Mortality in Randomized Trials of Antioxidant Supplements | Heart and Vascular Health |

 All randomized trials involving adults published by October 2005 comparing beta carotene, vitamin A, vitamin C (ascorbic acid), vitamin E, and selenium either singly or combined vs placebo or vs no intervention were included. The effect of antioxidant supplements on all-cause mortality was analyzed We included 68 randomized trials with 232 606 participants (385 publications).

Conclusions Treatment with beta carotene, vitamin A, and vitamin E may increase mortality. The potential roles of vitamin C and selenium on mortality need further study.