Liquorice, the root of the Glycyrrhiza species is known to have antioxidant & anti-inflammatory properties. The objective of a study by Kim et al was to explore the neuroprotective effect of dehydroglyasperin C (DGC), a liquorice component, against glutamate-induced oxidative stress in an animal model.
The results suggest for the first time that the liquorice component protects neuronal cells against glutamate-induced oxidative injury through the induction of HO-1 expression which is, in turn, activated possible key signaling pathways.
Alzheimer’s disease is now the most common form of dementia. Biasibetti et al studied an animal model system where chronic brain dysfunction was characterized by long-term and progressive deficits in learning and memory. Studies on Green Tea epigallocatechin gallate (EGCG) have previously suggested that it can have beneficial effects on cognition and memory. Oxidative stress markers and involvement of the nitric oxide (NO) system, acetylcholinesterase activity and glucose uptake were evaluated, amongst other markers.
Results show that EGCG was able to reverse various markers of cognitive deficit e.g. glutathione peroxidase activity, Nitric Oxide metabolites, and reactive oxygen species content. The data confirms that there is a neuroprotective potential for Green Tea catechins. These results also add to the knowledge of diseases accompanied by cognitive deficits and models of dementia.