In a new paper in Tissue Engineering: Part C, Brown University researchers describe a relatively accessible method for making a working -- though not thinking -- sphere of central nervous system tissue.
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Maureen Bunger's insight:
This report evaluates trends in peer-reviewed publication keywords in the bio-printing space over the last several years highlighting increased activity in polymers, microfluidics, and imaging.
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"In vitro fabricated biological tissue would be a valuable tool to screen newly synthesized drugs or understand the tissue development process," explain Takuya Matsumoto and his colleagues in a recent report.
Bioengineers have created three-dimensional brain-like tissue that functions like and has structural features similar to tissue in the rat brain and that can be kept alive in the lab for more than two months. The tissue could provide a superior model for studying normal brain function as well as injury and disease, and could assist in the development of new treatments for brain dysfunction.
BIO 2014: Innovations in 3-D Tissue for Disease and Drug Discovery Xconomy Beginning with the discovery that mammalian cells could be isolated and kept alive outside of the body (around the turn of the 20th century), scientists have endeavored to...
Genetic Engineering News Top-Down/ Bottom-Up Approaches Converge on Bioficial Organs Genetic Engineering News To date, this approach has been used to accomplish relatively simple repairs in human patients.
Interest Grows in Animal Testing Alternatives New York Times (blog) With China planning to relax its requirement that cosmetics and other personal care products be tested on animals before they can go to market, a government training program in...
If academic discoveries turn out to be wrong, one drug company wants its money back.
That’s the tough-minded proposal floated today by the chief medical officer of Merck & Co., one of the world’s 10 largest drug companies, as a way to fix the “reproducibility crisis,” or how many, if not most, published scientific reports turn out to be incorrect.
Michael Rosenblatt, Merck’s executive vice president and chief medical officer, said bad results from academic labs caused pharmaceutical companies to waste millions and “threatens the entire biomedical research enterprise.”
The problem of irreproducible research has been getting attention thanks partly to the efforts of a group of psychologists who have been redoing scores of classic experiments and have found most don’t mean much.
Wrong results are also a problem for translational research—the kind drug companies do when they try to turn biological discoveries into actual medicines. Since companies don’t want their cash draining down ratholes, they’re among the few organizations that have taken the trouble to doublecheck results.
Softpedia News Researchers Build Bionic Livers to Test Drug Toxicity Softpedia News Hence the fact that scientists are now hard at work trying to come up with alternatives to experimenting on rats and the like.
Maureen Bunger's insight:
The term "bionic" seems not quite right. I would term these "smart" livers. Great work.
Genetic Engineering & Biotechnology News (press release) Liver's Unsung Stem Cells Uncovered Genetic Engineering & Biotechnology News (press release) The liver's ability to renew itself in response to injury is not just the stuff of legend (thanks...
Getting to the Core Genetic Engineering News We here report the setup of a 3D cell culture compatible high-content screening system and the identification of nine substances from two commercially available drug libraries that specifically target...
Genetic Engineering News Stem Cells Taught to Self-Organize Thanks to Lessons in Geometry Genetic Engineering News Patterning of embryonic stem cells in culture has been achieved by geometric confinement.
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