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2 nuevas entregas de inmunopíldoras, para seguir con la inmunología a pequeñas dosis

2 nuevas entregas de inmunopíldoras, para seguir con la inmunología a pequeñas dosis | Immunopathology & Immunotherapy | Scoop.it
Píldoras de conocimiento de la asignatura "INMUNOLOGÍA HUMANA" Profesor: Alfredo Corell Almuzara.
Alfredo Corell's insight:
Alfredo Corell's insight:

Espero noticias, críticas sugerencias.

 

Este proyecto no tiene sentido si no involucra a estudiantes y otros profesores... y hagamos de la enseñanza y divulgación libre de la Inmunología una de nuestras metas.

 

OS ESPERO

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Alfredo Corell's curator insight, October 4, 2013 2:49 PM

Espero noticias, críticas sugerencias.

 

Este proyecto no tiene sentido si no involucra a estudiantes y otros profesores... y hagamos de la enseñanza y divulgación libre de la Inmunología una de nuestras metas.

 

OS ESPERO

Immunopathology & Immunotherapy
Latest advances in immunopathology diagnosis and treatment
Curated by Alfredo Corell
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KEY ADVANCES IN MEDICINE by Nature Reviews journals

KEY ADVANCES IN MEDICINE by Nature Reviews journals | Immunopathology & Immunotherapy | Scoop.it
Alfredo Corell's insight:

Including Immunology (pathology and therapies) topics:


  • 29 TYpE 2 DiAbETES MElliTUS | A central role of the gut in glucose homeostasis; Geltrude Mingrone and Lidia Castagneto-Gissey
  • 30 METAbOliSM | The gut microbiota manages host metabolism; Patrice D. Cani
  • 35 hEpATiTiS C | HCV causes systemic disorders that can be cured; Francesco Negro
  • 37 fAECAl MiCRObiOTA TRANSplANTATiON | Developing human gut microbiota as a class of therapeutics; Alexander Khoruts
  • 38 COEliAC DiSEASE | New insights in dietary-gluten-induced autoimmunity; Katri Kaukinen and Markku Mäki
  • 42 ibD | Enriching the therapeutic armamentarium for IBD;  Silvio Danese and Laurent Peyrin-Biroulet
  • 51 TRANSplANTATiON iMMUNOlOgY | New approaches to diagnosis of rejection; Nicholas A. Zwang and Laurence A. Turka
  • 65 MUlTiplE SClEROSiS | Novel triggers, treatment targets and brain atrophy measures; Xavier Montalban and Mar Tintoré
  • 71 SYSTEMiC lUpUS ERYThEMATOSUS | Taking a closer look at biologic therapy for SLE; David A. Isenberg and Anisur Rahman
  • 72 EpigENETiCS | DNA methylation and miRNA—key roles in systemic autoimmunity; Bruce C. Richardson and Dipak R. Patel
  • 74 RhEUMATOiD ARThRiTiS | Translational medicine in RA—time for change; Pierre Miossec


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Chimeric Antigen Receptor (CAR) T-Cell Immunotherapy for Leukemia and beyond

Chimeric Antigen Receptor (CAR) T-Cell Immunotherapy for Leukemia and beyond | Immunopathology & Immunotherapy | Scoop.it

OncLive
Chimeric Antigen Receptor (CAR) T-Cell Immunotherapy for Leukemia and beyond


Sagar B. Kudchodkar, PhD, and Marcela V. Maus, MD, PhD
Published Online: Friday, August 29, 2014
Alfredo Corell's insight:
Abstract

Chimeric antigen receptor (CAR) T-cell therapy is an immunotherapy in which the patient’s own T cells are isolated in the laboratory, redirected with a synthetic receptor to recognize a particular antigen or protein, and reinfused into the patient. Clinical trials of CAR T cells directed to the CD19 antigen have shown impressive results in advanced B-cell malignancies at multiple academic centers over the last 3 years. We describe the technology of CAR T cells, findings at 5 academic centers, and toxicities associated with CAR T cell-treatment and their management. Although CAR T cells for B-cell malignancies are the most advanced in terms of clinical testing, CAR T cells are the basis of a new platform technology that is poised to be expanded to other hematologic and nonhematologic malignancies, especially as new targets are identified and manufacturing processes are streamlined.
  - See more at: http://www.onclive.com/publications/contemporary-oncology/2014/August-2014/Chimeric-Antigen-Receptor-CAR-T-Cell-Immunotherapy-for-Leukemia-and-Beyond?__scoop_post=3c482f60-3053-11e4-b39b-842b2b775358&__scoop_topic=827181#__scoop_post=3c482f60-3053-11e4-b39b-842b2b775358&__scoop_topic=827181

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The prevalence of thyroid autoimmunity in patients with urticaria: a systematic review and meta-analysis

The prevalence of thyroid autoimmunity in patients with urticaria: a systematic review and meta-analysis | Immunopathology & Immunotherapy | Scoop.it
The prevalence of thyroid autoimmunity in patients with #urticaria: a systematic review and meta-analysis. http://t.co/RLgLl7jRna
Alfredo Corell's insight:
ENDOCRINE, July 27th, 2014


The meta-analysis results showed that the prevalence of positive thyroid autoantibodies in patients with urticaria was higher than non-urticaria controls (TgAb: OR 6.55, 95 % CI 3.19–13.42, P < 0.00001, I 2 = 67 %; TmAb: OR 4.51, 95 % CI 2.78–7.33, P < 0.00001, I 2 = 47 %; TPOAb: OR 8.71, 95 % CI 6.89–11.01,P < 0.00001, I 2 = 20 %, respectively). The results of this meta-analysis suggested that patients with urticaria were more likely to have thyroid autoimmunity than the control groups.

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With So Many Terrific New Drugs For Chronic Lymphocytic Leukemia, Why Worry?

With So Many Terrific New Drugs For Chronic Lymphocytic Leukemia, Why Worry? | Immunopathology & Immunotherapy | Scoop.it
Forbes
With So Many Terrific New Drugs For Chronic Lymphocytic Leukemia, Why Worry?
Forbes
It's hard to keep track of practice-changing drugs for chronic lymphocytic leukemia (CLL).
Alfredo Corell's insight:

It’s hard to keep track of practice-changing drugs for chronic lymphocytic leukemia (CLL). Since last November, the FDA has approved three new agents and expanded indications for another to treat this indolent cancer of white blood cells. As someone who spent over ten years studying this form of leukemia, I’m thrilled by the science behind these targeted medicines, and by the potentially life-saving new options for people with this condition.



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Newborn Screening for Severe Combined Immunodeficiency

Newborn Screening for Severe Combined Immunodeficiency | Immunopathology & Immunotherapy | Scoop.it
Opinion from JAMA — Newborn Screening for Severe Combined Immunodeficiency — Progress and Challenges (RT @JAMA_current: #Newborn Screening for Severe Combined #Immunodeficiency http://t.co/opTP3izQBP...
Alfredo Corell's insight:

September 30, 2014, marks the 50th anniversary of the Children’s Bureau recommendation for “the screening of all newborn infants for PKU [phenylketonuria] on a routine basis.”1 By 1968, 43 states had made screening for PKU mandatory.1 As a result of technological advances, newborn screening in the United States has been extended to as many as 37 core conditions in some states.2 As reported by Kwan and colleagues3 in this issue of JAMA, newborn screening for severe combined immunodeficiency (SCID) has been undertaken in 23 states and the Navajo Nation, beginning in Wisconsin in January 2008. The authors present data on more than 3 million newborns screened with a T-cell receptor excision circle (TREC) assay followed by confirmatory flow cytometry from 11 of these programs (10 states and the Navajo Nation).

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Are complement deficiencies really rare? Overview on prevalence,
clinical importance and modern diagnostic approach

Are complement deficiencies really rare? Overview on prevalence,<br/>clinical importance and modern diagnostic approach | Immunopathology & Immunotherapy | Scoop.it
http://www.bragid.org.br/_download/artigos/are_complement_def_rare.pdf
Alfredo Corell's insight:

Complement deficiencies comprise between 1 and 10% of all primary immunodeficiencies (PIDs) accord-ing to national and supranational registries. They are still considered rare and even of less clinicalimportance. This not only reflects (as in all PIDs) a great lack of awareness among clinicians and gen-eral practitioners but is also due to the fact that only few centers worldwide provide a comprehensivelaboratory complement analysis. To enable early identification, our aim is to present warning signs forcomplement deficiencies and recommendations for diagnostic approach. The genetic deficiency of anyearly component of the classical pathway (C1q, C1r/s, C2, C4) is often associated with autoimmune dis-eases whereas individuals, deficient of properdin or of the terminal pathway components (C5 to C9), arehighly susceptible to meningococcal disease. Deficiency of C1 Inhibitor (hereditary angioedema, HAE)results in episodic angioedema, which in a considerable number of patients with identical symptomsalso occurs in factor XII mutations. New clinical entities are now reported indicating disease associa-tion with partial complement defects or even certain polymorphisms (factor H, MBL, MASPs). Mutationsaffecting the regulators factor H, factor I, or CD46 and of C3 and factor B leading to severe dysregulationof the alternative pathway have been associated with renal disorders, such as atypical hemolytic uremicsyndrome (aHUS) and – less frequent – with membranoproliferative glomerulonephritis (MPGN). Wesuggest a multi-stage diagnostic protocol starting based on the recognition of so called warning signswhich should aid pediatricians and adult physicians in a timely identification followed by a step-wisecomplement analysis to characterize the defect at functional, protein and molecular level.© 2014 Published by Elsevier 

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ImmunizeCA App - Immunize Canada

ImmunizeCA App - Immunize Canada | Immunopathology & Immunotherapy | Scoop.it
The Canadian Public Health Association, Immunize Canada and the Ottawa Hospital Research Institute collaborated to develop an app for mobile devices that will help Canadians keep track of their vaccinations.
Alfredo Corell's insight:

The future is now

FOR CANADIANS:

Keeping track of your children vaccinations!!!

Provide Canadians with the ability to:

  • Easily record and store vaccine information
  • Access vaccination schedules
  • Manage vaccination appointments for the entire family
  • Access evidence-based and expert-reviewed information about recommended and routine vaccinations for children, adults and travellers
  • Receive alerts about disease outbreaks in their area
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Descubiertas unas ‘células escudo’ que protegen los tumores

Descubiertas unas ‘células escudo’ que protegen los tumores | Immunopathology & Immunotherapy | Scoop.it
Su desactivación facilita los tratamientos inmunológicos contra el cáncer
Alfredo Corell's insight:

La inmunoterapia contra el cáncer —enseñar al sistema de defensa del organismo a atacar a las células tumorales— se presenta como la nueva revolución en oncología. Pero no es fácil. La revista Nature Medicine ha publicado un artículo en el que el proceso no se centra directamente en combatir las células tumorales, sino en otras que pululan a su alrededor y que, de alguna manera, hacen de escudo.


artículo en Nature Medicine: http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3560.html

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Diagnostic criteria in Autoimmune diseases - Autoimmunity Reviews

Diagnostic criteria in Autoimmune diseases - Autoimmunity Reviews | Immunopathology & Immunotherapy | Scoop.it
Special Issues in Autoimmunity Reviews and Journal of Autoimmunity

Autoimmunity Reviews and the Journal of Autoimmunity both feature a special...
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Special Issues in Autoimmunity Reviews and Journal of Autoimmunity

Autoimmunity Reviews and the Journal of Autoimmunity both feature a special issue on diagnostic criteria in autoimmune diseases, to coincide with the 9th International Congress on Autoimmunity in Nice, France, in March 2014.

Here you can read both issues – free access until June 2014.

Diagnostic Criteria in Autoimmune Diseases
Autoimmunity Reviews, Volume 13, Issues 4–5, Pages 331-594 (April–May 2014)
Edited by Yehuda Shoenfeld and M. Eric Gershwin

Diagnostic Criteria in Autoimmune Diseases
Journal of Autoimmunity, Volumes 48–49, Pages 1-152 (February–March 2014)
Edited by M. Eric Gershwin and Yehuda Shoenfeld

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A major effort to understand a not so rare immunodeficiency

A major effort to understand a not so rare immunodeficiency | Immunopathology & Immunotherapy | Scoop.it
A major effort to understand a not so rare immunodeficiency
Alfredo Corell's insight:

Common variable immunodeficiency (CVID) is the most frequent of the large group of primary (inborn) immunodeficiencies. As the name indicates, the disease is highly variable. While the underlying defect is a lack of antibodies in the blood, patients develop a wide range of symptoms, from respiratory infections to autoimmune disorders and neoplasms, and treating such patients poses many challenges. Notably, the replacement of antibodies (known as immunoglobulin (Ig) replacement) alone does not seem to solve all symptoms; studies in the past have tried to group patients into different phenotypes, also to help identify suitable treatment, but our understanding of the disease remains limited.

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Molecular Mimicry and Autoimmune Disease

Molecular Mimicry and Autoimmune Disease | Immunopathology & Immunotherapy | Scoop.it

Those in self-nonself camp, the more dominant of the two camps, would see a threat in the molecular mimics and link those to autoimmunity. Whereas the danger or damage theory proponents would argue that the presence or absence of molecular mimicry by itself means nothing unless the mimicked code evokes damage. Data can be found supporting either argument. 

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Common Variable Immune Deficiency (CVID) | atypically found in an adult

Common Variable Immune Deficiency (CVID) | atypically found in an adult | Immunopathology & Immunotherapy | Scoop.it
Find information on Common Variable Immune Deficiency (CVID), including definition, diagnosis, treatment, and expectations for patients.
Alfredo Corell's insight:

An atypically adult with CVID recently published on "The Lancet"


The Lancet, Volume 383, Issue 9920, Page 926, 8 March 2014
doi:10.1016/S0140-6736(14)60415-3Cite or Link Using DOI
Common variable immunodeficiency syndrome in an adult
Dr Laura S Lourdes MD a Karen C Daily DO b
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A Cure for Chlamydia Arthritis? - New insights

A Cure for Chlamydia Arthritis? - New insights | Immunopathology & Immunotherapy | Scoop.it
A Cure for Chlamydia Arthritis?
MedPage Today
The possibility of a cure for an arthritic condition with antimicrobial treatment has long been a dream in the rheumatology community.
Alfredo Corell's insight:
Abstract

Chlamydia trachomatis and Chlamydia pneumoniae together comprise the most frequent causative pathogens that elicit reactive arthritis (ReA). Advances in our understanding of the molecular biology/molecular genetics of these organisms have improved significantly the ability to detect chlamydiae in the joint for diagnostic purposes, as well as extending our current understanding of the pathogenic processes they elicit in the joint and elsewhere. An important aspect of the latter is that synovial chlamydiae infect the joint in an unusual but metabolically active state. While some standard treatments can provide a palliative effect on the ReA disease phenotype, many reports have indicated that standard antibiotic treatment does not provide a cure. Of critical importance, however, two recent reports of controlled clinical trials demonstrated that Chlamydia-ReA can be treated successfully using combination antibiotic therapy. These observations offer the opportunity of a cure for this disease, thereby increasing the practical importance of awareness and diagnosis of the spondyloarthritis caused by Chlamydia. In this viewpoint, we provide an overview of recent key findings in the epidemiology, pathophysiology, clinical manifestations, diagnosis and treatment of Chlamydia-induced arthritis. Our intention is for these insights to be translated rapidly into clinical practice to overcome misdiagnosis and underdiagnosis of the disease, and for them to stimulate the continued development of a cure.

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CDC e-HAP FYI Updates: National Gay Mens's HIV/AIDS Awareness Day

CDC e-HAP FYI Updates: National Gay Mens's HIV/AIDS Awareness Day | Immunopathology & Immunotherapy | Scoop.it
Alfredo Corell's insight:
  •  Reasons/Razones is a bilingual campaign that encourages HIV testing among Latino gay and bisexual men.
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Cancer Immunotherapy: the role of PD-1 and PD-L1

Dan Chen MD, PhD from Stanford Medical Oncology and Genentech describes brilliantly how our immune system detects cancer cells and how tumors get past our im...
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An awesome, simple and understandable animation about the use of PD-1 and PD-L1 interactions in cancer immunotherapy.


A must see!!! Brilliant way to understand the effects of checkpoint inhibitors and cancer immunotherapy.

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Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition | Immunopathology & Immunotherapy | Scoop.it
Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK ...
Nature.com
Alopecia areata (AA) is a common autoimmune disease resulting from damage of the hair follicle by T cells.
Alfredo Corell's insight:
Nature Medicine (2014) doi:10.1038/nm.3645
Alopecia areata (AA) is a common autoimmune disease resulting from damage of the hair follicle by T cells. The immune pathways required for autoreactive T cell activation in AA are not defined limiting clinical development of rational targeted therapies1. Genome-wide association studies (GWAS)2 implicated ligands for the NKG2D receptor (product of the KLRK1 gene) in disease pathogenesis. Here, we show that cytotoxic CD8+NKG2D+ T cells are both necessary and sufficient for the induction of AA in mouse models of disease. Global transcriptional profiling of mouse and human AA skin revealed gene expression signatures indicative of cytotoxic T cell infiltration, an interferon-γ (IFN-γ) response and upregulation of several γ-chain (γc) cytokines known to promote the activation and survival of IFN-γ–producing CD8+NKG2D+ effector T cells. Therapeutically, antibody-mediated blockade of IFN-γ, interleukin-2 (IL-2) or interleukin-15 receptor β (IL-15Rβ) prevented disease development, reducing the accumulation of CD8+NKG2D+ T cells in the skin and the dermal IFN response in a mouse model of AA. Systemically administered pharmacological inhibitors of Janus kinase (JAK) family protein tyrosine kinases, downstream effectors of the IFN-γ and γc cytokine receptors, eliminated the IFN signature and prevented the development of AA, while topical administration promoted hair regrowth and reversed established disease. Notably, three patients treated with oral ruxolitinib, an inhibitor of JAK1 and JAK2, achieved near-complete hair regrowth within 5 months of treatment, suggesting the potential clinical utility of JAK inhibition in human AA.
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Personalized medicine against hereditary immunodeficiency

Personalized medicine against hereditary immunodeficiency | Immunopathology & Immunotherapy | Scoop.it
Researchers have found a method to repair the gene mutation causing agammaglobulinemia, an immunodeficiency disease that almost exclusively affects boys and in which the body lacks the ability to produce immunoglobulins (gamma globulin). The disease is characterized by recurring bacterial infections, mainly in the respiratory system, and persons who suffer from the illness currently need life-long gamma globulin treatment.
Alfredo Corell's insight:

X-linked agammaglobulinemia (XLA) is an inherited immunodeficiency that results from mutations within the gene encoding Bruton’s tyrosine kinase (BTK). Many XLA-associated mutations affect splicing of BTK pre-mRNA and severely impair B cell development. Here, we assessed the potential of antisense, splice-correcting oligonucleotides (SCOs) targeting mutated BTK transcripts for treating XLA. Both the SCO structural design and chemical properties were optimized using 2′-O-methyl, locked nucleic acid, or phosphorodiamidate morpholino backbones. In order to have access to an animal model of XLA, we engineered a transgenic mouse that harbors a BAC with an authentic, mutated, splice-defective human BTK gene. BTK transgenic mice were bred onto a Btk knockout background to avoid interference of the orthologous mouse protein. Using this model, we determined that BTK-specific SCOs are able to correct aberrantly spliced BTK in B lymphocytes, including pro–B cells. Correction of BTK mRNA restored expression of functional protein, as shown both by enhanced lymphocyte survival and reestablished BTK activation upon B cell receptor stimulation. Furthermore, SCO treatment corrected splicing and restored BTK expression in primary cells from patients with XLA. Together, our data demonstrate that SCOs can restore BTK function and that BTK-targeting SCOs have potential as personalized medicine in patients with XLA.


GO TO THE JOURNAL OF CLINICAL INVESTIGATION MANUSCRIPT:

http://www.jci.org/articles/view/76175

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Transplantation Outcomes for Severe Combined Immunodeficiency, 2000–2009 — NEJM

Transplantation Outcomes for Severe Combined Immunodeficiency, 2000–2009 — NEJM | Immunopathology & Immunotherapy | Scoop.it
Original Article from The New England Journal of Medicine — Transplantation Outcomes for Severe Combined Immunodeficiency, 2000–2009
Alfredo Corell's insight:

Sung-Yun Pai, M.D., Brent R. Logan, Ph.D., Linda M. Griffith, M.D., Ph.D., Rebecca H. Buckley, M.D., Roberta E. Parrott, B.S., Christopher C. Dvorak, M.D., Neena Kapoor, M.D., Imelda C. Hanson, M.D., Alexandra H. Filipovich, M.D., Soma Jyonouchi, M.D., Kathleen E. Sullivan, M.D., Ph.D., Trudy N. Small, M.D., Lauri Burroughs, M.D., Suzanne Skoda-Smith, M.D., Ann E. Haight, M.D., Audrey Grizzle, M.P.H., Michael A. Pulsipher, M.D., Ka Wah Chan, M.D., Ramsay L. Fuleihan, M.D., Elie Haddad, M.D., Ph.D., Brett Loechelt, M.D., Victor M. Aquino, M.D., Alfred Gillio, M.D., Jeffrey Davis, M.D., Alan Knutsen, M.D., Angela R. Smith, M.D., Theodore B. Moore, M.D., Marlis L. Schroeder, M.D., Frederick D. Goldman, M.D., James A. Connelly, M.D., Matthew H. Porteus, M.D., Ph.D., Qun Xiang, M.S., William T. Shearer, M.D., Ph.D., Thomas A. Fleisher, M.D., Donald B. Kohn, M.D., Jennifer M. Puck, M.D., Luigi D. Notarangelo, M.D., Morton J. Cowan, M.D., and Richard J. O'Reilly, M.D.

N Engl J Med 2014; 371:434-446July 31, 2014DOI: 10.1056/NEJMoa1401177

CONCLUSIONS

Transplants from donors other than matched siblings were associated with excellent survival among infants with SCID identified before the onset of infection. All available graft sources are expected to lead to excellent survival among asymptomatic infants. (Funded by the National Institute of Allergy and Infectious Diseases and others.)

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The clinical relevance of minor paroxysmal nocturnal hemoglobinuria clones in refractory cytopenia of childhood: a prospective study by EWOG-MDS

The clinical relevance of minor paroxysmal nocturnal hemoglobinuria clones in refractory cytopenia of childhood: a prospective study by EWOG-MDS | Immunopathology & Immunotherapy | Scoop.it

Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis, resulting in peripheral blood cytopenias, myeloid dysplasia and risk of leukemic transformation. 

Alfredo Corell's insight:

Leukemia (2014) 28, 189–192; doi:10.1038/leu.2013.195; published online 16 July 2013

The clinical relevance of minor paroxysmal nocturnal hemoglobinuria clones in refractory cytopenia of childhood: a prospective study by EWOG-MDS

A M Aalbers et al.

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Celiac Disease Autoimmunity - HLA susceptibility by haplotype and country - NEJM

Celiac Disease Autoimmunity - HLA susceptibility by haplotype and country - NEJM | Immunopathology & Immunotherapy | Scoop.it
I first came across the term “celiac disease autoimmunity” a few weeks ago as I read summaries of the article “Risk of Pediatric Celiac Disease According to HLA Haplotype and Country” that was published in the July 3, 2014 issue of the New England Journal of Medicine (NEJM).

Based on my re
Alfredo Corell's insight:

Liu E, Lee HS, Aronsson CA, et al. TEDDY Study Group. Risk of pediatric celiac disease according to HLA haplotype and country. N Engl J Med. 2014 Jul 3;371(1):42-9.

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Fibromyalgia: A New Paradigm?

Fibromyalgia: A New Paradigm? | Immunopathology & Immunotherapy | Scoop.it
Small fiber neuropathy, rather than central sensitization, may be responsible for the pain associated with fibromyalgia, some researchers have hypothesized. (Autoimmunity anyone ? If if walks and talks and smells like it .....
Alfredo Corell's insight:

Primary source: Arthritis & Rheumatology
Source reference: Caro X, Winter E "Evidence of abnormal epidermal nerve fiber density in fibromyalgia: clinical and immunologic implications" Arthritis Rheum 2014; DOI: 10.1002/art.38662.

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Infection and autoimmunity in Sjogren's syndrome: A clinical study and comprehensive review

Infection and autoimmunity in Sjogren's syndrome: A clinical study and comprehensive review | Immunopathology & Immunotherapy | Scoop.it
Highlights

The presence of antibodies against EBV-early-antigen, is associated with SS.

Anti-Ro/SSA and anti La/SSB correlate the presence of anti-EBVEA antibodies.

Specific cytokines and TAP alleles correlate with different clinical manifestations in SS.

Alfredo Corell's insight:
Abstract

Sjögren's syndrome (SS) is an autoimmune disease characterized primarily by lymphocytic infiltration of the exocrine glands, and autoantibody production. Multiple environmental factors affecting an individual with a genetic susceptibility may trigger the development of SS. Herein, we aimed to evaluate links between the different pebbles in the mosaic of SS. Demographic, clinical data and blood samples were gathered from 82 consecutive patients with SS, and 139 healthy controls. Samples were analyzed for infectious serology and auto-antibodies as well as for relevant genetic mutations (TAP genes) and cytokines levels. An immune response (IgG) against Epstein–Barr virus (EBV) early antigen (EA) was positively associated with SS (OR 4; 95% CI: 1.82–8.83, p = 0.001) while a protective effect of IgG anti-cytomegalovirus (CMV) was observed (OR 0.3; 95%CI: 0.16–0.74, p = 0.009). Anti-Ro/SSA, anti-LA/SSB, anti-nuclear, anti-gliadin, anti-TTG-IgG and anti-RNP antibodies were statistically more prevalent among SS patients than controls. Notably, the presence of anti-Ro/SSA and anti La/SSB correlated with anti-EBVEA IgG (OR 3.1; 95%CI: 1.08–8.74) and (OR 3.9; 95%CI: 1.37–10.96) respectively. Autoantibodies, cytokines and several genetic markers correlated with clinical manifestation of SS. Our data suggest that infectious agents may play both a causative and protective role in the pathogenesis of SS. Moreover certain autoantibodies, cytokines and specific TAP alleles correlate with clinical manifestations of SS, and may enable better prediction and/or directed therapy once confirmed in future studies.

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Patients with Primary Immunodeficiencies in Pediatric Intensive Care Unit: Outcomes and Mortality-Related Risk Factors

Patients with Primary Immunodeficiencies in Pediatric Intensive Care Unit: Outcomes and Mortality-Related Risk Factors | Immunopathology & Immunotherapy | Scoop.it
RT @Primary_Immune: Patients with Primary #Immunodeficiency in Pediatric ICUs: Risk, Outcomes & Mortality http://t.co/5M6TDf3cXt … #immun…
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Conclusions

This is the first study regarding the outcome and mortality-related risk factors for PID patients requiring PICU admission. We suggest that PICU management is as important as early diagnosis and treatment for these patients. Prediction of those at risk for poorer outcome might be beneficial for accurate intensive care management and survival.

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Review of Primary Immunodeficiencies - The Asthma Center

Review of Primary Immunodeficiencies - The Asthma Center | Immunopathology & Immunotherapy | Scoop.it

A small review about Immunodeficiencies. A "must" visit por Immunology students.

Alfredo Corell's insight:

You can also download the printable pdf of the review:  http://www.asthmacenter.com/uploads/ID%20printable.pdf

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El hombre con lupus y VIH que dio la pista para una vacuna contra el sida

El hombre con lupus y VIH que dio la pista para una vacuna contra el sida | Immunopathology & Immunotherapy | Scoop.it
En la historia de la lucha contra el sida, tener una enfermedad adicional a la infección por el VIH a veces depara sorpresas. Lo hizo en el caso de Timothy Brown, el famoso pacient
Alfredo Corell's insight:

Videoentrevista al autor del articulo:

http://youtu.be/4SIo0Q8E1b4 


Artículo en el Journal of Clinical Investigation:

http://www.jci.org/articles/view/73441 

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The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease | Immunopathology & Immunotherapy | Scoop.it
Largest Microbiome Study on Newly Diagnosed Patients Gives Insight Into Crohn's Disease and Shows Antibiotic Treatment May Worsen Disease
Alfredo Corell's insight:
Summary

Inflammatory bowel diseases (IBDs), including Crohn’s disease (CD), are genetically linked to host pathways that implicate an underlying role for aberrant immune responses to intestinal microbiota. However, patterns of gut microbiome dysbiosis in IBD patients are inconsistent among published studies. Using samples from multiple gastrointestinal locations collected prior to treatment in new-onset cases, we studied the microbiome in the largest pediatric CD cohort to date. An axis defined by an increased abundance in bacteria which include Enterobacteriaceae, Pasteurellacaea, Veillonellaceae, and Fusobacteriaceae, and decreased abundance in Erysipelotrichales, Bacteroidales, and Clostridiales, correlates strongly with disease status. Microbiome comparison between CD patients with and without antibiotic exposure indicates that antibiotic use amplifies the microbial dysbiosis associated with CD. Comparing the microbial signatures between the ileum, the rectum, and fecal samples indicates that at this early stage of disease, assessing the rectal mucosal-associated microbiome offers unique potential for convenient and early diagnosis of CD.


Divulgative news: http://www.sys-con.com/node/3009818

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