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The Pseudomonas aeruginosa N-Acylhomoserine Lactone Quorum Sensing Molecules Target IQGAP1 and Modulate Epithelial Cell Migration

The Pseudomonas aeruginosa N-Acylhomoserine Lactone Quorum Sensing Molecules Target IQGAP1 and Modulate Epithelial Cell Migration | Host Cell & Pathogen Interactions | Scoop.it

Quorum sensing (QS) signaling allows bacteria to control gene expression once a critical population density is achieved. The Gram-negative human pathogen Pseudomonas aeruginosa uses N-acylhomoserine lactones (AHL) as QS signals, which coordinate the production of virulence factors and biofilms. These bacterial signals can also modulate human cell behavior.

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Host Cell & Pathogen Interactions
Strategies of Microbial Virulence and Host Defense
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Is US biomedical research heading for a breakdown?

Is US biomedical research heading for a breakdown? | Host Cell & Pathogen Interactions | Scoop.it
Senior researchers who helped build the system now think it's unsustainable.
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Ana Sanchez's curator insight, April 16, 2:41 PM

A big piece of food for thought

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Interferon Regulatory Factor-1 Protects from Fatal Neurotropic Infection with Vesicular Stomatitis Virus by Specific Inhibition of Viral Replication in Neurons

Interferon Regulatory Factor-1 Protects from Fatal Neurotropic Infection with Vesicular Stomatitis Virus by Specific Inhibition of Viral Replication in Neurons | Host Cell & Pathogen Interactions | Scoop.it
From molecules to physiology
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Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression : Nature Medicine : Nature Publishing Group

Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression : Nature Medicine : Nature Publishing Group | Host Cell & Pathogen Interactions | Scoop.it
Mouw et al. delineate a molecular pathway by which matrix stiffness promotes tumor malignancy. Upon matrix stiffening, integrin signaling is engaged, triggering a signaling cascade that regulates the protumorigenic microRNA miR-18a. This leads to downregulation of PTEN and activation of oncogenic signaling. The pathway provides a link between mechanotransduction, miR regulation and oncogene activation that integrates biophysical changes into tumor progression and can also be altered in human tumors.
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A Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila

A Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila | Host Cell & Pathogen Interactions | Scoop.it
PLOS Biology is an open-access, peer-reviewed journal that features works of exceptional significance in all areas of biological science, from molecules to ecosystems, including works at the interface with other disciplines.
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Three-stranded antiviral attack

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A Powerful New Way to Edit DNA

A Powerful New Way to Edit DNA | Host Cell & Pathogen Interactions | Scoop.it
A technique is stirring excitement while raising profound questions.
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The Epstein-Barr Virus-Encoded MicroRNA MiR-BART9 Promotes Tumor Metastasis by Targeting E-Cadherin in Nasopharyngeal Carcinoma

The Epstein-Barr Virus-Encoded MicroRNA MiR-BART9 Promotes Tumor Metastasis by Targeting E-Cadherin in Nasopharyngeal Carcinoma | Host Cell & Pathogen Interactions | Scoop.it
From molecules to physiology
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Rescooped by Ken Yaw Agyeman-Badu from Virology and Bioinformatics from Virology.ca
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From Scourge to Cure: Viruses Versus Cancer

From Scourge to Cure: Viruses Versus Cancer | Host Cell & Pathogen Interactions | Scoop.it
Viruses versus cancer. Who's your money on?

With [oncolytic viruses] OV cancer therapeutics entering advanced-stage trials and showing clinical efficacy, strategies that further broaden OV targeting and replication capacity to address the heterogeneous nature of tumours and their associated vascular and stromal architecture will be extremely useful. Since such heterogeneity not only exists between patients but also within a given tumour/patient, where the metabolism, signal transduction, and antiviral states of cancer cells can be variably abnormal and, therefore, variably support OV replication, combinatorial strategies will be essential to promoting reliable tumour control and regression. Finally, continued efforts to identify components innate to the complex tumour microenvironment that promote OV replication will be critical to further improving OVs and developing new engineering strategies.


Via Ed Rybicki, Chris Upton + helpers
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Ed Rybicki's curator insight, February 13, 10:54 AM

The guru speaks - thanks, AJC!

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CRTC2 enhances HBV transcription and replication by inducing PGC1alpha expression

Hepatitis B virus (HBV) transcription and replication are essentially restricted to hepatocytes. Based on the HBV enhancer and promoter complex that links hepatic glucose metabolism to its transcription and replication, HBV adopts a regulatory system that is unique to the hepatic gluconeogenic genes. CRTC2, the CREB-regulated transcription coactivator 2, is a critical switch modulating the gluconeogenic program in response to both hormonal and intracellular signals. However, the relationship between CRTC2 and HBV transcription and replication remains unclear.
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Disassembly of the divisome in Escherichia coli: Evidence that FtsZ dissociates before compartmentalisation - Söderström - Molecular Microbiology - Wiley Online Library

Disassembly of the divisome in Escherichia coli: Evidence that FtsZ dissociates before compartmentalisation - Söderström - Molecular Microbiology - Wiley Online Library | Host Cell & Pathogen Interactions | Scoop.it
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Molecular Structure Reveals How HIV Infects Cells

Molecular Structure Reveals How HIV Infects Cells | Host Cell & Pathogen Interactions | Scoop.it
News Release
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The Ultimate Decoy: Scientists Find Protein That Helps Bacteria Misdirect Immune System

The Ultimate Decoy: Scientists Find Protein That Helps Bacteria Misdirect Immune System | Host Cell & Pathogen Interactions | Scoop.it
La Jolla, CA (Scicasts) – A team led by scientists at The Scripps Research Institute (TSRI) has discovered an unusual bacterial protein that attaches to virtually any antibody and prevents it from binding to its target. Protein M, as it is called, probably helps some bacteria evade the immune response and establish long-term infections.
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Puzzling Question in Bacterial Immune System Answered « Berkeley Lab News Center

Puzzling Question in Bacterial Immune System Answered « Berkeley Lab News Center | Host Cell & Pathogen Interactions | Scoop.it
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Targeted Prostaglandin E2 Inhibition Enhances Antiviral Immunity through Induction of Type I Interferon and Apoptosis in Macrophages: Immunity

Targeted Prostaglandin E2 Inhibition Enhances Antiviral Immunity through Induction of Type I Interferon and Apoptosis in Macrophages: Immunity | Host Cell & Pathogen Interactions | Scoop.it
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Rescooped by Ken Yaw Agyeman-Badu from Influenza
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Activation of the Interferon Induction Cascade by Influenza A Viruses Requires Viral RNA Synthesis and Nuclear Export


Via Mel Melendrez-Vallard
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Cell Reports - Marburgvirus Hijacks Nrf2-Dependent Pathway by Targeting Nrf2-Negative Regulator Keap1

Cell Reports - Marburgvirus Hijacks Nrf2-Dependent Pathway by Targeting Nrf2-Negative Regulator Keap1 | Host Cell & Pathogen Interactions | Scoop.it
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The Herpes Virus Fc Receptor gE-gI Mediates Antibody Bipolar Bridging to Clear Viral Antigens from the Cell Surface

The Herpes Virus Fc Receptor gE-gI Mediates Antibody Bipolar Bridging to Clear Viral Antigens from the Cell Surface | Host Cell & Pathogen Interactions | Scoop.it
From molecules to physiology
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Comparing Genome Editing Technologies

Comparing Genome Editing Technologies | Host Cell & Pathogen Interactions | Scoop.it
ZFN, TALEN, and CRISPR/Cas systems help scientists dissect
the vast amount of information accumulated through
the Genomic Revolution.
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The Post-transcriptional Regulator rsmA/csrA Activates T3SS by Stabilizing the 5′ UTR of hrpG, the Master Regulator of hrp/hrc Genes, in Xanthomonas

The Post-transcriptional Regulator rsmA/csrA Activates T3SS by Stabilizing the 5′ UTR of hrpG, the Master Regulator of hrp/hrc Genes, in Xanthomonas | Host Cell & Pathogen Interactions | Scoop.it
From molecules to physiology
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Implication of PMLIV in Both Intrinsic and Innate Immunity

Implication of PMLIV in Both Intrinsic and Innate Immunity | Host Cell & Pathogen Interactions | Scoop.it
From molecules to physiology
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Acid-bath stem-cell study under investigation

Acid-bath stem-cell study under investigation | Host Cell & Pathogen Interactions | Scoop.it
Japanese research institute launches inquiry after allegations of irregularities in blockbuster papers.
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The Master Regulator of the Cellular Stress Response (HSF1) Is Critical for Orthopoxvirus Infection

The Master Regulator of the Cellular Stress Response (HSF1) Is Critical for Orthopoxvirus Infection | Host Cell & Pathogen Interactions | Scoop.it
From molecules to physiology
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Salmonella Bacteria Uses Traitor Immune System Protein To Turn Against Host ... - Medical Daily

Salmonella Bacteria Uses Traitor Immune System Protein To Turn Against Host ... - Medical Daily | Host Cell & Pathogen Interactions | Scoop.it
Medical Daily
Salmonella Bacteria Uses Traitor Immune System Protein To Turn Against Host ...
Medical Daily
... by Salmonella and potentially other pathogens to evade interleukin-22's defenses.” Sources: O'Donnell H, Pham O, Li L, et al.

Via Gilbert Faure au nom de l'ASSIM
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The dual role of tetraspanin CD63 in HIV-1 replication

Previously, we showed that the tetraspanin membrane protein CD63 mediates both early and post-integration stages of the HIV-1 replication cycle. The temporal roles of CD63 were discerned using monoclonal antibodies and small interfering RNAs (siRNAs) to block CD63 function, and determining which of the sequential steps in HIV-1 replication were disrupted. Inhibition was shown to occur during early infection, suggestive of involvement in virus entry or reverse transcription. In addition, we have shown that treatment with CD63 siRNA post-infection, significantly inhibited virus production in supernatant, suggesting an important role for CD63 in macrophages during HIV-1 replication events occurring after proviral integration, and possibly during egress.
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Entry of influenza A virus: host factors and antiviral targets

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