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Heart and Vascular Health
Media, News & Topics on prevention, diagnosis & treatment of cardiovascular disease
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Top Line Results for SAVOR-TIMI-53 Cardiovascular Outcomes Trial of Onglyza (saxagliptin)

Top Line Results for SAVOR-TIMI-53 Cardiovascular Outcomes Trial of Onglyza (saxagliptin) | Heart and Vascular Health | Scoop.it

AstraZeneca and Bristol-Myers Squibb Announce Top Line Results for SAVOR-TIMI-53 Cardiovascular Outcomes Trial of Onglyza(R) (saxagliptin) PRINCETON, N.J. & WILMINGTON, Del., Jun 19, 2013

In this study of adult patients with type 2 diabetes with either a history of established cardiovascular disease or multiple risk factors, Onglyza met the primary safety objective of non-inferiority, and did not meet the primary efficacy objective of superiority, for a composite endpoint of cardiovascular death, non-fatal myocardial infarction or non-fatal ischaemic stroke, when added to a patient’s current standard of care (with or without other anti-diabetic therapies), as compared to placebo. These preliminary SAVOR-TIMI-53 data are being analyzed and the study results will be submitted to the European Society of Cardiology (ESC) for potential presentation at the ESC Congress in September.

Seth Bilazarian, MD's insight:

My comment:  we have struggled to move the ball forward for diabetes care and prevention of heart attacks.  Despite more than a dozen oral drug options that improve blood sugar control, we lack evidence that this approach lowers the risk of strokes and heart attacks.  Blood pressure control and cholesterol treatment are proven strategies for risk reduction, but there remains scant evidence that improving blood sugar control makes a difference.  (It may make a difference on other important issues like diabetic eye and kidney concerns).

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Scooped by Seth Bilazarian, MD
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Emergency Departments Can Identify Low-Risk Cardiac Patients Quickly

Emergency Departments Can Identify Low-Risk Cardiac Patients Quickly | Heart and Vascular Health | Scoop.it

Key Take Away for Patients:

When patients come to the Emergency Room with chest pain the main goal is to assess whether the patient is having a heart attack or at high risk for a heart attack.  In either circumstance the patient will be admitted overnight for treatment and testing.  Identifying low risk patients is a need, but has always been a concern because of the fear of missing someone who MIGHT be at risk and would be at risk for a heart attack or death if discharged.  Strategies to identify lower risk patients who can be discharged home and then seen for out-patient testing is an elusive goal, because there is no certainty.  This study discussed use of TIMI Risk score, EKG and 2 blood tests done 2 hours apart to identify lower risk patients. The negative predictive value of the diagnostic protocol was 99.7%: that means that for every 1000 considered low risk only 3 patients would be miscategorized.

TIMI Risk Score is online at http://goo.gl/vCJgh ;

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