Most pathogens access the body through the mucosal membranes. Therefore, effective vaccines that protect at these sites are much needed. However, despite early success with the live attenuated oral polio vaccine over 50 years ago, only a few new mucosal vaccines have been subsequently launched. This is partly due to problems with developing safe and effective mucosal adjuvants. In the past decade, however, the successful development of live attenuated mucosal vaccines against influenza virus and rotavirus infections has boosted interest in this field, and great expectations for new mucosal vaccines lie ahead. Here, I discuss the expanding knowledge and strategies used in the development of mucosal vaccines
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Immunopathology & Immunotherapy
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Latest advances in immunopathology diagnosis and treatment
Curated by
Alfredo Corell
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Hans Ochs de la Escuela de Medicina de la Universidad de Washington, en Seattle, describió un cuadro clínico genético, en cinco lactantes de pocos días de edad, que se caracterizaba por afectar diversos órganos y sistemas en forma devastadora. 
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It’s new, it’s updated! -- The ORGENTEC Autoimmunity Guide 1.1, a mobile healthcare app. You’ll find web links to the app's download, screenshots, QR code.
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ISG15 is an interferon (IFN)-α/β-inducible, ubiquitin-like intracellular protein. Its conjugation to various proteins (ISGylation) contributes to antiviral immunity in mice. We describe human patients with inherited ISG15 deficiency and mycobacterial, but not viral diseases. The lack of intracellular ISG15 production and protein ISGylation was not associated with cellular susceptibility to any viruses tested, consistent with the lack of viral diseases in these patients. By contrast, the lack of mycobacterium-induced ISG15 secretion by leukocytes—granulocytes in particular—reduced the production of IFN-γ by lymphocytes, including natural killer cells, probably accounting for the enhanced susceptibility to mycobacterial disease. This experiment of nature shows that human ISGylation is largely redundant for antiviral immunity, but that ISG15 plays an essential role as an IFN-γ–inducing secreted molecule for optimal antimycobacterial immunity.
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Correlagen Diagnostics is a CLIA-certified laboratory providing full-gene sequencing and careful variant analysis with rapid turn-around times, as well as information on genetic diseases and the benefits of genetic testing.
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Stroke, traumatic brain injury (TBI), and spinal cord injury (SCI) cause irreversible damage to the nervous system. Via Gilbert C FAURE
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immunodeficiency database... De un modo muy intuitivo ayuda en el diagnóstico de las Inmunodeficiencias Primarias y remite a laboratorios de referencia (principalmente americanos) para su diagnóstico.
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From
www
Vaccines, as with all products regulated by FDA, undergo a rigorous review of laboratory and clinical data to ensure the safety, efficacy, purity and potency of these products. Vaccines approved for marketing may also be required to undergo additional studies to further evaluate the vaccine and often to address specific questions about the vaccine's safety, effectiveness or possible side effects.
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For people with autoimmune diseases, getting a proper diagnosis can be one of the most difficult challenges they face. The American Autoimmune Related Diseases Association (AARDA) conducted a survey of autoimmune disease patients and found that the majority of those eventually diagnosed with serious autoimmune diseases had significant problems in getting a correct diagnosis. Many were incorrectly diagnosed with a variety of conditions that have no specific blood test to confirm the diagnosis. Many were told that their symptoms were in their heads or that they were under too much stress. Further, the survey revealed that 45 percent of autoimmune disease patients had been labeled hypochondriacs in the earliest stages of their illnesses.
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Under this exclusive agreement, Roche’s Pharma Research and Early Development (pRED) organization and AREVA Med will assess the efficacy of combining Roche-engineered antibodies with AREVA Med’s radionuclide, Lead-212, a compound that shows promise in treating some types of cancer. Roche retains exclusive rights to commercialise the cancer radio-immunotherapy after clinical development. The alliance combines Roche’s expertise in engineered antibodies with AREVA Med’s proficiency in developing radioactive isotopes.
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Melbourne scientists say they have made a major breakthrough in the search for an alternative to antibiotics. Proteína viral mucho mas potente que antibióticos actuales. Puede tener gran impacto sanitario en la lucha anti-bacteriana, pues cada vez hay mas patógenos multo resistentes.
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Allergy, Asthma and Immunology News Updated Daily by Board-certified Allergists and Assistant Professors at University of Chicago and NSU
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memory loss, loss of memory, alzheimer’s memory loss, normal memory loss, alzheimer memory, alzheimers memory, dementia memory, dementia memory loss, memory loss causes, short term memory loss, short term memory loss causes, what can cause memory...
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Activating the immune system for therapeutic benefit in cancer has long been a goal in immunology and oncology. After decades of disappointment, the tide has finally changed due to the success of recent proof-of-concept clinical trials.
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IDbases are locus-specific databases for immunodeficiency-causing mutations. They establish database for every immunodeficiency or provide links to those maintained elsewhere.
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Cancer Stem Cells Can Fuel Tumor Growth - ScienceNOW... Efectivamente, se lleva mucho tiempo sospechando de la existencia de células madre tumorales responsables del re-crecimiento de algunos tumores. La hipótesis ahora ya se ha demostrado.
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The Blog on Autoimmunity, Autoimmune Diseases, and Autoimmune Diagnostics by Orgentec (a reactive provider) but still a very good autoimmunity blog.
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Arthritis & Rheumatism is an official monthly journal of the American College of Rheumatology, and it contains peer-reviewed articles on diagnosis, treatment, laboratory research, and socioeconomic issues related to all forms of rheumatic disease.
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From
pulmccm
Hypersensitivity pneumonitis (HP) is a lung disease caused by inhaling an antigen to which a person has already been sensitized. HP may or may not also have systemic manifestations such as weight loss, myalgias and ...
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