Centella asiatica (Pennywort)
Pennywort contains a series of terpenes (oils), the most common of which is called Madecassoside. Recently, Liu et al investigated a therapeutic potential and underlying mechanisms of madecassoside on induced arthritis in an animal model.
The results suggest that components of Pennywort like madecassoside can prevent induced arthritis, and this component is the major active constituent of Centella asiatica responsible for clinical uses for rheumatoid arthritis.
The underlying mechanisms of action may be through regulating the abnormal humoral and cellular immunity as well as protecting joint destruction.