My comment: There is significant concen about the safety of Chantix. I explain to my patients that the risk of this drug has to be balanced against the risk of continued smoking (heart disease, stroke, cancer, erectile dysfunction) since this is the most effective strategy we have to help people succeed at qutitting their addiction to niocotine.
Danish registry of 35,000 patients comparing the safety of quitting smoking with Chantix (varenicline) comared to Wellbutrin or Zyban (bupropion) on safety of cardiovascular events.
At 6 months the rates were 0.69% vs. 7.1%. This study found no increased risk of major cardiovascular events associated with use of varenicline compared with bupropion for smoking cessation.