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WHO announces first ever human case of H10N8

WHO announces first ever human case of H10N8 | Influenza | Scoop.it
TweetThe World Health Organization recently announced that it was notified by the Chinese health authorities of the first ever confirmed human case of avian influenza A H10N8, resulting in death.
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Influenza
Flu in all Forms, Be Informed...Not Panicked.
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Viral evolution: Past, present and future of influenza viruses : Nature Reviews Microbiology : Nature Publishing Group

Viral evolution: Past, present and future of influenza viruses : Nature Reviews Microbiology : Nature Publishing Group | Influenza | Scoop.it
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Hong Kong Prioritizes Groups To Receive Emergency Flu Vaccine

Hong Kong Prioritizes Groups To Receive Emergency Flu Vaccine | Influenza | Scoop.it
  # 9848   The effect of this year’s vaccine mismatch due to a `drifted’ H3N2 virus has been keenly felt across the Northern Hemisphere, but perhaps no more so than in Hong Kong which has seen a doubling of severe cases and a tripling of deaths...
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Influenza Outbreak in a Vaccinated Population — USS Ardent, February 2014

#Influenza Outbreak in a Vaccinated Population — USS Ardent, February 2014 #vaccines http://t.co/IiKqHMJ3K2
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Human infection with avian influenza A(H7N9) virus – China - World Health Organization (press release)

On 9 March 2015, the National Health and Family Planning Commission (NHFPC) of China notified WHO of 59 additional laboratory-confirmed cases of human infection with avian influenza A(H7N9) virus, including 17 fatal cases.
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Dissemination, divergence and establishment of H7N9 influenza viruses in China

Dissemination, divergence and establishment of H7N9 influenza viruses in China | Influenza | Scoop.it
Since 2013 the occurrence of human infections by a novel avian H7N9 influenza virus in China has demonstrated the continuing threat posed by zoonotic pathogens.
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Egypt’s H5N1 Bird Flu Beat Goes On . . . .

Egypt’s H5N1 Bird Flu Beat Goes On . . . . | Influenza | Scoop.it
Credit WHO   # 9835   Despite the fact that Egypt is more than 4 months into the worst H5N1 outbreak since the virus emerged in the mid-1990s, with at last count – 115 human cases since November 1st – we get very little day-to-day information...
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Avian Flu Antibody Survey In Poultry Workers – Taiwan 2012

Avian Flu Antibody Survey In Poultry Workers – Taiwan 2012 | Influenza | Scoop.it
    # 9841   The recent emergence and rapid spread of several new HPAI H5 viruses (H5N8, H5N2, H5N3, and a `new’ H5N1), and the infection of a woman in Taiwan in 2013 with H6N1, has elevated concerns that one of these avian viruses could...
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H1N1 variant suspected in Indian influenza outbreak - Healio

An outbreak of influenza A(H1N1) in India with more than 8,000 reported cases and 800 deaths is suspected to be a drifted strain from the 2009 pandemic influenza A(H1N1) virus, according to a recent study.“Although there are limited Indian-origin ...
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India's virology institute rejects MIT study claiming deadly swine flu mutation - International Business Times UK

National Institute of Virology claims the current swine flu strain is unchanged from the 2009 strain.
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Bird flu strains, H10N8 and H6N1, do not infect people easily: Researchers - Outbreak News Today

Bird flu strains, H10N8 and H6N1, do not infect people easily: Researchers
Outbreak News Today
... we shouldn't be complacent about our ability to predict the viral changes required to get a pandemic,” said Ian A.
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Global Avian Influenza Surveillance in Wild Birds: A Strategy to Capture Viral Diversity - Volume 21, Number 4—April 2015 - Emerging Infectious Disease journal - CDC

Global Avian Influenza Surveillance in Wild Birds: A Strategy to Capture Viral Diversity - Volume 21, Number 4—April 2015 - Emerging Infectious Disease journal - CDC | Influenza | Scoop.it
Wild birds play a major role in the evolution, maintenance, and spread of avian influenza viruses. However, surveillance for these viruses in wild birds is sporadic, geographically biased, and often limited to the last outbreak virus. To identify opportunities to optimize wild bird surveillance for understanding viral diversity, we reviewed responses to a World Organisation for Animal Health–administered survey, government reports to this organization, articles on Web of Knowledge, and the Influenza Research Database. At least 119 countries conducted avian influenza virus surveillance in wild birds during 2008–2013, but coordination and standardization was lacking among surveillance efforts, and most focused on limited subsets of influenza viruses. Given high financial and public health burdens of recent avian influenza outbreaks, we call for sustained, cost-effective investments in locations with high avian influenza diversity in wild birds and efforts to promote standardized sampling, testing, and reporting methods, including full-genome sequencing and sharing of isolates with the scientific community.
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Co-infection with Avian (H7N9) and Pandemic (H1N1) 2009 Influenza Viruses, China - Volume 21, Number 4—April 2015 - Emerging Infectious Disease journal - CDC

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Reverse zoonosis of influenza to swine: new perspectives on the human–animal interface: Trends in Microbiology

RT @OxonAndrew: "Humans transmit far more influenza viruses to swine than swine transmit to humans" @TrendsMicrobiol http://t.co/JedAI4vLya
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Ahead of Print -Pathologic Changes in Wild Birds Infected with Highly Pathogenic Avian Influenza A(H5N8) Viruses, South Korea, 2014 - Volume 21, Number 5—May 2015 - Emerging Infectious Disease jour...

Ahead of Print -Pathologic Changes in Wild Birds Infected with Highly Pathogenic Avian Influenza A(H5N8) Viruses, South Korea, 2014 - Volume 21, Number 5—May 2015 - Emerging Infectious Disease jour... | Influenza | Scoop.it
In January 2014, an outbreak of infection with highly pathogenic avian influenza (HPAI) A(H5N8) virus began on a duck farm in South Korea and spread to other poultry farms nearby.
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Mortality amongst Patients with Influenza-Associated Severe Acute Respiratory Illness, South Africa, 2009-2013

by Cheryl Cohen, Jocelyn Moyes, Stefano Tempia, Michelle Groome, Sibongile Walaza, Marthi Pretorius, Halima Dawood, Meera Chhagan, Summaya Haffejee, Ebrahim Variava, Kathleen Kahn, Anne von Gottberg, Nicole Wolter, Adam L.
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Pathogenesis of novel reassortant avian influenza virus A (H5N8) Isolates in the ferret

Pathogenesis of novel reassortant avian influenza virus A (H5N8) Isolates in the ferret http://t.co/JcrhI0jkEp
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New flu strains prove difficult to contract

New flu strains prove difficult to contract | Influenza | Scoop.it
TweetA recent study by The Scripps Research Institute (TSRI) revealed evidence that two new influenza strains are not easy for humans to contract, making a pandemic unlikely.
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Defra: Update On HPAI Avian Flu In Europe, America & The Middle East

Defra: Update On HPAI Avian Flu In Europe, America & The Middle East | Influenza | Scoop.it
  # 9834   An indication of how quickly things are changing, although this document was put online today and carries a March 13th release date, HPAI H5 has been reported in a 10th American State (Kansas) since this report was written.
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Broadly Neutralizing Anti-Influenza Virus Antibodies: Enhancement of Neutralizing Potency in Polyclonal Mixtures and IgA Backbones

Influenza viruses remain one of the most worrisome global public health threats due to their capacity to cause pandemics. While seasonal vaccines fail to protect against the emergence of pandemic strains, a new class of broadly neutralizing antibodies has been recently discovered and may be the key to developing a “universal” influenza virus vaccine. While much has been learned about the biology of these antibodies, most studies have focused only on monoclonal antibodies of IgG subtypes. However, the study of monoclonal antibodies often fails to capture the complexity of antibody functions that occur during natural polyclonal responses.


Here, we provide the first detailed analyses of the biological activity of these antibodies in polyclonal contexts, comparing both IgG and IgA isotypes isolated from human donors. The striking differences observed in the functional properties of broadly neutralizing antibodies in polyclonal contexts will be essential for guiding design of “universal” influenza virus vaccines and therapeutics.


Via Krishan Maggon
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Krishan Maggon 's curator insight, March 16, 1:10 PM
Accepted manuscript posted online 14 January 2015, doi:10.1128/JVI.03099-14                                                                 J. Virol. April 2015 vol. 89 no. 73610-3618
Broadly Neutralizing Anti-Influenza Virus Antibodies: Enhancement of Neutralizing Potency in Polyclonal Mixtures and IgA BackbonesWenqian Hea, Caitlin E. Mullarkeya, J. Andrew Dutya, Thomas M. Morana,Peter Palesea,b and Matthew S. Millera,c
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Bird flu mutating in southern China, pandemic threatens

Bird flu mutating in southern China, pandemic threatens | Influenza | Scoop.it
Image credit: @doug88. The deadly strain of the bird flu virus
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Influenza Type B overtakes A in Colorado during 2015, but still well below peak - The Denver Channel

Hospitalizations for Influenza Type B have outpaced hospitalizations for Type A in Colorado over the past several weeks.
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Oseltamivir Expands Quasispecies of Influenza Virus through Cell-to-cell Transmission : Scientific Reports : Nature Publishing Group

The population of influenza virus consists of a huge variety of variants, called quasispecies, due to error-prone replication.

Via burkesquires
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Flu genomes trace H7N9's evolution and spread in China - Nature.com

But surveillance of avian influenza viruses is patchy and slow.
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Influenza A and B Viruses but Not MERS-CoV in Hajj Pilgrims, Austria, 2014 - Volume 21, Number 4—April 2015 - Emerging Infectious Disease journal - CDC

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Avian Influenza A(H7N9) Virus Antibodies in Close Contacts of Infected Persons, China, 2013–2014 - Volume 21, Number 4—April 2015 - Emerging Infectious Disease journal - CDC

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