Immunology and Biotherapies
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Rescooped by Gilbert C FAURE from Institut Pasteur de Tunis-معهد باستور تونس
onto Immunology and Biotherapies
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Medical History

Medical History | Immunology and Biotherapies | Scoop.it

Via Seth Dixon, Institut Pasteur de Tunis - معهد باستور تونس‎
Gilbert C FAURE's insight:

but nowadays, researchers spend much time to get money to work.... and to learn and on the other hand, biotherapies market is skyrocketting!

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Seth Dixon's curator insight, December 13, 2013 11:31 AM

I found this on social media (unfortunately I don't have an original source to link to fo documentation) and was greatly impressed by the information here, but also the historical implications of this information.  Could/would this happen today?  How would the world be different is this was the 'new normal?'  How would the world be different if this never did happen?

Immunology and Biotherapies
Page Ressources et Actualités du DIU immunologie et biothérapies
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Resources for DIU Immunologie et Biothérapies

DIU Immunologie et Biotherapies is a french diploma associating many french universities and immunology laboratories. It is dedicated to the involvement of immunology in new biotherapies, either molecular or cellular

Gilbert C FAURE's insight:

We choose Scoop.it as the best curation tool to collect, select, comment informations flowing on the web in this rapidly evolving theme to keep teachers abreast of scientific knowledge and help students surf the wave...

Feel free to be a follower!

 

If you are interested

in Immunology also use http://www.scoop.it/t/immunology

in Mucosal Immunity http://www.scoop.it/t/mucosal-immunity

in Flow Cytometry and Cytomics http://www.scoop.it/t/from-flow-cytometry-to-cytomics

in Allergy an Clinical Immunology http://www.scoop.it/t/allergy-and-clinical-immunology

in Autoimmunity http://www.scoop.it/t/autoimmunity

 

For further informantions on Immune monitoring of Immune therapies, go to

http://www.scoop.it/t/immune-monitoring-1

by MdC

 

Looking for cancer applications inside this topic, use

http://www.scoop.it/t/immunology-and-biotherapies?q=cancer

 

Looking for cytokines and chemokines, use

http://www.scoop.it/t/cytokines-et-chimiokines

 

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Kite opens commercial CAR T-cell plant ahead of anticipated 2017 therapy launch

Kite opens commercial CAR T-cell plant ahead of anticipated 2017 therapy launch | Immunology and Biotherapies | Scoop.it
Kite Pharma has opened a T-cell manufacturing facility in California it says can overcome the logistical problems of autologous therapies and treat up to 5,000 patients per year.
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Newly Discovered Antibodies Efficiently 'Neutralize' the Zika Virus

Newly Discovered Antibodies Efficiently 'Neutralize' the Zika Virus | Immunology and Biotherapies | Scoop.it
European scientists announced that they had discovered antibodies which attack Zika, a step they hope will pave the way for a protective vaccine against the virus.
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Innate lymphoid cells in defense, immunopathology and immunotherapy. - PubMed - NCBI

Innate lymphoid cells in defense, immunopathology and immunotherapy. - PubMed - NCBI | Immunology and Biotherapies | Scoop.it
Nat Immunol. 2016 Jun 21;17(7):755-757. doi: 10.1038/ni.3448.
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Concise Review: Stem Cells and Epithelial-Mesenchymal Transition in Cancer: Biological Implications and Therapeutic Targets

Concise Review: Stem Cells and Epithelial-Mesenchymal Transition in Cancer: Biological Implications and Therapeutic Targets | Immunology and Biotherapies | Scoop.it
Cancer stem cells (CSCs) constitute a small subpopulation of cancer cells with stem-like properties that are able to self-renew, generate differentiated daughter cells, and give rise to heterogeneous tumor tissue.
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Rescooped by Gilbert C FAURE from Top Selling Monoclonal Antibodies 2014
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Big pharma pursues next generation of antibodies | May 2, 2016 Issue - Vol. 94 Issue 18 | Chemical & Engineering News

Big pharma pursues next generation of antibodies | May 2, 2016 Issue - Vol. 94 Issue 18 | Chemical & Engineering News | Immunology and Biotherapies | Scoop.it
RT @GeproResearch: Big #pharma pursues next generation of antibodies |Chemical & Engineering News https://t.co/Uk28rnSHcd #mabs
Via Krishan Maggon
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Rescooped by Gilbert C FAURE from Biotech Pharma Innovation in Immuno-Oncology & beyond. Cancer - Immunology - Immunotherapy.
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CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer

CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer | Immunology and Biotherapies | Scoop.it
Cancer immunotherapies are more effective in tumors with robust T cell infiltrates, but mechanisms to convert T cell-devoid tumors with active immunosuppression to those capable of recruiting T cells remain incompletely understood. Here, using genetically engineered mouse models of pancreatic ductal adenocarcinoma (PDA), we demonstrate that a single dose of agonistic CD40 antibody with chemotherapy rendered PDA susceptible to T cell-dependent destruction and potentiated durable remissions. CD40 stimulation caused a clonal expansion of T cells in the tumor, but the addition of chemotherapy optimized myeloid activation and T cell function. Although recent data highlight the requirement for innate sensors in cancer immunity, these canonical pathways—including TLRs, inflammasome, and type I interferon/STING—played no role in mediating the efficacy of CD40 and chemotherapy. Thus, CD40 functions as a non-redundant mechanism to convert the tumor microenvironment immunologically. Our data provide a rationale for a newly initiated clinical trial of CD40 and chemotherapy in PDA.

Via Dominique Blanchard
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Radionuclide-embedded gold nanoparticles for enhanced dendritic cell-based cancer immunotherapy, sensitive and quantitative tracking of dendritic cells with PET and Cerenkov luminescence

Radionuclide-embedded gold nanoparticles for enhanced dendritic cell-based cancer immunotherapy, sensitive and quantitative tracking of dendritic cells with PET and Cerenkov luminescence | Immunology and Biotherapies | Scoop.it
AM - NPG Asia Materials is an open access, international journal publishing primary research and reviews covering all aspects of the materials science.
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Update on the mechanisms of homing of adipose tissue–derived stem cells

Update on the mechanisms of homing of adipose tissue–derived stem cells | Immunology and Biotherapies | Scoop.it
RT @ELShematology: Update on the mechanisms of homing of adipose tissue–derived stem cells https://t.co/y0UM8iF9IE https://t.co/NeOmeZef62
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Engineered Bispecific Antibodies with Exquisite HIV-1-Neutralizing Activity.

Engineered Bispecific Antibodies with Exquisite HIV-1-Neutralizing Activity. | Immunology and Biotherapies | Scoop.it
Engineered Bispecific Antibodies with Exquisite HIV-1-Neutralizing Activity.
Cell.
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Cotton candy machines may hold key for making artificial organs

Cotton candy machines may hold key for making artificial organs | Immunology and Biotherapies | Scoop.it
Vanderbilt engineers have modified a cotton candy machine to create complex microfluidic networks that mimic the capillary system in living tissue and have demonstrated that these networks can keep cells alive and functioning in an artificial three-dimensional matrix.
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High-Throughput, High-Resolution Peptide Maps | GEN Magazine Articles | GEN

High-Throughput, High-Resolution Peptide Maps | GEN Magazine Articles | GEN | Immunology and Biotherapies | Scoop.it
Thermo Fisher Scientific’s fast, sensitive protein characterization approach integrates enzymatic digestion, chromatographic separation, mass-spec detection, and data processing.
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Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment

Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment | Immunology and Biotherapies | Scoop.it
Generating antibodies specific for the peptide–MHCII complexes has been challenging, with only a handful made to date.
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Pegylated Interferon α-2a Triggers NK-Cell Functionality and Specific T-Cell Responses in Patients with Chronic HBV Infection without HBsAg Seroconversion

Pegylated interferon α-2a (Peg-IFN-α) represents a therapeutic alternative to the prolonged use of nucleos(t)ide analog (NA) in chronic hepatitis B (CHB) infection. The mechanisms leading to a positive clinical outcome remain unclear.
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A review of blinatumomab, a novel immunotherapy

Blinatumomab is a novel bispecific CD19-directed CD3 T-cell engager recently approved for the treatment of relapsed or refractory Ph-negative acute lymphoblastic leukemia in adults.
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Rescooped by Gilbert C FAURE from Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights
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Targeting the complement cascade: novel treatments coming down the pike.

Targeting the complement cascade: novel treatments coming down the pike. | Immunology and Biotherapies | Scoop.it
Related Articles
Targeting the complement cascade: novel treatments coming down the pike.
Kidney Int.

Abstract The complement cascade is a vital component of both the innate and adaptive immune systems. Complement activation also contributes to the pathogenesis of many diseases, however, and the kidney is particularly susceptible to complement-mediated injury. Drugs that block complement activation can rapidly reduce tissue inflammation and also attenuate the adaptive immune response to foreign and tissue antigens. Eculizumab is a monoclonal antibody that prevents the cleavage of C5. It has been approved for the treatment of atypical hemolytic uremic syndrome, and it has been used in selected patients with other kidney diseases. Many additional drugs are also in development for blocking the complement cascade, including new monoclonal antibodies, recombinant proteins, small molecules, and small interfering RNA agents. Validation of these new drugs as effective treatments for kidney diseases faces several challenges. Many complement-mediated kidney diseases are rare, so it is not feasible to test all of the new drugs in numerous different rare diseases. The onset and course of the diseases are heterogeneous; many of these diseases also carry a lifelong risk of recurrence, and it is not clear how long complement inhibition must be maintained. In spite of these challenges, new therapeutic options for targeting the complement system will likely become available in the near future and may prove useful for treating patients with kidney disease. 

KEYWORDS: complement; glomerulonephritis; inflammation

Via Krishan Maggon
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Krishan Maggon 's curator insight, June 22, 8:25 AM
Kidney Int. 2016 Jun 18. pii: S0085-2538(16)30185-5. doi: 10.1016/j.kint.2016.04.018. [Epub ahead of print] Targeting the complement cascade: novel treatments coming down the pike. Thurman JM1, Le Quintrec M2.
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Concise Review: Dental Pulp Stem Cells: A Novel Cell Therapy for Retinal and Central Nervous System Repair

Concise Review: Dental Pulp Stem Cells: A Novel Cell Therapy for Retinal and Central Nervous System Repair | Immunology and Biotherapies | Scoop.it
Dental pulp stem cells (DPSC) are neural crest-derived ecto-mesenchymal stem cells that can relatively easily and non-invasively be isolated from the dental pulp of extracted postnatal and adult teeth.
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Rescooped by Gilbert C FAURE from Top Selling Monoclonal Antibodies 2014
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Antibody engineering and antibody therapy

Antibody engineering and antibody therapy | Immunology and Biotherapies | Scoop.it
Biotem has established a large technological platform to develop therapeutic antibodies

Via Krishan Maggon
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Rescooped by Gilbert C FAURE from Biotech Pharma Innovation in Immuno-Oncology & beyond. Cancer - Immunology - Immunotherapy.
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Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma: Immunity

Genetically modified T cells expressing chimeric antigen receptors (CARs) demonstrate robust responses against lineage restricted, non-essential targets in hematologic cancers. However, in solid tumors, the full potential of CAR T cell therapy is limited by the availability of cell surface antigens with sufficient cancer-specific expression. The majority of CAR targets have been normal self-antigens on dispensable hematopoietic tissues or overexpressed shared antigens. Here, we established that abnormal self-antigens can serve as targets for tumor rejection. We developed a CAR that recognized cancer-associated Tn glycoform of MUC1, a neoantigen expressed in a variety of cancers. Anti-Tn-MUC1 CAR T cells demonstrated target-specific cytotoxicity and successfully controlled tumor growth in xenograft models of T cell leukemia and pancreatic cancer. These findings demonstrate the therapeutic efficacy of CAR T cells directed against Tn-MUC1 and present aberrantly glycosylated antigens as a novel class of targets for tumor therapy with engineered T cells.

Via Dominique Blanchard
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Ultramicroscopy as a novel tool to unravel the tropism of AAV gene therapy vectors in the brain

Ultramicroscopy as a novel tool to unravel the tropism of AAV gene therapy vectors in the brain | Immunology and Biotherapies | Scoop.it
Recombinant adeno-associated viral (AAV) vectors have advanced to the vanguard of gene therapy.
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Autoimmunity Reviews

Autoimmunity Reviews | Immunology and Biotherapies | Scoop.it

IVIG in autoimmune disease — Potential next generation biologics

Adrian W. Zuercher, Rolf Spirig, Adriana Baz Morelli, Fabia
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Scientists discover mechanism of thalidomide

Scientists discover mechanism of thalidomide | Immunology and Biotherapies | Scoop.it
In the 1950s, thalidomide (Contergan) was prescribed as a sedative drug to pregnant women, resulting in a great number of infants with serious malformations. Up to now, the reasons for these disastrous birth defects have remained unclear.
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Biosimilar Era Gets Rolling in Oncology

Biosimilar Era Gets Rolling in Oncology | Immunology and Biotherapies | Scoop.it
After years of anticipation, biosimilar versions of the most widely administered monoclonal antibodies in oncology care are moving closer to fruition for the US market, starting with a new form of trastuzumab (Herceptin).
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Perspectives on Anti-Glycan Antibodies Gleaned from Development of a Community Resource Database

Perspectives on Anti-Glycan Antibodies Gleaned from Development of a Community Resource Database | Immunology and Biotherapies | Scoop.it
Antibodies are used extensively for a wide range of basic research and clinical applications.
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European Society of Cardiology Selects CardioCells Heart Failure HF Study Results For ESC Congress 2016 Late Breaking Science Session

European Society of Cardiology Selects CardioCells Heart Failure HF Study Results For ESC Congress 2016 Late Breaking Science Session | Immunology and Biotherapies | Scoop.it
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