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Symplicity HTN-3 Clinical Trial

Symplicity HTN-3 Clinical Trial | Heart and Vascular Health | Scoop.it

Website from the manufacturer Medtronic sponsoring the US trial for renal denervation in resistent hypertension.  This device is available for use in Australia, Canada and Europe, but not yet approved in the US.  The trial Symplicity HTN-3 is a US Pivotal trial for American patients with resistant hypertension defined as blood pressure greater than 160 despite at least 3 maximum dose medications including at least one diuretic.  The trial section http://www.symplifybptrial.com/candidate/ gives patients an opportunity to see if they are candidates fotr the trial.

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Catheter based Renal Nerve Ablation Safely Lowers BP in kidney disease patients

Catheter based Renal Nerve Ablation Safely Lowers BP in kidney disease patients | Heart and Vascular Health | Scoop.it

My comment for patients:  More good news for renal nerve denervation.  This catheter based treatment done like a heart catheterization from the artery in the groin has been show to have significant BP improvement for those patients who can't be controlled with 3 or more drugs, called resistnt hypertension.  This study shows that this treatment also works in patients with chronic kidney disease.  We won't have this available in the US for two or more years but the future for this technolopgy looks bright.

 

From the article:

Catheter-based renal nerve ablation helps lower resistant hypertension, but now researchers have found that it works as well in those with chronic kidney disease (CKD), a pilot study showed.  n 15 patients with resistant hypertension and stage 3 and 4 CKD, bilateral renal denervation lowered blood pressure by a mean of 34/14 mmHg at 1 month and 32/15 mmHg at 6 months.

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Controlling Hypertension (High Blood Pressure) Via Kidney = Renal Denervation

Controlling Hypertension (High Blood Pressure)  Via Kidney = Renal Denervation | Heart and Vascular Health | Scoop.it

New experimental treatment for stubborn hypertension: Singeing the walls of nerve-lined arteries leading to the kidneys, blocking the organs' ability to raise blood pressure.

 

Medtronic is investigating a renal denervation strategy in a trial called Symplicity.  Procedure takes about 30 - 40 minutes. The study will target 530 patients with systolic blood pressure over 160 despite taking at least three medicines.  "Until now, there were no other options for such patients, other than adding more drugs".

 

For patients with resistant hypertension interested in clinical trial participation in Symplicity contact the clincial research office at (978) 469-5494 or visit the website http://www.pmaonline.com/clinical-trials.htm ;

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