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Quid de l'immunologie en stage ? | Immuno On News

Quid de l'immunologie en stage ? | Immuno On News | ImmunoUPS | Scoop.it
Maintenant pour ce qui est de faire un lien avec l'immunologie, je vous avouerais que je n'ai pas été spécialement inspirée par le sujet… Mais qu'à cela ne tienne, étant moi-même en stage actuellement, et de surcroît dans le ...
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ImmunoUPS
Le journal de l'enseignement d'immunologie de Licence à l'Université Paul Sabatier de Toulouse
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Rescooped by Denis Hudrisier from Immunology, vaccine & infectious diseases
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Frontiers | The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design | Vaccines and Molecular Therapeutics

Frontiers | The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design | Vaccines and Molecular Therapeutics | ImmunoUPS | Scoop.it
The task of epitope discovery and vaccine design is increasingly reliant on bioinformatics analytic tools and access to depositories of curated data relevant to immune reactions and specific pathogens. The Immune Epitope Database and Analysis Resource (IEDB) was indeed created to assist biomedical researchers in the development of new vaccines, diagnostics, and therapeutics. The Analysis Resource is freely available to all researchers and provides access to a variety of epitope analysis and prediction tools. The tools include validated and benchmarked methods to predict MHC class I and class II binding. The predictions from these tools can be combined with tools predicting antigen processing, TCR recognition, and B cell epitope prediction. In addition the resource contains a variety of secondary analysis tools that allow the researcher to calculate epitope conservation, population coverage, and other relevant analytic variables. The researcher involved in vaccine design and epitope discovery will also be interested in accessing experimental published data, relevant to the specific indication of interest. The database component of the IEDB contains a vast amount of experimentally derived epitope data that can be queried through a flexible user interface. The IEDB is linked to other pathogen-specific and immunological database resources.
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How does the immune system know friend from foe in gut bacteria?

How does the immune system know friend from foe in gut bacteria? | ImmunoUPS | Scoop.it
New study shows how immune surveillance cells are trained to prevent attack on friendly gut bacteria even though they are clearly not part of host tissue.
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Cancer immunotherapy: Revived T cells still need fuel

Cancer immunotherapy: Revived T cells still need fuel | ImmunoUPS | Scoop.it
Anti-cancer drugs blocking the PD-1 pathway - known as checkpoint inhibitors - are now FDA-approved for melanoma, lung cancer and several other types of cancer. These drugs are often described as "releasing the brakes" o
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Frontiers | Editorial: Microbial and Environmental Factors in Autoimmune and Inflammatory Diseases | Microbial Immunology

Frontiers | Editorial: Microbial and Environmental Factors in Autoimmune and Inflammatory Diseases | Microbial Immunology | ImmunoUPS | Scoop.it
Editorial: Microbial and Environmental Factors in Autoimmune and Inflammatory Diseases
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Game Review- The Blood Typing Game

Game Review- The Blood Typing Game | ImmunoUPS | Scoop.it
The Blood Typing Game was produced by Nobel Media with the aim of communicating Nobel achievements to younger audiences. The game was the 2012 winner of the Best Game at the Swedish Learning Awards  and was designed for teenagers aged 14-17. The company also develops other broadcast, digital media, events and published content. Based upon research that…
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Frontiers | Editorial: T-Cell Migration in Health and Disease | T Cell Biology

Frontiers | Editorial: T-Cell Migration in Health and Disease | T Cell Biology | ImmunoUPS | Scoop.it
Editorial: T-Cell Migration in Health and Disease
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3D printing of macromolecular models

The video summarizes our attempts to 3-D print macromolecular models for educational purpose
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Kawakami model demo

Kawakami model demo | ImmunoUPS | Scoop.it
Users can feel how a part of the heavy chain of the antibody gets into the pocket of the receptor, and clamps the receptor in an inactive conformational state.This model can be separated into three parts to access the ligand-binding site.
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Frontiers | High Endothelial Venules and Other Blood Vessels: Critical Regulators of Lymphoid Organ Development and Function | Inflammation

Frontiers | High Endothelial Venules and Other Blood Vessels: Critical Regulators of Lymphoid Organ Development and Function | Inflammation | ImmunoUPS | Scoop.it
The blood vasculature regulates both the development and function of secondary lymphoid organs by providing a portal for entry of haemopoietic cells. During the development of lymphoid organs in the embryo, blood vessels deliver lymphoid tissue inducer cells which initiate and sustain the development of lymphoid tissues. In adults, the blood vessels are structurally distinct from those in other organs due to the requirement for high levels of lymphocyte recruitment under non-inflammatory conditions. In lymph nodes and Peyer’s patches, high endothelial venules (HEV) especially adapted for lymphocyte trafficking form a spatially organised network of blood vessels which controls the both the type of lymphocyte and the site of entry into lymphoid tissues. Uniquely, HEV express vascular addressins which regulate lymphocyte entry into lymphoid organs and are, therefore, critical to the function of lymphoid organs. Recent studies have demonstrated important roles for CD11c+ dendritic cells in the induction, as well as the maintenance, of vascular addressin expression and, therefore, the function of HEV. Tertiary lymphoid organs (TLOs) are HEV containing, lymph node-like structures that develop inside organised tissues undergoing chronic immune-mediated inflammation. In autoimmune lesions, the development of TLOs is thought to exacerbate disease. In cancerous tissues, the development of HEV and TLOs is associated with improved patient outcomes in several cancers. Therefore, it is important to understand what drives the development of HEV and TLOs and how these structures contribute to pathology. In several human diseases and experimental animal models of chronic inflammation, there are some similarities between the development and function of HEVs in LN and TLOs. This review will summarise current knowledge of how haemopoietic cells with lymphoid tissue-inducing, HEV-inducing and HEV-maintaining properties are recruited from the bloodstream to induce the development and control the function of lymphoid organs.
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A History of Immunology in 60 Objects | British Society for Immunology

A History of Immunology in 60 Objects | British Society for Immunology | ImmunoUPS | Scoop.it
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Development of conventional dendritic cells: from common bone marrow progenitors to multiple subsets in peripheral tissues : Mucosal Immunology

Our review of DC ontogeny/subsets is now out in Mucosal Immunology. Hope you like it! #DCs #firstlastauthorpaper https://t.co/v244sUhrdR
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Denis Hudrisier's curator insight, March 17, 3:41 PM
A review on dendritic cell differentiation
Rescooped by Denis Hudrisier from Immunology, vaccine & infectious diseases
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Immunology: Live and let live - Scienmag: Latest Science and Health News

Immunology: Live and let live - Scienmag: Latest Science and Health News | ImmunoUPS | Scoop.it
In order to maintain the microflora in the gut, the immune system must be taught to tolerate foreign bacteria. Ludwig-Maximilians-Universitaet (LMU) in Munich researches have now shown how immune surv..
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Oxygen can impair immune response in mice

Oxygen can impair immune response in mice | ImmunoUPS | Scoop.it
Researchers have identified a mechanism in mice by which anticancer immune responses are inhibited within the lungs, a common site of metastasis for many cancers.
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Rescooped by Denis Hudrisier from Immunology, vaccine & infectious diseases
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The history of vaccination

The history of vaccination | ImmunoUPS | Scoop.it
Long before anybody understood anything about vaccination, it was noticed that, if people recovered from a disease, they didn’t get that particular disease again.
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Denis Hudrisier's curator insight, March 5, 8:03 AM
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Immunologie, inflammation, infectiologie et microbiologie (I3M) - Dossiers d'information

Nous mettons à votre disposition des dossiers d’information en santé et en recherche sur la thématique Immunologie, inflammation, infectiologie et microbiologie.
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Human immunity against EBV—lessons from the clinic

Human immunity against EBV—lessons from the clinic | ImmunoUPS | Scoop.it
The mammalian immune system has evolved over many millennia to be best equipped to protect the host from pathogen infection. In many cases, host and pathogen have coevolved, each acquiring sophisticated ways of inducing or protecting from disease. Epstein-Barr virus (EBV) is a human herpes virus that infects >90% of individuals. Despite its ubiquity, infection by EBV is often subclinical; this invariably reflects the necessity of the virus to preserve its host, balanced with sophisticated host immune mechanisms that maintain viral latency. However, EBV infection can result in various, and often fatal, clinical sequelae, including fulminant infectious mononucleosis, hemophagocytic lymphohistiocytosis, lymphoproliferative disease, organomegaly, and/or malignancy. Such clinical outcomes are typically observed in immunosuppressed individuals, with the most extreme cases being Mendelian primary immunodeficiencies (PIDs). Although these conditions are rare, they have provided critical insight into the cellular, biochemical, and molecular requirements for robust and long-lasting immunity against EBV infection. Here, we review the virology of EBV, mechanisms underlying disease pathogenesis in PIDs, and developments in immune cell–mediated therapy to treat disorders associated with or induced by EBV infection.
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ImmunoUPS's Thingiverse Profile

ImmunoUPS's Thingiverse Profile | ImmunoUPS | Scoop.it
Thingiverse is a universe of things. Download our files and build them with your lasercutter, 3D printer, or CNC.
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3D Printing of a macromolecule

This movie illustrates the different steps of my first attempt to 3D print a macromolecule.
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Alfredo Corell's curator insight, October 12, 2013 2:18 PM

Denis tried to print a 3D model of HLA-class I molecule.

 

Good luck for the next time!!! and keep showing us

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Immunothérapie : vers un traitement universel du cancer

Immunothérapie : vers un traitement universel du cancer | ImmunoUPS | Scoop.it
En quoi consiste l’immunothérapie ? D’où vient cette technique ? Pourquoi dit-on que cette méthode est “révolutionnaire”, qu’elle propose un changement radical de point de vue dans la manière de considérer le cancer ?
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Rescooped by Denis Hudrisier from Immunology, vaccine & infectious diseases
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Haematopoietic stem cells: past, present and future

Haematopoietic stem cells: past, present and future | ImmunoUPS | Scoop.it
The discovery and characterisation of haematopoietic stem cells has required decades of research.
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Denis Hudrisier's curator insight, February 7, 3:30 PM
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Frontiers | Neutrophil extracellular traps and its implications in inflammation: an overview | Inflammation

Frontiers | Neutrophil extracellular traps and its implications in inflammation: an overview | Inflammation | ImmunoUPS | Scoop.it
In addition to physical barriers, neutrophils are considered a part of the first line of immune defense. They can be found in the bloodstream, with a lifespan of 6-8 hours, and in tissue, where they can last up to seven days. The mechanisms that neutrophils utilize for host defense are phagocytosis, degranulation, cytokine production and, the most recently described, neutrophil extracellular trap (NET) production. NETs are DNA structures released due to chromatin decondensation and spreading, and they thus occupy 3-5 times the volume of condensed chromatin. Several proteins adhere to NETs, including histones and over 30 components of primary and secondary granules, among them components with bactericidal activity such as elastase, myeloperoxidase, cathepsin G, lactoferrin, pentraxin 3, gelatinase, proteinase 3, LL-37, peptidoglycan-binding proteins and others with bactericidal activity able to destroy virulence factors. Three models for NETosis are known to date. a) Suicidal NETosis, with a duration of 2-4 hours, is the best described model. b) In vital NETosis with nuclear DNA release, neutrophils release NETs without exhibiting loss of nuclear or plasma membrane within 5-60 minutes, and it is independent of ROS and the Raf/MERK/ERK pathway. c). The final type is Vital NETosis with release of mitochondrial DNA that is dependent on ROS and produced after stimuli with GM-CSF and LPS. Recent research has revealed neutrophils as more sophisticated immune cells that are able to precisely regulate their granular enzymes release by ion fluxes and can release immunomodulatory cytokines and chemokines that interact with various components of the immune system. Therefore, they can play a key role in autoimmunity and in autoinflammatory and metabolic diseases. In this review, we intend to show the two roles played by neutrophils: as a first line of defense against microorganisms and as a contributor to the pathogenesis of various illnesses, such as autoimmune, autoinflammatory and metabolic diseases.
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