Influenza
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Influenza
Flu in all Forms, Be Informed...Not Panicked.
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A model-based economic analysis of pre-pandemic influenza vaccination cost-effectiveness

A model-based economic analysis of pre-pandemic influenza vaccination cost-effectiveness | Influenza | Scoop.it
A model-based economic analysis of pre-pandemic influenza vaccination cost-effectiveness - up-to-the-minute news and headlines. 7thSpace is a online portal covering topics such as Family, Business, Entertainment, Headlines, Recipes and more. A place for the whole family featuring many different sections to chose from.
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Data and statistics on the Influenza virus life cycle | Zanran

Data and statistics on the Influenza virus life cycle | Zanran | Influenza | Scoop.it

Data & statistics on influenza virus life cycle: Inhibition of influenza A/PR/8/34 multiplication in MDCK Cav-1 knock-down cells. Titres of A/PR8 infected MDCK Cav-1 knock-down cells at day 13-17 after RNAi vector treatment and infection with influenza A/PR/8/34. Standard errors are depicted. Analysis using a paired t-test (n = 9) revealed that the 1,5 to 3 fold reduction in titres compared to MDCK control cells is statistically highly significant ..., Influenza A virus NS1 full length protein sequences aligned using the MUSCL program and subsequently order as a phylogenetic tree using CLUSTALW. The results of the single-linkage clustering determined there are 6 NS1 clades in the Influenza samples., The 1918 Spanish Influenza Flu Pandemic...


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Temporally structured metapopulation dynamics and persistence of influenza A H3N2 virus in humans. [Proc Natl Acad Sci U S A. 2011] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Attributable deaths due to influenza: a comp... [Eur J Epidemiol. 2012] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Continuing reassortment leads to the genetic diversity of Influenza H7N9 in Guangdong China (J Virol., abstract, edited)

[Source: Journal of Virology, full page: (LINK).
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Rhode Island To Track H1N1 Influenza Using E-Pharmacy Records - iHealthBeat

Rhode Island To Track H1N1 Influenza Using E-Pharmacy Records - iHealthBeat | Influenza | Scoop.it
Today, Rhode Island officials launched a new initiative designed to monitor H1N1 influenza activity through electronic pharmacy records.
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Johns Hopkins center to develop new ways to identify and track flu viruses

Johns Hopkins center to develop new ways to identify and track flu viruses | Influenza | Scoop.it
Johns Hopkins center to develop new ways to identify and track influenza viruses viruses
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Influenza virus H1N1 activates platelets through FcγRIIA signaling and thrombin generation

Influenza virus H1N1 activates platelets through FcγRIIA signaling and thrombin generation | Influenza | Scoop.it
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Suppressor of Cytokine Signaling 4 (SOCS4) Protects against Severe Cytokine Storm and Enhances Viral Clearance during Influenza Infection

Suppressor of Cytokine Signaling 4 (SOCS4) Protects against Severe Cytokine Storm and Enhances Viral Clearance during Influenza Infection | Influenza | Scoop.it
by Lukasz Kedzierski, Edmond M. Linossi, Tatiana B. Kolesnik, E. Bridie Day, Nicola L. Bird, Benjamin T. Kile, Gabrielle T. Belz, Donald Metcalf, Nicos A. Nicola, Katherine Kedzierska, Sandra E.
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Rescooped by Mel Melendrez-Vallard from Viruses and Bioinformatics from Virology.uvic.ca
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Identification, Characterization, and Natural Selection of Mutations Driving Airborne Transmission of A/H5N1 Virus: Cell

Identification, Characterization, and Natural Selection of Mutations Driving Airborne Transmission of A/H5N1 Virus: Cell | Influenza | Scoop.it

Recently, A/H5N1 influenza viruses were shown to acquire airborne transmissibility between ferrets upon targeted mutagenesis and virus passage. The critical genetic changes in airborne A/Indonesia/5/05 were not yet identified. Here, five substitutions proved to be sufficient to determine this airborne transmission phenotype. Substitutions in PB1 and PB2 collectively caused enhanced transcription and virus replication. One substitution increased HA thermostability and lowered the pH of membrane fusion. Two substitutions independently changed HA binding preference from α2,3-linked to α2,6-linked sialic acid receptors. The loss of a glycosylation site in HA enhanced overall binding to receptors. The acquired substitutions emerged early during ferret passage as minor variants and became dominant rapidly. Identification of substitutions that are essential for airborne transmission of avian influenza viruses between ferrets and their associated phenotypes advances our fundamental understanding of virus transmission and will increase the value of future surveillance programs and public health risk assessments.


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Modeling Genome-Wide Dynamic Regulatory Network in Mouse Lungs with Influenza Infection Using High-Dimensional Ordinary Differential Equations

Modeling Genome-Wide Dynamic Regulatory Network in Mouse Lungs with Influenza Infection Using High-Dimensional Ordinary Differential Equations | Influenza | Scoop.it
by Shuang Wu, Zhi-Ping Liu, Xing Qiu, Hulin Wu
The immune response to viral infection is regulated by an intricate network of many genes and their products.
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The Devastation of 1918: Finding Pockets of Hope in the Great Flu Pandemic - Pacific Standard

The Devastation of 1918: Finding Pockets of Hope in the Great Flu Pandemic - Pacific Standard | Influenza | Scoop.it
The Devastation of 1918: Finding Pockets of Hope in the Great Flu Pandemic Pacific Standard Influenza viruses weren't isolated until the 1930s, and the genetic make-up of the 1918 flu virus wasn't characterized until Jeffery Taubenberger, now at...
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Avian Flu Diary: mBio: Evolutionarily Distinct H11N2 Avian Flu Found In Antarctica

Avian Flu Diary: mBio: Evolutionarily Distinct H11N2 Avian Flu Found In Antarctica | Influenza | Scoop.it
Mel Melendrez-Vallard's insight:

penguin flu!

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Comparing clinical characteristics between hospitalized adults with laboratory-confirmed influenza A and B virus infection

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WHO | Human infection with avian influenza A(H7N9) virus – update

On 12 May 2014, the National Health and Family Planning Commission (NHFPC) of China notified WHO of five additional laboratory-confirmed cases of human infection with avian influenza A(H7N9) virus.
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The 2009 pandemic influenza virus... [Curr Top Microbiol Immunol. 2013] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Enhanced human receptor binding by H5 haemagglutinins (Virology, abstract, edited)

[Source: Science Direct, full page: (LINK). Abstract, edited.]
Virology, Volumes 456–457, May 2014, Pages 179–187
Enhanced human receptor binding by H5 haemagglutinins
Xiaoli Xiong, Haixia Xiao1, Stephen R.
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Scientists identify protein that could minimize flu pandemics

TweetScientists from Melbourne’s Walter and Eliza Hall Institute recently announced that a protein called SOCS4 shows the ability to serve as a handbrake to the immune system’s runaway reaction to flu infection, which could lead to a way of minimizing...
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Novel Avian Influenza A (H7N9) Virus Induces Impaired Interferon Responses in Human Dendritic Cells (PLoS One., abstract, edited)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
PLoS One. 2014 May 7;9(5):e96350. doi: 10.1371/journal.pone.0096350. eCollection 2014.
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We finally know why the 1918 influenza pandemic killed 50 million people

We finally know why the 1918 influenza pandemic killed 50 million people | Influenza | Scoop.it
The answer might have an impact on how we vaccinate against future pandemics.
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Analysis of recombinant H7N9 wild type and mutant viruses in pigs shows Q226L in HA is important for transmission (J Virol., abstract, edited)

[Source: Journal of Virology, full page: (LINK).
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Vaccination coverage for seasonal influenza among residents and health care workers in Norwegian nursing homes during the 2012/13 season, a cross-sectional study

Background:
WHO has set a goal of 75% vaccination coverage (VC) for seasonal influenza for residents and also recommends immunization for all healthcare workers (HCWs) in nursing homes (NHs).
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Random Analytics: Comparing H7N9 and MERS by Key Occupations

Random Analytics: Comparing H7N9 and MERS by Key Occupations | Influenza | Scoop.it
"Theatre Staff Nurse | King Faisal Specialist Hospital, Riyadh! Excellent tax-free income | 54 days annual leave | Free & secure furnished accommodation | Free medical insurance & emergency...

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Ian M Mackay, PhD's curator insight, May 7, 2014 6:39 PM

So much we really don't know about H7N9 and MERS-CoV. Here's a bunch of the less talked about items.

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Serologic assay for avian-origin influenza A (H7N9) virus in adults of Shanghai, Guangzhou and Yunnan, China (J Clin Virol., abstract, edited)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
J Clin Virol. 2014 Apr 13. pii: S1386-6532(14)00138-3. doi: 10.1016/j.jcv.2014.04.006.
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Highly pathogenic avian influenza H5N6, Laos (OIE, May 7 2014): No New Outbreak, New Reassortant Isolated - FluTrackers

Highly pathogenic avian influenza H5N6, Laos (OIE, May 7 2014): No New Outbreak, New Reassortant Isolated - FluTrackers | Influenza | Scoop.it
Highly pathogenic avian influenza H5N6, Laos (OIE, May 7 2014): No New Outbreak, New Reassortant Isolated Laos (HP #avian #influenza #H5N6, #Laos (#OIE, May 7 14): No New Outbreak, New #Reassortant Isolated @FluTrackers
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