Healing Chronic P...
Follow
Find tag "Bilazarian"
1.2K views | +0 today
Healing Chronic Pain & Disease
Don't just cover up symptoms with pharmaceuticals. Heal chronic pain and disease naturally and live a full, healthy, happy life again.
Curated by askdrmaxwell
Your new post is loading...
Your new post is loading...
Rescooped by askdrmaxwell from Heart and Vascular Health
Scoop.it!

Do Statins cause dementia?

Do Statins cause dementia? | Healing Chronic Pain & Disease | Scoop.it

Adults with no history of cognitive dysfunction treated with statins were included from high-quality randomized controlled trials and prospective cohort studies after formal bias assessment. Sixteen studies were included in qualitative & 11 in quantitative synthesis.

Short-term trials did not show a consistent effect of statin therapy on cognitive end points. Long-term cognition studies included 23,443 patients with a mean exposure duration of 3 to 24.9 years. Three studies found no association between statin use and incident dementia, and 5 found a favorable effect. Pooled results revealed a 29% reduction in incident dementia in statin-treated patients.

Conclusion In patients without baseline cognitive dysfunction, short-term data are most compatible with no adverse effect of statins on cognition, and long-term data may support a beneficial role for statins in the prevention of dementia.


Via Seth Bilazarian, MD
more...
Seth Bilazarian, MD's curator insight, January 19, 2014 1:43 PM

Patients are understandably concerned that a medicine might cause problems with their ability to think and function as they age.  For proponents  (like me) of statin type cholesterol lowering medicines the long-term benefit of improved vascular health provided by statins is compelling.  The theoretical benefit on long term brain health from improved vascular health is also interesting but conflicts with some reports taht memory might be effected by statin use.  The authors from Johns Hopkins have provided a useful review of the literature and concluded that statins are neutral to positive for long term brain health and function, and may "support a beneficial role for statins in the prevention of dementia".

Rescooped by askdrmaxwell from Heart and Vascular Health
Scoop.it!

10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes

10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes | Healing Chronic Pain & Disease | Scoop.it

During the United Kingdom Prospective Diabetes Study (UKPDS), patients with type 2 diabetes mellitus who received intensive glucose therapy had a lower risk of microvascular complications than did those receiving conventional dietary therapy. We conducted post-trial monitoring to determine whether this improved glucose control persisted and whether such therapy had a long-term effect on macrovascular outcomes.

Results Between-group differences in glycated hemoglobin levels were lost after the first year. In the sulfonylurea–insulin group, relative reductions in risk persisted at 10 years for any diabetes-related end point (9%, P=0.04) and microvascular disease (24%, P=0.001), and risk reductions for myocardial infarction (15%, P=0.01) and death from any cause (13%, P=0.007) emerged over time, as more events occurred. In the metformin group, significant risk reductions persisted for any diabetes-related end point (21%, P=0.01), myocardial infarction (33%, P=0.005), and death from any cause (27%, P=0.002).

Conclusions

Despite an early loss of glycemic differences, a continued reduction in microvascular risk and emergent risk reductions for myocardial infarction and death from any cause were observed during 10 years of post-trial follow-up. A continued benefit after metformin therapy was evident among overweight patients. (UKPDS 80; Current Controlled Trials number.


Via Seth Bilazarian, MD
more...
Seth Bilazarian, MD's curator insight, October 8, 2013 9:36 AM

Amazing! Twenty five years ago the UKPDS published the follow-up of metformin in diabetes showing a benefit on heart attack and death even years after patients came off the drug.  Despite years of basic science and clinical research and billions of dollars spent on development of new therapies we still don't have a single other diabetes drug that reduces heart attack risk. Many drugs have been developed for blood sugar control but all have shown no benefit over placebo for reduction of heart attack risk for diabetics.  Only metformin.