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Why New Drugs Are So Expensive | MIT Technology Review

Why New Drugs Are So Expensive | MIT Technology Review | From Health Care to Health | Scoop.it
Today’s medicines can cost hundreds of thousands of dollars a year.
matthew kapp's insight:

Patients2.0..... Pharma are the innovation engine for disease cures but their customers are the insurance and medical payers, not the patients, and the consumers, needing treatments and cures who ultimately want health not healthcare solutions for being healthy not just cures for when it goes wrong. Today the Healthcare and Pharma system is that, Healthcare not health and it's stacked unfavorably and focused on large population treatments where revenues can match the huge costs of clinical trials in drug development and the self intersts in between . So many diseases get little to no attention and are labeled orphan diseases because there is no payback for the investment needed. In the way social media web 2.0 disrupted the advertising industry with mass personalization through new channels touching the consumers experience, there is an emerging real world trials model that will touch patients and the consumer crowd in the same way. This will cut costs whilst  Pharma continue to achieve their 850B$ of revenues, but it will be  across many many more treatments and delivering treatments to orphan disease.

 

Regulations need to adapt  to allow technology to change the way markets work advancing development and affordability of treatments for many more diseases.

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Intel’s CEO Envisions A Future Where Wearables Don’t Look Like Wearables — And It’s Not That Far Away | TechCrunch

Intel’s CEO Envisions A Future Where Wearables Don’t Look Like Wearables — And It’s Not That Far Away | TechCrunch | From Health Care to Health | Scoop.it
Intel CEO Brian Krzanich foresees a day when a wearable is no longer seen a one-size-fits-all device that you put on your wrist. That day could be coming..
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HP Machine technology rethinks the basics of computing

HP Machine technology rethinks the basics of computing | From Health Care to Health | Scoop.it
We've seen bits and pieces of technology that hint at the future of computing, but HP has just taken a big, big step toward bringing them all together.
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Recurrent glioblastoma: Does the timing of bevacizumab treatment impact survival? | 2014 ASCO Annual Meeting Abstracts

RT @subatomicdoc: Recurrent glioblastoma: Does the timing of bevacizumab treatment impact survival? http://t.co/0wxAYHR2Zd #ASCO14 #btsm
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The frequency and impact of ROS1 rearrangement on clinical outcomes in GBM. | 2014 ASCO Annual Meeting Abstracts

ROS1 mutation linked to worse survival in glioblastoma http://t.co/Lxz9GtPGu4 #ASCO14 #btsm
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Big Hospital Finally telling the truth about Cancer, Johns Hopkins

Big Hospital Finally telling the truth about Cancer, Johns Hopkins | From Health Care to Health | Scoop.it
LATEST CANCER INFORMATION from Johns Hopkins AFTER YEARS OF TELLING PEOPLE CHEMOTHERAPY IS THE ONLY WAY TO TRY AND ELIMINATE CANCER, JOHNS HOPKINS IS FINALLY STARTING TO TELL YOU THERE IS AN ALTERN...
matthew kapp's insight:

Systems biology! When a person has cancer it indicates the person has multiple nutritional deficiencies. These could be due to genetic, environmental, food and lifestyle factors.

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Academics dig into EMRs to discover genetic causes of disease

Academics dig into EMRs to discover genetic causes of disease | From Health Care to Health | Scoop.it
In the 13 years since the publication of the rough draft of the human genetic code, scientists have run thousands of genome-wide association studies to find links between DNA and disease.
matthew kapp's insight:
This is an example of IT Big Data and Genome sequencing technologies converging and driving exponential results to discovery what DNA and it's expression correlates to a disease as well as a cure. It will help identify the markers for the disease as well as the markers for resistance to the drugs that may be prescribed and a good understanding of how each individual is likely to benefit or not from treatments. Not only can this progress a more precise approach to what drugs can cure or help patients it also can ensure treatments are not unnecessarily prescribed and harming patients. This targeted approach to find the disease markers will save lives, suffering and save billions in health care costs. If not for health, then the later being an economic imperative should result in policy inertia to change impediments in the current system and policies. Disease markers are unique combinations of chemical indicators, such as DNA and proteins, that can be detected in tissue samples. They can indicate a person’s risk of developing a particular form of disease , as well as how they might respond to a specific treatment. Though researchers believe that thousands of clinically useful markers exist, only a handful have been identified to date. As more markers are discovered, doctors will be able to detect disease earlier and personalize treatment based on a patient’s genetic profile – both of which usually result in significantly better treatment outcomes. With pharma's 850b$ a year in revenue generated from an ongoing annual pipeline of only approximately 29 new drugs a year, it takes an expected 22b$ per new drug on average to sustain development. That's not going to scale and tackle all the diseases out there, let alone personalizing drug treatments. This new approach coupled with new adaptive more efficient clinical trial models has the potential to scale massively and pinpoint markers and effective cures, drastically reducing cost for pharma and allowing exponential shift in drug discovery and treating more diseases. The issue is the privacy around our EMR and genetic data. With the potential of ubiquitous DNA data coming available, the opportunity for disease prediction and early treatment is going to be to important. Additionally the potential to not just correlate our DNA with disease but also our environmental exposures, lifestyle, diet and so on will give us much better predictors and alternative types of treatments. While patients may not control how to share their EMR, disease social networks and research sites like PatientsLikeMe with 250,000 critically ill patients, fill the gap and become patient driven research pools of immense value to find these markers.
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How To Track Everything In Your Life Without Going Crazy

These days, you can track just about anything with the right device: how you move, how you sleep, and even how you eat, giving us the opportunity to q...
matthew kapp's insight:
Quantified self. Insights into the process.
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British surgeons to use 3D printing to reconstruct a man's FACE

British surgeons to use 3D printing to reconstruct a man's FACE | From Health Care to Health | Scoop.it
Surgeons in Swansea, South Wales, have used CT scans to create detailed three-dimensional images which will be used to create the printed implants. (RT @CortesSteve: #3Dprinting used to reconstruct injured man's face, amazing.
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Physicists decode decision circuit of cancer metastasis

Physicists decode decision circuit of cancer metastasis | From Health Care to Health | Scoop.it
Cancer researchers from Rice Univ. have deciphered the operating principles of a genetic switch that cancer cells use to decide when to metastasize and invade other parts of the body. The study found that the on-off switch's ...
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Study Identifies Mechanism That Makes Ordinary Stem Cells Create Tumors - Science Daily (press release)

Study Identifies Mechanism That Makes Ordinary Stem Cells Create Tumors - Science Daily (press release) | From Health Care to Health | Scoop.it
Study Identifies Mechanism That Makes Ordinary Stem Cells Create Tumors
Science Daily (press release)
Nov.
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Live better, together!

PatientsLikeMe is a patient network that improves lives and a real-time research platform that advances medicine. Through our network, people connect with ot...
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The Basis B1 Fitness Band Is Amazing But Still Needs Polish | TechCrunch

The Basis B1 Fitness Band Is Amazing But Still Needs Polish | TechCrunch | From Health Care to Health | Scoop.it
Being as chiseled as I am is tough. You have to eat right (brownies only every other day), exercise (take the stairs to the attic), and keep tabs on things..
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Vinod Khosla: The Case for Machines Taking Our Jobs

Speaking recently at a conference, venture capitalist Vinod Khosla discussed the impact that technology will have on an evolving workforce.
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Phase II study of atorvastatin in combination with radiotherapy and temozolomide in patients with glioblastoma. | 2014 ASCO Annual Meeting Abstracts

RT @subatomicdoc: Phase II trial of atorvastatin with radiation+temozolomide for glioblastoma http://t.co/18dx84H8mS #ASCO14 #btsm
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FLT-PET Fails to Distinguish True Glioblastoma Progression | Cancer Network

FLT-PET Fails to Distinguish True Glioblastoma Progression | Cancer Network | From Health Care to Health | Scoop.it
Positron emission tomography using [18]F-fluorothymidine as a tracer failed to distinguish true progression of glioblastoma from pseudoprogression in a small single-center study presented at the 2014 ASCO Annual Meeting.
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The Doctor's Office Of The Future: Coffeeshop, Apple Store, And Fitness Center

The Doctor's Office Of The Future: Coffeeshop, Apple Store, And Fitness Center | From Health Care to Health | Scoop.it
As health care reform starts to reshape how we think about wellness we're going to need new medical spaces that help encourage more healthy behavior...
matthew kapp's insight:
"Primary care physicians must get into the business of managing peoples health rather than their diseases"
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Join the World’s Largest Cancer Research Team to Help Find Cancer Markers | Citizen IBM Blog

Join the World’s Largest Cancer Research Team to Help Find Cancer Markers | Citizen IBM Blog | From Health Care to Health | Scoop.it
Earlier this year, actress Angelina Jolie made headlines when she announced that she had chosen to have a pre-emptive double mastectomy because she carries a
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Seattle's Sage Bionetworks seeks a drug-discovery revolution

Seattle's Sage Bionetworks seeks a drug-discovery revolution | From Health Care to Health | Scoop.it
When Stephen Friend formed the nonprofit Sage Bionetworks, his aim was nothing short of revolutionizing the way drug discovery is done so patients don't have to wait for help.
matthew kapp's insight:
"BEFORE WE get to the revolution, let's establish something up front: Medicine is failing us. We're talking mainly here about drug discovery. It takes too long to develop new drugs; it costs too much; and the drugs that make it out of the pipeline work for only about half the people who take them."
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Why our personal health data will become less private

Why our personal health data will become less private | From Health Care to Health | Scoop.it
In health care, I can envision having a system where one trades privacy for premium fees.
matthew kapp's insight:
With heath costs spiraling out of control as the system is basically stacked against patients driving health care not health, open Big Data mining can bring about an evidence based measures to not only drive lower cost of treatments but to drive preventative medicine and more effectively target cures to personalised medicine. Population data matched against efficacy of what treatments work and health problem early warning signals will have tremendous benefits to research, treatments, costs and longevity with better health. Transparency will transform healthcare. Anonymity should be protected but there will be risks just as we have seen in other areas. Can we really choose no to our populations better health and no to lowering the economic burden that's inflationary spiral will cripple our economies.
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Journal for ImmunoTherapy of Cancer | Full text | Adoptive transfer of IL13Rα2-specific T cells for the treatment of glioblastoma: building on clinical achievements with second-generation CARs

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Cancer's Deadly Darwinian Imperative - Discover Magazine Blogs

Cancer's Deadly Darwinian Imperative - Discover Magazine Blogs | From Health Care to Health | Scoop.it
Cancer is a disease of information, in which a cell becomes reprogrammed into a precision killing machine. In the consensus that has emerged from decades o.
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Dean Ornish, M.D. at TEDxSF (7 Billion Well)

Dean Ornish, M.D., is the founder and president of the non-profit Preventive Medicine Research Institute and Clinical Professor of Medicine at the University...
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