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HCN and KV7 (M-) channels as targets for epilepsy treatment

HCN and KV7 (M-) channels as targets for epilepsy treatment | Tonic Clonic & Partial Seizures Information Hub | Scoop.it

Voltage-gated ion channels are important determinants of cellular excitability. The Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) and KV7 (M-) channels are voltage-gated ion channels. Both channels are activated at sub-threshold potentials and have biophysical properties that mirror each other. KV7 channels inhibit neuronal excitability. Thus, mutations in KV7 channels that are associated with Benign Familial Neonatal Convulsions (BFNC) are likely to be epileptogenic. Mutations in HCN channels have also been associated with idiopathic epilepsies such as GEFS+. In addition, HCN channel expression and function are modulated during symptomatic epilepsies such as temporal lobe epilepsy. It is, though, unclear as to whether the changes in HCN channel expression and function associated with the various forms of epilepsy promote epileptogenesis or are adaptive. In this review, we discuss this as well as the potential for KV7 and HCN channels as drug targets for the treatment of epilepsy. (...) - by Shah MM et al., Neuropharmacology, Volume 69, June 2013, Pages 75–81


Via Julien Hering, PhD
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I'll appreciate your time & help to visit my website on #seizures #epilepsy at http://seizures.dolyan.com/. Thank you :)

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Tonic Clonic & Partial Seizures Information Hub
Hi, seizures.dolyan.com has been setup to give a very clear and easy to understand explanation on seizure disorders. It includes longer articles or reviews with full explanations as well as short, Q&A type, fun and simple answers to the many questions people may have. No technical knowledge or medical background is required in order to understand the articles. That is the strength of seizures.dolyan.com – giving all the information to the people on complicated topics, but in very easy English so that everyone can understand. Both people suffering from epilepsy/seizures and friends and family can find this site useful. Enjoy reading!
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My Experience With Pseudo Seizures

My Experience With Pseudo Seizures | Tonic Clonic & Partial Seizures Information Hub | Scoop.it
Pseudo seizures are a physical manifestation of an emotional disturbance. They resemble epileptic seizures, but, its not caused by epilepsy.
Janys Venne's insight:

Pseudo seizures are a physical manifestation of an emotional disturbance. They resemble epileptic seizures, but, unlike the seizures caused by epilepsy, they are not caused by electrical disruptions in the brain.

 

See more at http://seizures.dolyan.com/my-experience-with-pseudo-seizures/

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Montco Commissioners declare November Epilepsy Awareness Month - The Times Herald

Montco Commissioners declare November Epilepsy Awareness Month - The Times Herald | Tonic Clonic & Partial Seizures Information Hub | Scoop.it
Montco Commissioners declare November Epilepsy Awareness Month
The Times Herald
21 that November would be Epilepsy Awareness Month.
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Cayman goes blue for World Autism Awareness Day | ieyenews

Cayman goes blue for World Autism Awareness Day | ieyenews | Tonic Clonic & Partial Seizures Information Hub | Scoop.it
iNews #Cayman: Cayman goes blue for World Autism Awareness Day http://t.co/ceUjk6tCRj

Via Katrina Moody
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I'll appreciate your time & help to visit my website on seizures #epilepsy at http://seizures.dolyan.com/. Thank you :)

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JHS Senior To Host Benefit For Twin Sister With Epilepsy - Jamestown Post Journal

JHS Senior To Host Benefit For Twin Sister With Epilepsy - Jamestown Post Journal | Tonic Clonic & Partial Seizures Information Hub | Scoop.it
Jamestown Post Journal JHS Senior To Host Benefit For Twin Sister With Epilepsy Jamestown Post Journal In honor of national epilepsy awareness month, a Jamestown High School senior has taken up the charge of bringing support to her twin sister by...
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I'll appreciate your time & help to visit my website on seizures epilepsy at http://seizures.dolyan.com/. Thank you :)

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'Can my son stop taking his epilepsy meds?' - Independent Online

'Can my son stop taking his epilepsy meds?' - Independent Online | Tonic Clonic & Partial Seizures Information Hub | Scoop.it
'Can my son stop taking his epilepsy meds?
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I'll appreciate your time & help to visit my website on seizures epilepsy at http://seizures.dolyan.com/. Thank you :)

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Aptiom approved to treat seizures - Medical Xpress

Aptiom approved to treat seizures - Medical Xpress | Tonic Clonic & Partial Seizures Information Hub | Scoop.it
Science World Report
Aptiom approved to treat seizures
Medical Xpress
(HealthDay)—Aptiom (eslicarbazepine acetate) has been approved by the U.S. Food and Drug Administration as an add-on drug to help treat adults with partial epileptic seizures.
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I'll appreciate your time & help to visit my website on seizures epilepsy at http://seizures.dolyan.com/. Thank you :)

 

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A more ethical way to compare epilepsy treatments

A more ethical way to compare epilepsy treatments | Tonic Clonic & Partial Seizures Information Hub | Scoop.it

For the first time, a new research methodology recently approved by the Food and Drug Administration has been used to demonstrate that converting patients from one anti-epileptic drug to another – in this case, lamotrigine extended-release (LTG XR) – is well-tolerated, effective and safe.


Via Dimitris Agorastos
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I'll appreciate your time & help to visit my website on #seizures #epilepsy at http://seizures.dolyan.com/. Thank you :)

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(EN) - Glossary of Epilepsy Terms | webmd.com

(EN) - Glossary of Epilepsy Terms | webmd.com | Tonic Clonic & Partial Seizures Information Hub | Scoop.it

"WebMD provides a list of terms associated with epilepsy and their definitions."


Via Stefano KaliFire
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I'll appreciate your time & help to visit my website on #seizures #epilepsy at http://seizures.dolyan.com/. Thank you :)

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(EN) - Glossary of terms pertaining to canine epilepsy and other health issues in dogs | canine-epilepsy-guardian-angels.com

(EN) - Glossary of terms pertaining to canine epilepsy and other health issues in dogs | canine-epilepsy-guardian-angels.com | Tonic Clonic & Partial Seizures Information Hub | Scoop.it

"A glossary of veterinary medical terms used to describe canine epilepsy and related diseases.

dogs, seizures, seizures in dogs, canine epilepsy, cluster seizures, partial seizures, focal seizures, canine, K9"


Via Stefano KaliFire
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I'll appreciate your time & help to visit my website on #seizures #epilepsy at http://seizures.dolyan.com/. Thank you :)

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Schools Must Support Health Conditions

Schools Must Support Health Conditions | Tonic Clonic & Partial Seizures Information Hub | Scoop.it
Schools in England will have a legal obligation to support children with long-term health conditions, such as diabetes, epilepsy and asthma.   A written statement from Education Secretary Mich...

Via britishroses
Janys Venne's insight:


I'll appreciate your time & help to visit my website on #seizures #epilepsy at http://seizures.dolyan.com/. Thank you :)

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Joel Roberts's curator insight, March 7, 9:39 PM

I believe this is a great article which will help students with health conditions in the school system.  This article states that UK schools will have a legal obligation to support children with health conditions such as asthma, diabetes, and epilepsy.  I believe that the schools having a legal obligation to support students with health conditions is a great idea.  This ensures that the schools have to help and look out for their students with health conditions so they benefit from the school system.  This will also make the parents feel confident that their children will benefit from the school system and they do not have to worry about their children just being a number and overlooked while in school.  Without the schools having a legal obligation to look after these students, many schools might not care about students with health conditions and these students will not benefit from the school system.

Ashlyn Durham's comment, March 19, 9:49 PM
I agree with Joel, that this is a great article which will help students with health conditions in the school system. I believe that schools should hold a responsibility on caring for their students and their students' health concerns. Providing a child with aid and protection throughout the school day can make the learning experience be a learning experience. It will become a learning experience because they will no longer have to worry about their symptom controlling their education process.
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VIDEO: 19mins The surprising story of medical marijuana & pediatric epilepsy

Josh will sift through the propaganda, fear and greed encompassing medical marijuana. Recently featured on CNN, Josh and his brothers developed a non-psychot...

Via Julian Buchanan
Janys Venne's insight:


I'll appreciate your time & help to visit my website on #seizures #epilepsy at http://seizures.dolyan.com/. Thank you :)

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Julian Buchanan's comment, October 30, 2013 11:08 PM
Hey Janys - do you know if anyone in the UK is prescribing cannabis to patients with epilepsy - my son is interested in giving it a go
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Northwest Epilepsy Conferences to Highlight Epilepsy Topics - Sacramento Bee

Northwest Epilepsy Conferences to Highlight Epilepsy Topics - Sacramento Bee | Tonic Clonic & Partial Seizures Information Hub | Scoop.it
Northwest Epilepsy Conferences to Highlight Epilepsy Topics
Sacramento Bee
SEATTLE, Oct.
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I'll appreciate your time & help to visit my website on #seizures #epilepsy at http://seizures.dolyan.com/. Thank you :)

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Medical Marijuana For Pets In Pain

Medical Marijuana For Pets In Pain | Tonic Clonic & Partial Seizures Information Hub | Scoop.it

More people are using medical marijuana to treat pets for a variety of conditions, ranging from separation anxiety and noise phobia to cancer/epilepsy/seizures, according to the Journal of the American Veterinary Medical Association (JAVMA) News.

Janys Venne's insight:

Not all dogs suffer from similar symptoms, symptoms of dog seizures will greatly vary from one dog to another dog. There are some dogs who will just merely twitch a limb, and some other dogs may fall down to the ground, become unconscious and suffer from whole body spasms. For owners who can witness their dogs having a seizure for the first time can be very traumatic. There are medications that can be used to help in treating dog seizures. Medications will greatly depend on the causative factor of the seizure. Dog seizures can be caused by caffeine poisoning, rat poisoning, neurological disorders such as epilepsy, and many more.

 

See more at http://seizures.dolyan.com/dog-seizure-medications/

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Seizures and Teens | Primary Seizures

Seizures and Teens | Primary Seizures | Tonic Clonic & Partial Seizures Information Hub | Scoop.it
Among the different types of seizures the primary ones are Absence Seizures, Myoclonic Seizures, Tonic-Clonic.
Janys Venne's insight:

Being A ‪‎Teenager‬ Is Tough. Being A Teenager With ‪‎Epilepsy‬ Is A Little Tougher, But It Is Something That Can Be Worked Out.

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National Epilepsy Awareness Month Story Days | epilepsy.com

National Epilepsy Awareness Month Story Days | epilepsy.com | Tonic Clonic & Partial Seizures Information Hub | Scoop.it
Epilepsy Foundation Metropolitan New York


To view "Story Days" videos from earlier in November, click on the red "Story Days Archive" button above.

Via Velvet Martin
Janys Venne's insight:

I'll appreciate your time & help to visit my website on seizures epilepsy at http://seizures.dolyan.com/. Thank you :)

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Does The Side Effect Of Medicines Cause Grand Mal Seizure | Grand Mal Seizures

Does The Side Effect Of Medicines Cause Grand Mal Seizure | Grand Mal Seizures | Tonic Clonic & Partial Seizures Information Hub | Scoop.it
Read the article to learn about various causes of grand mal/tonic clonic seizures and that the side effect of medicines we intake is the most renowned
Janys Venne's insight:

Medication without proper prescription of the doctor is the main reason of the incidence of seizures. Exposure to certain toxins and side effects of medicines are the well known causes. It is also said that those people who used to consume a lot of alcohol and now taking medicines for its less consumption are the first ones to be hunted by grand mal seizures; tranquilizers are very dangerous because they can lead you to lethal seizures and liver disorders especially in the case of physical withdrawal.

 

See more at http://seizures.dolyan.com/does-the-side-effect-of-medicines-cause-grand-mal-seizure/

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Vagus Nerve Stimulation for Children With Epilepsy - Medscape

Vagus Nerve Stimulation for Children With Epilepsy
Medscape
The first vagus nerve stimulator (VNS) was implanted in 1988. Since then, more than 70,000 have been implanted for epilepsy worldwide.
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I'll appreciate your time & help to visit my website on seizures epilepsy at http://seizures.dolyan.com/. Thank you :)

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Your Child Have Seizures? - Learn About Childhood Seizures

Your Child Have Seizures? - Learn About Childhood Seizures | Tonic Clonic & Partial Seizures Information Hub | Scoop.it
Infants that experience seizure episodes may be caused by problems during pregnancy, neurological disorders, nerve disorders, and/or birth defects.
Janys Venne's insight:

Seizures in neonates or newborn babies (below 2 months old) are more common than seizures that happen in infants or at older people. Neonatal Onset Epilepsy is believed to be the major cause of seizures in neonates.

 

See more at http://seizures.dolyan.com/infant-seizure-symptoms/

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Ion channels in genetic and acquired forms of epilepsy

Ion channels in genetic and acquired forms of epilepsy | Tonic Clonic & Partial Seizures Information Hub | Scoop.it

Genetic mutations causing dysfunction of both voltage- and ligand-gated ion channels make a major contribution to the cause of many different types of familial epilepsy. Key mechanisms comprise defective Na+ channels of inhibitory neurons, or GABAA receptors affecting pre- or postsynaptic GABAergic inhibition, or a dysfunction of different types of channels at axon initial segments. Many of these ion channel mutations have been modelled in mice, which has largely contributed to the understanding of where and how the ion channel defects lead to neuronal hyperexcitability. Animal models of febrile seizures or mesial temporal epilepsy have shown that dendritic K+ channels, hyperpolarization-activated cation channels and T-type Ca2+ channels play important roles in the generation of seizures. For the latter, it has been shown that suppression of their function by pharmacological mechanisms or in knock-out mice can antagonize epileptogenesis. Defects of ion channel function are also associated with forms of acquired epilepsy. Autoantibodies directed against ion channels or associated proteins, such as K+ channels, LGI1 or NMDA receptors, have been identified in epileptic disorders that can largely be included under the term limbic encephalitis which includes limbic seizures, status epilepticus and psychiatric symptoms. We conclude that ion channels and associated proteins are important players in different types of genetic and acquired epilepsies. Nevertheless, the molecular bases for most common forms of epilepsy are not yet clear, and evidence to be discussed indicates just how much more we need to understand about the complex mechanisms that underlie epileptogenesis. - Lerche H et al., The Journal of Physiology, 591, 753-764., February 15, 2013


Via Julien Hering, PhD
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I'll appreciate your time & help to visit my website on #seizures #epilepsy at http://seizures.dolyan.com/. Thank you :)

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HCN and KV7 (M-) channels as targets for epilepsy treatment

HCN and KV7 (M-) channels as targets for epilepsy treatment | Tonic Clonic & Partial Seizures Information Hub | Scoop.it

Voltage-gated ion channels are important determinants of cellular excitability. The Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) and KV7 (M-) channels are voltage-gated ion channels. Both channels are activated at sub-threshold potentials and have biophysical properties that mirror each other. KV7 channels inhibit neuronal excitability. Thus, mutations in KV7 channels that are associated with Benign Familial Neonatal Convulsions (BFNC) are likely to be epileptogenic. Mutations in HCN channels have also been associated with idiopathic epilepsies such as GEFS+. In addition, HCN channel expression and function are modulated during symptomatic epilepsies such as temporal lobe epilepsy. It is, though, unclear as to whether the changes in HCN channel expression and function associated with the various forms of epilepsy promote epileptogenesis or are adaptive. In this review, we discuss this as well as the potential for KV7 and HCN channels as drug targets for the treatment of epilepsy. (...) - by Shah MM et al., Neuropharmacology, Volume 69, June 2013, Pages 75–81


Via Julien Hering, PhD
Janys Venne's insight:


I'll appreciate your time & help to visit my website on #seizures #epilepsy at http://seizures.dolyan.com/. Thank you :)

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Talking About Sudden Unexpected Death in Epilepsy (SUDEP) - PAME

Talking About Sudden Unexpected Death in Epilepsy (SUDEP) - PAME | Tonic Clonic & Partial Seizures Information Hub | Scoop.it

Upcoming Webinars

Talking About Sudden Unexpected Death in Epilepsy (SUDEP)  ...
Wednesday, October 23, 2013 
Eastern: 3:00 PM   Central: 2:00 PM   Mountain: 1:00 PM   Pacific: 12:00 PM
Presenters:

  Elizabeth Donner, MD, FRCPC,   Faculty of Medicine, University of Toronto   Pediatric Neurologist, The Hospital for Sick Children   Co-Founder, SUDEP Aware Click here to view Bio      Nancy Collins, MD   Associate Professor of Neurology, Chicago Medical School Clinical Ethicist Click here to view Bio
Webinar Description:
Talking about death, or the possibility of death is hard – even for doctors and nurses. But talking about sudden unexplained death in epilepsy (SUDEP) is an important first step to understanding it. During this webinar the presenters will discuss when and how nurses and doctors should ideally talk about SUDEP with a patient and their family, what people with epilepsy and their families should be asking their doctors. Also included will be a review of what research studies say those living with epilepsy and their families want to hear from doctors about SUDEP. A review the ethics of SUDEP disclosure will also be included. Finally, the presenters will explore the perspective of those who are bereaved by the loss of a loved one to epilepsy and what information they believe should be disclosed. Participants will leave with a basic understanding of SUDEP and the knowledge about how and when to discuss SUDEP appropriately. Plenty of time will be left to answer your questions and the end of the webinar.
  Thank you for your interest in this webinar! This webinar is set up with a suggested $25 donation to support PAME activities.
Use coupon code 03PAME in the coupon code box at checkout If you would prefer to attend this webinar without donating.
https://live.blueskybroadcast.com/bsb/client/CL_DEFAULT.asp?Client=955477&PCAT=6221&CAT=6221  (I hope the link works. I can't figure out how else to direct to it because it comes as an email to me from epilepsy.com - webmaster@epilepsytherapyproject.org  )


Via Velvet Martin
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I'll appreciate your time & help to visit my website on #seizures #epilepsy at http://seizures.dolyan.com/. Thank you :)

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Velvet Martin's curator insight, October 17, 2013 1:35 PM

(I hope the link works. I can't figure out how else to direct to it because it comes as an email to me from epilepsy.com - webmaster@epilepsytherapyproject.org  )

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Families of children with epilepsy moving to Colorado, drawn by success of marijuana oil

Families of children with epilepsy moving to Colorado, drawn by success of marijuana oil | Tonic Clonic & Partial Seizures Information Hub | Scoop.it
When Mohammad Halabi was a boy, his parents fled war in Lebanon to give their child a chance at life. This month, as Halabi drove to Denver International Airport to pick up his wife and 2-year-old daughter, he realized he was doing the same thing.

Via Troy Mccomas (troy48)
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I'll appreciate your time & help to visit my website on #seizures #epilepsy at http://seizures.dolyan.com/. Thank you :)

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Veterinary marijuana?

Veterinary marijuana? | Tonic Clonic & Partial Seizures Information Hub | Scoop.it

People need to understand that this isn’t about getting my dog high. It’s about improving his quality of life.”

Denise, a pet owner who turned to marijuana to help her dog, dying of cancer


Via jana rade
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Child with seizures to get medical marijuana - Columbus Ledger-Enquirer

Child with seizures to get medical marijuana - Columbus Ledger-Enquirer | Tonic Clonic & Partial Seizures Information Hub | Scoop.it
Child with seizures to get medical marijuana Columbus Ledger-Enquirer JANESVILLE, Iowa — The parents of a northeast Iowa baby say they have run out of options to help their daughter with seizures so they're turning to medical marijuana to see if it...
Janys Venne's insight:

I'll appreciate your time & help to visit my website on #seizures #epilepsy at http://seizures.dolyan.com/. Thank you :)

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