions due to excessive mast cell mediator release.

Objective

The aim of this study was to investigate the prevalence and trigger factors of anaphylactic reactions among adult SM patients. We also explored the clinical spectrum of mast cell mediator-related symptoms in SM patients.

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Anaphylaxis is more prevalent in SM patients, predominantly in atopic SM patients. Hymenoptera venom-induced or idiopathic anaphylaxis were the most frequent elicitors. Our findings implicate that all mastocytosis patients with anaphylaxis should undergo detailed allergological assessment before considering treatment and preventive measures.

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Hospitalizations after a Decade of Pneumococcal Vaccination — NEJM

Hospitalizations after a Decade of Pneumococcal Vaccination — NEJM | Immunology for University Students | Scoop.it
Correspondence from The New England Journal of Medicine — Hospitalizations after a Decade of Pneumococcal Vaccination
Alfredo Corell's insight:

Griffin and colleagues (July 11 issue)1 report a reduction in the incidence of pneumonia after the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7). The authors address the concern regarding serotype replacement, whereby a vaccine-mediated reduction in the disease burden of Streptococcus pneumoniae PCV7 serotypes is offset by a proportional increase in nonvaccine serotypes. However, species replacement by other pathogens, particularlyStaphylococcus aureus, is equally troubling.2

There has been an increasing incidence of S. aureus infections in the United States since the widespread adoption of PCV7.3 According to Gause's law of competitive exclusion, bacteria compete for resources within the nasopharynx, which serves as a common nidus for infections. The S. pneumoniae pili interfere with S. aureus colonization4; however, PCV7 may disrupt this natural competitive advantage.2

The extended serotype coverage of newer pneumococcal vaccines may confer an incremental benefit in preventing pneumococcal pneumonia and invasive pneumococcal disease.5 However, this artificial-selection pressure risks shifting the disease burden toward other pathogens; this is an important point in consideration of the adoption and monitoring of future bacterial vaccines.

Reed A. Siemieniuk, M.D.
University of Toronto, Toronto, ON, Canada 
reed.siemieniuk@mail.utoronto.ca

Anushka Weeraratne, M.D.
McMaster University, Hamilton, ON, Canada

No potential conflict of interest relevant to this letter was reported.

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Partial Sleep Restriction Activates Immune Response-Related Gene Expression Pathways: Experimental and Epidemiological Studies in Humans

Partial Sleep Restriction Activates Immune Response-Related Gene Expression Pathways: Experimental and Epidemiological Studies in Humans | Immunology for University Students | Scoop.it
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
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Epidemiological studies have shown that short or insufficient sleep is associated with increased risk for metabolic diseases and mortality. To elucidate mechanisms behind this connection, we aimed to identify genes and pathways affected by experimentally induced, partial sleep restriction and to verify their connection to insufficient sleep at population level. The experimental design simulated sleep restriction during a working week: sleep of healthy men (N = 9) was restricted to 4 h/night for five nights. The control subjects (N = 4) spent 8 h/night in bed. Leukocyte RNA expression was analyzed at baseline, after sleep restriction, and after recovery using whole genome microarrays complemented with pathway and transcription factor analysis. Expression levels of the ten most up-regulated and ten most down-regulated transcripts were correlated with subjective assessment of insufficient sleep in a population cohort (N = 472). Experimental sleep restriction altered the expression of 117 genes. Eight of the 25 most up-regulated transcripts were related to immune function. Accordingly, fifteen of the 25 most up-regulated Gene Ontology pathways were also related to immune function, including those for B cell activation, interleukin 8 production, and NF-κB signaling (P<0.005). Of the ten most up-regulated genes, expression of STX16 correlated negatively with self-reported insufficient sleep in a population sample, while three other genes showed tendency for positive correlation. Of the ten most down-regulated genes, TBX21 andLGR6 correlated negatively and TGFBR3 positively with insufficient sleep. Partial sleep restriction affects the regulation of signaling pathways related to the immune system. Some of these changes appear to be long-lasting and may at least partly explain how prolonged sleep restriction can contribute to inflammation-associated pathological states, such as cardiometabolic diseases.

  
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Immunopills collection ordered by topic: Complement System

Immunopills collection ordered by topic: Complement System | Immunology for University Students | Scoop.it
My own learning pills on immunology
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A new way of collect and order the Immunopills collection.

Now also in Huzzaz video-organizer

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El periódico de los alumnos de Inmunología de la UVa se vuelve a editar en 2013-2014

El periódico de los alumnos de Inmunología de la UVa se vuelve a editar en 2013-2014 | Immunology for University Students | Scoop.it
Immunology: pathology and therapies, by Alfredo Corell: Immunology, Immunopathology and Immunotherapy for University Students
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Desde esta semana, el diario de Inmunología de todos los estudiantes universitarios de la Universidad de Valladolid se pone en marcha con ilusiones renovadas, y cientos de nuevos contribuyentes.

 

El hashtag para incluir noticias es #Inmuva

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Nueva Inmunopíldora: genes y diversidad del TcR en linfocitos T.

8.9 MECANISMOS DE GENERACIÓN DE LA DIVERSIDAD DE LINFOCITOS T Y B. Inmunología Humana. Alfredo Corell Almuzara. Universidad de Valladolid. Contenidos: * Viab...
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Entrega nº 9 de mecanismos de generación (y amplificación) de la diversidad de linfocitos T y B.

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#Immunology - MHC I and II Processing - YouTube

https://www.facebook.com/ArmandoHasudungan
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Another handwritten mini-lecture by Armando Hasudungan


for class II processing: http://www.youtube.com/watch?v=TMnkihN6zVM&feature=youtu.be&a 

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T cell functions. Immunology Lecture 10 (five Video parts)

This is the concluding lecture about the T cells. Function of T helper 1, and 2, cytotoxic T cells, NK cells and T regulator cells (T17) are discussed.
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Another video-series by Mobeen Syed

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Libro de las enfermedades alérgicas de la Fundación BBVA

Libro de las enfermedades alérgicas de la Fundación BBVA | Immunology for University Students | Scoop.it

Libro publicado en 2012 con el patrocinio de la SEAIC

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dirigido por

JOSE MANUEL ZUBELDIA

Mª LUISA BAEZA

IGNACIO JAÚREGUI

CARLOS J. SENENT

escrito por más de 50 alergólogos de prestigio.

 

Descarga el libro en pdf: http://www.alergiafbbva.es/alergia.pdf ;

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Subcutaneous immunoglobulin therapy at home - Nursing Times

Subcutaneous immunoglobulin therapy at home - Nursing Times | Immunology for University Students | Scoop.it

Subcutaneous immunoglobulin therapy at home
Nursing Times
... home, rather than with intravenous immunoglobulin (IVIg) therapy in hospital.

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5 KEY POINTSImmuno-globulins are antibodies prepared from plasma that help keep the body free from infectionBefore the introduction of antibiotics, patients diagnosed with antibody deficiency died prematurely from acute respiratory infectionsSubcutaneous immuno-globulin (SCIg) therapy reduces patients’ susceptibility to recurrent acute and chronic respiratory infectionsManaging their own treatment gives patients greater control over their condition and promotes concordanceDelivering SCIg therapy at home saves the NHS money and is popular with patients
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The Oracle of the T Cell — immune response prediction by using a mathematical model.

The Oracle of the T Cell — immune response prediction by using a mathematical model. | Immunology for University Students | Scoop.it
A new online platform predicts how the human immune system reacts to foreign substances
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The online platform developed by Dr. Utz-Uwe Haus and Prof. Dr. Robert Weismantel from the Department of Mathematics of ETH Zurich in collaboration with Dr. Jonathan Lindquistand Prof. Dr. Burkhart Schraven from the Institute of Molecular and Clinical Immunology of the University of Magdeburg and the Helmholtz Center for Infection Research in Braunschweig allows researchers to click through the signaling network of the T cells: Users can switch on twelve receptors, including the T cell receptor, identify the signals on the surface of other cells, or bind messengers.

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Inmunomedia 3.0 Primer Premio Consejo Social 2013 de Innovación Educativa

Inmunomedia 3.0 Primer Premio Consejo Social 2013 de Innovación Educativa | Immunology for University Students | Scoop.it

El proyecto “InmunoMedia 3.0” propone nuevas funciones del profesor-tutor con el uso de las nuevas tecnologías

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En la Modalidad A: Proyectos actualmente vivos o en marcha y aprobados por la Comisión de Formación e Innovación Educativa en sus convocatorias de Proyectos de Innovación Docente 2011-2012 y 2013-2014, el premio ha sido para el proyecto “InmunoMedia 3.0”. Sus autores son: Alfredo Corell Almuzara (Coordinador), José Ramón Regueiro González Barros, Rodrigo Blanco Salado, David Pérez Torres, Juan Carlos Aragón Vasco y Luis Alfonso Sanz Díez, y está adscrito al departamento de Pediatría e Inmunología, Obstetricia y Ginecología, Nutrición y Bromatología, Psiquiatría e Historia de la Ciencia de la Universidad de Valladolid.
El Jurado ha valorado la aportación del proyecto a los cambios propiciados por el desarrollo de las TICs y la creación del EEES (Espacio Europeo de Educación Superior), que implican que el profesor-tutor de las nuevas generaciones deba desempeñar nuevas funciones que incluyen el uso de las nuevas tecnologías tanto para diseñar Materiales Educativos Multimedia (MEM), como para supervisar el aprendizaje del alumnado. El proyecto destaca por el desarrollo y difusión del aprendizaje multimedia en el área de Inmunología (apuntes y píldoras de conocimiento) en lengua española, y por la necesidad de filtrar la gran cantidad de información existente, proponiendo sólo la válida y contrastada, y clasificándola y etiquetándola para su mejor uso.
El proyecto se articula en tres ejes: El primero contempla el desarrollo de Objetos de aprendizaje-MEM del área de Inmunología y extensibles a otros alumnos universitarios de Ciencias BioSanitarias en cualquier parte del mundo. El segundo, la colección, selección, filtro y propuestas de enlaces multimedia para la profundización del estudio. Y el tercero, la implicación de los estudiantes en la elaboración de un Diario de la Asignatura.

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En la Modalidad A: Proyectos actualmente vivos o en marcha y aprobados por la Comisión de Formación e Innovación Educativa en sus convocatorias de Proyectos de Innovación Docente 2011-2012 y 2013-2014, el premio ha sido para el proyecto “InmunoMedia 3.0”. Sus autores son: Alfredo Corell Almuzara (Coordinador), José Ramón Regueiro González Barros, Rodrigo Blanco Salado, David Pérez Torres, Juan Carlos Aragón Vasco y Luis Alfonso Sanz Díez, y está adscrito al departamento de Pediatría e Inmunología, Obstetricia y Ginecología, Nutrición y Bromatología, Psiquiatría e Historia de la Ciencia de la Universidad de Valladolid.
El Jurado ha valorado la aportación del proyecto a los cambios propiciados por el desarrollo de las TICs y la creación del EEES (Espacio Europeo de Educación Superior), que implican que el profesor-tutor de las nuevas generaciones deba desempeñar nuevas funciones que incluyen el uso de las nuevas tecnologías tanto para diseñar Materiales Educativos Multimedia (MEM), como para supervisar el aprendizaje del alumnado. El proyecto destaca por el desarrollo y difusión del aprendizaje multimedia en el área de Inmunología (apuntes y píldoras de conocimiento) en lengua española, y por la necesidad de filtrar la gran cantidad de información existente, proponiendo sólo la válida y contrastada, y clasificándola y etiquetándola para su mejor uso.
El proyecto se articula en tres ejes: El primero contempla el desarrollo de Objetos de aprendizaje-MEM del área de Inmunología y extensibles a otros alumnos universitarios de Ciencias BioSanitarias en cualquier parte del mundo. El segundo, la colección, selección, filtro y propuestas de enlaces multimedia para la profundización del estudio. Y el tercero, la implicación de los estudiantes en la elaboración de un Diario de la Asignatura.

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Immunology Part 1- hypersensitivity states...

Immunology Part 1- hypersensitivity states... | Immunology for University Students | Scoop.it
Immunology as a branch of biomedical science, covers various aspects of immune system in organisms.It covers physiological functions of immune system in states of diseases and health. This video on...
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Not too worked videos (at least in eddition) introducing hypersensitivity states 3 and 4.

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Contrasting the Microbiomes from healthy volunteers and patients with chronic Rhinosinusitis

Contrasting the Microbiomes from healthy volunteers and patients with chronic Rhinosinusitis | Immunology for University Students | Scoop.it

Chronic rhinosinusitis (CRS) is the persistent inflammation of the sinus and nasal passages lasting over 3 months. The etiology of CRS is not well understood.

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obtained findings support the theory that in some cases CRS result form an immune hyperresponsiveness to commensal organisms.

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Macrophages: The shape of things to come : Nature Reviews Immunology : Nature Publishing Group

Macrophages: The shape of things to come : Nature Reviews Immunology : Nature Publishing Group | Immunology for University Students | Scoop.it
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Differences in the cell morphology of macrophages in either pro-inflammatory (M1)-polarizing or pro-healing (M2)-polarizing conditions have been previously observed. As described in this study, M1-polarizing stimuli (LPS plus IFNγ) cause cells to flatten into a round, pancake-like shape, whereas M2-polarizing stimuli (IL-4 and IL-13) induce an elongated cell shape.

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The Immunopills mini-video-lecture collection (Immunology University Level) reachs >30.000 visits in only 3 months

The Immunopills mini-video-lecture collection (Immunology University Level) reachs >30.000 visits in only 3 months | Immunology for University Students | Scoop.it
Píldoras de conocimiento de la asignatura "INMUNOLOGÍA HUMANA" Profesor: Alfredo Corell Almuzara.
Alfredo Corell's insight:

Thanks to all visitors!!!

The Immunopills mini-video-lecture collections reachs more than 30.000.

Visitors are from Mexico, Peru, Colombia, Chile, Argentina, España,

 

In few months... I hope all of them will have english subtitles.

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Immunology by Alfredo Corell at ZEEF

Immunology by Alfredo Corell at ZEEF | Immunology for University Students | Scoop.it
Immunology is a branch of biomedical science that covers the study of all aspects of the immune system (defenses between inner and outer body organisms) in humans and other animals.
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My collection of interesting Immunology links in a easy to find format.

 

Contribute!!!, thanks

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La primera Inmunopíldora supera las 4000 visitas. Gracias a todos

11.1 EL SISTEMA DE COMPLEMENTO Y SUS RECEPTORES. Inmunología Humana. Alfredo Corell Almuzara. Universidad de Valladolid. Contenidos: * Introducción: concepto...
Alfredo Corell's insight:

La primera inmunopíldora colgada (introducción al sistema de complemento y vía clásica de activación) ha superado hoy las 4000 visitas a tan sólo 2 meses y medio de su publicación - y con el verano de por medio.

El proyecto InmunoMedia 3.0

El proyecto Saber, Extender

 

estamos de enorabuena. Gracias a todos

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