MIT biological engineers have devised a way to record complex histories in the DNA of human cells, allowing them to retrieve "memories" of past events, such as inflammation, by sequencing the DNA.
This analog memory storage system—the first that can record the duration and/or intensity of events in human cells—could also help scientists study how cells differentiate into various tissues during embryonic development, how cells experience environmental conditions, and how they undergo genetic changes that lead to disease.
"To enable a deeper understanding of biology, we engineered human cells that are able to report on their own history based on genetically encoded recorders," says Timothy Lu, an associate professor of electrical engineering and computer science, and of biological engineering. This technology should offer insights into how gene regulation and other events within cells contribute to disease and development, he adds.
Lu, who is head of the Synthetic Biology Group at MIT's Research Laboratory of Electronics, is the senior author of the new study, which appears in the Aug. 18 online edition of Science. The paper's lead authors are Samuel Perli SM '10, PhD '15 and graduate student Cheryl Cui.
A new concept could bring highly efficient solar power by combining three types of technologies that convert different parts of the light spectrum and also store energy for use after sundown.
Combining the technologies could make it possible to harness and store far more of the spectrum of sunlight than is possible using any one of the technologies separately.
"Harvesting the full spectrum of sunlight using a hybrid approach offers the potential for higher efficiencies, lower power production costs, and increased power grid compatibility than any single technology by itself," said Peter Bermel, an assistant professor in Purdue University's School of Electrical and Computer Engineering. "The idea is to use technologies that, for the most part exist now, but to combine them in a creative way that allows us to get higher efficiencies than we normally would."
The approach combines solar photovoltaic cells, which convert visible and ultraviolet light into electricity, thermoelectric devices that convert heat into electricity, and steam turbines to generate electricity. The thermoelectric devices and steam turbines would be driven by heat collected and stored using mirrors to focus sunlight onto a newly designed "selective solar absorber and reflector."
"This is a spectrally selective system, so it is able to efficiently make use of as much of the spectrum as possible," he said. "The thermal storage allows for significant flexibility in the time of power generation, so the system can produce power for hours after sunset, providing a consistent source of power throughout the day."
Findings from the research are detailed in a paper with an advance online publication date of Aug. 15, and the paper is scheduled to appear in a future print issue of the journal Energy & Environmental Science.
Archaeologists believe they have identified a new way of putting accurate dates to great events of prehistory. Rare and spectacular storms on the sun appear to have left their mark in forests and fields around the planet over the past 5,000 years.
Michael Dee, of Oxford University’s research laboratory for archaeology and the history of art, thinks evidence of such solar storms could help put precise years to some of the great uncertainties of history: the construction of Egypt’s Great Pyramid of Giza, the collapse of the ancient Mayan civilisation in Central America, and perhaps even the arrival of the Vikings in the Americas. Lost cities #7: how Nasa technology uncovered the 'megacity' of Angkor Read more
Every tree maintains its own almanac in the form of annual growth rings. For decades dendrochronologists have been using tree-ring evidence and radiocarbon dating to build a timetable of events that confirm historical accounts, even those predating the first written chronicles.
Humans living in the pre-Hispanic Mexican city of Teotihuacan may have bred rabbits and hares for food, fur and bone tools, according to a study published Aug. 17, 2016, in the open-access journal PLOS ONE by Andrew Somerville from the University of California San Diego, US, and colleagues.
Physicists are hunting for a particle that they hope could clue us in on some of the biggest mysteries in the universe. Questions like: Why the heck do we exist?
But after scouring an entire year’s worth of data from the largest particle detector on the planet, scientists at IceCube Neutrino Observatory have some bleak news. They're 99% sure the particle doesn’t exist.
Scientists in Germany have developed a new approach that may prevent leukemia and lymphoma patients from developing graft-versus-host disease (GvHD) after therapeutic bone marrow transplants. The researchers describe the successful application of their strategy in mice in 'Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion,' which will be published online Aug. 15 ahead of issue in the Journal of Experimental Medicine.
Brown dwarfs are smaller than stars, but more massive than giant planets. As such, they provide a natural link between astronomy and planetary science. However, they also show incredible variation when it comes to size, temperature, chemistry, and more, which makes them difficult to understand, too.
New work led by Carnegie's Jacqueline Faherty surveyed various properties of 152 suspected young brown dwarfs in order to categorize their diversity and found that atmospheric properties may be behind much of their differences, a discovery that may apply to planets outside the solar system as well. The work is published by The Astrophysical Journal Supplement Series.
Scientists are very interested in brown dwarfs, which hold promise for explaining not just planetary evolution, but also stellar formation. These objects are tougher to spot than more-massive and brighter stars, but they vastly outnumber stars like our Sun. They represent the smallest and lightest objects that can form like stars do in the Galaxy so they are an important "book end" in Astronomy.
For the moment, data on brown dwarfs can be used as a stand-in for contemplating extrasolar worlds we hope to study with future instruments like the James Webb Space Telescope.
"Brown dwarfs are far easier to study than planets, because they aren't overwhelmed by the brightness of a host star," Faherty explained.
A Northwestern University team recently caught DNA doing something that has never been seen before: it blinked.
For decades, textbooks have stated that macromolecules within living cells, such as DNA, RNA, and proteins, do not fluoresce on their own. Technology instead relies on special fluorescence dyes to enhance contrast when macromolecules are imaged.
But now Professors Vadim Backman, Hao Zhang, and Cheng Sun have discovered that macromolecule structures in living cells do, in fact, naturally fluoresce. This finding could open the next frontier of biological discovery by paving a new way for label-free, super-resolution nanoscopic imaging and expanding the understanding of biological processes.
"Everybody has overlooked this effect because nobody asked the right question," said Backman, Walter Dill Scott Professor of Biomedical Engineering in Northwestern's McCormick School of Engineering. "It sounds cliché, but you get the answer to the question you ask. When we actually asked the right question, we got a very different answer than expected."
The work by Negishi et al., published recently in the electronic journal eLife, has revealed that in the sea squirt embryo, the orientation of the cell division machinery in epithelial cells is controlled by a unique cell membrane structure, which we call an 'invagination.'
Palaeontologist Jørn Hurum came across the dusty fossil in 2011 down in the storage shelves of the Natural History Museum in Oslo. It had originally been found on Spitzbergen by the geologist Jenö Nagy in 1962.
Now, five years on, Hurum and a group of scientists have published a study showing this to be a remnant of a small bird or bird-like dinosaur that lived about 113 to 100 million years ago.
Researchers have developed a method for achieving an order-of-magnitude enhancement of the light emission from a class of two-dimensional (2D) materials called transition metal dichalcogenides (TMDs). The large light enhancement arises when the 2D material is placed on a photonic hypercrystal, which is an artificial optical material first proposed in 2014 by Evgenii E. Narimanov at Purdue University, who is one of the authors of the new study.
The research team is led by Vinod M. Menon, a physics professor at the City College of the City University of New York (CUNY), and Yi-Hsien Lee, a professor of materials science and engineering at National Tsing-Hua University in Hsinchu, Taiwan. Their work is published in a recent issue of Nano Letters.
In recent years, 2D materials such as 2D TMDs have attracted a great deal of attention because their atomic-scale thickness leads to exceptional electronic and optical properties, making them potential candidates for future optoelectronic devices.
2D TMDs are particularly appealing because they spontaneously emit light due to their direct band gaps, which enables electrons to directly emit photons. Currently, however, 2D TMDs don't produce enough light to make them useful as practical light-emitting devices.
In the new study, the researchers have shown that photonic hypercrystal substrates can transform low-light-emitting TMDs into much brighter sources of light.
When you hear a sound, only some of the neurons in the auditory cortex of your brain are activated. This is because every auditory neuron is tuned to a certain range of sound, so that each neuron is more sensitive to particular types and levels of sound than others. In a new study, researchers have designed a neuromorphic ("brain-inspired") computing system that mimics this neural selectivity by using artificial level-tuned neurons that preferentially respond to specific types of stimuli.
In the future, level-tuned neurons may help enable neuromorphic computing systems to perform tasks that traditional computers cannot, such as learning from their environment, pattern recognition, and knowledge extraction from big data sources.
The researchers, Angeliki Pantazi et al., at IBM Research-Zurich and École Polytechnique Fédérale de Lausanne, both in Switzerland, have published a paper on the new neuromorphic architecture in a recent issue of Nanotechnology.
Like all neuromorphic computing architectures, the proposed system is based on neurons and their synapses, which are the junctions where neurons send signals to each other. In this study, the researchers physically implemented artificial neurons using phase-change materials. These materials have two stable states: a crystalline, low-resistivity state and an amorphous, high-resistivity state. Just as in traditional computing, the states can be switched by the application of a voltage. When the neuron's conductance reaches a certain threshold, the neuron fires.
"We have demonstrated that phase-change-based memristive devices can be used to create artificial neurons and synapses to store and process data," coauthor Evangelos Eleftheriou at IBM Research-Zurich told Phys.org. "A phase-change neuron uses the phase configuration of the phase-change material to represent its internal state, the membrane potential. For the phase-change synapse, the synaptic weight—which is responsible for the plasticity—is encoded by the conductance of the nanodevice."
Researchers at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) and UC Berkeley have created a sort of nanoscale display case that enables new atomic-scale views of hard-to-study chemical and biological samples.
Their work, published online Aug. 18 in the journal Science, could help to reveal new structural details for a range of challenging molecules—including complex chemical compounds and potentially new drugs—by stabilizing them inside sturdy structures known as metal-organic frameworks (MOFs).
The researchers introduced a series of different molecules that were chemically bound inside these porous MOFs, each measuring about 100 millionths of a meter across, and then used X-ray techniques to determine the precise molecular structure of the samples inside the MOFs.
The samples ranged from a simple alcohol to a complex plant hormone, and the new method, dubbed "CAL" for covalent alignment (the molecules form a type of chemical bond known as a covalent bond in the MOFs), enables researchers to determine the complete structure of a molecule from a single MOF crystal that contains the sample molecules in its pores.
The MOFs in the study, which are identical and are easy to manufacture in large numbers, provided a sort of backbone for the sample molecules that held them still for the X-ray studies—the molecules otherwise can be wobbly and difficult to stabilize. The researchers prepared the samples by dipping the MOFs into solutions containing different molecular mixes and then heating them until they crystallized.
University of Adelaide research has for the first time statistically proven that the earliest standing stone monuments of Britain, the great circles, were constructed specifically in line with the movements of the Sun and Moon, 5000 years ago.
Jeff Steinhauer, a physicist at Technion University in Israel, has created an acoustic black hole and observed particles slipping out of its grasp, providing the strongest evidence to date of one of Stephen Hawking's most famous predictions.
In 1974, Stephen Hawking predicted that black holes might not be the bottomless pits we imagine them to be. According to Hawking's calculations, some information might escape black holes in the form of energy, or Hawking radiation.
Here's how it works: Throughout the universe, matter-antimatter pairs of particles are constantly flickering in and out of existence (because matter and antimatter quickly annihilate each other).
But if one of these particles is dragged into the event horizon of a black hole — the point where not even light can escape — before the pair annihilates, the other particle might slip away as Hawking radiation.
The universe is governed by four fundamental forces.
There’s gravity and electromagnetism, and then the lesser known weak and nuclear forces.
But a group of theoretical physicists at the University of California, Irvine (UCI) thinks there might just be a fifth fundamental force lurking in the shadows.
And this force could revolutionize our understanding of physics, unlocking the mysterious dark universe and potentially even leading to a holy grail of physics: a Grand Unified Theory that merges all of the fundamental forces into one. The researchers explain their findings in a paper published August 11 in the journal Physical Review Letters.
“The four known forces have very obvious jobs holding our universe together,” Jonathan Feng, one of the study’s authors, told Business Insider. “That’s how we discovered them. Gravity holds the planets in orbit around the sun. You see electricity and magnetism in lightning and magnets. The role of this force is going to be much more subtle. If it weren’t, we would have found it a long time ago.”
A new look at the debris from an exploded star in our galaxy has astronomers re-examining when the supernova actually happened. Recent observations of the supernova remnant called G11.2-0.3 with NASA's Chandra X-ray Observatory have stripped away its connection to an event recorded by the Chinese in 386 CE.
Historical supernovas and their remnants can be tied to both current astronomical observations as well as historical records of the event. Since it can be difficult to determine from present observations of their remnant exactly when a supernova occurred, historical supernovas provide important information on stellar timelines. Stellar debris can tell us a great deal about the nature of the exploded star, but the interpretation is much more straightforward given a known age.
New Chandra data on G11.2-0.3 show that dense clouds of gas lie along the line of sight from the supernova remnant to Earth. Infrared observations with the Palomar 5-meter Hale Telescope had previously indicated that parts of the remnant were heavily obscured by dust. This means that the supernova responsible for this object would simply have appeared too faint to be seen with the naked eye in 386 CE. This leaves the nature of the observed 386 CE event a mystery.
For nearly nine decades, science's favorite explanation for the origin of life has been the "primordial soup". This is the idea that life began from a series of chemical reactions in a warm pond on Earth's surface, triggered by an external energy source such as lightning strike or ultraviolet (UV) light. But recent research adds weight to an alternative idea, that life arose deep in the ocean within warm, rocky structures called hydrothermal vents.
A study published last month in Nature Microbiology suggests the last common ancestor of all living cells fed on hydrogen gas in a hot iron-rich environment, much like that within the vents. Advocates of the conventional theory have been sceptical that these findings should change our view of the origins of life. But the hydrothermal vent hypothesis, which is often described as exotic and controversial, explains how living cells evolved the ability to obtain energy, in a way that just wouldn't have been possible in a primordial soup.
Under the conventional theory, life supposedly began when lightning or UV rays caused simple molecules to join together into more complex compounds. This culminated in the creation of information-storing molecules similar to our own DNA, housed within the protective bubbles of primitive cells. Laboratory experiments confirm that trace amounts of molecular building blocks that make up proteins and information-storing molecules can indeed be created under these conditions. For many, the primordial soup has become the most plausible environment for the origin of first living cells.
Researchers from Polytechnique Montréal, Université de Montréal and McGill University have just achieved a spectacular breakthrough in cancer research. They have developed new nanorobotic agents capable of navigating through the bloodstream to administer a drug with precision by specifically targeting the active cancerous cells of tumours. This way of injecting medication ensures the optimal targeting of a tumour and avoids jeopardizing the integrity of organs and surrounding healthy tissues. As a result, the drug dosage that is highly toxic for the human organism could be significantly reduced.
This scientific breakthrough has just been published in the prestigious journal Nature Nanotechnology in an article titled "Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions." The article notes the results of the research done on mice, which were successfully administered nanorobotic agents into colorectal tumours.
"These legions of nanorobotic agents were actually composed of more than 100 million flagellated bacteria - and therefore self-propelled - and loaded with drugs that moved by taking the most direct path between the drug's injection point and the area of the body to cure," explains Professor Sylvain Martel, holder of the Canada Research Chair in Medical Nanorobotics and Director of the Polytechnique Montréal Nanorobotics Laboratory, who heads the research team's work. "The drug's propelling force was enough to travel efficiently and enter deep inside the tumours."
When they enter a tumour, the nanorobotic agents can detect in a wholly autonomous fashion the oxygen-depleted tumour areas, known as hypoxic zones, and deliver the drug to them. This hypoxic zone is created by the substantial consumption of oxygen by rapidly proliferative tumour cells. Hypoxic zones are known to be resistant to most therapies, including radiotherapy.
But gaining access to tumours by taking paths as minute as a red blood cell and crossing complex physiological micro-environments does not come without challenges. So Professor Martel and his team used nanotechnology to do it.
Graphene nanoribbons (GNRs) bend and twist easily in solution, making them adaptable for biological uses like DNA analysis, drug delivery and biomimetic applications, according to scientists at Rice University.
Knowing the details of how GNRs behave in a solution will help make them suitable for wide use in biomimetics, according to Rice physicist Ching-Hwa Kiang, whose lab employed its unique capabilities to probe nanoscale materials like cells and proteins in wet environments. Biomimetic materials are those that imitate the forms and properties of natural materials.
The research led by recent Rice graduate Sithara Wijeratne, now a postdoctoral researcher at Harvard University, appears in the Nature journal Scientific Reports.
Graphene nanoribbons can be thousands of times longer than they are wide. They can be produced in bulk by chemically "unzipping" carbon nanotubes, a process invented by Rice chemist and co-author James Tour and his lab.
Their size means they can operate on the scale of biological components like proteins and DNA, Kiang said. "We study the mechanical properties of all different kinds of materials, from proteins to cells, but a little different from the way other people do," she said. "We like to see how materials behave in solution, because that's where biological things are." Kiang is a pioneer in developing methods to probe the energy states of proteins as they fold and unfold.
She said Tour suggested her lab have a look at the mechanical properties of GNRs. "It's a little extra work to study these things in solution rather than dry, but that's our specialty," she said.
Recent findings indicating the possible discovery of a previously unknown subatomic particle may be evidence of a fifth fundamental force of nature, according to a paper published in the journal Physical Review Letters by theoretical physicists at the University of California, Irvine.
"If true, it's revolutionary," said Jonathan Feng, professor of physics & astronomy. "For decades, we've known of four fundamental forces: gravitation, electromagnetism, and the strong and weak nuclear forces. If confirmed by further experiments, this discovery of a possible fifth force would completely change our understanding of the universe, with consequences for the unification of forces and dark matter."
The UCI researchers came upon a mid-2015 study by experimental nuclear physicists at the Hungarian Academy of Sciences who were searching for "dark photons," particles that would signify unseen dark matter, which physicists say makes up about 85 percent of the universe's mass. The Hungarians' work uncovered a radioactive decay anomaly that points to the existence of a light particle just 30 times heavier than an electron.
"The experimentalists weren't able to claim that it was a new force," Feng said. "They simply saw an excess of events that indicated a new particle, but it was not clear to them whether it was a matter particle or a force-carrying particle."
Scientists from Russia and Australia put forward a simple new way of counting microscopic particles in optical materials. A laser beam passing through such a material splits and forms a pattern of numerous bright spots on a projection screen. The researchers found that the number of these spots corresponds to the number of particles in the material. This finding allows to determine the material structure without resorting to microscopy. The work was published in Scientific Reports.
When placed in an acoustic field, small objects experience a net force that can be used to levitate the objects in air. In a new study, researchers have experimentally demonstrated the acoustic levitation of a 50-mm (2-inch) solid polystyrene sphere using ultrasound—acoustic waves that are above the frequency of human hearing.
The demonstration is one of the first times that an object larger than the wavelength of the acoustic wave has been acoustically levitated. Previously, this has been achieved only for a few specific cases, such as wire-like and planar objects. In the new study, the levitated sphere is 3.6 times larger than the 14-mm acoustic wavelength used here.
The researchers, Marco Andrade and Julio Adamowski at the University of São Paulo in Brazil, along with Anne Bernassau at Heriot-Watt University in Edinburgh, UK, have published a paper on the acoustic levitation demonstration in a recent issue of Applied Physics Letters.
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