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Immunology for University Students
Resources and Material for Lecturers and Students - Immunology (University level)
Curated by Alfredo Corell
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#PKNVA mi presentación completa en PechaKucha Night Valladolid vol.05 sobre Anticuerpos

#PKNVA mi presentación completa en PechaKucha Night Valladolid vol.05 sobre Anticuerpos | Immunology for University Students | Scoop.it

20 diapositivas x 20 segundos:

400 segundos hablando al público asistente cómo son los anticuerpos y explicando porqué son tan importantes en nuestra vida

Alfredo Corell's insight:
MUCHAS GRACIAS A TODOS POR VUESTRA ASISTENCIA
  • Se usan para determinar el grupo sanguíneo
  • Se usan para realizar el test de embarazo
  • Cuando nos ponen la anti-tetánica... ahí hay anticuerpos
  • Cuando se dice que alguien es "seropositivo", es porque hay anticuerpos
  • etc...
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Alfredo Corell's curator insight, August 5, 2014 3:00 PM
MUCHAS GRACIAS A TODOS POR VUESTRA ASISTENCIA
  • Se usan para determinar el grupo sanguíneo
  • Se usan para realizar el test de embarazo
  • Cuando nos ponen la anti-tetánica... ahí hay anticuerpos
  • Cuando se dice que alguien es "seropositivo", es porque hay anticuerpos
  • etc...
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Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny.

Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny. | Immunology for University Students | Scoop.it
Nature Reviews Immunology 14571–578 (2014)
 
doi:10.1038/nri3712 - Published online 18 July 2014
Alfredo Corell's insight:

ABSTRACT: The mononuclear phagocyte system (MPS) has historically been categorized into monocytes, dendritic cells and macrophages on the basis of functional and phenotypical characteristics. However, considering that these characteristics are often overlapping, the distinction between and classification of these cell types has been challenging. In this Opinion article, we propose a unified nomenclature for the MPS. We suggest that these cells can be classified primarily by their ontogeny and secondarily by their location, function and phenotype. We believe that this system permits a more robust classification during both steady-state and inflammatory conditions, with the benefit of spanning different tissues and across species.

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Color atlas of immunology - free e-book in slideshare - 2003 edition

Immunology_Atlas

Alfredo Corell's insight:

Be careful, this slideshare version is an old 2003 edition. Thus, some novel findings in the fast growing field of Immunology may not be included

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Las defensas se "alían" con la web 3.0

Las defensas se "alían" con la web 3.0 | Immunology for University Students | Scoop.it

Reflexiones sobre el proyecto Inmunomedia 3.0 en el suplemento Innovadores de "El Mundo".

Alfredo Corell's insight:

No tengo por menos que agradecer a todos los que estáis ahí al otro lado (cerca o lejos, como profesores, estudiantes o amigos). El impacto de Inmunomedia (Canal Defensas e Inmunopíldoras) es cada vez mayor.


Canal Defensas: https://www.youtube.com/playlist?list=PLSbo9kXA_LczFn2uGvkAti9lFBDmeUKZw 


Inmunopíldoras: https://www.youtube.com/playlist?list=PLSbo9kXA_Lcwc1ouBQcafihsdvEmW2dng


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#CanalDefensas entrega 3: VACUNA TUS DEFENSAS - no te juegues la salud de tus hijos

Canal Youtube del Servicio de Medios Audiovisuales de la Universidad de Valladolid (España)
Alfredo Corell's insight:

En la tercera entrega de la serie, Adrian López (alumno de inmunología, 2º de medicina, Universidad de Valladolid) nos explica el daño que puede hacer a la salud de los niños (y de toda la población) las nuevas prácticas anti-vacunas importadas desde EEUU como son las fiestas del sarampión y de la varicela.

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#CanalDefensas SE ABRE AL PUBLICO CON 7 dosis: empieza por DESCUBRE TUS DEFENSAS

¿en qué consisten nuestras defensas?

Alfredo Corell's insight:

Adrian Margarida, Alumno de 2º de medicina de la UVa nos explica las 3 lineas de defensas básicas del organismo. Para hacerlo se pone del lado de los patógenos... video muy logrado.

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The effects of anti-vaccine conspiracy theories on vaccination intentions | Vaccinews Blog

The effects of anti-vaccine conspiracy theories on vaccination intentions | Vaccinews Blog | Immunology for University Students | Scoop.it
A belief in anti-vaccine conspiracy theories may have significant and detrimental consequences for children's health, new research from the University has shown.
Alfredo Corell's insight:

Daniel Jolley said: ‘This research is timely in the face of declining vaccination rates and recent outbreaks of vaccinated-against diseases in the UK, such as measles. Our studies demonstrate that anti-vaccine conspiracy theories may present a barrier to vaccine uptake, which may potentially have significant and detrimental consequences for children’s health.’


Go to PLOS one publication: http://www.vaccinews.net/downloads/blog/March_3.pdf 

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Can antibiotics cause autoimmunity?

Can antibiotics cause autoimmunity? | Immunology for University Students | Scoop.it
A certain class of antibiotics prompts cells to produce low levels of novel self proteins that could trigger an autoimmune disease, research suggests.
Alfredo Corell's insight:

Link to the PNAS journal: http://www.pnas.org/content/early/2014/03/26/1402670111 


Significance

Many genetic disorders, including Duchenne muscular dystrophy and cystic fibrosis, are caused by a defective protein resulting from a premature termination codon (PTC) in the mutant gene. Aminoglycosides have been proposed as therapies for these disorders because they increase the frequency of translational read-through of PTCs, permitting expression of full-length protein. We consider the possibility that this approach may prompt an autoimmune response to HLA-presented epitopes encoded downstream of the PTC or other stop codons. We demonstrate that gentamicin induces immunologically relevant levels of an epitope derived from PTC read-through. Furthermore, we identify multiple HLA class I-binding peptides derived from read-through of conventional stop codons in gentamicin-treated cells. These results substantiate the possibility of immune autoreactivity from read-through therapies.

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Desarrollan un chip que recrea cómo actua el bazo

Desarrollan un chip que recrea cómo actua el bazo | Immunology for University Students | Scoop.it
Investigadores del Centro de Investigación en Salud Internacional de Barcelona (CRESIB) y del Instituto de Bioingeniería de Cataluña (IBEC) han desarrollado por primera vez un modelo funcional de un bazo integrado en un chip que es capaz de actuar como este órgano filtrando los glóbulos rojos de la sangre.
Alfredo Corell's insight:

En concreto, lo han conseguido recreando a microescala las propiedades físicas y las fuerzas hidrodinámicas de la unidad funcional de la pulpa roja del bazo y, según los autores, este dispositivo podría servir para detectar posibles fármacos contra la malaria y otras enfermedades hematológicas.

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Video rewind: 'Bubble Boy' 30 years later

Video rewind: 'Bubble Boy' 30 years later | Immunology for University Students | Scoop.it
David Vetter, aka "Bubble Boy," was born in 1971 with a rare hereditary disorder called severe combined immunodeficiency (SCID). He could not be exposed to any germs or he would die.
Alfredo Corell's insight:

We should not forget the scientific and medical errors done in the past. 

David literally lived in a bubble his whole life

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Identificado un nuevo mecanismo inmunológico clave para el desarrollo de vacunas

Identificado un nuevo mecanismo inmunológico clave para el desarrollo de vacunas | Immunology for University Students | Scoop.it

Científicos del Instituto Hospital del Mar de Investigaciones Médicas han descrito un nuevo subtipo de células linfoides innatas esenciales para la producción de anticuerpos, un hallazgo que puede desembocar en el desarrollo de vacunas más eficaces contra las bacterias encapsuladas.

Alfredo Corell's insight:

Estas células linfoides innatas son la primera línea de defensa inmunológica de las superficies del cuerpo más expuestas a bacterias, como el intestino o la piel


Referencia bibliográfica:

Giuliana Magri, Michio Miyajima, Sabrina Bascones, Arthur Mortha, Irene Puga, Linda Cassis, Carolina M. Barra, Laura Comerma, Aleksey Chudnovskiy, Maurizio Gentile, David Llige, Montserrat Cols, Sergi Serrano, Juan Ignacio Aróstegui, Manel Juan, Jordi Yagüe, Miriam Merad, Sidonia Fagarasan & Andrea Cerutti. "Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells". Nature Immunology. DOI: 10.1038/ni.2830.


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Immense Immunology Insight

Immense Immunology Insight | Immunology for University Students | Scoop.it
Alfredo Corell's insight:

A lot of drawings, quests, facts, tests, mnemonics... about immunology

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Severe combined immunodeficiency

Andras Fazakas Severe combined immunodeficiency - A deadly combination of defects of T & B lymphocytes + Natural killer cells Its a primary immunodeficiency ...
Alfredo Corell's insight:

a really clear, understandable and visual presentation on Severe combined immunodeficiency.


Strongly Recommended for university students.

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All Basic Immunology in 27 video - lectures UCIrvine ocw

All Basic Immunology in 27 video - lectures UCIrvine ocw | Immunology for University Students | Scoop.it
Antibodies, antigens, antigen-antibody reactions, cells and tissues of lymphoreticular and hematopoietic systems, and individual and collective components...
Alfredo Corell's insight:

You have here, on a row... al 27 basic immunology lectures, from introduction to final review.


Enjoy, while learning Immunology

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Immunomodulation by Gut Microbiota: Role of Toll-Like Receptor Expressed by T Cells

Immunomodulation by Gut Microbiota: Role of Toll-Like Receptor Expressed by T Cells http://t.co/ZTBwPJrLpH
Alfredo Corell's insight:

A close relationship exists between gut microbiota and immune responses. An imbalance of this relationship can determine local and systemic immune diseases. In fact the immune system plays an essential role in maintaining the homeostasis with the microbiota that normally resides in the gut, while, at the same time, the gut microbiota influences the immune system, modulating number and function of effector and regulatory T cells. To achieve this aim, mutual regulation between immune system and microbiota is achieved through several mechanisms, including the engagement of toll-like receptors (TLRs), pathogen-specific receptors expressed on numerous cell types. TLRs are able to recognize ligands from commensal or pathogen microbiota to maintain the tolerance or trigger the immune response. In this review, we summarize the latest evidences about the role of TLRs expressed in adaptive T cells, to understand how the immune system promotes intestinal homeostasis, fights invasion by pathogens, and is modulated by the intestinal microbiota.
Read more at http://ivancevichmd.blogspot.com/2014/07/immunomodulation-by-gut-microbiota-role.html#uJoxPLxwCzjbUuEo.99

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#CanalDefensas entrega 5: ANIMA TUS DEFENSAS - una sonrisa ayuda

Comparte tus vídeos con amigos, familia y el mundo.
Alfredo Corell's insight:

Más que nunca, poned una sonrisa. En esta estrega de Canal Defensas Esteban Sánchez, Becario Predoctoral en el IOBA y en InmunoLAB, en la Facultad de Medicina de Valladolid, nos va a contar cómo el estado de ánimo, el estrés o la euforia incluyen en nuestro sistema inmune. Así que "ANIMA TUS DEFENSAS".

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#CanalDefensas entrega 4: COMPARTE TUS DEFENSAS - como hacerse donante de médula ósea

Comparte tus vídeos con amigos, familia y el mundo.
Alfredo Corell's insight:

En esta entrega de Canal Defensas hablamos de cuándo y cómo hacerse donante, y por qué es importante. De ello nos habla Mercedes Nocito, inmunóloga en el Hospital Clínico Universitario de Valladolid. Así que, más que nunca, sé solidario y "COMPARTE TUS DEFENSAS".

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#CanalDefensas 2ª entrega: ENTRENA TUS DEFENSAS

El deporte moderado estimula las defensas. El deporte extenuante las desgasta.

Alfredo Corell's insight:

Esta nueva entrega de Canal Defensas la presenta Mario Martino, técnico de laboratorio en InmunoLAB, en la Facultad de Medicina de la Universidad de Valladolid. Nos cuenta cómo hacer un ejercicio moderado potencia nuestro sistema inmune, bajo el eslógan "ENTRENA TUS DEFENSAS".

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Las inmunopíldoras superan las 110.000 visitas con un promedio de 450 visitas diarias

Las inmunopíldoras superan las 110.000 visitas con un promedio de 450 visitas diarias | Immunology for University Students | Scoop.it
Píldoras de conocimiento de la asignatura "INMUNOLOGÍA HUMANA"
Profesor: Alfredo Corell Almuzara.
Alfredo Corell's insight:

La colección ha superado las 110.000 visitas totales, y la píldora 11.1 de introducción al sistema de complemento ha superado las 14.000 reproducciones.


La reproducción media es de 450 visitas diarias desde lugares como México, Perú, Colombia, Argentina, Rusia y por supuesto España (Valladolid, Cadiz, Granada, León entre otros). Gracias a todos, por vuestras visitas, vuestro apoyo y vuestros "me gusta".

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Denis Hudrisier's curator insight, May 16, 2014 4:47 AM

A remarkable work done by Alfredo Corell for the teaching of immunology!

Denis Hudrisier's curator insight, May 16, 2014 4:48 AM

Des cours d'immunologie en vidéo bien faites (en espagnol pour le moment)

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Immunology at a glance 7th ed

Alfredo Corell's insight:

A classical manual based upon good (not coloured, not very visual) summaries.

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Los pediatras piden incluir la vacuna de varicela en el calendario vacunal común a los 12 meses y a los 2 años

Los pediatras piden incluir la vacuna de varicela en el calendario vacunal común a los 12 meses y a los 2 años | Immunology for University Students | Scoop.it
Ante la problemática causada por la ausencia de la vacuna de la varicela en las farmacias españolas, así como la aparición de los primeros casos de varicela grave en nuestro país, la Asociación Española de Pediatría (AEP) ha solicitado incluir en...
Alfredo Corell's insight:

   El calendario común de vacunación infantil para 2014 del Ministerio de Sanidad contempla la inmunización frente a la varicela a los 12 añosen aquellos niños que no hayan pasado todavía la enfermedad. En este sentido, el coordinador del CAV-AEP, David Moreno, ha avisado de un 15 por ciento de los casos de varicela pueden complicarse, a veces, de forma grave.

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Immune System Strongly Tied to Children's Brain Development

Immune System Strongly Tied to Children's Brain Development | Immunology for University Students | Scoop.it

A young child’s immune system appears to have a significant effect on his or her brain development, according to a new study from the University of Virginia School of Medicine (UVA).

Alfredo Corell's insight:

“What is of the most interest and of a great novelty is the fact that [inflammation-fighting cytokines] have positive correlation with cognitive function. My lab published results showing that these IL-4 cytokines are required for proper brain function in mice, and this work from Dr. Petri’s lab completely independently shows similar correlation in humans.”


Link to the BMC publication http://www.biomedcentral.com/1471-2431/14/50/abstract 

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Intestinal epithelial cells: regulators of barrier function and immune homeostasis

Intestinal epithelial cells: regulators of barrier function and immune homeostasis | Immunology for University Students | Scoop.it
Nature Reviews Immunology 14, 141 (2014).
doi:10.1038/nri3608
Authors: Lance W.
Alfredo Corell's insight:

The abundance of innate and adaptive immune cells that reside together with trillions of beneficial commensal microorganisms in the mammalian gastrointestinal tract requires barrier and regulatory mechanisms that conserve host–microbial interactions and tissue homeostasis. This homeostasis depends on the diverse functions of intestinal epithelial cells (IECs), which include the physical segregation of commensal bacteria and the integration of microbial signals. Hence, IECs are crucial mediators of intestinal homeostasis that enable the establishment of an immunological environment permissive to colonization by commensal bacteria. In this Review, we provide a comprehensive overview of how IECs maintain host–commensal microbial relationships and immune cell homeostasis in the intestine.


Free download with registration: http://www.nature.com/nri/journal/v14/n3/pdf/nri3608.pdf 

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The weak link: adult immunisations

The weak link: adult immunisations | Immunology for University Students | Scoop.it
Adults account for 95 percent of individuals who die from vaccine-preventable diseases (The weak link: adult immunisations. Adults account for 95% of individuals who die from vaccine-preventable diseases.
Alfredo Corell's insight:

Adults account for 95 percent of individuals who die from vaccine-preventable diseases. Yet vaccination rates among adults remain “very low”. The latest feature film from Chain of Protection discusses the importance and need for adult immunisation in the fight against preventable infectious diseases.

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Immunology in the skin (and psoriasis) - a new video by Nature Immunology

Immunology in the skin (and psoriasis) - a new video by Nature Immunology | Immunology for University Students | Scoop.it
The skin is the body's main barrier against physical insults and microbial pathogens. Diverse and functionally specialized subsets of immune cells in the ski...
Alfredo Corell's insight:

a remarkable video about skin immune system and pathogenesis in the particular case of psoriasis.

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