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Molecular cartography of the human skin surface in 3D

Molecular cartography of the human skin surface in 3D | Science, Technology, and Current Futurism | Scoop.it

The human skin is an organ with a surface area of 1.5–2 m2 that provides our interface with the environment. The molecular composition of this organ is derived from host cells, microbiota, and external molecules. The chemical makeup of the skin surface is largely undefined. Here we advance the technologies needed to explore the topographical distribution of skin molecules, using 3D mapping of mass spectrometry data and microbial 16S rRNA amplicon sequences. Our 3D maps reveal that the molecular composition of skin has diverse distributions and that the composition is defined not only by skin cells and microbes but also by our daily routines, including the application of hygiene products. The technological development of these maps lays a foundation for studying the spatial relationships of human skin with hygiene, the microbiota, and environment, with potential for developing predictive models of skin phenotypes tailored to individual health.


Amina Bouslimani, Carla Porto, Christopher M. Rath, Mingxun Wang, Yurong Guo, Antonio Gonzalez, Donna Berg-Lyon, Gail Ackermann, Gitte Julie Moeller Christensen, Teruaki Nakatsuji, Lingjuan Zhang, Andrew W. Borkowski, Michael J. Meehan, Kathleen Dorrestein, Richard L. Galla, Nuno Bandeira, Rob Knight, Theodore Alexandrova,j,k,l,2, and Pieter C. Dorrestein

PNAS

doi: 10.1073/pnas.1424409112


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Our Skin's Sense Of Time Helps Protect Against UV Damage

Our Skin's Sense Of Time Helps Protect Against UV Damage | Science, Technology, and Current Futurism | Scoop.it
This discovery could eventually lead to better understanding of aging and skin cancer.
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