Big Pharma has known all along that SSRI and SNRI antidepressants don't work. An FOIA request shows that they've known all along, that most of their studies showed no benefit.
Irving Kirsch of Harvard Medical School has studied the placebo effect for over 30 years. He requested the data for studies that had not been published. When those results were added in, almost no benefit could be shown for antidepressants.