The design is intended for giving plants to the ability to detoxify formaldehyde by expression of cell wall-anchored formaldehyde dehydrogenase. The enzyme is based on formaldehyde dehydrogenase from Pseudomonas putida.
In this design, a signal peptide is added to its N-terminus whereas a cellulose-binding protein from Heterodera schachtii is fused to the C-terminus. This enzyme catalyze a dismutation in the cell wall, so that it efficiently protects plant body from extracellular formaldehyde. Furthermore, the transgenic plants have potential as a material for formaldehyde-detoxifying fiber.
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