Physiology and Toxicology In vitro
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Physiology and Toxicology In vitro
Curated news on advancements in utility of in vitro-based technologies for drug and biomarker discovery, physiology, pharmacology, and toxicology.
Curated by Maureen Bunger
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New approach methodologies face huge barriers in supporting read-across

New approach methodologies face huge barriers in supporting read-across | Physiology and Toxicology In vitro | Scoop.it
Difficulties will deter registrants from using NAM in chemical dossiers, workshop finds
Maureen Bunger's insight:
Article sheds some light on reasons behind slow uptake of the chemical industry to using and applying in vitro and in silico approaches for assessing hazards.  
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An accessible approach to making a mini-brain - EurekAlert (press release)

An accessible approach to making a mini-brain - EurekAlert (press release) | Physiology and Toxicology In vitro | Scoop.it
In a new paper in Tissue Engineering: Part C, Brown University researchers describe a relatively accessible method for making a working -- though not thinking -- sphere of central nervous system tissue.
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Bioprinting Market Dynamics | Insight & Intelligence™ | GEN

Bioprinting Market Dynamics | Insight & Intelligence™ | GEN | Physiology and Toxicology In vitro | Scoop.it
Get the latest in biotechnology through daily news coverage as well as analysis, features, tutorials, webinars, podcasts, and blogs. Learn about the entire bioproduct life cycle from early-stage R&D, to applied research including omics, biomarkers, as well as diagnostics, to bioprocessing and commercialization.
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This report evaluates trends in peer-reviewed publication keywords in the bio-printing space over the last several years highlighting increased activity in polymers, microfluidics, and imaging.  

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Scientist: Most complete human brain model to date is a ‘brain changer’

Scientist: Most complete human brain model to date is a ‘brain changer’ | Physiology and Toxicology In vitro | Scoop.it
A nearly complete human brain in a dish has been developed that equals the brain maturity of a 5-week-old fetus
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Better Animal Testing Alternatives Are Coming to U.S. | Qmed

Qmed (formerly Medical Device Link) is the world's first completely prequalified supplier directory and news source for medical device OEMs. Find medical device suppliers and IVD suppliers who are FDA-registered, ISO 13485- and ISO 9001-certified.

Via Emblation Microwave
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Update on the state of the field and regulatory acceptance for non-animal medical device toxicity testing.  

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Studies on peptide-modified cultures demonstrate control over both tissue ... - Medical Xpress

Studies on peptide-modified cultures demonstrate control over both tissue ... - Medical Xpress | Physiology and Toxicology In vitro | Scoop.it
"In vitro fabricated biological tissue would be a valuable tool to screen newly synthesized drugs or understand the tissue development process," explain Takuya Matsumoto and his colleagues in a recent report.
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Certara Launches Its Simcyp In Vitro (Data) Analysis Toolkit to Improve Drug ... - Business Wire (press release)

Certara Launches Its Simcyp In Vitro (Data) Analysis Toolkit to Improve Drug ... - Business Wire (press release) | Physiology and Toxicology In vitro | Scoop.it
Certara today announced the launch of its Simcyp In Vitro (Data) Analysis (SIVA) Toolkit, version 1.0. The SIVA Toolkit is designed to enable the anal
Maureen Bunger's insight:

Long awaited.  Excited to see the use of this tool and applications to in vitro experiments

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GEN | Magazine Articles:3D Tissue Models Mirror Diseases in Depth

GEN | Magazine Articles:3D Tissue Models Mirror Diseases in Depth | Physiology and Toxicology In vitro | Scoop.it
Has “disease in a dish” come to seem not only flat, but also weary, stale, and unprofitable? Try “disease in a tissue”—a 3D in vitro assay approach.
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Mimetas Raises $5.2M to Support Organ-on-a-Chip Development - GenomeWeb

Mimetas Raises $5.2M to Support Organ-on-a-Chip Development - GenomeWeb | Physiology and Toxicology In vitro | Scoop.it
 
Maureen Bunger's insight:

Another funding grab for complex culture models.  

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Bioengineers create functional 3-D brain-like tissue

Bioengineers create functional 3-D brain-like tissue | Physiology and Toxicology In vitro | Scoop.it
Bioengineers have created three-dimensional brain-like tissue that functions like and has structural features similar to tissue in the rat brain and that can be kept alive in the lab for more than two months. The tissue could provide a superior model for studying normal brain function as well as injury and disease, and could assist in the development of new treatments for brain dysfunction.
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BIO 2014: Innovations in 3-D Tissue for Disease and Drug Discovery - Xconomy

BIO 2014: Innovations in 3-D Tissue for Disease and Drug Discovery - Xconomy | Physiology and Toxicology In vitro | Scoop.it
BIO 2014: Innovations in 3-D Tissue for Disease and Drug Discovery Xconomy Beginning with the discovery that mammalian cells could be isolated and kept alive outside of the body (around the turn of the 20th century), scientists have endeavored to...
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Top-Down/ Bottom-Up Approaches Converge on Bioficial Organs - Genetic Engineering News

Top-Down/ Bottom-Up Approaches Converge on Bioficial Organs - Genetic Engineering News | Physiology and Toxicology In vitro | Scoop.it
Genetic Engineering News
Top-Down/ Bottom-Up Approaches Converge on Bioficial Organs
Genetic Engineering News
To date, this approach has been used to accomplish relatively simple repairs in human patients.
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Interest Grows in Animal Testing Alternatives - New York Times (blog)

Interest Grows in Animal Testing Alternatives New York Times (blog) With China planning to relax its requirement that cosmetics and other personal care products be tested on animals before they can go to market, a government training program in...
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Merck Wants Its Money Back if University Research Is Wrong

Merck Wants Its Money Back if University Research Is Wrong | Physiology and Toxicology In vitro | Scoop.it
If academic discoveries turn out to be wrong, one drug company wants its money back.

That’s the tough-minded proposal floated today by the chief medical officer of Merck & Co., one of the world’s 10 largest drug companies, as a way to fix the “reproducibility crisis,” or how many, if not most, published scientific reports turn out to be incorrect.

Michael Rosenblatt, Merck’s executive vice president and chief medical officer, said bad results from academic labs caused pharmaceutical companies to waste millions and “threatens the entire biomedical research enterprise.”

The problem of irreproducible research has been getting attention thanks partly to the efforts of a group of psychologists who have been redoing scores of classic experiments and have found most don’t mean much.

Wrong results are also a problem for translational research—the kind drug companies do when they try to turn biological discoveries into actual medicines. Since companies don’t want their cash draining down ratholes, they’re among the few organizations that have taken the trouble to doublecheck results.

Via Dominique Blanchard, Manuel GEA
Maureen Bunger's insight:
Interesting approach.  The contrary to this would be why not share profits with universities when pharma companies do succeed at translating work produced at universities.  
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Guest Post: Role of the Physio-chemical Environment in Steering Stem Cell Differentiation

Guest Post: Role of the Physio-chemical Environment in Steering Stem Cell Differentiation | Physiology and Toxicology In vitro | Scoop.it
This guest post by JM Wilkinson and Kelly S. Davidge of Kirkstall Ltd. highlights an emerging technology, organotypic cell cultures.
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Johns Hopkins' Study Identifies Malaria Parasite at Beginning Stages; Research May Be Key in Discovering a Vaccine - Triangle Research Labs

Johns Hopkins' Study Identifies Malaria Parasite at Beginning Stages; Research May Be Key in Discovering a Vaccine - Triangle Research Labs | Physiology and Toxicology In vitro | Scoop.it
In a June issue of PLOS ONE, researchers from the Bloomberg School of Public Health at Johns Hopkins University (JHSPH) released the results of a study des
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Great use of primary hepatocytes for in vitro infectious disease research 

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3D Printing of Airway Tissue Advances Research Capabilities

3D Printing of Airway Tissue Advances Research Capabilities | Physiology and Toxicology In vitro | Scoop.it
A single 3D-printer head prints complex tissue with a customized phenotype for pharmaceutical testing.
Maureen Bunger's insight:

An emerging and potentially less expensive method for 3D printing tissues.  This is definitely a company to watch..

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Researchers Build Bionic Livers to Test Drug Toxicity - Softpedia News

Softpedia News
Researchers Build Bionic Livers to Test Drug Toxicity
Softpedia News
Hence the fact that scientists are now hard at work trying to come up with alternatives to experimenting on rats and the like.
Maureen Bunger's insight:

The term "bionic" seems not quite right.  I would term these "smart" livers.  Great work. 

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Liver's Unsung Stem Cells Uncovered - Genetic Engineering & Biotechnology News (press release)

Genetic Engineering & Biotechnology News (press release) Liver's Unsung Stem Cells Uncovered Genetic Engineering & Biotechnology News (press release) The liver's ability to renew itself in response to injury is not just the stuff of legend (thanks...
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GEN | Magazine Articles:More True-to-Life Cell-Based Assays

GEN | Magazine Articles:More True-to-Life Cell-Based Assays | Physiology and Toxicology In vitro | Scoop.it
To keep your cells “in character,” give them the right motivation (reprogramming), direction (transfection payload), and staging (culture conditions).
Maureen Bunger's insight:

This article expands on new cell based assays that are supporting therapeutic antibody toxicity studies.  This is an area to keep an eye on.

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Molecular beacon–enabled purification of living cells by targeting cell type ... - Nature.com

Molecular beacon–enabled purification of living cells by targeting cell type ... - Nature.com | Physiology and Toxicology In vitro | Scoop.it
Molecular beacon–enabled purification of living cells by targeting cell type ...
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I am curious to know how this works to separate cell types isolated from adult human tissues.  

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GEN | Magazine Articles:3D Tissue Models Mirror Diseases in Depth

GEN | Magazine Articles:3D Tissue Models Mirror Diseases in Depth | Physiology and Toxicology In vitro | Scoop.it
Has “disease in a dish” come to seem not only flat, but also weary, stale, and unprofitable? Try “disease in a tissue”—a 3D in vitro assay approach.
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Getting to the Core - Genetic Engineering News

Getting to the Core - Genetic Engineering News | Physiology and Toxicology In vitro | Scoop.it
Getting to the Core Genetic Engineering News We here report the setup of a 3D cell culture compatible high-content screening system and the identification of nine substances from two commercially available drug libraries that specifically target...
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Stem Cells Taught to Self-Organize Thanks to Lessons in Geometry - Genetic Engineering News

Stem Cells Taught to Self-Organize Thanks to Lessons in Geometry - Genetic Engineering News | Physiology and Toxicology In vitro | Scoop.it
Genetic Engineering News
Stem Cells Taught to Self-Organize Thanks to Lessons in Geometry
Genetic Engineering News
Patterning of embryonic stem cells in culture has been achieved by geometric confinement.
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Hepregen Launches Human HepatoMune(TM) Assay Kit to Evaluate ... - EIN News (press release)

Hepregen Launches Human HepatoMune(TM) Assay Kit to Evaluate ... - EIN News (press release) | Physiology and Toxicology In vitro | Scoop.it
Hepregen Launches Human HepatoMune(TM) Assay Kit to Evaluate ...
EIN News (press release)
Dr.
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