The white root disease caused by Rigidoporus microporus (Sw.) Overeem is a destructive disease in rubber plantation, particularly in southern Thailand. It persists on dead or live root debris for a long time. In this study, resistant clones of white root disease were screened. Pathagenicity tests of R.microporus in 10 local clones (PSU1, PSU2), Kantang, Bangmark, Sakraphangsurin, Bangrak, Khaowiset, Wangkere, Bangdee and Huaiyot districts) were done, compared with clone RRIM 600 and GT 1. The experiment was designed as a completely randomized design (CRD) with 5 replications. The following data were recorded for 2-week interval within 5 months: root distributions, area under disease progress curves (AUDPC), growth and symptom of rubber seedlings. Results indicated that the most of active root proliferation of 45-60 cm soil layer depth from the soil surface. Root growth of seedlings from clone Bangmark and Huaiyot districts showed significantly higher than RRIM 600, GT 1 and the other clones. With the AUDPC observation, the seedlings from clone Bangmark, Kantang and Prince of Songkla University (PSU1) were significanly higher P>0.05 )AUDPC) than the other clones. Growth of each clone was monitored by measuring height, circumference and number of petiole per seedling, the seedlings from clone Bangrak exhibited the highest growth. Symptom development of the seedlings from clone Kantang, Khaowiset districts and GT 1 clones were evident, around 50%. Among 10 local clones, RRIM 600 and GT 1 clones, the seedlings from Sakraphangsurin, Bangrak districts, PSU1 and PSU2 clones tended to exhibit white root disease resistance.