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Media, News & Topics on prevention, diagnosis & treatment of cardiovascular disease
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FDA Drug Safety Communication: Safety review update of Chantix (varenicline) and risk of cardiovascular adverse events

FDA Drug Safety Communication: Safety review update of Chantix (varenicline) and risk of cardiovascular adverse events | Heart and Vascular Health | Scoop.it
FDA is informing the public about a meta-analysis of trials that compared patients who received the smoking cessation drug Chantix (varenicline). FDA first notified the public about a possible increased risk of cardiovascular adverse events with Chantix in its June 2011 Drug Safety Communication (DSC).
The meta-analysis showed higher rates of composite outcomes on Chantix. Although these findings were not statistically significant, they were consistent. It should be noted that the incidence of cardiovascular mortality (Chantix 0.05% [2/4190] vs. placebo 0.07% [2/2812]) and all-cause mortality (Chantix 0.14% [6/4190] vs. placebo 0.25% [7/2812]) was lower in the Chantix group compared to the placebo group, although this finding was also not statistically significant.
Seth Bilazarian, MD's insight:

Balancing the risk of ongoing smoking vs. these tiny differences during 6 months of treatment with Chantix will have to be made individulally by patients and their doctors.  Ideally patients quit smoking without any added drugs but for many patients addicted to smoking this is not possible.

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Is Quitting Smoking Harder for Women?

Is Quitting Smoking Harder for Women? | Heart and Vascular Health | Scoop.it

THE BOTTOM LINE According to the strongest data, men do not have an easier time giving up smoking than women.

 

Conventional wisdom says it is harder to quit for women, but the largest study of the claim to date finds that there is little difference in successful cessation rates among men and women.

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