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The pacemaker of the future might be made of heart cells

The pacemaker of the future might be made of heart cells | Gentleman's Corner & Health | Scoop.it

Cardiologists in Los Angeles have developed a gene-therapy technique that allows them to transform working heart-muscle cells into cells that regulate a pigs’ heartbeat. This procedure, described today in the Science Translational Medicine, restored normal heart rates for two weeks in pigs that usually rely on mechanical pacemakers. The experiment, researchers say, could lead to lifesaving therapies for people who suffer infections following the implantation of a mechanical pacemaker.


"We have been able for the first time to create a biological pacemaker using minimally invasive methods and to show that the new pacemaker suffices to support the demands of daily life," Eduardo Marbán, a cardiologist at the Cedars-Sinai Heart Institute and lead author of the study, told the press yesterday. The approach is practical, added Eugenio Cingolani, a cardiogeneticist also at Cedars-Sinai and a co-author of the study, because "no open-heart surgery is required to inject this gene."


In the study, researchers injected a gene called Tbx18 into the pigs’ hearts. This gene, which is also found in humans, reprogrammed a small number of heart-muscle cells into cells that emit electrical impulses and drive the beating of the heart. The area in which this change occurred — about the size of a peppercorn — doesn't normally initiate heartbeats.


"We were able to get the biological pacemaker to turn on within 48 hours," Marbán said. To get the gene to the heart, the researchers sent a modified virus into the right ventricle through a catheter. The viral vector isn’t harmful, the researchers said, because the virus they employed was engineered to be "replication deficient" — meaning that it will not reproduce and spread beyond the heart.


Overall, the results of the study demonstrate that the pigs who received the gene therapy experienced an increase in heart rate that allowed them to be much less dependent on backup pacemakers. In contrast, the backup pacemakers were responsible for more than 40 percent of the beats in pigs who didn’t receive the gene therapy, but still underwent surgery.


more at http://www.theverge.com/2014/7/16/5906563/biological-pacemakers-gene-therapy-heart-muscle-cells



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Toxins, the Environment, and Your Health: EWG's Men's Health Guide

Toxins, the Environment, and Your Health: EWG's Men's Health Guide | Gentleman's Corner & Health | Scoop.it
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A Beginner's Guide to Meditation: Dan Harris on Meditation

A Beginner's Guide to Meditation: Dan Harris on Meditation | Gentleman's Corner & Health | Scoop.it
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Why Older Men May Want to Eat More Meat: Protein fights functional decline

Why Older Men May Want to Eat More Meat: Protein fights functional decline | Gentleman's Corner & Health | Scoop.it
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'Masterminds and Wingmen': Preparing your son for the pitfalls of a boy's world - TODAY.com

'Masterminds and Wingmen': Preparing your son for the pitfalls of a boy's world - TODAY.com | Gentleman's Corner & Health | Scoop.it
In a changing world, proactive parenting can be the key to steering your child around the many impediments towards young adulthood. In...
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Raising boys..

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The Barry White Syndrome: Why Are Deep Voices Attractive?

The Barry White Syndrome: Why Are Deep Voices Attractive? | Gentleman's Corner & Health | Scoop.it

Darth Vader had one thing going for him: a deep voice.

The ranks of George Clooney, Denzel Washington, Clint Eastwood, Don LaFontaine, and Barry White includes a common factor: A lower pitched voice—considered a positive masculine feature associated with with older, heavier, taller, hairier, and more attractive men.

 

Read more: The Barry White Syndrome: Why Are Deep Voices Attractive? | Anthropology in Practice, Scientific American Blog Network http://bit.ly/y4jC9Y


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Inspiring Story: Denzel Washington Finds Success with Help of Mentors - Guideposts

Inspiring Story: Denzel Washington Finds Success with Help of Mentors - Guideposts | Gentleman's Corner & Health | Scoop.it
Denzel Washington's inspiring story of success reminds us that there are always mentors out there to help us along the way.

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shelbylaneMD's curator insight, August 18, 2013 9:56 PM

Mentorship s the foundation of success. Congrats!

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5 Lessons from Denzel Washington

5 Lessons from Denzel Washington | Gentleman's Corner & Health | Scoop.it
The lessons you can learn on the screen and off from Denzel Washington.

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Sanjay Gupta Reverses On Marijuana: ‘We Have Been Terribly And Systematically Misled’

Sanjay Gupta Reverses On Marijuana: ‘We Have Been Terribly And Systematically Misled’ | Gentleman's Corner & Health | Scoop.it

CNN’s Chief Medical Correspondent Dr. Sanjay Gupta reversed his position on marijuana’s health benefits on Thursday and apologized for his previous stand against it.

 

“I apologize because I didn’t look hard enough, until now,” he said. “I didn’t look far enough. I didn’t review papers from smaller labs in other countries doing some remarkable research, and I was too dismissive of the loud chorus of legitimate patients whose symptoms improved on cannabis.”

 

Here is the actual article on CNN:

 

http://edition.cnn.com/2013/08/08/health/gupta-changed-mind-marijuana/index.html


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Sepp Hasslberger's curator insight, August 8, 2013 6:46 PM

A big step in the right direction ... 

Naomie Mullins's comment, August 12, 2013 8:36 AM
When it is mainstream like this, I have to suspect that a patent is ready for profiteers.
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Must-Have Medical Tests for Men by Rob Huntley - Men's Health - InsidersHealth.com

When was the last time you visited the doctor’s office? A year ago? Three? Five? If you’re a guy, you might be surprised at the many important tests you should have done on a regular basis . . . especially as you get older. Let’s take a look at the “must-have” medical tests for men.


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The last time most guys saw a doctor was for that high school sports physical, or the pro sports physical or the job physical or the urgent care injury.   And that's why...men suffer in the long run.

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Lower Bad LDL Cholesterol With Vitamin D: Lower Bad LDL Cholesterol With Vitamin D

Lower Bad LDL Cholesterol With Vitamin D: Lower Bad LDL Cholesterol With Vitamin D | Gentleman's Corner & Health | Scoop.it
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Laird's Guide to Getting Back in Shape: How to Get Back in Shape

Laird's Guide to Getting Back in Shape: How to Get Back in Shape | Gentleman's Corner & Health | Scoop.it
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6 Ways to Argue More Effectively: How to Argue

6 Ways to Argue More Effectively: How to Argue | Gentleman's Corner & Health | Scoop.it
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Men's Journal Magazine - Men's Style, Travel, Fitness and Gear

Men's Journal Magazine - Men's Style, Travel, Fitness and Gear | Gentleman's Corner & Health | Scoop.it
The best gear and travel destinations, plus guides to men's health, fitness, food, drinks, adventures, and style.
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10 Questions Men Should Ask Their Doctor for Better Health Care — AARP

10 Questions Men Should Ask Their Doctor for Better Health Care — AARP | Gentleman's Corner & Health | Scoop.it
Reluctant to open up to your doctor? Here are 10 key topics every man should discuss with his doctor to stay on top of his health.
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Sex and secret men's business

Sex and secret men's business | Gentleman's Corner & Health | Scoop.it
Men who have surgery for prostate cancer struggle to get proper advice about, or effective treatment for, its terrible side effects, writes Bettina Arndt.

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Denzel Washington Piles On The Pounds For 'Flight': 'I Ate Big Meals And I Loved It' - Celebrity Gossip, News & Photos, Movie Reviews, Competitions - Entertainmentwise

Denzel Washington Piles On The Pounds For 'Flight': 'I Ate Big Meals And I Loved It' - Celebrity Gossip, News & Photos, Movie Reviews, Competitions - Entertainmentwise | Gentleman's Corner & Health | Scoop.it
Whilst most Hollywood stars are on a constant battle to shed those unwanted pounds, actor Denzel Washington has revealed that he was more than happy to pile the fat on to play in current movie role in 'Flight.'...

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An Open Letter To Denzel Washington

An Open Letter To Denzel Washington | Gentleman's Corner & Health | Scoop.it
CHUCK CREEKMUR PENS A LETTER TO THE ICONIC DENZEL WASHINGTON...

 

"But, I’m writing you about something else … frankly, something that concerns me. It was your closing remark in your GQ cover story, where you talked about Black men. You said:
“Take responsibility. One of the things that saddens me the most about my people is fathers that don’t take care of their sons and daughters. And you can’t blame that on The Man or getting frisked. Take responsibility. Look in the mirror and say, “What can I do better?” There is opportunity; you can make it. Whatever it is that you choose, be the best at it. You have an African-American president. You can do it. But take responsibility. Put your slippers way under your bed so when you get up in the morning, you have to get on your knees to find them. And while you’re down there, start your day with prayer. Ask for wisdom. Ask for understanding. I’m not telling you what religion to be, but work on your spirit. You know, mind, body, and spirit. Imagine—work the brain muscle. Keep the body in tune—it’s your temple. All things in moderation. Continue to search. That’s the best part of life for me—continue to try to be the best man.”


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Denzel Washington Struggles with his weight - Celebrity Balla

Denzel Washington Struggles with his weight - Celebrity Balla | Gentleman's Corner & Health | Scoop.it

During an appearance on 'The Late Show with David Letterman' last night (07.29.13), he said: "Actually at one point I got to 247 lbs. I was directing a movie and I was editing the film so I was very nervous about it and I'm in the dark in the editing room for five or six months and I'm just eating."
Read more at http://www.celebrityballa.com/2013/07/102675/denzel-washington-struggles-his-weight#SrZVFBCOp8Br6x8g.99 ;


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10 Ways We Get Smarter As We Age | TIME.com

10 Ways We Get Smarter As We Age | TIME.com | Gentleman's Corner & Health | Scoop.it
As we age, the brain's processing speed begins to slow, and memory may sometimes slip. But there are other ways that our mental powers grow as we get older.

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The beusty of aging and wisdom

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Testosterone Deficiency in Men by Darren Clair, M.D. - Men's Health - InsidersHealth.com

Testosterone Deficiency in Men by Darren Clair, M.D. - Men's Health - InsidersHealth.com | Gentleman's Corner & Health | Scoop.it
Were you one of those guys that secretly envied the other guys in high school who could grow full mustache? Were you a puberty “late bloomer?” Maybe you have a testosterone deficiency. Keep reading to learn more!

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Fellas, it's time to get proper testing and proper treatment>

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