Genetics - GEG Tech top picks
916 views | +2 today
Follow
Your new post is loading...
Your new post is loading...
Scooped by BigField GEG Tech
Scoop.it!

Shaping up to make the cut - LMU Munich

Shaping up to make the cut - LMU Munich | Genetics - GEG Tech top picks | Scoop.it
BigField GEG Tech's insight:

Before RNA copies of genes can program the synthesis of proteins, the non-coding regions are removed by the spliceosome. Munich researchers report that distinct conformations of a member of this molecular complex play a vital role in the process.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

Scientists at the CNIO have deconstructed 1 of the myths of biological innovation

Scientists at the CNIO have deconstructed 1 of the myths of biological innovation | Genetics - GEG Tech top picks | Scoop.it

Click here to edit the content

BigField GEG Tech's insight:

While the number of coding genes (those that produce proteins) in the human species has been consistently dwindling in recent years - the figures have fallen to fewer than 20,000-, it has been claimed that the dimension of the proteome, the element that executes the instructions in the genome, could be larger. This diversity of proteins has become one of the main sources of complexity in mammals, including the human species. 

A study of the Alfonso Valencia's group at the Spanish National Cancer Research Centre (CNIO) published in the journal Trends in Biochemical Sciences, conclued that while there are many alternative variants of RNAs from a single gene, only a few genes (246, slightly more than 1 per cent of the human genome) presented clear evidence of producing more than one protein.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

Genes Essential to Life Found in Mouse Mutants are Related to Many Human Disease Genes

Genes Essential to Life Found in Mouse Mutants are Related to Many Human Disease Genes | Genetics - GEG Tech top picks | Scoop.it
BigField GEG Tech's insight:

About one-third of all genes in the mammalian genome are essential for life. An international, multi-institutional research collaboration identified, for the first time, mutant traits in the mouse for 52 human disease genes, which significantly contributes to the understanding of the genetic bases for some human diseases, including cardiovascular defects, spina bifida, and metabolic disorders, among many others.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects

Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects | Genetics - GEG Tech top picks | Scoop.it
BigField GEG Tech's insight:

The scientists herein describe two Coats plus patients with telomere and genomic defects; both harbor distinct, novel mutations in STN1, a member of the human CTC1–STN1–TEN1 (CST) complex, thus linking this gene for the first time to a human telomeropathy.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections

CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections | Genetics - GEG Tech top picks | Scoop.it
BigField GEG Tech's insight:

Here, the authors set out to combat both productive and latent herpesvirus infections by exploiting the CRISPR/Cas9 system to target viral genetic elements important for virus fitness Their studies indicate that the CRISPR/Cas9 system can be effectively targeted to herpesvirus genomes as a potent prophylactic and therapeutic anti-viral strategy that may be used to impair viral replication and clear latent virus infection.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

Rare Evolutionary Event Detected in University of Texas Lab

Rare Evolutionary Event Detected in University of Texas Lab | Genetics - GEG Tech top picks | Scoop.it

http://www.pnas.org/content/early/2016/05/19/1605113113

BigField GEG Tech's insight:

It took nearly a half trillion tries before researchers at The University of Texas at Austin witnessed a rare event and perhaps solved an evolutionary puzzle about how introns, noncoding sequences of DNA located within genes, multiply in a genome. The results, published today in the Proceedings of the National Academy of Sciences, address fundamental questions about the evolution of new species and could expand our understanding of gene expression and the causes of diseases such as cancer.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

Loss of Y Chromosome Linked to Alzheimer's 

Loss of Y Chromosome Linked to Alzheimer's  | Genetics - GEG Tech top picks | Scoop.it
BigField GEG Tech's insight:

About one in five men over age 80 lose the Y chromosome from their blood cells, and this condition has now been linked to an increased risk of Alzheimer’s disease, researchers said.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

First gene linked to temperature sex switch identified

First gene linked to temperature sex switch identified | Genetics - GEG Tech top picks | Scoop.it
BigField GEG Tech's insight:

The sex of many reptile species is set by temperature. New research reported in the journalGENETICS identifies the first gene associated with temperature-dependent sex determination in any reptile.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

Genetic diversity helps to limit infectious disease

Genetic diversity helps to limit infectious disease | Genetics - GEG Tech top picks | Scoop.it
The diversity-generating benefits of a prokaryotic adaptive immune system

 

http://www.nature.com/nature/journal/v532/n7599/full/nature17436.html

 

BigField GEG Tech's insight:

New research by University of Exeter academics shows that genetic diversity helps to reduce the spread of diseases by limiting parasite evolution.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

New Epigenetic Mark Confirmed in Mammals 

New Epigenetic Mark Confirmed in Mammals  | Genetics - GEG Tech top picks | Scoop.it
BigField GEG Tech's insight:

The most well-studied epigenetic mark is methylation of cytosine, and in fact 5-methylcytosine (the attachment of a methyl group to the fifth atom in the six-atom ring, counting counterclockwise from the nitrogen at the bottom) was the only known type of methylation in mammalian cells, according to GenomeWeb. But researchers from Yale University have documented that mammalian adenine bases can also carry methylation marks. The team published its results this week (March 3) in Nature.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

Gene Study Offers Hint of Schizophrenia Cause | MIT Technology Review

Gene Study Offers Hint of Schizophrenia Cause | MIT Technology Review | Genetics - GEG Tech top picks | Scoop.it
BigField GEG Tech's insight:

A massive genetic study has sketched out a molecular link between schizophrenia and how the brain is shaped in adolescence.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

Like father like son: Epigenetics in wild guinea pigs

Like father like son: Epigenetics in wild guinea pigs | Genetics - GEG Tech top picks | Scoop.it
BigField GEG Tech's insight:

Fathers are able to adjust to increasing temperatures within their own lifetime and do transmit this information to their offspring. This has now been shown for the first time in a wild animal.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recurrently deleted in human cancer - Nature Genetics

The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recurrently deleted in human cancer - Nature Genetics | Genetics - GEG Tech top picks | Scoop.it
BigField GEG Tech's insight:

Thanks to the CRISPR systaem, Paul Khavari and colleagues analyze tumor genomes to identify snoRNAs showing frequent copy number loss of adjacently encoded snoRNAs SNORD50A and SNORD50B. These snoRNAs directly bound K-Ras and their loss leads to increased activity of both wild-type and oncogenic K-Ras and is associated with reduced survival.


www.geg-tech.com/Vectors

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

Humans' close relatives, chimps and bonobos, were kissing cousins

Humans' close relatives, chimps and bonobos, were kissing cousins | Genetics - GEG Tech top picks | Scoop.it
BigField GEG Tech's insight:

The study, involving researchers from ICREA in Barcelona, revealed chimps (pictured) interbred with their cousins just like humans and Neanderthals did in the past, leaving a lasting genetic legacy.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

NIH Researchers find gene, PIEZO2 responsible for 'six sense'

NIH Researchers find gene, PIEZO2 responsible for 'six sense' | Genetics - GEG Tech top picks | Scoop.it

http://www.nejm.org/doi/full/10.1056/NEJMoa1602812#t=article

BigField GEG Tech's insight:

With the help of two young patients with a unique neurological disorder, an initial study by scientists at the National Institutes of Health (NIH) suggests that a gene called PIEZO2 controls specific aspects of human touch and proprioception, a “sixth sense” describing awareness of one’s body in space. Mutations in the gene caused the two to have movement and balance problems and the loss of some forms of touch. Despite their difficulties, they both appeared to cope with these challenges by relying heavily on vision and other senses.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

Identification of 15 genetic loci associated with risk of major depression in individuals of European descent - Nature Genetics 

Identification of 15 genetic loci associated with risk of major depression in individuals of European descent - Nature Genetics  | Genetics - GEG Tech top picks | Scoop.it
BigField GEG Tech's insight:

Ashley Winslow, Roy Perlis, David Hinds and colleagues report the identification of 15 genetic loci associated with risk of major depressive disorder in individuals of European descent. They find that several loci are also associated with risk of other psychiatric traits, including schizophrenia and neuroticism.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

Guide RNAs: A Glimpse at the Sequences that Drive CRISPR–Cas Systems

Guide RNAs: A Glimpse at the Sequences that Drive CRISPR–Cas Systems | Genetics - GEG Tech top picks | Scoop.it

Click here to edit the content

BigField GEG Tech's insight:

Here the authors discuss the biological significance of Type II CRISPR–Cas elements, including the tracrRNA, crRNA, Cas9, and protospacer-adjacent motif (PAM), and look at the native function of these elements to understand how they can be engineered, enhanced, and optimized for genome editing applications.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

‘Undead’ genes come alive days after life ends - Science

‘Undead’ genes come alive days after life ends - Science | Genetics - GEG Tech top picks | Scoop.it

Work may aid organ transplants, crime scene investigations

BigField GEG Tech's insight:

A study shows that that at least one aspect of life continues: Genes remain turned on days after animals die. Researchers may be able to parlay this postmortem activity into better ways of preserving donated organs for transplantation and more accurate methods of determining when murder victims were killed.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

Coronary Artery Disease Risk, Non-HDL Cholesterol Lower in Europeans with Rare ASGR1 Mutations

Coronary Artery Disease Risk, Non-HDL Cholesterol Lower in Europeans with Rare ASGR1 Mutations | Genetics - GEG Tech top picks | Scoop.it

http://www.nejm.org/doi/full/10.1056/NEJMoa1508419#t=article

BigField GEG Tech's insight:

An international team led by investigators at Decode Genetics-Amgen has identified a rare, non-coding deletion in the asialoglycoprotein receptor gene ASGR1 that appears to protect against coronary artery disease in individuals of European ancestry.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

How Fish Can Regenerate Eye Injuries at the Cellular Level - Communications and Marketing - Heidelberg University

How Fish Can Regenerate Eye Injuries at the Cellular Level - Communications and Marketing - Heidelberg University | Genetics - GEG Tech top picks | Scoop.it
Press Information University of Heidelberg
BigField GEG Tech's insight:

Unlike what is possible with the human eye, fish are able to regenerate injuries to the retina at the cellular level. Scientists at Heidelberg University's Centre for Organismal Studies (COS) have now decoded how this regeneration starts, using studies of the model organism of the Medaka fish. Surprisingly, a single genetic factor triggers two central steps in the process of regeneration – cell division and the differentiation of progenitors into the different retinal cell types

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

The MC1R Gene and Youthful Looks - Current Biology

The MC1R Gene and Youthful Looks - Current Biology | Genetics - GEG Tech top picks | Scoop.it
BigField GEG Tech's insight:

Scientists in The Netherlands have discovered that a gene which keeps people looking young for their age is the same that produces red hair and fair skin.

Researchers at Erasmus University in Rotterdam studied the faces of almost 2,700 elderly Dutch Europeans, and found that those carrying a variation of the MC1R gene looked on average two years younger than they actually are.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

Penn Study Brings New Understanding to How Fundamental DNA Sequences Govern Gene Activity

Penn Study Brings New Understanding to How Fundamental DNA Sequences Govern Gene Activity | Genetics - GEG Tech top picks | Scoop.it

http://www.cell.com/molecular-cell/abstract/S1097-2765(16)00179-9?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276516001799%3Fshowall%3Dtrue

BigField GEG Tech's insight:

A team of researchers from the Perelman School of Medicine at the University of Pennsylvania have shed new light on how the structure of regulatory sequences in DNA is packaged in a cell.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

Translational Psychiatry - Toward dissecting the etiology of schizophrenia: HDAC1 and DAXX regulate GAD67 expression in an in vitro hippocampal GABA neuron model

Translational Psychiatry - Toward dissecting the etiology of schizophrenia: HDAC1 and DAXX regulate GAD67 expression in an in vitro hippocampal GABA neuron model | Genetics - GEG Tech top picks | Scoop.it
Translational Psychiatry explores the more translational area between the research in neuroscience and conceptually novel treatments
BigField GEG Tech's insight:

In this study, the authors investigated the contribution of epigenetic factors HDAC1 and DAXX to the developmental perturbation hypothesized to underlie schizophrenia (SZ). For this purpose, they designed lentiviral vectors carrying short hairpin RNA interference (shRNAi) for HDAC1 and DAXX. Their results point to a key role of both HDAC1 and DAXX in the regulation of GAD67 in GABAergic HiB5 cells, strongly suggesting that these epigenetic/transcription factors contribute to mechanisms underlying GABA cell dysfunction in SZ.


www.geg-tech.com/Vectors

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

Dog DNA probed for clues to human psychiatric ills

Dog DNA probed for clues to human psychiatric ills | Genetics - GEG Tech top picks | Scoop.it
BigField GEG Tech's insight:

Pet project hunts genetic links to behaviour by polling owners on their companions’ quirks.

more...
No comment yet.
Scooped by BigField GEG Tech
Scoop.it!

Researchers elucidate network of genes that control when puberty begins: Discovery may pave way for linking environmental factors to early-onset puberty in females

Researchers elucidate network of genes that control when puberty begins: Discovery may pave way for linking environmental factors to early-onset puberty in females | Genetics - GEG Tech top picks | Scoop.it
BigField GEG Tech's insight:

In expanding our knowledge of how the brain controls the process of sexual development, researchers have identified, for the first time, members of an elaborate superfamily of genes that regulate the timing of puberty in highly evolved nonhuman primates.

more...
No comment yet.