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Circulating Avian Influenza Viruses Closely Related to the 1918 Virus Have Pandemic Potential: Cell Host & Microbe

Circulating Avian Influenza Viruses Closely Related to the 1918 Virus Have Pandemic Potential: Cell Host & Microbe | Influenza | Scoop.it

Wild birds harbor a large gene pool of influenza A viruses that have the potential to cause influenza pandemics. Foreseeing and understanding this potential is important for effective surveillance. Our phylogenetic and geographic analyses revealed the global prevalence of avian influenza virus genes whose proteins differ only a few amino acids from the 1918 pandemic influenza virus, suggesting that 1918-like pandemic viruses may emerge in the future. To assess this risk, we generated and characterized a virus composed of avian influenza viral segments with high homology to the 1918 virus. This virus exhibited pathogenicity in mice and ferrets higher than that in an authentic avian influenza virus. Further, acquisition of seven amino acid substitutions in the viral polymerases and the hemagglutinin surface glycoprotein conferred respiratory droplet transmission to the 1918-like avian virus in ferrets, demonstrating that contemporary avian influenza viruses with 1918 virus-like proteins may have pandemic potential


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Influenza
Flu in all Forms, Be Informed...Not Panicked.
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Viral evolution: Past, present and future of influenza viruses : Nature Reviews Microbiology : Nature Publishing Group

Viral evolution: Past, present and future of influenza viruses : Nature Reviews Microbiology : Nature Publishing Group | Influenza | Scoop.it
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Serologic screenings for H7N9 from three sources among high-risk groups in the early stage of H7N9 circulation in Guangdong Province, China

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The aim of this study was to assess the prevalence of the novel avian influenza A virus (H7N9) in three high risk groups.
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BMC Infectious Diseases | Abstract | Knowledge, attitudes and practices relating to influenza A(H7N9) risk among live poultry traders in Guangzhou City, China

Live poultry traders (LPTs) have greater risk to avian influenza due to occupational exposure to poultry. This study investigated knowledge, attitudes and practices of LPTs relating to influenza A (H7N9).
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Health News - JAMA Findings Reveal Vaccine Approach to Fight Pandemic Bird Flu

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Questions and Answers on the Executive Order Adding Potentially Pandemic Influenza Viruses to the List of Quarantinable Diseases | Quarantine | CDC

Questions and Answers on the Executive Order Adding Potentially Pandemic Influenza Viruses to the List of Quarantinable Diseases | Quarantine | CDC | Influenza | Scoop.it
@statesdj @Farzad_MD @ddiamond added by exec order http://t.co/GouIV3qWOs
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Scientists "must get better" at assessing pandemic threat from flu viruses

RT @ImperialSpark: Scientists "must get better" at assessing pandemic threat from flu viruses http://t.co/exynzEvLKg @Cambridge_Uni @elife
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Throwback Thursday | The 1918 Influenza Pandemic

What lessons can we learn from past outbreaks in controlling epidemics today?
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BioTechniques - Flu Epidemic Hits GenBank

Over 10,000 influenza genomes are now in GenBank. How was this accomplished? Find out...
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Virulence Determinants in the PB2 Gene 1 of a Mouse-Adapted H9N2 Virus

Virulence Determinants in the PB2 Gene 1 of a Mouse-Adapted H9N2 Virus http://t.co/2rar2OSGxq
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H1N1 mutation muddles immune responses in adults

TweetScientists investigating why an unusually high number of middle-aged individuals contracted H1N1 influenza last year are blaming the increase on a newly discovered mutation in the virus.
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Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013–2014 influenza season

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ViroBlog: Throwback Thursday | The 1918 Influenza Pandemic - New York Times (blog)

Throwback Thursday | The 1918 Influenza Pandemic - New York Times (blog): Throwback Thursday | The 1918 Influe... http://t.co/FVF9qdQ45l
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Human H7N9 and H5N1 Influenza Viruses Differ in Induction of Cytokines and Tissue Tropism

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Titer on Chip: New Analytical Tool for Influenza Vaccine Potency Determination

by Laura R. Kuck, Michelle Sorensen, Erin Matthews, Indresh Srivastava, Manon M. J. Cox, Kathy L. Rowlen
Titer on Chip (Flu-ToC) is a new technique for quantification of influenza hemagglutinin (HA) concentration.
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Immunogenicity of an Avian Influenza Vaccine

Research from JAMA — Immunogenicity of Avian Influenza A/Anhui/01/2005(H5N1) Vaccine With MF59 Adjuvant — A Randomized Clinical Trial
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NC DHHS: NC Flu Update: Facts and Figures

RT @NCPublicHealth: #NC #Flu Report (ending 10/11/14): http://t.co/vqq9PeieRN Flu sporadic, geographically. Influenza-like illness (ILI) low
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A Beneficiary Role for Neuraminidase in Influenza Virus Penetration through the Respiratory Mucus

A Beneficiary Role for Neuraminidase in Influenza Virus Penetration through the Respiratory Mucus | Influenza | Scoop.it
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.

Via Gilbert Faure au nom de l'ASSIM, Ken Yaw Agyeman-Badu
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Popular Science's Strange Reporting Of The 1918 Spanish Flu Pandemic

Popular Science's Strange Reporting Of The 1918 Spanish Flu Pandemic | Influenza | Scoop.it
The flu was clearly on our editors' minds, but they seemed to have left the more straightforward reporting to other outlets.
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Avian Flu Diary: EID Journal: Avian Influenza (H7N9) Virus Infection in Chinese Tourist in Malaysia, 2014

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Patent Approved for New Pandemic Flu Test

The government has awarded a patent to the TGen and Northern Arizona University for a test that can detect the H1N1 pandemic flu strain.
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