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Preferential recognition of avian-like receptors in human influenza A H7N9 viruses - Science 2013

Preferential recognition of avian-like receptors in human influenza A H7N9 viruses - Science 2013 | Influenza | Scoop.it

The 2013 outbreak of avian-origin H7N9 influenza in eastern China has raised concerns about its ability to transmit in the human population. The hemagglutinin glycoprotein of most human H7N9 viruses carries Leu226, a residue linked to adaptation of H2N2 and H3N2 pandemic viruses to human receptors. However, glycan array analysis of the H7 hemagglutinin reveals negligible binding to humanlike α2-6–linked receptors and strong preference for a subset of avian-like α2-3–linked glycans recognized by all avian H7 viruses. Crystal structures of H7N9 hemagglutinin and six hemagglutinin-glycan complexes have elucidated the structural basis for preferential recognition of avian-like receptors. These findings suggest that the current human H7N9 viruses are poorly adapted for efficient human-to-human transmission


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Influenza
Flu in all Forms, Be Informed...Not Panicked.
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Viral evolution: Past, present and future of influenza viruses : Nature Reviews Microbiology : Nature Publishing Group

Viral evolution: Past, present and future of influenza viruses : Nature Reviews Microbiology : Nature Publishing Group | Influenza | Scoop.it
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A Model formulation for the Transmission Dynamics of Avian Influenza

IOSR Journal of Mathematics (IOSR-JM) vol.10 issue.6 version.6

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Avian Flu Diary: Study: Recombinant H5N2 Avian Influenza Virus Strains In Vaccinated Chickens

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Avian Flu Diary: EID Journal: Emergence of D225G Variant A/H1N1, 2013–14 Flu Season, Florida

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Avian influenza H9N2 seroprevalence among pig population and pig farm staff in Shandong, China

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Shandong province of China has a large number of pig farms with the semi-enclosed houses, allowing crowds of wild birds to seek food in the pig houses.
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Human infection with avian influenza A(H5N6) virus – China - World Health Organization (press release)

On 23 February 2015, the Department of Health, Hong Kong Special Administrative Region (SAR), China notified WHO of 1 additional laboratory-confirmed case of human infection with avian influenza A(H7N9) virus.
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ECDC Influenza on Twitter

ECDC Influenza on Twitter | Influenza | Scoop.it
#Flu continues to affect most European countries, at much higher levels compared to previous #influenza season. pic.twitter.com/UFz0MrmTtz
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The Year of the Flu

The Year of the Flu | Influenza | Scoop.it
Health experts are already calling 2015 one of the most complicated ever for influenza outbreaks, and the prevalence of lethal strains normally found in birds is especially troubling, writes CFR’s Laurie Garrett.
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Immunogenicity and Protective Efficacy of a Vero Cell Culture-Derived Whole-Virus H7N9 Vaccine in Mice and Guinea Pigs

by Walter Wodal, Michael G. Schwendinger, Helga Savidis-Dacho, Brian A. Crowe, Christine Hohenadl, Richard Fritz, Peter Brühl, Daniel Portsmouth, Anita Karner-Pichl, Dalida Balta, Leopold Grillberger, Otfried Kistner, P.
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Phylogenomic analyses data of the avian phylogenomics project

Background:
Determining the evolutionary relationships among the major lineages of extant birds has been one of the biggest challenges in systematic biology.
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Studies on Influenza Virus Transmission between Ferrets: the Public Health Risks Revisited

RT @thelonevirologi: Studies on Influenza Virus Transmission between Ferrets: the Public Health Risks Revisited http://t.co/MlobmTFDhr
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Clinical, Virological and Immunological Features from Patients Infected with Re-Emergent Avian-Origin Human H7N9 Influenza Disease of Varying Severity in Guangdong Province

Clinical, Virological and Immunological Features from Patients Infected with Re-Emergent Avian-Origin Human H7N9 Influenza Disease of Varying Severity in Guangdong Province | Influenza | Scoop.it
Background The second wave of avian influenza H7N9 virus outbreak in humans spread to the Guangdong province of China by August of 2013 and this virus is now endemic in poultry in this region. Methods Five patients with H7N9 virus infection admitted to our hospital during August 2013 to February 2014 were intensively investigated. Viral load in the respiratory tract was determined by quantitative polymerase chain reaction (Q-PCR) and cytokine levels were measured by bead-based flow
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Avian influenza viruses found in Northwestern states - American Veterinary Medical Association

Highly pathogenic strains of avian influenza virus, including one that killed turkeys in California, have been found in five Northwestern
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WHO warns about influenza co-circulation, bird outbreaks - CIDRAP

The WHO notes signs that flu strains, especially avian ones, are co-circulating at unprecedented levels.
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Warning signals from the volatile world of influenza viruses - World Health Organization (press release)

Warning signals from the volatile world of influenza viruses - World Health Organization (press release) | Influenza | Scoop.it
CTV News
Warning signals from the volatile world of influenza viruses
World Health Organization (press release)
The current global influenza situation is characterized by a number of trends that must be closely monitored.
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Advances in the development of influenza virus vaccines : Nature Reviews Drug Discovery : Nature Publishing Group

Abstract

Influenza virus infections are a major public health concern and cause significant morbidity and mortality worldwide. Current influenza virus vaccines are an effective countermeasure against infection but need to be reformulated almost every year owing to antigenic drift. Furthermore, these vaccines do not protect against novel pandemic strains, and the timely production of pandemic vaccines remains problematic because of the limitations of current technology. Several improvements have been made recently to enhance immune protection induced by seasonal and pandemic vaccines, and to speed up production in case of a pandemic. Importantly, vaccine constructs that induce broad or even universal influenza virus protection are currently in preclinical and clinical development.


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NATURE REVIEWS DRUG DISCOVERY | REVIEW

 Advances in the development of influenza virus vaccinesFlorian Krammer& Peter PaleseAffiliationsCorresponding authorsNature Reviews Drug Discovery 14, 167–182 (2015) doi:10.1038/nrd4529Published online 27 February 2015
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BMC Genomics | Full text | Analysis of the genetic diversity of influenza A viruses using next-generation DNA sequencing

Influenza viruses exist as a large group of closely related viral genomes, also called quasispecies. The composition of this influenza viral quasispecies can be determined by an accurate and sensitive sequencing technique and data analysis pipeline.
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Avian Flu Diary: WHO: Recommended Composition Of 2015-16 Northern Hemisphere Flu Vaccine

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Avian Flu Diary: HK’s Imported H7N9 Case Dies, Seasonal Flu Continues Strong

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