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Media, News & Topics on prevention, diagnosis & treatment of cardiovascular disease
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Relation Between Optimism and Lipids in Midlife

Relation Between Optimism and Lipids in Midlife | Heart and Vascular Health | Scoop.it

The hypothesis that optimism is associated with a healthier lipid profile was tested. The participants were 990 mostly white men and women from the Midlife in the United States study, who were, on average, 55 years old.  Models examined the cross-sectional association between optimism and lipid levels, accounting for education and health status (e.g., chronic medical conditions).

After adjustment the results suggested that greater optimism was associated with greater HDL cholesterol and lower triglycerides. Optimism was not associated with low-density lipoprotein or total cholesterol. The findings were robust to a variety of modeling strategies including the effect of cholesterol treatment. The results also indicated that diet and body mass index might link optimism with lipids.

This is the first study to suggest that optimism is associated with a healthy lipid profile; moreover, these associations can be explained, in part, by the presence of healthier behaviors and a lower body mass index.

Seth Bilazarian, MD's insight:

The associations were small but clinically significant. The optimism effect is similar in size to the effect of physical activity.  From the paper, "optimism might serve as a precursor to healthy behavior by motivating " behavior for favorable expectations of the future.

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Risk of coronary heart disease is associated with triglycerides and high-density lipoprotein cholesterol in women

Risk of coronary heart disease is associated with triglycerides and high-density lipoprotein cholesterol in women | Heart and Vascular Health | Scoop.it

The graded risk for patients is well shown in these charts.  The cut point for the HDL for women is less than 50 and for men les than 40. The triglyceride cutpoint is 150 for both men and women.

The bars are very steep for women (on the left).  Blue is the patients with both good level of HDL & triglyceride.  The purple bar is for patients with both levels in an undesitrable range.  For women the incidence is 2.4 for every 1000 person years in the best group and 13.4 in the worst group.

These parameters diffentiate risk for men less well (low rate of 13.1 and high rate of 22.1)

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New Rules for Boosting Good Cholesterol

New Rules for Boosting Good Cholesterol | Heart and Vascular Health | Scoop.it
Scientists agree that raising HDL (or good) cholesterol can reduce the risk of heart disease. But after a string of surprising clinical trials, they're not sure whether drugs can do the job.
Seth Bilazarian, MD's insight:

We do not have an effective medicine that raisies the good cholesterol (HDL) AND is proven to lower heart and vascular disease.  The great hope that the B vitamin niacin would fill this promise has been dashed by two consecutive studies.  No point in using these medicines that have cost and side effect now that they have disappointed us twice on the prevention front.

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