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Influenza
Flu in all Forms, Be Informed...Not Panicked.
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This year's flu season remembered for deaths of those age 65 and younger

This year's flu season remembered for deaths of those age 65 and younger | Influenza | Scoop.it
During most of this year's flu season, the influenza A (H1N1) 2009 pandemic was the main strain making people ill, but more influenza B was being reported.
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Influenza B Virus Making a Strong Spring Appearance - Guardian Liberty Voice

Influenza B Virus Making a Strong Spring Appearance - Guardian Liberty Voice | Influenza | Scoop.it
Guardian Liberty Voice
Influenza B Virus Making a Strong Spring Appearance
Guardian Liberty Voice
influenza The Influenza strain B virus is making a strong appearance, although spring is not its usual time of year.
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Wikipedia Usage Estimates Prevalence of Influenza-Like Illness in the United States in Near Real-Time

Wikipedia Usage Estimates Prevalence of Influenza-Like Illness in the United States in Near Real-Time | Influenza | Scoop.it
by David J. McIver, John S. Brownstein
Circulating levels of both seasonal and pandemic influenza require constant surveillance to ensure the health and safety of the population.
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Modelling the effects of media during an influenza epidemic

Background:
Mass media is used to inform individuals regarding diseases within a population.
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UT Researchers Find New Target for Influenza A Virus - The Horn

UT Researchers Find New Target for Influenza A Virus - The Horn | Influenza | Scoop.it
Vaccine News Daily
UT Researchers Find New Target for Influenza A Virus
The Horn
Researchers at the University of Texas at Austin have identified a new protein target on the Influenza A virus.
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Hyperimmune intravenous immunoglobulin containing high titers of pandemic H1N1 hemagglutinin and neuraminidase antibodies provides dose-dependent protection against lethal virus challenge in SCID mice

Background: Convalescent plasma and fractionated immunoglobulins have been suggested as prophylactic or therapeutic interventions during an influenza pandemic.FindingsIntravenous immunoglobulin (IVIG) preparations manufactured from human plasma...
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NIH Funds Influenza Research and Surveillance Network

RT @sanofipasteur: U.S. NIH funds #influenza research and surveillance network http://t.co/ZwjCzXRe9K
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Tamiflu: A poster child for transparency in clinical trials?

Tamiflu: A poster child for transparency in clinical trials? | Influenza | Scoop.it
Thursday 10 April saw the publication of the Cochrane systematic review on oseltamivir and zanamivir, or Tamiflu (Roche) and Relenza (GlaxoSmithKline) to give them their better-known trade names. In short, the review found that Tamiflu doesn’t work quite as well as we thought; a finding that is the culmination of a four-and-a-half year battle for access to the raw data from the clinical trials.
The authors – Jefferson, Heneghan and colleagues – uncovered what they characterized as ‘multisystem failure’, with poorly-defined endpoints and confusion as to the authorship and contribution of the clinical trials. They also found that all studies were conducted against placebo, rather than against current best practice. Overall, the reviewers felt that the published studies were ...Read more
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WHO | Human infection with avian influenza A(H7N9) virus – update

The Centre for Health Protection (CHP), Hong Kong, SAR, China and the National Health and Family Planning Commission (NHFPC) of China recently notified WHO of 2 additional laboratory-confirmed cases of human infection with avian influenza A(H7N9)...
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Reasons to be cheeful: Influenza treatment

Reasons to be cheeful: Influenza treatment | Influenza | Scoop.it
Maybe there is some reason to be more optimistic about treating influenza.
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Pandemic Influenza: The Perpetual Challenge

Pandemic Influenza: The Perpetual Challenge | Influenza | Scoop.it

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Multisystem failure: the story of anti-influenza drugs | BMJ

Multisystem failure: the story of anti-influenza drugs | BMJ | Influenza | Scoop.it
Emergence of problemsOfficials have not unambiguously documented their reasons for stockpiling oseltamivir and zanamivir, but the decision seems to be based on the assumptions that the drugs would reduce hospital admissions and serious...
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Rhode Island | Flu declared widespread again – H3N2 and influenza B dominant strains | Big Medicine

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PLOS Computational Biology : Wikipedia Usage Estimates Prevalence of Influenza-Like Illness in the…

PLOS Computational Biology : Wikipedia Usage Estimates Prevalence of Influenza-Like Illness in the… | Influenza | Scoop.it
PLOS Computational Biology : Wikipedia Usage Estimates Prevalence of Influenza-Like Illness in the… http://t.co/MINfVcMsPF
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Impact of Different Oseltamivir Regimens on Treating Influenza A Virus Infection and Resistance Emergence: Insights from a Modelling Study

Impact of Different Oseltamivir Regimens on Treating Influenza A Virus Infection and Resistance Emergence: Insights from a Modelling Study | Influenza | Scoop.it
by Laetitia Canini, Jessica M. Conway, Alan S. Perelson, Fabrice Carrat
Several studies have proven oseltamivir to be efficient in reducing influenza viral titer and symptom intensity.
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What the Tamiflu saga tells us about drug trials and big pharma

What the Tamiflu saga tells us about drug trials and big pharma | Influenza | Scoop.it
Ben Goldacre: We now know the government's Tamiflu stockpile wouldn't have done us much good in the event of a flu epidemic. But the secrecy surrounding clinical trials means there's a lot we don't know about other medicines we take
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Can Monitoring Wikipedia Hits Show How Many People Have the Flu? - International Business Times UK

Can Monitoring Wikipedia Hits Show How Many People Have the Flu? - International Business Times UK | Influenza | Scoop.it
Can Monitoring Wikipedia Hits Show How Many People Have the Flu?
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Identifying the genetic basis of antigenic change in influenza A(H1N1)

Identifying the genetic basis of antigenic change in influenza A(H1N1) | Influenza | Scoop.it
Identifying the genetic basis of antigenic change in influenza A(H1N1) William T. Harvey, Victoria Gregory, Donald J. Benton, James P. J. Hall, Rodney S. Daniels, Trevor Bedford, Daniel T. Haydon, ...
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WHO provides update on avian influenza A (H7N9) in China

WHO provides update on avian influenza A (H7N9) in China | Influenza | Scoop.it
TweetThe World Health Organization said on Monday that four additional human cases of avian influenza (H7N9) were reported by the National Health and Family Planning Commission of China. Two cases were reported in Guangzhou City, Guangdong Province.
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Proteomic analysis at the subcellular level for host targets against influenza A virus (H1N1). - Antiviral Res. 2013

Influenza viruses (IVs) trigger a series of intracellular signaling events and induce complex cellular responses from the infected host cell. Accumulating evidence suggests that host cell proteins play an essential role in viral propagation and represent novel antiviral therapeutic targets. Subcellular proteomic technology provides a method for understanding regional differences at the protein level. The present study, which utilized subcellular proteomic technology, aimed to identify host cell proteins involved in influenza virus (HIN1) infection. Two-dimensional gel electrophoresis (2-DE) combined with mass spectrum (MS) was performed on protein extracts from the nuclei, cytoplasm, and mitochondria of infected and control human lung epithelial cells (A549). In total, 112 differentially expressed protein molecules were identified; 80 protein spots were successfully validated using MS. The differential expression of ISG15, MIF, PDCD5, and UCHL1 was confirmed by western blot. Furthermore, antisense oligodeoxyribonucleotide (ODN) targeting ISG15, MIF, PDCD5, and UCHL1 significantly mitigated HIN1 propagation, cytopathic effects, vRNA by RT-qPCR, and rescued cell viability in A549 cells. Taken together, the differentially expressed proteins identified in this study might provide novel targets for anti-influenza drug development.


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Japan: Detection Of H5 Avian Flu At Poultry Farm

Japan: Detection Of H5 Avian Flu At Poultry Farm | Influenza | Scoop.it
Credit Wikipedia   # 8467   It’s been three years since Japan has had to deal with an H5 avian flu outbreak in poultry or wild birds (see OIE reports 29/06/11 Final report 48089 & 25/06/11 Final report 48022), but that respite appears over as...
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WHO | Human infection with avian influenza A(H7N9) virus – update

On 8 April 2014, the National Health and Family Planning Commission (NHFPC) of China notified WHO of two additional laboratory-confirmed cases of human infection with avian influenza A(H7N9) virus.
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