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Flu in all Forms, Be Informed...Not Panicked.
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London study finds 77 percent of influenza infections are asymptomatic

London study finds 77 percent of influenza infections are asymptomatic | Influenza | Scoop.it
TweetA recent study conducted by University College London, United Kingdom, found that influenza reach is larger than previously believed since approximately 77 percent of persons infected are asymptomatic.
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Flusurvey study shows correlation between exercise and decreased risk of influenza infection

Flusurvey study shows correlation between exercise and decreased risk of influenza infection | Influenza | Scoop.it
TweetThe London School of Hygiene & Tropical Medicine recently released the preliminary results of this year’s Flusurvey study and found a correlation between vigorous exercise and decreased risk of influenza infection.
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H5N1: Pandemic potential of emerging influenza

Via The Lancet Infectious Diseases, an editorial: Pandemic potential of emerging influenza. Excerpt: Throughout the 20th century, four pandemics primed our current approaches to influenza surveillance. The 1918—20 pandemic was by far the most devastating on a global scale. At...
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H5N1: Study fingers chickens, quail, in spread of H7N9 influenza virus

Via MedicalXpress.com: Study fingers chickens, quail, in spread of H7N9 influenza virus. Click through for the full report and relevant links. Excerpt: Among the copious species of poultry in China, quail and chickens are the likely sources of infection of...
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HK CHP: Follow Up Epidemiological Investigation Into Imported H7N9 Case

HK CHP: Follow Up Epidemiological Investigation Into Imported H7N9 Case | Influenza | Scoop.it
  H7N9 Awareness Campaign Summer 2013 - Photo credit Hong Kong’s CHP   # 8385   Yesterday, in HK CHP Investigating Imported H7N9 Case, we learned of the arrival in that city of a 5-month-old girl from neighboring Guangdong Province, who was...
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Avian Flu Diary: PLoS One: North Atlantic Flyways Provide Opportunities For Spread Of Avian Influenza Viruses

Avian Flu Diary: PLoS One: North Atlantic Flyways Provide Opportunities For Spread Of Avian Influenza Viruses | Influenza | Scoop.it
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Comparative community burden and severity of seasonal and pandemic influenza: results of the Flu Watch cohort study : The Lancet Respiratory Medicine

BackgroundAssessment of the effect of influenza on populations, including risk of infection, illness if infected, illness severity, and consultation rates, is essential to inform future control and prevention. We aimed to compare the community burden and severity of seasonal and pandemic influenza across different age groups and study years and gain insight into the extent to which traditional surveillance underestimates this burden.MethodsUsing preseason and postseason serology, weekly illness reporting, and RT-PCR identification of influenza from nasal swabs, we tracked the course of seasonal and pandemic influenza over five successive cohorts (England 2006—11; 5448 person-seasons' follow-up). We compared burden and severity of seasonal and pandemic strains. We weighted analyses to the age and regional structure of England to give nationally representative estimates. We compared symptom profiles over the first week of illness for different strains of PCR-confirmed influenza and non-influenza viruses using ordinal logistic regression with symptom severity grade as the outcome variable.FindingsBased on four-fold titre rises in strain-specific serology, on average influenza infected 18% (95% CI 16—22) of unvaccinated people each winter. Of those infected there were 69 respiratory illnesses per 100 person-influenza-seasons compared with 44 per 100 in those not infected with influenza. The age-adjusted attributable rate of illness if infected was 23 illnesses per 100 person-seasons (13—34), suggesting most influenza infections are asymptomatic. 25% (18—35) of all people with serologically confirmed infections had PCR-confirmed disease. 17% (10—26) of people with PCR-confirmed influenza had medically attended illness. These figures did not differ significantly when comparing pandemic with seasonal influenza. Of PCR-confirmed cases, people infected with the 2009 pandemic strain had markedly less severe symptoms than those infected with seasonal H3N2.InterpretationSeasonal influenza and the 2009 pandemic strain were characterised by similar high rates of mainly asymptomatic infection with most symptomatic cases self-managing without medical consultation. In the community the 2009 pandemic strain caused milder symptoms than seasonal H3N2.FundingMedical Research Council and the Wellcome Trust.


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Three-Fourths of Flu Infected People Won’t Know It: Study Shows

Three-Fourths of Flu Infected People Won’t Know It: Study Shows | Influenza | Scoop.it
Nearly three fourths of all influenza infections each season are asymptomatic, according to a recent study, indicating officials know less about the influenza virus than once thought.

 

Influenza causes roughly 250 000—500 000 deaths worldwide each year.[1] In the 20th century there were three influenza pandemics for which there are varying mortality estimates: 1918 A/H1N1 at least 20—40 million excess deaths, 1957 A/H2N2 about 4 million excess deaths, and 1968 A/H3N2 about 2 million excess deaths.[2—4] In 2009 a new pandemic virus,[5] influenza A(H1N1) pdm09, emerged in Mexico[6] and spread globally over 2009—10, causing an estimated 200 000 respiratory deaths and 83 000 cardiovascular deaths during the first 12 months of circulation.[7] WHO declared an end to the pandemic on Aug 10, 2010.[8] However, a further pandemic wave occurred in some European and other countries outside North America[9] in 2010—11 with reports of excess deaths in, for example, England.[10]
Internationally, influenza activity surveillance provides real-time information to inform prevention and control policy.[11] Surveillance focuses on cases seeking medical attention: the so-called tip of the iceberg of infection. Underestimation of the number of community cases leads to overestimates of severity.[12, 13] Heightened concern during a pandemic can change patient consultation thresholds and clinician recording and investigation behavior, thus distorting surveillance information.[14] Information on the community burden of influenza is key to informing control,[15] but is not routinely collected. For example, influenza transmission models, which are widely used to consider the efficacy and cost-effectiveness of vaccines, antivirals, and non-pharmaceutical countermeasures, depend on valid epidemiological estimates of the community occurrence of disease.
Testing the blood of the participants at the end of each season allowed researchers to conclude that while a great many participants proved to have been infected each year, approximately 77 percent of them never displayed any symptoms of infection, proving to be asymptomatic. Whether or not the flu infections cause unusual adverse symptoms in any of these infected participants remained unclear.

 

What does this mean? The study concluded that the human body might be more capable at fighting off or at least quelling the influenza virus than what is commonly thought. Health organization in North America and Europe both push for vaccination for the seasonal influenza virus in order to help stifle the virus's spread, but it has been revealed by past studies of these same organizations that the influenza virus only proves effective at preventing an infection 50 to 60 percent of the time.

 

The study was funded by the Medical Research Council and Wellcome Trust and published by The Lancet on March 17.


Via Dr. Stefan Gruenwald
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3 Mammoth Flu Myths -- Busted! (AZN, GSK, NVS, SNY)

3 Mammoth Flu Myths -- Busted! (AZN, GSK, NVS, SNY) | Influenza | Scoop.it
Tackling the three most pervasive flu myths while educating and amusing investors as to how they could take advantage of an improvement in flu vaccination rates. - Sean Williams - Health Care
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Korea Detects H5N8 Antibodies In Farm Dog

Korea Detects H5N8 Antibodies In Farm Dog | Influenza | Scoop.it
    # 8374   In addition to announcing that the number of domestic birds culled in South Korea’s 2 month-old H5N8 outbreak has now exceeded 10 million (see Reuters South Korea culls over six percent of poultry to curb bird flu),...
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Viral evolution: Past, present and future of influenza viruses : Nature Reviews Microbiology : Nature Publishing Group

Viral evolution: Past, present and future of influenza viruses : Nature Reviews Microbiology : Nature Publishing Group | Influenza | Scoop.it
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Serological report of pandemic (H1N1) 2009 infection among cats in Northeastern China in 2012-02 and 2013-03

Background:
Influenza A virus has a wide range of hosts. It has not only infected human, but also been reported interspecies transmission from humans to other animals, such as pigs, poultry, dogs and cats.
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OIE: Libya - 1st Outbreak Of HPAI H5N1 (In Poultry)

OIE: Libya - 1st Outbreak Of HPAI H5N1 (In Poultry) | Influenza | Scoop.it
Credit OIE   # 8372     My thanks to @Ironorehopper on FluTrackers for tweeting the link to this OIE report on Libya’s first recorded outbreak of HPAI H5N1 in poultry, on a farm near the Mediterranean coast - in the vicinity of Tubruq ( Kroum...
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Cambodia Ministry of Health confirms new human case of avian influenza

Cambodia Ministry of Health confirms new human case of avian influenza | Influenza | Scoop.it
TweetThe Ministry of Health of the Kingdom of Cambodia said on Monday that a new human case of H5N1 avian influenza has been confirmed in Kampot province, bringing the total to 56 cases.
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Comparative community burden and severity of seasonal and pandemic influenza: results of the Flu Watch cohort study : The Lancet Respiratory Medicine

Comparative community burden and severity of seasonal and pandemic influenza: results of the Flu Watch cohort study. By - Dr Andrew C Hayward MD, Ellen B Fragaszy MSc, Alison Bermingham PhD, Lili W...
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The co-pathogenesis of influenza viruses with bacteria in the lung

The co-pathogenesis of influenza viruses with bacteria in the lung | Influenza | Scoop.it

Concern that a highly pathogenic virus might cause the next influenza pandemic has spurred recent research into influenza and its complications. Bacterial superinfection in the lungs of people suffering from influenza is a key element that promotes severe disease and mortality. This co-pathogenesis is characterized by complex interactions between co-infecting pathogens and the host, leading to the disruption of physical barriers, dysregulation of immune responses and delays in a return to homeostasis. The net effect of this cascade can be the outgrowth of the pathogens, immune-mediated pathology and increased morbidity. In this Review, advances in our understanding of the underlying mechanisms are discussed, and the key questions that will drive the field forwards are articulated.

  


Via Ed Rybicki, Chris Upton + helpers
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Ed Rybicki's curator insight, March 17, 2014 3:18 AM

Don't never forget the bacteria...a nasty team, bugs and flu viruses.

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Avian Flu Diary: The Lancet: Effectiveness Of NAI Antivirals In Reducing Mortality In Hospitalized H1N1pdm09 Cases

Avian Flu Diary: The Lancet: Effectiveness Of NAI Antivirals In Reducing Mortality In Hospitalized H1N1pdm09 Cases | Influenza | Scoop.it
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Avian Flu Diary: Lancet: Community Burden & Severity Of Seasonal And Pandemic Influenza

Avian Flu Diary: Lancet: Community Burden & Severity Of Seasonal And Pandemic Influenza | Influenza | Scoop.it
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Teen Scientist Researches New Drugs to Fight Flu - Wall Street Journal

Teen Scientist Researches New Drugs to Fight Flu
Wall Street Journal
Teen Scientist Researches New Drugs to Fight Flu.
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Co-circulation of three HA and two NA subtypes of avian influenza viruses in Huzhou, China, April 2013: implication for the origin of the novel H7N9 virus.

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Three-year-old Cambodian boy dies from H5N1 influenza infection

Three-year-old Cambodian boy dies from H5N1 influenza infection | Influenza | Scoop.it
TweetThe Ministry of Health of the Kingdom of Cambodia recently announced a novel human case of avian influenza H5N1 affected a 3-year-old boy and led to his death.
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