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Lemongrass and Inflammation

Lemongrass and Inflammation | Herbs & Spices InnOrbit | Scoop.it

In a recent article by Bachiega and Sforcin, in an animal model study, they suggest that lemongrass extracts can exert an anti-inflammatory action and may be involved in the inhibitory effects on cytokine production. They suggest that a possible mechanism involved in such results could be the inhibition of the transcription factor NF-κB. A similar result had also recently been shown here with comparable natural herbs. More evidence that natural ingredients like lemongrass can demonstrate an anti-imflammatory effect.

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InnOrbit Products Review: Wellbeing Magazine

InnOrbit Products Review: Wellbeing Magazine | Herbs & Spices InnOrbit | Scoop.it
InnOrbit products reviewes in this months Wellbeing magazine. Check this link out for a full review of the The Wise Herb Company’s natural functional infusions – packed with Ayurvedic goodnes...
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A little bit about InnOrbit: We source our herbs & spices from India following strict “fair trade” principles. We buy directly from small farmer families cutting out the middle man and give the farmers, our suppliers, the best price possible and as a consequence adding value to local communities in India. Additionally we sponsor the education of young girls from the farmer’s families. In doing so we guarantee their education for 10 years.  Check out our products by clicking on the image below:

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Liquorice components could recover glucocorticoid resistance

Liquorice components could recover glucocorticoid resistance | Herbs & Spices InnOrbit | Scoop.it
Glucocorticoids are often used as treatments for inflammatory diseases, such as asthma and chronic obstructive pulmonary disease. Patients however are suffering from glucocorticoid resistance and t...
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Glucocorticoids are often used as treatments for inflammatory diseases, such as asthma and chronic obstructive pulmonary disease. Patients however are suffering from glucocorticoid resistance and this can present a serious problem for doctors who may look for healthy and efficient alternatives.

 

Glycyrrhizic acid (GA) and 18β-glycyrrhetinic acid (18βGA) are bioactive compounds in liquorice and used to treat ailments such as coughs and colds.

GA and 18βGA have already shown to exhibit potential anti-inflammatory and antioxidant properties.

Kao et al have designed an in vitro glucocorticoid resistance model to verify the effects of GA and 18βGA on glucocorticoid resistance that was induced by Reactive Oxygen Species (ROS).

Results have shown that these two phytochemicals from Liquorice can restor glucocorticoid sensitivity by consuming ROS. Various mechanisms are postulated in this article.

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Ayurvedic Herbal Teas

Ayurvedic Herbal Teas | Herbs & Spices InnOrbit | Scoop.it
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The inhibitory effect of L-theanine, an amino acid derivative found in Green Tea, was studied (Di et al) in conjunction with the potential addictive effects of nicotine. The investigators also studied the underlying mechanisms of this action.

Green tea can help you quit smoking: Lifestyle Magazine

They found that L-theanine, in an animal model system, inhibited the rewarding effects of nicotine and reduced the excitatory status induced by nicotine.

 

Further assays indicated that L-theanine significantly inhibited nicotine-induced tyrosine hydroxylase (TH) expression and dopamine production in the animal model and additionally decreased the number of cells that could react to nicotine.

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Flavanols from Green Tea: Healthy Ageing

Flavanols from Green Tea: Healthy Ageing | Herbs & Spices InnOrbit | Scoop.it
We have designed YOUNG&FUN, with the help of Ayurvedic doctors to help with healthy ageing, well-being and cognitive function. Many of the ingredients have component like Flavanols which have been reported in the scientific press and which appear to have some function in keeping us healthy for longer.

 

 

In a paper by Mikutis et al, from the Jacobs University of Bremen in Germany, the nature of this phenomenon was investigated.

Epigallocatechin gallate (EGCG) from Green Tea and a selection of theaflavins from black tea were combined with model cell nuclear structures (histone proteins, double stranded DNA and quadruplex DNA) and the resultant interactions investigated using mass spectrometry amongst other techniques.

The selected polyphenols were shown to display affinity to all of the selected cell nuclear structures.

In conclusion these data suggest the chemopreventive effect of tea against cancer and other chronic diseases, and a possible role & mechanism of tea phenolics in healthy ageing.

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Green Tea: Protection against cerebrovascular disease

Green Tea: Protection against cerebrovascular disease | Herbs & Spices InnOrbit | Scoop.it
The results from a variety of clinical studies recently have shown that regular consumption of Green Tea could significantly reduces the risk of cardiovascular diseases, including ischemic stroke.

 

Ischemic stroke occurs when an artery to the brain is blocked. The brain depends on its arteries to bring fresh blood from the heart and lungs. The blood carries oxygen and nutrients to the brain, and takes away carbon dioxide and cellular waste. If an artery is blocked, the brain cells (neurons) cannot make enough energy and will eventually stop working. If the artery remains blocked for more than a few minutes, the brain cells may die. This is why immediate medical treatment is critical. The Internet Stroke Center.

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Remember the InnOrbit drinks portfolio can help with Sport

Remember the InnOrbit drinks portfolio can help with Sport | Herbs & Spices InnOrbit | Scoop.it

Simple Nutritional Regime for a Week of Exercise Cycling:

Throughout the week I will take between 2 and 3 cups of InnOrbit Up&Go and/or Slim&Fit infusion (per day). Both of these drinks have natural ingredients which help to energise the body and reinvigorate the immune system. During the week I do between 60 and 120 km. So, I will need to be able to maintain my levels of energy. Long distance athletes like to train their bodies to burn fat….Slim&Fit has herbs like Caralluma fimbriata which can help with this. Depending on how I feel after these mid-week rides I may take a Calm&Relax drink to help with recovery and rest (ginger is packed with anti-inflammatory functionality which helps with muscle soreness etc.).

When I feel like it, and there is time, I also take a Young&Fun infusion….I have to work too and sometimes I even think! Young&Fun is packed with ingredients that help to reinforce memory and help with mental agility.

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Green Tea Health Benefits: The Latest Science

Green Tea Health Benefits: The Latest Science | Herbs & Spices InnOrbit | Scoop.it

Green Tea has a wide range of health benefits and have been used medicinally for many hundreds of years. Here we review the latest health benefits from the science world...

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Notes on Hypertension: From The Wise Herb Company

Notes on Hypertension: From The Wise Herb Company | Herbs & Spices InnOrbit | Scoop.it

High blood pressure or hypertension can cause strokes, heart and kidney diseases. It is called the “slient killer” because most of the time, there are no symptoms, but when high blood pressure goes untreated, it damages arteries and vital organs throughout the body by high blood pressure. There are some natural ingredients (e.g. Herbs & Spices) that can help but it is important to lead a healthy wider lifestyle too. The Products from the Wise Herb Company can help to complement a healthy lifestyle and potentially reduce hypertension.

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Green Tea: Inflammation and risk factors for Chronic diseases

Green Tea: Inflammation and risk factors for Chronic diseases | Herbs & Spices InnOrbit | Scoop.it
“Serum C-reactive protein (CRP) is a biomarker for chronic inflammation and a sensitive risk factor for cardiovascular diseases. CRP has been reported to be related to food intake” Ock et al, The Journal of Nutrition (2008).

 

Kobayashi et al examined the association between dietary total antioxidants and serum C-Reative Protein concentration in young Japanese women using different four assays. 443 young Japanese women aged 18–22 years were studied along with a self-administered diet questionnaire.

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4 herbal plants & Weight Control

4 herbal plants & Weight Control | Herbs & Spices InnOrbit | Scoop.it
We have seen in the last few posts how Ayurvedic ingredients can really help in certain areas of our life.

Four herbs or spices that could help with weight control are:

Caralluma
Garcinia
Green tea
Nutgrass (Cyperus Rotundus)
Check the links out for more information. At InnOrbit we have designed Slim&Fit to contain these functional & natural ingredients and be tasty at the same time:

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Hibiscus & Antidepressant activity

Hibiscus & Antidepressant activity | Herbs & Spices InnOrbit | Scoop.it

Extracts of hibiscus were tested on a model animal system and the mechanism of action involved in antidepressant activity was investigated by observing the effect of extract after pre-treatment with low doses of anti-depresant drugs.

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Lemongrass and Inflammation

Lemongrass and Inflammation | Herbs & Spices InnOrbit | Scoop.it

In a recent article by Bachiega and Sforcin, in an animal model study, they suggest that lemongrass extracts can exert an anti-inflammatory action and may be involved in the inhibitory effects on cytokine production. They suggest that a possible mechanism involved in such results could be the inhibition of the transcription factor NF-κB. A similar result had also recently been shown here with comparable natural herbs. More evidence that natural ingredients like lemongrass can demonstrate an anti-imflammatory effect.

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Caffeine and Health Update

Caffeine and Health Update | Herbs & Spices InnOrbit | Scoop.it
How does it work?

About Caffeine Chemistry: Caffeine is believed to work by blocking adenosine receptors in the brain and other organs. This reduces the ability of adenosine to bind to the receptors, which would slow down cellular activity. The stimulated nerve cells release the hormone epinephrine (adrenaline), which increases heart rate, blood pressure, and blood flow to muscles, decreases blood flow to the skin and organs, and causes the liver to release glucose. Caffeine also increases levels of the neurotransmitter dopamine.

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Potential Effects of Ginger Supplementation on Corectal Cancer

Potential Effects of Ginger Supplementation on Corectal Cancer | Herbs & Spices InnOrbit | Scoop.it
Citronberg et al studied the effects of Ginger on apoptosis, proliferation, and differentiation in the normal-appearing colonic mucosa using a randomized approach.   They measured expression and di...
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Results from a pilot study suggest that ginger may reduce proliferation in the normal-appearing colorectal epithelium and increase apoptosis (automatic cell death – useful in cancerous cells).

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Ginger component: Preventive activity against obesity

Ginger component: Preventive activity against obesity | Herbs & Spices InnOrbit | Scoop.it
Two types of Ginger were investigated for a component – 1′-acetoxychavicol acetate (ACA) – which is naturally obtained from Ginger rhizomes and seeds. Ginger is noted for its anti...
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Two types of Ginger were investigated for a component – 1′-acetoxychavicol acetate (ACA) – which is naturally obtained from Ginger rhizomes and seeds. Ginger is noted for its antioxidant and anti-inflammatory properties.

 

Ohnishi et al, investigated the anti-obesity effects of the ginger component ACA in adipocytes in an animal model (fed a high fat diet).

The ginger component was shown to significantly decrease in the activity of GPDH in 3T3-L1 adipocytes without eliciting cell cytotoxicity, and it inhibited cellular lipid accumulation.

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Neem: Immunological Non-Toxic potential against Cancer

Neem: Immunological Non-Toxic potential against Cancer | Herbs & Spices InnOrbit | Scoop.it
The investigators conclude that accumulated evidence strongly suggests the non-toxic nature of the Neem glycoprotein and could be recommended for human use in anti-cancer therapy.

Neem is a key natural ingredient of The Wise Herb Company range of beverages.

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Ginger and Anti-Cancer Benefits

Ginger and Anti-Cancer Benefits | Herbs & Spices InnOrbit | Scoop.it
The objective of a study by Plengsuriyakarn et al was to investigate the cytotoxicity, toxicity, and anticancer activity of an extract of ginger (Zingiber officinale) against a certain type of cancer (Cholangiocarcinoma).

Ginger: A key ingredient of the functional health drinks from The Wise Herb Company

Various controlled trails were conducted in an animal model system. Results from these in vitro and in vivo investigations indicate that Ginger may have anticancer activity in this type of cancer. There was also absence of significant toxicity.

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Liquorice and Anti-Viral Benefits against Rotavirus

Liquorice and Anti-Viral Benefits against Rotavirus | Herbs & Spices InnOrbit | Scoop.it

Glycyrrhizin is a bioactive component found in liquorice root. It is rapidly metabolized by gut bacteria into 18β- glycyrrhetinic acid. These compounds have been shown to have antiviral and anti-inflammatory activity, amongst other benefits in vitro or in vivo. In a study by Hendricks et al, the ability of glycyrrhetinic acid to modulate immune responses of the small intestinal mucosa was studied in an animal model system.

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Focus on Hibiscus

Focus on Hibiscus | Herbs & Spices InnOrbit | Scoop.it
Phenolic acids and flavonols like quercetin were identified in Hibiscus by Fernández-Arroyo et al. Phenolic acids have antioxidant activity. The study proposes that flavonol-conjugated forms (quercetin and kaempferol) may be the compounds responsible for the observed antioxidant effects and contribute to the healthy effects of Hibiscus extract.

Diabetes and Sugar Control

A study by Adisakwattana et al evaluated the intestinal alpha-glucosidase and pancreatic alpha-amylase inhibitory activities of several plants including Hibiscus. Their investigations suggest that Hibiscus could be useful for developing functional foods for treatment and prevention of diabetes mellitus due to its amylase inhibiting effects.

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Ginger and Airway Anti-Viral Benefits

Ginger and Airway Anti-Viral Benefits | Herbs & Spices InnOrbit | Scoop.it
Ginger (Zingiber officinale) is a spice used widely as a medicinal plant in India and China. Ginger in medicinal herbal mixes has been proved to have antiviral activity against human respiratory syncytial virus (HRSV).

In a study by Chang et al, they tested the hypothesis that ginger can effectively decrease HRSV-induced plaque formation in respiratory mucosal cell lines.

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Blood pressure lowering antioxidant activities of cardamom

Blood pressure lowering antioxidant activities of cardamom | Herbs & Spices InnOrbit | Scoop.it

Cardamom was evaluated by Verma et al for its anti-hypertensive potential and its effect on some of the cardiovascular risk factors in individuals with hypertension. 

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Mint Component: Antispasmodic effect and mode of action

Mint Component: Antispasmodic effect and mode of action | Herbs & Spices InnOrbit | Scoop.it
A study by Souza et al was made on Carvone a component of Mint. (-)-Carvone is a monoterpene found in Mint essential oil.

In this study (-)-carvone anti-spasmodic effect was investigated in animal model system. The effect of (-)-carvone was compared with that of the classical calcium channel blocker verapamil.

Carvone reduced the contractions induced and was almost 100 times more potent than verapamil.

In conclusion (-)-carvone showed a typical and potent calcium channel blocker action. The effects described for both (-)-carvone and mint can be explained as a calcium channel blocker mode of action.

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Neuroprotective effect of Green Tea component Theanine

Neuroprotective effect of Green Tea component Theanine | Herbs & Spices InnOrbit | Scoop.it
In a study, by Zukhurova et al, the neuroprotective effect of L-theanine, a Green Tea component in an animal model system after a stroke. The effect of L-theanine on brain injury during reperfusion was evaluated via neurological deficit and infarct size.

The results suggest that L-theanine substantially reduced the size of brain infarct and neurological status was improved when L-theanine was administered. Repeated intrastriatal injections of L-theanine at a total dose of 800 µg/kg during reperfusion prevented brain injury caused by glutamate receptor agonists.

Neurosoup

The investgators conclude that L-theanine at reperfusion exerts neuroprotective effect in the in vivo animal stroke model. Treatment with L-theanine at reperfusion also helps to prevent brain injury.

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Cancer Inhibition by Neem Component

Cancer Inhibition by Neem Component | Herbs & Spices InnOrbit | Scoop.it
The molecular mechanisms involved were studied on human breast cancer cell lines.

The cancer growth inhibitory effect of nimbolide was assessed and Apoptosis induction was determined

Treatment with the Neem component resulted in dose and time-dependent inhibition of growth of cancer cells. The occurrence of apoptosis in these cells was also suggested

They conclude that Nimbolide induces the cleavage of pro-caspase-8, pro-caspase-3 and PARP and induces apoptosis by both the intrinsic and extrinsic pathways.

They suggest that the Neem component nimbolide exhibits anticancer effect through its apoptosis-inducing property and could be potentially used as a anticancer therapy.

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Flavanoid consumption from Plants and reduced Cancer survival levels

Flavanoid consumption from Plants and reduced Cancer survival levels | Herbs & Spices InnOrbit | Scoop.it

A reduced risk of breast cancer associated with dietary intake of certain classes of flavonoids has been proposed. The effects of flavonoids on survival, however, are not known. A population-based study of breast cancer patients, was investigated by Fink et al on if dietary flavonoid intake before diagnosis is associated with subsequent survival

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