"The reason why a sustained high concentration of insulin induces laminitis in horses remains unclear. Cell proliferation occurs in the lamellae during insulin-induced laminitis and in other species high concentrations of insulin can activate receptors for the powerful cell mitogen, insulin-like growth factor (IGF)-1.
"The first aim of this study was to determine if IGF-1 receptors (IGF-1R) are activated in the hoof during insulin-induced laminitis..."
Click on the headline or image to read the full abstract on PubMed (National Institutes of Health research library). The paper, published in The Veterinary Journal, is behind a paywall on the Elsevier platform.