Influenza
1.0K views | +0 today
Influenza
Flu in all Forms, Be Informed...Not Panicked.
Your new post is loading...
Your new post is loading...
Scooped by Mel Melendrez-Vallard
Scoop.it!

Molecular Signatures of Hemagglutinin Stem-Directed Heterosubtypic Human Neutralizing Antibodies against Influenza A Viruses

Molecular Signatures of Hemagglutinin Stem-Directed Heterosubtypic Human Neutralizing Antibodies against Influenza A Viruses | Influenza | Scoop.it
by Yuval Avnir, Aimee S. Tallarico, Quan Zhu, Andrew S. Bennett, Gene Connelly, Jared Sheehan, Jianhua Sui, Amr Fahmy, Chiung-yu Huang, Greg Cadwell, Laurie A. Bankston, Andrew T. McGuire, Leonidas Stamatatos, Gerhard Wagner, Robert C.
more...
No comment yet.
Scooped by Mel Melendrez-Vallard
Scoop.it!

Highly pathogenic avian influenza H5N8, Korea (Rep. of) (OIE, April 30 2014, edited)

[Source: OIE, full page: (LINK). Edited.]
Highly pathogenic avian influenza H5N8, Korea (Rep.
more...
No comment yet.
Scooped by Mel Melendrez-Vallard
Scoop.it!

Phylogenetic and antigenic characterization of reassortant H9N2 avian influenza viruses isolated from wild waterfowl in the East Dongting Lake wetland in 2011-2012

Background:
Wild waterfowl are recognized as the natural reservoir for influenza A viruses. Two distinct lineages, the American and Eurasian lineages, have been identified in wild birds. Gene flow between the two lineages is limited.
more...
No comment yet.
Scooped by Mel Melendrez-Vallard
Scoop.it!

Characterization of H7 Influenza A Virus in Wild and Domestic Birds in Korea

Characterization of H7 Influenza A Virus in Wild and Domestic Birds in Korea | Influenza | Scoop.it
by Hyun-Mi Kang, Ha-Young Park, Kyu-Jun Lee, Jun-Gu Choi, Eun-Kyoung Lee, Byung-Min Song, Hee-Soo Lee, Youn-Jeong Lee During surveillance programs in Korea between January 2006 and March 2011, 31 H7 avian influenza viruses were isolated from wild...
more...
No comment yet.
Scooped by Mel Melendrez-Vallard
Scoop.it!

Severe influenza A H7N9 pneumonia with rapid vi... [Eur Respir J. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
more...
No comment yet.
Rescooped by Mel Melendrez-Vallard from Viral Modeling and Simulation
Scoop.it!

Dynamics of influenza virus and human host interactions during infection and replication cycle - Bull Math Biol. 2013

The replication and life cycle of the influenza virus is governed by an intricate network of intracellular regulatory events during infection, including interactions with an even more complex system of biochemical interactions of the host cell. Computational modeling and systems biology have been successfully employed to further the understanding of various biological systems, however, computational studies of the complexity of intracellular interactions during influenza infection is lacking. In this work, we present the first large-scale dynamical model of the infection and replication cycle of influenza, as well as some of its interactions with the host's signaling machinery. Specifically, we focus on and visualize the dynamics of the internalization and endocytosis of the virus, replication and translation of its genomic components, as well as the assembly of progeny virions. Simulations and analyses of the models dynamics qualitatively reproduced numerous biological phenomena discovered in the laboratory. Finally, comparisons of the dynamics of existing and proposed drugs, our results suggest that a drug targeting PB1:PA would be more efficient than existing Amantadin/Rimantaine or Zanamivir/Oseltamivir.


Via burkesquires
more...
No comment yet.
Scooped by Mel Melendrez-Vallard
Scoop.it!

Comparison of Filtering Methods for the Modeling and Retrospective Forecasting of Influenza Epidemics

Comparison of Filtering Methods for the Modeling and Retrospective Forecasting of Influenza Epidemics | Influenza | Scoop.it
by Wan Yang, Alicia Karspeck, Jeffrey Shaman
A variety of filtering methods enable the recursive estimation of system state variables and inference of model parameters.
more...
No comment yet.
Scooped by Mel Melendrez-Vallard
Scoop.it!

H5-based DNA constructs derived from selected highly pathogenic H5N1 avian influenza virus induce high levels of humoral antibodies in Muscovy ducks against low pathogenic viruses

Background:
H5 low pathogenic avian influenza virus (LPAIV) infection in domestic ducks is a major problem in duck producing countries. Their silent circulation is an ongoing source of potential highly pathogenic or zoonotic emerging strains.
more...
No comment yet.
Scooped by Mel Melendrez-Vallard
Scoop.it!

Induction of neutralizing antibodies to influenza A virus H7N9 by inactivated whole virus in mice and nonhuman primates (Antiviral Res., abstract, edited)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
Antiviral Res. 2014 Apr 15. pii: S0166-3542(14)00109-0. doi: 10.1016/j.antiviral.2014.04.003.
more...
No comment yet.
Scooped by Mel Melendrez-Vallard
Scoop.it!

Iceland – a hotbed for bird flu viruses

Iceland – a hotbed for bird flu viruses | Influenza | Scoop.it
Scientists at the University of Iceland, in collaboration with American and Icelandic colleagues, demonstrated that bird flu viruses from both continental Europe and North-America, as well as mixed virus strains are found in wild birds in Iceland.
more...
No comment yet.
Rescooped by Mel Melendrez-Vallard from Viral Modeling and Simulation
Scoop.it!

Intra-host dynamics of influenza virus reassortment

The segmented nature of the influenza virus genome allows reassortment between co-infecting viruses. This process of genetic exchange vastly increases the diversity of circulating influenza viruses. The importance of reassortment to public health is clear from its role in the emergence of a number of epidemiologically important viruses, including novel pandemic and epidemic strains. To gauge its impact on within-host genomic variation, we tracked reassortment in co-infected guinea pigs over time and given matched or discordant doses of co-infecting viruses. To ensure unbiased detection of reassortants, we used parental viruses of equivalent fitness that differ only by non-coding nucleotide changes. These viruses were based on the isolate A/Panama/2007/1999 (H3N2). At a dose of 2×102 PFU, one parental virus was absent from each guinea pig throughout the time course, indicating the presence of a bottleneck. With an intermediate dose of 2×103 PFU, genomic diversity present in nasal lavage samples increased from 1-3 days post-infection (d.p.i.) and then declined by 6 d.p.i. With a high dose of 2×106 PFU, however, reassortment levels were high (avg. 59%) at 1 d.p.i. and remained stable. Even late in the course of infection, parental viruses were not eclipsed by reassortants, suggesting that a uniformly high multiplicity of infection was not achieved in vivo. Inoculation with approximately 10-fold discordant doses did not reduce reassortment relative to equivalent inputs, but markedly changed the spectrum of genotypes produced. Our data reveal the potential for reassortment to contribute to intra-host diversity in mixed influenza virus infection.

Importance Influenza virus reassortment is prevalent in nature and is a major contributor to the diversity of influenza viruses circulating in avian, swine, human and other host species. This diversity, in turn, increases the potential for influenza viruses to evade selective pressures or adapt to new host environments. As examples, reassortment was key to the emergence of the 1957, 1968 and 2009 pandemics; the unusually severe influenza epidemics of 2003, 1951 and 1947; and the rise in adamantane resistance among currently circulating human H3N2 viruses. Herein we reveal the diversity of viral genotypes generated over time in a host co-infected with two influenza viruses. We find that intra-host diversity driven by reassortment is dynamic and dependent on the amount of each virus initiating infection. Our results demonstrate the readiness with which reassortant influenza viruses arise, offering new insight into this important mechanism of influenza virus evolution.

 


Via burkesquires
more...
No comment yet.
Scooped by Mel Melendrez-Vallard
Scoop.it!

This year's flu season remembered for deaths of those age 65 and younger

This year's flu season remembered for deaths of those age 65 and younger | Influenza | Scoop.it
During most of this year's flu season, the influenza A (H1N1) 2009 pandemic was the main strain making people ill, but more influenza B was being reported.
more...
No comment yet.
Scooped by Mel Melendrez-Vallard
Scoop.it!

Influenza B Virus Making a Strong Spring Appearance - Guardian Liberty Voice

Influenza B Virus Making a Strong Spring Appearance - Guardian Liberty Voice | Influenza | Scoop.it
Guardian Liberty Voice
Influenza B Virus Making a Strong Spring Appearance
Guardian Liberty Voice
influenza The Influenza strain B virus is making a strong appearance, although spring is not its usual time of year.
more...
No comment yet.
Scooped by Mel Melendrez-Vallard
Scoop.it!

Novel Reassortant Influenza A(H5N8) Viruses in Domestic Ducks, Eastern China (Emerg Infet Dis., abstract, edited)

[Source: US Centers for Disease Control and Prevention, Emerging Infectious Diseases Journal, full page: (LINK).
more...
No comment yet.
Scooped by Mel Melendrez-Vallard
Scoop.it!

Sandman & Lanard On The Cochrane Tamiflu Report

Sandman & Lanard On The Cochrane Tamiflu Report | Influenza | Scoop.it
  # 8550   Somehow, with all of the MERS news coming out of the Middle East, I managed to miss a terrific piece of analysis by our favorite Risk Communications experts, Dr. Peter Sandman and Dr.
more...
No comment yet.
Scooped by Mel Melendrez-Vallard
Scoop.it!

Disparities among 2009 Pandemic Influenza A (H1N1) Hospital Admissions: A Mixed Methods Analysis – Illinois, April–December 2009

Disparities among 2009 Pandemic Influenza A (H1N1) Hospital Admissions: A Mixed Methods Analysis – Illinois, April–December 2009 | Influenza | Scoop.it
by Kenneth Soyemi, Andrew Medina-Marino, Ronda Sinkowitz-Cochran, Amy Schneider, Rashid Njai, Marian McDonald, Maleeka Glover, Jocelyn Garcia, Allison E.
more...
No comment yet.
Scooped by Mel Melendrez-Vallard
Scoop.it!

An experimentally determined evolutionary model dramatically improves phylogenetic fit

An experimentally determined evolutionary model dramatically improves phylogenetic fit | Influenza | Scoop.it
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
more...
No comment yet.
Rescooped by Mel Melendrez-Vallard from Virology and Bioinformatics from Virology.ca
Scoop.it!

Ultrastructural characterization of avian influenza A (H7N9) virus infecting humans in China

Ultrastructural characterization of avian influenza A (H7N9) virus infecting humans in China | Influenza | Scoop.it

Via Ed Rybicki
more...
No comment yet.
Scooped by Mel Melendrez-Vallard
Scoop.it!

Novel Agent for Tamiflu-Resistant pH1N1 Influenza Virus Discovered

Novel Agent for Tamiflu-Resistant pH1N1 Influenza Virus Discovered | Influenza | Scoop.it
The Medical Systems Virology group at Institute for Molecular Medicine Finland (FIMM), together with collaborators has recently sequenced genomes of 135 pH1N1 influenza strains isolated from Finnish patients in 2009-2013 and found one...
more...
No comment yet.
Scooped by Mel Melendrez-Vallard
Scoop.it!

Taiwan Announces 3rd Imported Case Of H7N9

Taiwan Announces 3rd Imported Case Of H7N9 | Influenza | Scoop.it
    # 8512   Even though the number of H7N9 cases being reported on the Chinese mainland has decreased markedly over the past month, we continue to see exported cases turning up in places like Hong Kong, Malaysia, and today - for the third time...
more...
No comment yet.
Scooped by Mel Melendrez-Vallard
Scoop.it!

Avian Flu Diary: Taiwan CDC: Epidemiological Follow Up On Imported H7N9 Case

Avian Flu Diary: Taiwan CDC: Epidemiological Follow Up On Imported H7N9 Case | Influenza | Scoop.it
more...
No comment yet.
Scooped by Mel Melendrez-Vallard
Scoop.it!

Severe atypical pneumonia outbreak associated with influenza A(H1N1)pdm09 in Egypt, 2013–2014 season (Wkly Epidemiol Rec., edited)

[Source: World Health Organization, Weekly Epidemiological Record, full PDF document: (LINK). Edited.]
Weekly epidemiological record / Relevé épidémiologique hebdomadaire - 18 APRIL 2014, 89th year / 18 AVRIL 2014, 89e année, No.
more...
No comment yet.
Scooped by Mel Melendrez-Vallard
Scoop.it!

Rhode Island | Flu declared widespread again – H3N2 and influenza B dominant strains | Big Medicine

more...
No comment yet.