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3D Printing of a macromolecule

This movie illustrates the different steps of my first attempt to 3D print a macromolecule.

Via Denis Hudrisier
Alfredo Corell's insight:

Denis tried to print a 3D model of HLA-class I molecule.

 

Good luck for the next time!!! and keep showing us

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Denis Hudrisier's curator insight, September 30, 2013 3:12 PM

I believe 3D printing of molecules of high immunological interest could help my students at the University of Toulouse (http://www.univ-tlse3.fr/) understand key points of the immune response.

I started from the X-ray data of an MHC class I molecule (a macromolecule controling many events of the immune response) (ID: 1CE6 from protein data bank; http://www.rcsb.org/pdb/home/home.do). I generated a .stl file using Chimera (http://www.cgl.ucsf.edu/chimera/) then 3D printed it on a Mini UP 3D printer (http://3dprintingsystems.com/products/up-mini-3d-printer/) @ the Artilect FabLab (http://artilect.fr/) in Toulouse with the great help of Christian Cenac. Thanks Christian!

For next attempt, I will reinforce the structure (by enlarging the diameter of several parts of the structure) to prevent the molecule from being broken during removal of the support material, which unfortunately happened for the current attempt ��).

Immunology for University Students
Resources and Material for Lecturers and Students - Immunology (University level)
Curated by Alfredo Corell
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INMUNOMEDIA 3.0 en la Aventura del Saber

En este video se muestra le entrevista que me han hecho en la Aventura del Saber y que se ha emitido el 5 de febrero de 2014

Alfredo Corell's insight:

Enlace al programa completo en rtve: http://www.rtve.es/alacarta/videos/la-aventura-del-saber/aventura-del-saber-05-02-14/2377592/ 


Enlace al videoclip de la entrevista en rtve a la carta: http://www.rtve.es/alacarta/videos/la-aventura-del-saber/aventura-del-saber-alfredo-corell/2374403/

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Nuria Parra Macías's curator insight, February 8, 3:24 AM

Inmunomedia 3.0: una pica en Flandes en innovación docente. El ejemplo de flipped classroom de la facultad de Medicina de la universidad de Valladolid.

Nuria Parra Macías's comment, February 9, 4:06 PM
A ti por la iniciativa :-)
Alfredo Corell's comment, February 12, 3:20 PM
Cualquier tipo de difusión entre personal docente afin es bienvenida, así que gracias de corazón!!1
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#CanalDefensas entrega 4: COMPARTE TUS DEFENSAS - como hacerse donante de médula ósea

Comparte tus vídeos con amigos, familia y el mundo.
Alfredo Corell's insight:

En esta entrega de Canal Defensas hablamos de cuándo y cómo hacerse donante, y por qué es importante. De ello nos habla Mercedes Nocito, inmunóloga en el Hospital Clínico Universitario de Valladolid. Así que, más que nunca, sé solidario y "COMPARTE TUS DEFENSAS".

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#CanalDefensas 2ª entrega: ENTRENA TUS DEFENSAS

El deporte moderado estimula las defensas. El deporte extenuante las desgasta.

Alfredo Corell's insight:

Esta nueva entrega de Canal Defensas la presenta Mario Martino, técnico de laboratorio en InmunoLAB, en la Facultad de Medicina de la Universidad de Valladolid. Nos cuenta cómo hacer un ejercicio moderado potencia nuestro sistema inmune, bajo el eslógan "ENTRENA TUS DEFENSAS".

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Las inmunopíldoras superan las 110.000 visitas con un promedio de 450 visitas diarias

Las inmunopíldoras superan las 110.000 visitas con un promedio de 450 visitas diarias | Immunology for University Students | Scoop.it
Píldoras de conocimiento de la asignatura "INMUNOLOGÍA HUMANA"
Profesor: Alfredo Corell Almuzara.
Alfredo Corell's insight:

La colección ha superado las 110.000 visitas totales, y la píldora 11.1 de introducción al sistema de complemento ha superado las 14.000 reproducciones.


La reproducción media es de 450 visitas diarias desde lugares como México, Perú, Colombia, Argentina, Rusia y por supuesto España (Valladolid, Cadiz, Granada, León entre otros). Gracias a todos, por vuestras visitas, vuestro apoyo y vuestros "me gusta".

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Denis Hudrisier's curator insight, May 16, 4:47 AM

A remarkable work done by Alfredo Corell for the teaching of immunology!

Denis Hudrisier's curator insight, May 16, 4:48 AM

Des cours d'immunologie en vidéo bien faites (en espagnol pour le moment)

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Immunology at a glance 7th ed

Alfredo Corell's insight:

A classical manual based upon good (not coloured, not very visual) summaries.

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Los pediatras piden incluir la vacuna de varicela en el calendario vacunal común a los 12 meses y a los 2 años

Los pediatras piden incluir la vacuna de varicela en el calendario vacunal común a los 12 meses y a los 2 años | Immunology for University Students | Scoop.it
Ante la problemática causada por la ausencia de la vacuna de la varicela en las farmacias españolas, así como la aparición de los primeros casos de varicela grave en nuestro país, la Asociación Española de Pediatría (AEP) ha solicitado incluir en...
Alfredo Corell's insight:

   El calendario común de vacunación infantil para 2014 del Ministerio de Sanidad contempla la inmunización frente a la varicela a los 12 añosen aquellos niños que no hayan pasado todavía la enfermedad. En este sentido, el coordinador del CAV-AEP, David Moreno, ha avisado de un 15 por ciento de los casos de varicela pueden complicarse, a veces, de forma grave.

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Immune System Strongly Tied to Children's Brain Development

Immune System Strongly Tied to Children's Brain Development | Immunology for University Students | Scoop.it

A young child’s immune system appears to have a significant effect on his or her brain development, according to a new study from the University of Virginia School of Medicine (UVA).

Alfredo Corell's insight:

“What is of the most interest and of a great novelty is the fact that [inflammation-fighting cytokines] have positive correlation with cognitive function. My lab published results showing that these IL-4 cytokines are required for proper brain function in mice, and this work from Dr. Petri’s lab completely independently shows similar correlation in humans.”


Link to the BMC publication http://www.biomedcentral.com/1471-2431/14/50/abstract 

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Intestinal epithelial cells: regulators of barrier function and immune homeostasis

Intestinal epithelial cells: regulators of barrier function and immune homeostasis | Immunology for University Students | Scoop.it
Nature Reviews Immunology 14, 141 (2014).
doi:10.1038/nri3608
Authors: Lance W.
Alfredo Corell's insight:

The abundance of innate and adaptive immune cells that reside together with trillions of beneficial commensal microorganisms in the mammalian gastrointestinal tract requires barrier and regulatory mechanisms that conserve host–microbial interactions and tissue homeostasis. This homeostasis depends on the diverse functions of intestinal epithelial cells (IECs), which include the physical segregation of commensal bacteria and the integration of microbial signals. Hence, IECs are crucial mediators of intestinal homeostasis that enable the establishment of an immunological environment permissive to colonization by commensal bacteria. In this Review, we provide a comprehensive overview of how IECs maintain host–commensal microbial relationships and immune cell homeostasis in the intestine.


Free download with registration: http://www.nature.com/nri/journal/v14/n3/pdf/nri3608.pdf 

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The weak link: adult immunisations

The weak link: adult immunisations | Immunology for University Students | Scoop.it
Adults account for 95 percent of individuals who die from vaccine-preventable diseases (The weak link: adult immunisations. Adults account for 95% of individuals who die from vaccine-preventable diseases.
Alfredo Corell's insight:

Adults account for 95 percent of individuals who die from vaccine-preventable diseases. Yet vaccination rates among adults remain “very low”. The latest feature film from Chain of Protection discusses the importance and need for adult immunisation in the fight against preventable infectious diseases.

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Immunology in the skin (and psoriasis) - a new video by Nature Immunology

Immunology in the skin (and psoriasis) - a new video by Nature Immunology | Immunology for University Students | Scoop.it
The skin is the body's main barrier against physical insults and microbial pathogens. Diverse and functionally specialized subsets of immune cells in the ski...
Alfredo Corell's insight:

a remarkable video about skin immune system and pathogenesis in the particular case of psoriasis.

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El movimiento antivacunas amenaza la salud mundial

El movimiento antivacunas amenaza la salud mundial | Immunology for University Students | Scoop.it
Las vacunas son uno de los pilares básicos entre los que se asienta la medicina científica y la sanidad actuales.  Y aunque desde nuestra visión occidental marcada por el ideal de progreso y supera...
Alfredo Corell's insight:

Estamos llegando a límites insospechados. El movimiento anti-vacunas que últimamente está creciendo (por poner un ejemplo están llegando ya a Valencia las llamadas "small-pox parties") puede poner en jaque el sistema sanitario de muchos países.

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Meta-analysisProbiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis

Meta-analysisProbiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis | Immunology for University Students | Scoop.it
Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: system... http://t.co/gP1CfCGOp0
Alfredo Corell's insight:

Conclusions We found no evidence to support a protective association between perinatal use of probiotics and doctor diagnosed asthma or childhood wheeze. Randomised controlled trials to date have not yielded sufficient evidence to recommend probiotics for the primary prevention of these disorders. Extended follow-up of existing trials, along with further clinical and basic research, are needed to accurately define the role of probiotics in the prevention of childhood asthma.
Read more at http://ivancevichmd.blogspot.com/2014/02/probiotic-supplementation-during.html#vCTo9712tLuWOjig.99

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Innate immunity: The inside story on complement activation

Innate immunity: The inside story on complement activation | Immunology for University Students | Scoop.it

NATURE REVIEWS IMMUNOLOGY | RESEARCH HIGHLIGHT

INNATE IMMUNITY

The inside story on complement activation

Nature Reviews Immunology 1461 (2014)
 
doi:10.1038/nri3603
Alfredo Corell's insight:

The evolutionarily ancient complement system might have started life as an intracellular activation pathway rather than as a liver-derived serum effector cascade. 

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Las defensas se "alían" con la web 3.0

Las defensas se "alían" con la web 3.0 | Immunology for University Students | Scoop.it

Reflexiones sobre el proyecto Inmunomedia 3.0 en el suplemento Innovadores de "El Mundo".

Alfredo Corell's insight:

No tengo por menos que agradecer a todos los que estáis ahí al otro lado (cerca o lejos, como profesores, estudiantes o amigos). El impacto de Inmunomedia (Canal Defensas e Inmunopíldoras) es cada vez mayor.


Canal Defensas: https://www.youtube.com/playlist?list=PLSbo9kXA_LczFn2uGvkAti9lFBDmeUKZw 


Inmunopíldoras: https://www.youtube.com/playlist?list=PLSbo9kXA_Lcwc1ouBQcafihsdvEmW2dng


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#CanalDefensas entrega 3: VACUNA TUS DEFENSAS - no te juegues la salud de tus hijos

Canal Youtube del Servicio de Medios Audiovisuales de la Universidad de Valladolid (España)
Alfredo Corell's insight:

En la tercera entrega de la serie, Adrian López (alumno de inmunología, 2º de medicina, Universidad de Valladolid) nos explica el daño que puede hacer a la salud de los niños (y de toda la población) las nuevas prácticas anti-vacunas importadas desde EEUU como son las fiestas del sarampión y de la varicela.

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#CanalDefensas SE ABRE AL PUBLICO CON 7 dosis: empieza por DESCUBRE TUS DEFENSAS

¿en qué consisten nuestras defensas?

Alfredo Corell's insight:

Adrian Margarida, Alumno de 2º de medicina de la UVa nos explica las 3 lineas de defensas básicas del organismo. Para hacerlo se pone del lado de los patógenos... video muy logrado.

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The effects of anti-vaccine conspiracy theories on vaccination intentions | Vaccinews Blog

The effects of anti-vaccine conspiracy theories on vaccination intentions | Vaccinews Blog | Immunology for University Students | Scoop.it
A belief in anti-vaccine conspiracy theories may have significant and detrimental consequences for children's health, new research from the University has shown.
Alfredo Corell's insight:

Daniel Jolley said: ‘This research is timely in the face of declining vaccination rates and recent outbreaks of vaccinated-against diseases in the UK, such as measles. Our studies demonstrate that anti-vaccine conspiracy theories may present a barrier to vaccine uptake, which may potentially have significant and detrimental consequences for children’s health.’


Go to PLOS one publication: http://www.vaccinews.net/downloads/blog/March_3.pdf 

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Can antibiotics cause autoimmunity?

Can antibiotics cause autoimmunity? | Immunology for University Students | Scoop.it
A certain class of antibiotics prompts cells to produce low levels of novel self proteins that could trigger an autoimmune disease, research suggests.
Alfredo Corell's insight:

Link to the PNAS journal: http://www.pnas.org/content/early/2014/03/26/1402670111 


Significance

Many genetic disorders, including Duchenne muscular dystrophy and cystic fibrosis, are caused by a defective protein resulting from a premature termination codon (PTC) in the mutant gene. Aminoglycosides have been proposed as therapies for these disorders because they increase the frequency of translational read-through of PTCs, permitting expression of full-length protein. We consider the possibility that this approach may prompt an autoimmune response to HLA-presented epitopes encoded downstream of the PTC or other stop codons. We demonstrate that gentamicin induces immunologically relevant levels of an epitope derived from PTC read-through. Furthermore, we identify multiple HLA class I-binding peptides derived from read-through of conventional stop codons in gentamicin-treated cells. These results substantiate the possibility of immune autoreactivity from read-through therapies.

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Desarrollan un chip que recrea cómo actua el bazo

Desarrollan un chip que recrea cómo actua el bazo | Immunology for University Students | Scoop.it
Investigadores del Centro de Investigación en Salud Internacional de Barcelona (CRESIB) y del Instituto de Bioingeniería de Cataluña (IBEC) han desarrollado por primera vez un modelo funcional de un bazo integrado en un chip que es capaz de actuar como este órgano filtrando los glóbulos rojos de la sangre.
Alfredo Corell's insight:

En concreto, lo han conseguido recreando a microescala las propiedades físicas y las fuerzas hidrodinámicas de la unidad funcional de la pulpa roja del bazo y, según los autores, este dispositivo podría servir para detectar posibles fármacos contra la malaria y otras enfermedades hematológicas.

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Video rewind: 'Bubble Boy' 30 years later

Video rewind: 'Bubble Boy' 30 years later | Immunology for University Students | Scoop.it
David Vetter, aka "Bubble Boy," was born in 1971 with a rare hereditary disorder called severe combined immunodeficiency (SCID). He could not be exposed to any germs or he would die.
Alfredo Corell's insight:

We should not forget the scientific and medical errors done in the past. 

David literally lived in a bubble his whole life

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Identificado un nuevo mecanismo inmunológico clave para el desarrollo de vacunas

Identificado un nuevo mecanismo inmunológico clave para el desarrollo de vacunas | Immunology for University Students | Scoop.it

Científicos del Instituto Hospital del Mar de Investigaciones Médicas han descrito un nuevo subtipo de células linfoides innatas esenciales para la producción de anticuerpos, un hallazgo que puede desembocar en el desarrollo de vacunas más eficaces contra las bacterias encapsuladas.

Alfredo Corell's insight:

Estas células linfoides innatas son la primera línea de defensa inmunológica de las superficies del cuerpo más expuestas a bacterias, como el intestino o la piel


Referencia bibliográfica:

Giuliana Magri, Michio Miyajima, Sabrina Bascones, Arthur Mortha, Irene Puga, Linda Cassis, Carolina M. Barra, Laura Comerma, Aleksey Chudnovskiy, Maurizio Gentile, David Llige, Montserrat Cols, Sergi Serrano, Juan Ignacio Aróstegui, Manel Juan, Jordi Yagüe, Miriam Merad, Sidonia Fagarasan & Andrea Cerutti. "Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells". Nature Immunology. DOI: 10.1038/ni.2830.


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Immense Immunology Insight

Immense Immunology Insight | Immunology for University Students | Scoop.it
Alfredo Corell's insight:

A lot of drawings, quests, facts, tests, mnemonics... about immunology

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Severe combined immunodeficiency

Andras Fazakas Severe combined immunodeficiency - A deadly combination of defects of T & B lymphocytes + Natural killer cells Its a primary immunodeficiency ...
Alfredo Corell's insight:

a really clear, understandable and visual presentation on Severe combined immunodeficiency.


Strongly Recommended for university students.

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Obtienen nanocápsulas con actividad antitumoral en líneas celulares de cáncer de mama

Obtienen nanocápsulas con actividad antitumoral en líneas celulares de cáncer de mama | Immunology for University Students | Scoop.it
SINC, Servicio de Información y Noticias Científicas, plataforma multimedia de comunicación científica (Obtienen nanocápsulas con actividad antitumoral en líneas celulares de cáncer de mama http://t.co/AZYAuzAGh4)...
Alfredo Corell's insight:

Enlace al artículo científico:

http://pubs.acs.org/doi/abs/10.1021/bm401103t 

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Teaching the Relevance of Evolution to Understanding Immune Recognition

Teaching the Relevance of Evolution to Understanding Immune Recognition | Immunology for University Students | Scoop.it

This is a crucial step to understand the vast diversity of Immune specific receptors.

Alfredo Corell's insight:

Neil Greenspan Website http://www.case.edu/med/pathology/faculty/greenspan.html ;

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