Cinnamon extract were administrated and serum levels of TNF-alpha and interleukin (IL)-6 were determined 1 hour after Lipopolysaccharide stimulation. Various biomarkers were assayed for viability, cytokine expression and signaling molecules upon stimulation. Liposaccharides act as endotoxins and elicit strong immune responses in animals.
The results show that oral administration of cinnamon in an animal model system significantly decreased the serum levels of TNF-alpha and IL-6. CWE treatment in vitro decreased the mRNA expression of TNF-alpha. The scientist conclude that treatment with cinnamon extract decreased LPS-induced TNF-alpha in serum and the results indicate that the observed anti-inflammatory action of Cinnamon extract may originate from the presence of polyphenols.