Influenza
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Influenza
Flu in all Forms, Be Informed...Not Panicked.
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Avian Flu Diary: CDC Statement On LAIV Effectiveness Against H1N1 In 2013-14 Flu Season

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Regulation of Influenza A Virus Nucleoprotein Oligomerisation by Phosphorylation

In the influenza virus ribonucleoprotein complex the oligomerisation of the nucleoprotein is mediated by an interaction between the tail-loop of one molecule and the groove of the neighbouring molecule. In this study we show that phosphorylation of a serine residue (S165) within the groove of influenza A virus nucleoprotein inhibits oligomerisation and, consequently, ribonucleoprotein activity and viral growth. We propose that nucleoprotein oligomerisation in infected cells is regulated by reversible phosphorylation.


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Two influenza strains circulating in Iowa

Two influenza strains circulating in Iowa | Influenza | Scoop.it
TweetEven though Iowa’s flu cases are currently few in number, the Iowa Department of Public Health (IDPH) and Iowa Influenza Surveillance Network warn that two influenza strains are circulating in the state.
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Influenza, a Familiar Virus, Requires Attention, Too

The Centers for Disease Control and Prevention recommends flu shots for everyone 6 months old and older.
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Influenza A virus uses the aggresome processing machinery for host cell entry

During cell entry, capsids of incoming influenza A viruses (IAVs) must be uncoated before viral ribonucleoproteins (vRNPs) can enter the nucleus for replication. After hemagglutinin-mediated membrane fusion in late endocytic vacuoles, the vRNPs and the matrix proteins dissociate from each other and disperse within the cytosol. Here, we found that for capsid disassembly, IAV takes advantage of the host cell’s aggresome formation and disassembly machinery. The capsids mimicked misfolded protein aggregates by carrying unanchored ubiquitin chains that activated a histone deacetylase 6 (HDAC6)–dependent pathway. The ubiquitin-binding domain was essential for recruitment of HDAC6 to viral fusion sites and for efficient uncoating and infection. That other components of the aggresome processing machinery, including dynein, dynactin, and myosin II, were also required suggested that physical forces generated by microtubule- and actin-associated motors are essential for IAV entry.


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Avian Flu Diary: BMC: H10N8 Antibodies In Animal Workers – Guangdong Province, China

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Serologic screenings for H7N9 from three sources among high-risk groups in the early stage of H7N9 circulation in Guangdong Province, China

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The aim of this study was to assess the prevalence of the novel avian influenza A virus (H7N9) in three high risk groups.
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Improving pandemic influenza risk assessment

eLife - Open access to the most promising advances in science
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BMC Infectious Diseases | Abstract | Knowledge, attitudes and practices relating to influenza A(H7N9) risk among live poultry traders in Guangzhou City, China

Live poultry traders (LPTs) have greater risk to avian influenza due to occupational exposure to poultry. This study investigated knowledge, attitudes and practices of LPTs relating to influenza A (H7N9).
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Health News - JAMA Findings Reveal Vaccine Approach to Fight Pandemic Bird Flu

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Avian Flu Diary: UK: Defra Preliminary Assessment On Germany’s H5N8 Outbreak In Poultry

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1808-1809, The Influenza Epidemic

1808-1809, The Influenza Epidemic | Influenza | Scoop.it
Influenza When the Influenza epidemics struck New York and Ricketson's immediate community, it occurred at a time of the year that was persistent, but very different from the more common febrile ep...

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Brian Altonen's curator insight, October 30, 2014 11:01 PM

How did we come to learn the uses for epidemiology and disease mapping?    

 

Yellow Fever certainly had its influence, as demonstrated by the first ever map of cases produced by New York's physician, Valentine Seaman.  Seaman's purpose was to determine if the yellow fever came from the ships landing in the ports nearby, following their arrival from Jamaica and other warmer climate settings, or if it was due to local climate and wind patterns.    

 

But the months of late summer and early fall weren't the only time that doctors were trying to map particular disease.  The Influenza, sometimes referred to as a severe catarrh or 'bout with the cold', was an upper respiratory disease that often struck New Yorkers about the same time of the year, right after the Yellow Fever season was over.    

 

Quaker physician Shadrach Ricketson wrote about these seasonal disease events and their semi-predictability numerous times, most of these  items published in the Medical Repository.    

 

His most famous, most commonly used term for this sometimes warmer spells of November into December was "Indian Summer."  Indian Summer meant that autumnal fevers could re-emerge.    

  

There is one particular research project Ricketson initiated which was quite unique.  He sent hundreds of letters (by the slower horseback and wagoneer mail delivery to postal offices back then).  They were addressed to his medical colleagues around the state of New York.      


Dr. Ricketson asked these physician s about the influenza and how it behaved by the seasons, changes in weather and other natural events.  Most of the physicians of the state had responded, representing most of the state.  He then published his essay on this study, a first of its kind.      


This same procedure for analyzing disease pattern geography became the standards over the next several decades, and became a regular activity engaged in several times per year by regional and state medical boards by the 1870s.    

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Novavax H7N9 influenza vaccine fast-tracked by FDA

Novavax H7N9 influenza vaccine fast-tracked by FDA | Influenza | Scoop.it
TweetThe latest avian influenza vaccine developed by Novavax was recently fast-tracked by the U.S. Food and Drug Administration (FDA).
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Influenza: common questions answered - World Health Organization (press release)

Influenza: common questions answered - World Health Organization (press release) | Influenza | Scoop.it
WHO recommends that people with a higher risk of developing serious health complications as a result of influenza be vaccinated against seasonal influenza every autumn.
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Human Influenza A(H7N9) Virus Infection Associated with Poultry Farm, Northeastern China - Volume 20, Number 11—November 2014 - Emerging Infectious Disease journal - CDC

We report on a case of human infection with influenza A(H7N9) virus in Jilin Province in northeastern China. This case was associated with a poultry farm rather than a live bird market, which may point to a new focus for public health surveillance and interventions in this evolving outbreak.
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Virulence Determinants in the PB2 Gene 1 of a Mouse-Adapted H9N2 Virus

Virulence Determinants in the PB2 Gene 1 of a Mouse-Adapted H9N2 Virus http://t.co/2rar2OSGxq
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H1N1 mutation muddles immune responses in adults

TweetScientists investigating why an unusually high number of middle-aged individuals contracted H1N1 influenza last year are blaming the increase on a newly discovered mutation in the virus.
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Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013–2014 influenza season

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ViroBlog: Throwback Thursday | The 1918 Influenza Pandemic - New York Times (blog)

Throwback Thursday | The 1918 Influenza Pandemic - New York Times (blog): Throwback Thursday | The 1918 Influe... http://t.co/FVF9qdQ45l
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Human H7N9 and H5N1 Influenza Viruses Differ in Induction of Cytokines and Tissue Tropism

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Titer on Chip: New Analytical Tool for Influenza Vaccine Potency Determination

by Laura R. Kuck, Michelle Sorensen, Erin Matthews, Indresh Srivastava, Manon M. J. Cox, Kathy L. Rowlen
Titer on Chip (Flu-ToC) is a new technique for quantification of influenza hemagglutinin (HA) concentration.
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