Hematology
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Scooped by Gilbert C FAURE
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Hematology, or Haematology

... was a major interest for our lab, during many years in the context of the GEIL still thriving, then EGIL, then European Leukemia Net.

 

Gilbert C FAURE's insight:

Hospital choices did not allow to pursue the efforts locally...

but to stay informed and allow others to surf the information wave....

 

Much information is available in the cloud, focusing on immunophenotyping of leukemias, and also on other haematology topics.


Blood cells being also immunocompetent cells, other topics curated should be of interest

http://www.scoop.it/t/immunology

http://www.scoop.it/t/from-flow-cytometry-to-cytomics

http://www.scoop.it/t/immunology-and-biotherapies

 

 

 

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Allogeneic Hematopoietic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia: Results from a Single Center, 1993-2011. - PubMed - NCBI

Allogeneic Hematopoietic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia: Results from a Single Center, 1993-2011. - PubMed - NCBI | Hematology | Scoop.it
Int J Hematol Oncol Stem Cell Res. 2017 Jan 1;11(1):58-62.
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New England Journal of Medicine publishes long-term results of Gleevec for patients with chronic myeloid leukemia

New England Journal of Medicine publishes long-term results of Gleevec for patients with chronic myeloid leukemia | Hematology | Scoop.it
In 2001 the U.S. Food and Drug Administration granted priority review for imatinib mesylate, sold under the name Gleevec, as an oral therapy for patients with chronic myeloid leukemia, or CML.
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Morphologic and Immunophenotypic Features of Hairy Cell Leukemia Involving Lymph Nodes and Extranodal Tissues

Morphologic and Immunophenotypic Features of Hairy Cell Leukemia Involving Lymph Nodes and Extranodal Tissues | Hematology | Scoop.it
Hairy cell leukemia (HCL) is a rare B‐cell neoplasm that mainly affects bone marrow (BM), peripheral blood (PB), and spleen. Involvement of lymph nodes and extranodal structures is considere
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Gene Therapy in a Patient with Sickle Cell Disease — NEJM

Gene Therapy in a Patient with Sickle Cell Disease — NEJM | Hematology | Scoop.it
Original Article from The New England Journal of Medicine — Gene Therapy in a Patient with Sickle Cell Disease
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NEJM Data Highlight Blinatumomab OS Benefit in Acute Lymphoblastic Leukemia

NEJM Data Highlight Blinatumomab OS Benefit in Acute Lymphoblastic Leukemia | Hematology | Scoop.it
Treatment with blinatumomab (Blincyto) led to a median overall survival of 7.7 months versus 4 months with standard chemotherapy in patients with Philadelphia chromosome-negative relapsed or refractory B-cell precursor acute lymphoblastic leukemia, according to results from the phase III TOWER study published in <em>The New England Journal of Medicine</em>.
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Rescooped by Gilbert C FAURE from from Flow Cytometry to Cytomics
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Research in morphology and flow cytometry is at the heart of hematology

Research in morphology and flow cytometry is at the heart of hematology | Hematology | Scoop.it
Through its inherent implication in such major physiological systems as oxygenation, coagulation, protection against infections and tumor proliferation, hematology is a nearly boundless field for research and discovery. Indeed, hematology has been at the heart of such fundamental work as the
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Leukemia and Lymphoma Learning Center - myCME.com

Leukemia and Lymphoma Learning Center - myCME.com | Hematology | Scoop.it
Free online CME & CE programs for physicians, nurse practitioners, physician assistants & other health care professionals from myCME
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Childhood hematologic cancer and residential proximity to oil and gas development

Childhood hematologic cancer and residential proximity to oil and gas development | Hematology | Scoop.it
Background Oil and gas development emits known hematological carcinogens, such as benzene, and increasingly occurs in residential areas. We explored whether residential proximity to oil and gas development was associated with risk for hematologic cancers using a registry-based case-control study design. Methods Participants were 0–24 years old, living in rural Colorado, and diagnosed with cancer between 2001–2013. For each child in our study, we calculated inverse distance weighted (IDW) oil and gas well counts within a 16.1-kilometer radius of residence at cancer diagnosis for each year in a 10 year latency period to estimate density of oil and gas development. Logistic regression, adjusted for age, race, gender, income, and elevation was used to estimate associations across IDW well count tertiles for 87 acute lymphocytic leukemia (ALL) cases and 50 non-Hodgkin lymphoma (NHL) cases, compared to 528 controls with non-hematologic cancers. Findings Overall, ALL cases 0–24 years old were more likely to live in the highest IDW well count tertiles compared to controls, but findings differed substantially by age. For ages 5–24, ALL cases were 4.3 times as likely to live in the highest tertile, compared to controls (95% CI: 1.1 to 16), with a monotonic increase in risk across tertiles (trend p-value = 0.035). Further adjustment for year of diagnosis increased the association. No association was found between ALL for children aged 0–4 years or NHL and IDW well counts. While our study benefited from the ability to select cases and controls from the same population, use of cancer-controls, the limited number of ALL and NHL cases, and aggregation of ages into five year ranges, may have biased our associations toward the null. In addition, absence of information on O&G well activities, meteorology, and topography likely reduced temporal and spatial specificity in IDW well counts. Conclusion Because oil and gas development has potential to expose a large population to known hematologic carcinogens, further study is clearly needed to substantiate both our positive and negative findings. Future studies should incorporate information on oil and gas development activities and production levels, as well as levels of specific pollutants of interest (e.g. benzene) near homes, schools, and day care centers; provide age-specific residential histories; compare cases to controls without cancer; and address other potential confounders, and environmental stressors.
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NCLEX Medical Surgical Nursing Exam for Acute Leukemia | NCLEXExam.NET

This 26 Questions and answer NCLEX Medical Surgical Nursing Exam for Acute Leukemia | NCLEXExam.NET In Video Mode: All questions and answers are given fo
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lncRNA co-expression network model for the prognostic analysis of acute myeloid leukemia | lncRNA Blog

lncRNA co-expression network model for the prognostic analysis of acute myeloid leukemia | lncRNA Blog | Hematology | Scoop.it
#lncRNA #coexpressionnetwork model for the prognostic analysis of #acutemyeloidleukemia - https://t.co/WmH7emcb8K
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Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre–B ALL

Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre–B ALL | Hematology | Scoop.it
Inactivation of the tumor suppressor gene encoding the transcriptional regulator Ikaros ( IKZF1 ) is a hallmark of BCR-ABL1+ precursor B cell acute lymphoblastic leukemia (pre–B ALL). However, the mechanisms by which Ikaros functions as a tumor suppressor in pre–B ALL remain poorly understood. Here, we analyzed a mouse model of BCR-ABL1+ pre–B ALL together with a new model of inducible expression of wild-type Ikaros in IKZF1 mutant human BCR-ABL1+ pre–B ALL. We performed integrated genome-wide chromatin and expression analyses and identified Ikaros target genes in mouse and human BCR-ABL1+ pre–B ALL, revealing novel conserved gene pathways associated with Ikaros tumor suppressor function. Notably, genetic depletion of different Ikaros targets, including CTNND1 and the early hematopoietic cell surface marker CD34, resulted in reduced leukemic growth. Our results suggest that Ikaros mediates tumor suppressor function by enforcing proper developmental stage–specific expression of multiple genes through chromatin compaction at its target genes.
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Rescooped by Gilbert C FAURE from Cancer Immunotherapy Review
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Multiple Myeloma - Society for Immunotherapy of Cancer

Multiple Myeloma - Society for Immunotherapy of Cancer | Hematology | Scoop.it
Multiple #myeloma, a general category of hematologic cancers, primarily affects the blood, bone marrow & lymph nodes https://t.co/SnlUfNGSCE https://t.co/hEF03thjoh

Via Krishan Maggon
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Lung and platelets

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors
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Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia — NEJM

Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia — NEJM | Hematology | Scoop.it
Original Article from The New England Journal of Medicine — Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia
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MLL, IBM, Illumina Partner on Cognitive Platform for Leukemia and Lymphoma | GEN Genetic Engineering & Biotechnology News - Biotech from Bench to Business | GEN

MLL, IBM, Illumina Partner on Cognitive Platform for Leukemia and Lymphoma | GEN Genetic Engineering & Biotechnology News - Biotech from Bench to Business | GEN | Hematology | Scoop.it
MLL will harness Illumina's NovaSeq technology and Watson Health Computing to aid better diagnosis and personalised therapy
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Sickle Cell Disease — A History of Progress and Peril — NEJM

Sickle Cell Disease — A History of Progress and Peril — NEJM | Hematology | Scoop.it
Perspective from The New England Journal of Medicine — Sickle Cell Disease — A History of Progress and Peril
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Game Review- The Blood Typing Game

Game Review- The Blood Typing Game | Hematology | Scoop.it
The Blood Typing Game was produced by Nobel Media with the aim of communicating Nobel achievements to younger audiences. The game was the 2012 winner of the Best Game at the Swedish Learning Awards  and was designed for teenagers aged 14-17. The company also develops other broadcast, digital media, events and published content. Based upon research that…
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ESH Training Course on WHO Classification: Towards Personalized Medicine in Haematology, March 9-11, 2017 - Saggart (Dublin), Ireland

ESH Training Course on WHO Classification: Towards Personalized Medicine in Haematology, March 9-11, 2017 - Saggart (Dublin), Ireland | Hematology | Scoop.it
RT @ESHaematology: ESH Training Course on WHO Classification: Towards Personalized Medicine in Haematology - https://t.co/VEUzKzygGM
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Flow cytometric analysis as an additional predictive tool of treatment response in children with chronic‐phase chronic myeloid leukemia treated with imatinib

Bone marrow samples of newly diagnosed children with chronic‐phase chronic myeloid leukemia (CML) were obtained at diagnosis and after imatinib initiation and stained with anti‐human CD34, CD38
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$100 Million African Pediatric Hematology-Oncology Initiative Launched

A daily news, jobs, rfp service of the Foundation Center. Philanthropy-related articles and features culled from print and electronic media outlets nationwide.
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Expert Explains WHO Classification Refinements in Hematologic Malignancies

Expert Explains WHO Classification Refinements in Hematologic Malignancies | Hematology | Scoop.it
Changes are underway in the field of hematologic malignancies, as the World Health Organization is publishing a revised classification of tumors of hematopoietic and lymphoid tissues&mdash;slated to be released in early 2017.
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Key Information - European Hematology Association

Key Information - European Hematology Association | Hematology | Scoop.it

Welcome to the 22nd Congress
This is the first congress EHA is organizing in Madrid and we are very excited to welcome you to Spain again. The congress center IFEMA is located conveniently between the city and Barajas airport and will be an excellen
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Diagnosing "Castleman Disease"

  Castleman disease was discovered in the 1950s, but until this year doctors had no reliable sources to consistently and accurately diagnose the disea
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Quality of Life in Patients with Multiple Myeloma: A Qualitative Study

Quality of Life in Patients with Multiple Myeloma: A Qualitative Study | Hematology | Scoop.it
Abstract
Objective: Multiple myeloma (MM) accounts for approximately 15% of hematological cancers. Although still
incurable, the prognosis of MM has much improved wit..
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