Immunology for University Students
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Human Complement Receptor Type 1/CD35 Is an Epstein-Barr Virus Receptor

Human Complement Receptor Type 1/CD35 Is an Epstein-Barr Virus Receptor | Immunology for University Students | Scoop.it
Alfredo Corell's insight:

Cell Reports, Volume 3, Issue 2, 371-385, 14 February 2013
Copyright © 2013 The Authors
10.1016/j.celrep.2013.01.023

 

AuthorsJavier G. Ogembo, Lakshmi Kannan, Ionita Ghiran, Anne Nicholson-Weller, Robert W. Finberg, George C. Tsokos, Joyce D. FingerothHighlights:Human CD35, like CD21, binds EBVgp350/220, the major virion envelope glycoproteinCD35 mediates latent EBV infection when the fusion coreceptor HLA II is expressedTemperature, tempo, structure, and regulation distinguish CD35-mediated infectionCD35 is a physiologically relevant EBV receptor
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Immunology for University Students
Resources and Material for Lecturers and Students - Immunology (University level)
Curated by Alfredo Corell
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INMUNOMEDIA 3.0 en la Aventura del Saber

En este video se muestra le entrevista que me han hecho en la Aventura del Saber y que se ha emitido el 5 de febrero de 2014

Alfredo Corell's insight:

Enlace al programa completo en rtve: http://www.rtve.es/alacarta/videos/la-aventura-del-saber/aventura-del-saber-05-02-14/2377592/ 


Enlace al videoclip de la entrevista en rtve a la carta: http://www.rtve.es/alacarta/videos/la-aventura-del-saber/aventura-del-saber-alfredo-corell/2374403/

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Nuria Parra Macías's curator insight, February 8, 2014 3:24 AM

Inmunomedia 3.0: una pica en Flandes en innovación docente. El ejemplo de flipped classroom de la facultad de Medicina de la universidad de Valladolid.

Nuria Parra Macías's comment, February 9, 2014 4:06 PM
A ti por la iniciativa :-)
Alfredo Corell's comment, February 12, 2014 3:20 PM
Cualquier tipo de difusión entre personal docente afin es bienvenida, así que gracias de corazón!!1
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Educate Your Immune System: Our bodies are confused by this 21st-century world

Educate Your Immune System: Our bodies are confused by this 21st-century world | Immunology for University Students | Scoop.it

The Microbioma... crucial in Immune Education

 

The world today is very different from the one our immune system evolved to anticipate — not just in what we encounter, but in when we first encounter it. Preventing autoimmune disorders may require emulating aspects of that “dirtier” world: safely bottling the kinds of microbes that protect the Russian kids, so we can give them to everyone and guide the “postmodern” immune system along a healthier path of development.

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The Joint Vaccine Education Resource Center

The Joint Vaccine Education Resource Center | Immunology for University Students | Scoop.it


Welcome to the Joint Vaccine Education Resource Center. Co-hosted by the American Journal of Preventive Medicine and Vaccine, this educational website has been designed to provide the latest information in the field of immunization. Here you will find an extensive selection of peer-reviewed articles selected from the literature, as well as links to valuable resources for scientists, clinicians, and their patients, all focused on the most commonly used vaccinations.

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You can find research papers, educational videos and much more. All about vaccines!!!

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TSRI scientists solve 3-D structure of protein that guides the immune system

TSRI scientists solve 3-D structure of protein that guides the immune system | Immunology for University Students | Scoop.it
In a new study, researchers from The Scripps Research Institute and Duke University Medical Center reveal the three-dimensional structure of a crucial ion channel. Their findings shed light on the channel's possible role in immune functions such as detecting infection and inflammation.
Alfredo Corell's insight:

The new study was published Jan. 18, 2016, in the journal Nature Structural and Molecular Biology.

An Important Sensor

Lander and his colleagues focused on an ion channel called the transient receptor potential vanilloid-2 (TRPV2), which resides within the membranes of cells throughout the body. Previous research had suggested TRPV2 was involved in sensing physical stresses, such as changes in pressure and temperature, as well as in detecting immune challenges and activating the immune system's T cells.

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Unraveling the Influence of Gut Microbes on the Mind and Mood

Unraveling the Influence of Gut Microbes on the Mind and Mood | Immunology for University Students | Scoop.it
Within the last decade, the phrase “gut feelings” has taken on a whole new meaning. Traditionally, scientists have focused on the role of the central nervous system in regulating our moods and behaviors, but a paradigm shift is afoot, with new research revealing a unique role of our gut...
Alfredo Corell's insight:

A seminal study published in 2004 provided some of the first evidence of bidirectional interaction between gut bacteria and the brain, demonstrating that germ-free (GF) mice without commensal microorganisms have an exaggerated response to stress, accompanied by altered brain chemistry and elevated stress hormones, which could be normalized by administration of a single type of bacterium, Bifidobacterium infantis (Sudo N et al. J Physiol. 2004;558[pt 1]:263-275).

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Sanidad estudia levantar el bloqueo a la vacuna de la varicela

Sanidad estudia levantar el bloqueo a la vacuna de la varicela | Immunology for University Students | Scoop.it
Las sociedades científicas reclaman la vacunación a los 12 meses y no a los 12 años
Alfredo Corell's insight:

El Ministerio de Sanidad estudia levantar el bloqueo a la vacuna de la varicela que aplicó hace dos años, cuando Ana Mato era la titular del departamento. El actual ministro, Alfonso Alonso, ha reconocido hoy que hablará con las comunidades autónomas de la posibilidad de volver a administrar esta vacuna a edades tempranas. Actualmente, y pese a la recomendación unánime de los pediatras, esta inmunización no se puede recibir en España hasta los 12 años. Sanidad llegó a retirar de las farmacias Varivax, la vacuna de Sanofi Pasteur MSD, para evitar que los padres la compraran por su cuenta.

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El proyecto “InmunoMedia 4.0” del profesor Alfredo Corell, finalista de los Premios Fundación Lilly

El proyecto “InmunoMedia 4.0” del profesor Alfredo Corell, finalista de los Premios Fundación Lilly | Immunology for University Students | Scoop.it

Uno de los productos estrella de este proyecto son las píldoras de conocimiento, pequeños vídeos que ilustran aspectos de la inmunología que se pueden ver actualmente en youtube

Alfredo Corell's insight:

El proyecto “InmunoMedia 4.0: Enseñando y aprendiendo Inmunología”, presentado por el profesor titular de Inmunología Alfredo Corell Almuzara, ha sido finalista del Premio al Mejor Proyecto o Trabajo en la Enseñanza de Grado que otorga la Fundación Lilly-Universidad Complutense de Madrid en el marco de los Premios de Educación Médica 2014. A este proyecto liderado por la Facultad de Medicina de la Universidad de Valladolid se han sumado la Universidad Complutense de Madrid, la Universidad de Alicante y, más recientemente, la Universidad de Toulouse.


EnlaceEnlacePíldoras del conocimiento
EnlaceEnlaceCanal Defensas
EnlaceEnlacePeriódico Universitario de Inmunología


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Autoinflammatory vs. Autoimmune: What is the Difference?

Autoinflammatory vs. Autoimmune: What is the Difference? | Immunology for University Students | Scoop.it
Autoinflammatory vs. autoimmune: The periodic fever syndromes fall into the autoinflammatory disease category.
Alfredo Corell's insight:

Sometimes the differences between autoinflammatory and Autoimmune pathologies are not so obvious.


This blog post summarizes this 2 groupos of pathologies with an excelent list of reference links.

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If helper T cells have nothing to help, they kill their host

If helper T cells have nothing to help, they kill their host | Immunology for University Students | Scoop.it
For vaccines, CD4+ T cells can spell trouble

The ideal vaccine elicits immune memory—either antibodies or memory T cells—to protect the host from subsequent infections. T cell–mediated immunity requires both helper CD4+ T cells and cytotoxic CD8+ T cells to kill virus-infected cells. But what happens when a vaccine only elicits CD4+ memory T cells? Penaloza-MacMaster et al. probed this question by giving mice a vaccine that generated only memory CD4+ T cells against lymphocytic choriomeningitis virus (LCMV). Instead of protecting mice against chronic LCMV, vaccinated mice developed massive inflammation and died. Virus-specific CD8+ T cells or antibodies protected mice from the pathology. These results may have implications for vaccines against chronic viruses such as HIV.

Science 16 January 2015: 
Vol. 347 no. 6219 pp. 278-282 
DOI: 10.1126/science.aaa2148

Alfredo Corell's insight:

CD4 T cells promote innate and adaptive immune responses, but how vaccine-elicited CD4 T cells contribute to immune protection remains unclear. We evaluated whether induction of virus-specific CD4 T cells by vaccination would protect mice against infection with chronic lymphocytic choriomeningitis virus (LCMV). Immunization with vaccines that selectively induced CD4 T cell responses resulted in catastrophic inflammation and mortality after challenge with a persistent strain of LCMV. Immunopathology required antigen-specific CD4 T cells and was associated with a cytokine storm, generalized inflammation, and multi-organ system failure. Virus-specific CD8 T cells or antibodies abrogated the pathology. These data demonstrate that vaccine-elicited CD4 T cells in the absence of effective antiviral immune responses can trigger lethal immunopathology.

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Immunology: Fifty years of B lymphocytes

Immunology: Fifty years of B lymphocytes | Immunology for University Students | Scoop.it
Alexander D. Gitlin and Michel C.
Alfredo Corell's insight:

Alexander D. Gitlin and Michel C. Nussenzweig reflect on the discovery of two lineages of adaptive immune cells, and how it influenced vaccination, cancer therapy and the development of a class of antibody-based drugs.

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Las InmunoPíldoras alcanzan las 400.000 reproducciones en 15 meses

Las InmunoPíldoras alcanzan las 400.000 reproducciones en 15 meses | Immunology for University Students | Scoop.it

Desde este enlace se accede a la colección completa de Inmunopíldoras: 43 entregas hasta el momento

Alfredo Corell's insight:

En Enero de 2015 entregaremos al menos otras 10 píldoras de la sección de patología, para empezar el año con buen pié.

Estamos también preparando el subtitulado de las píldoras al inglés y al frandes... os iré informando.

Tengo que agradecer a todo el equipo técnico de la UVa y a los compañeros docentes de Valladolid, Madrid, Alicante y Toulouse su ayuda a que las píldoras sigan creciendo e internacionalizándose.

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Extreme Orange Allergy Nearly Kills Toddler in First Recorded Case

Extreme Orange Allergy Nearly Kills Toddler in First Recorded Case | Immunology for University Students | Scoop.it

Fruits like oranges don’t commonly cause allergic reactions, and even when they do, the symptoms are usually mild and involve irritation and itching of the mouth.No need to give up your morning glass of OJ, though.

Alfredo Corell's insight:

A 2-year-old girl in Pennsylvania nearly died recently after she suffered an unusually severe allergic reaction to eating an orange, her doctors reported.

The toddler picked up the orange in a supermarket, and within a few minutes of eating it, she developed a reaction that required a prompt trip to the emergency room, and later a helicopter ride to an intensive care unit at the Children's Hospital of Philadelphia.


other review at LiveScience: http://www.livescience.com/48636-this-girl-nearly-died-from-orange-allergy.html 

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In space, astronauts' immune systems get totally confused - Washington Post

In space, astronauts' immune systems get totally confused - Washington Post | Immunology for University Students | Scoop.it
Science Codex In space, astronauts' immune systems get totally confused Washington Post "If this situation persisted for longer deep space missions, it could possibly increase risk of infection, hypersensitivity, or autoimmune issues for...
Alfredo Corell's insight:

But it isn't certain that these changes would significantly increase the risks of long-term spaceflight. An upcoming year-long mission will provide further data for study. If the evidence suggests that immune system confusion could pose a threat to astronauts, the next step will be figuring out how to counteract it. Whatever they develop could make its way back to earth, providing new tools to help immune-compromised patients here at home.


Original Manuscript at the Journal of Interferon & Cytokine Research

DOI: 10.1089/jir.2013.0129

http://online.liebertpub.com/doi/pdf/10.1089/jir.2013.0129

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La conexión entre la mente y el sistema inmune (o la psicología profunda de la enfermedad)

La conexión entre la mente y el sistema inmune (o la psicología profunda de la enfermedad) | Immunology for University Students | Scoop.it
Sabemos actualmente que nuestros estados de ánimo se reflejan directamente en nuestra salud. La eudaimonia, o la felicidad que viene del alma, parece ser clave para regular nuestro sistema inmune. Encontrar la eudaimonia, sin embargo, significa hacerle caso a nuestro demonio personal
Alfredo Corell's insight:

La psiconeuroinmunología es apasionante. Lo "sientes" antes de tener síntomas...

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Innate immunity in vertebrates: an overview - Riera Romo - 2016 - Immunology - Wiley Online Library

Innate immunity is a semi-specific and widely distributed form of immunity, which represents the first line of defence against pathogens. 

Alfredo Corell's insight:

Innate immunity is a semi-specific and widely distributed form of immunity, which represents the first line of defence against pathogens. This type of immunity is critical to maintain homeostasis and prevent microbe invasion, eliminating a great variety of pathogens and contributing with the activation of the adaptive immune response. The components of innate immunity include physical and chemical barriers, humoral and cell-mediated components, which are present in all jawed vertebrates. The understanding of innate defence mechanisms in non-mammalian vertebrates is the key to comprehend the general picture of vertebrate innate immunity and its evolutionary history. This is also essential for the identification of new molecules with applications in immunopharmacology and immunotherapy. In this review, we describe and discuss the main elements of vertebrate innate immunity, presenting core findings in this field and identifying areas that need further investigation.

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Evolution of the immune system in humans from infancy to old age

Evolution of the immune system in humans from infancy to old age | Immunology for University Students | Scoop.it
This article reviews the development of the immune response through neonatal, infant and adult life, including pregnancy, ending with the decline in old age. A picture emerges of a child born with an immature, innate and adaptive immune system, which ...
Alfredo Corell's insight:
Proc Biol Sci. 2015 Dec 22; 282(1821): 20143085. 
PMCID: PMC4707740
Evolution of the immune system in humans from infancy to old age

Abstract

This article reviews the development of the immune response through neonatal, infant and adult life, including pregnancy, ending with the decline in old age. A picture emerges of a child born with an immature, innate and adaptive immune system, which matures and acquires memory as he or she grows. It then goes into decline in old age. These changes are considered alongside the risks of different types of infection, autoimmune disease and malignancy.

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Inmunomedia se hace internacional: primera píldora subtitulada en español, francés e inglés

El proyecto Inmunomedia 4.0 se hace internacional: la primera inmmnopíldora con subtítulos en español, inglés y francés YA ESTÁ DISPONIBLE. Gracias a todo el equipo y a todos los seguidores.

Alfredo Corell's insight:

Le project INMUNOMEDIA 4.0 devient international. La première pilule immunologique sous-titré en espagnol, anglais et français est déjà disponible.


The Inmunomedia 4.0 project is now international: the first Immunepill  subtitled onto Spanish, English and French is now available. Thanks to the whole team and to all our followers.

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Las defensas salieron "de cañas" el 29 de abril en Valladolid

Las defensas salieron "de cañas" el 29 de abril en Valladolid | Immunology for University Students | Scoop.it

Día de Valladolid, 29 de abril.

 

Organizan la actividad "Inmunomedia 4.0" (grupo de Innovacion docente de la UVa) e InmunoLAB (laboratorio de Inmunologia de la UVa)

Alfredo Corell's insight:

Profesores y estudiantes, becarios, tecnicos de laboratorio, de la Facultad de Medicina salen "de cañas" para explicar e intercambiar dudas sobre todos los aspectos relacionados con nuestras defensas.

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Más de MEDIO MILLÓN de visitas a las #Inmunopíldoras

Más de MEDIO MILLÓN de visitas a las #Inmunopíldoras | Immunology for University Students | Scoop.it

En marzo de 2015 la colección de Inmunopíldoras de la Universidad de Valladolid ha superado el medio millón de visitas. El equipo responsable del proyecto Inmunomedia 4.0 se siente muy agradecido por la acogida y sigue trabajando en nuevas entregas.

Alfredo Corell's insight:

Cuando se comenzaron a grabar las primeras píldoras en julio de 2013 no imaginábamos la gran acogida que iban a tener. Más de medio millón de visitas, cientos de correos de agradecimientos de estudiantes de todo el mundo (no citaré paises por no dejarme ninguno fuera).

Si resaltar que los países con más visitas son Colombia, México y España, pero con un grandísimo nivel de visitas de todos los paises de Iberoamérica. También en Europa tenemos alumnos estudiando con las inmunopíldoras.

Estamos trabajando en el subtitulado al inglés y al francés, que en breve estarán disponibles para algunas entregas. Y por supuesto diseñando las nuevas grabaciones, si cabe con más ánimo y dedicación.

Medio millón de gracias se quedarían cortas.

El equipo de Inmunomedia4.0

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Stanford researchers unravel secrets of shape-shifting bacteria

Stanford researchers unravel secrets of shape-shifting bacteria | Immunology for University Students | Scoop.it
Working on observations of bacteria going undercover in ways that might trick the human immune system, Stanford bioengineers have created a time-lapse video that shows this process step by step.
Alfredo Corell's insight:

Using time-lapse microscopy, Stanford bioengineer K.C. Huang and colleagues reveal how bacteria lose the cell walls that define their shapes, become less visible to the immune system, then revert to original form and regain full infectious potential.

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Inmunomedia 4.0 finalista en los Premios de la Cátedra de Educación Médica Fundación Lilly – UCM 2014

Inmunomedia 4.0 finalista en los Premios de la Cátedra de Educación Médica Fundación Lilly – UCM 2014 | Immunology for University Students | Scoop.it

Madrid, 20 de enero de 2015.- La Cátedra de Educación Médica Fundación Lilly-Universidad Complutense de Madrid (UCM) ha galardonado los proyectos presentados por el Centro Nacional de Investigaciones Cardiovasculares (CNIC) que dirige el doctor Valentín Fuster, y por el doctor Jordi Casademont, “Formación de posgrado en Investigación Cardiovascular” y “Situación actual de la enseñanza de la Patología General en España”, respectivamente, con sus Premios de Educación Médica 2014. El acto de entrega de los premios tendrá lugar el próximo día 29 de enero a las 19:00 horas en la Facultad de Medicina de la Universidad Complutense de Madrid.

Alfredo Corell's insight:

Además, la iniciativa “InmunoMedia 4.0: Enseñando y aprendiendo Inmunología”, basado en el uso de las nuevas tecnologías multimedia y las redes sociales para la docencia de esta especialidad, ha resultado finalista en la categoría de enseñanza de grado.

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El medio ambiente, y no los genes, dicta la variación inmunológica humana

El medio ambiente, y no los genes, dicta la variación inmunológica humana | Immunology for University Students | Scoop.it

Resumen de hallazgos en BITNAVEGANTES

El medio ambiente, y no los genes, dicta la variación inmunológica humana http://t.co/q8HqsaB6GE

Alfredo Corell's insight:
Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences
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Animation: Immunology of the lung : Nature Immunology

Animation: Immunology of the lung : Nature Immunology | Immunology for University Students | Scoop.it
Nature Immunology is a multidisciplinary journal that publishes papers of the highest quality and significance in all areas of immunology. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity and tumor immunology, microbial immunopathology; and transplantation.
Alfredo Corell's insight:

Another impressive animation about mucosal immunology by The Nature jornal

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Why You Are Still Alive - The Immune System Explained - YouTube

Every second of your life you are under attack. Bacteria, viruses, spores and more living stuff wants to enter your body and use its resources for itself. Th...
Alfredo Corell's insight:

A very simple video to have an overview of the immune system functions.... have a look

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New comic book explains to children about Primary Immunodeficiency

New comic book explains to children about Primary Immunodeficiency | Immunology for University Students | Scoop.it
New comic book explains to children about Primary Immunodeficiency
News-Medical.net
Explaining the effects and lifestyle impact of PID to a child can be very challenging for families, especially during times of anxiety and stress around diagnosis.
Alfredo Corell's insight:

the book will cost 14,45 USD


link to the book shop: http://shop.medikidz.com/products/medikidz-explain-primary-immunodeficiency

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a video overview on B lymphocytes (B cells)

Overview of B cells (B lymphocytes) and how they are activated and produce antibodies (#Immunology - Overview of B cells (B lymphocytes) and how they are activated and produce antibodies http://t.co/3WRtkI1Vq4...
Alfredo Corell's insight:

another video lecture from Khan academy,this time about the basic facts of B-cells

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