A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR techniques. In addition, the plausible metabolic network of these isolated products is proposed. Compound 1 showed moderate cytotoxic activity against HL-60 and A549 cancer cell lines.
Guangwei Wu † , Aiqun Lin † , Qianqun Gu, Tianjiao Zhu* and Dehai Li*
Mar. Drugs 2013, 11(4), 1399-1408; doi:10.3390/md11041399
Wawooo....this demonstrates more the value of nature. Cancer is one of the killer diseases today. This discovery brings hope to many, but they had to go deep into the see for it. We have tree species with very positive results against cancer, but nobody has picked interest in researching their properties!!!
Air Force Col. Morris Davis, who served as chief prosecutor of the military commissions for two years, said, "...there are too many fiascos in too short an order to be the result of random chance. I suspect they are painting the picture to show it's taken too long, and there's no end in sight; it's too fatally flawed to save; it creates too much damage to our standing in the eyes of our allies and enemies alike; and it costs too much money at a time when money is tight to continue trying to spit-shine the Gitmo cow-pile in hopes that someday it will shine up nice and look pretty."
"From the shiny, strong nacre that gives abalone shells an unbreakable, opaline sheen, to the goopy mix of proteins fired by a velvet worm that solidify and snare prey upon impact, nature is packed with inspiration for scientists designing new. Waterproof adhesives and self-cleaning surfaces, mineralized teeth and hairy insect feet, the seemingly impossible-to-replicate awesomeness of spider silk: Here are a few of our favorite bio-inspired materials, and their natural sources."
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