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Influenza
Flu in all Forms, Be Informed...Not Panicked.
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Rescooped by Mel Melendrez-Vallard from Virology News
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Potential for H3N2 influenza pandemic

Potential for H3N2 influenza pandemic | Influenza | Scoop.it

The 2009 swine-origin H1N1 influenza, though antigenically novel to the population at the time, was antigenically similar to the 1918 H1N1 pandemic influenza, and consequently was considered to be [ldquo]archived[rdquo] in the swine species before reemerging in humans. Given that the H3N2 is another subtype that currently circulates in the human population and is high on WHO pandemic preparedness list, we assessed the likelihood of reemergence of H3N2 from a non-human host. Using HA sequence features relevant to immune recognition, receptor binding and transmission we have identified several recent H3 strains in avian and swine that present hallmarks of a reemerging virus. IgG polyclonal raised in rabbit with recent seasonal vaccine H3 fail to recognize these swine H3 strains suggesting that existing vaccines may not be effective in protecting against these strains.

 

Vaccine strategies can mitigate risks associated with a potential H3N2 pandemic in humans.


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Ed Rybicki's curator insight, May 13, 2013 1:24 PM

No-one think of H3N2...except, as it happens, these folk - who have shown quite convincingly that circulating strains of H3N2 in birds and pigs would be quite capable of avoiding vaccine-conferred immunity, and potentially of causing a pandemic, if they reassorted with human-infecting viruses.  

 

I can't help but feel that there are several ticking influenza pandemic time bombs out there...H5N1, H7N9, and now H3N2.

Rescooped by Mel Melendrez-Vallard from Virology News
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Mississauga Article: Making vaccine for new bird flu virus could be a challenge

Mississauga Article: Making vaccine for new bird flu virus could be a challenge | Influenza | Scoop.it
TORONTO — Making a vaccine to protect against the new bird flu virus that has emerged in eastern China could prove to be problematic, influenza experts acknowledged yesterday.

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Ed Rybicki's curator insight, April 12, 2013 9:17 AM

"...clinical trials of vaccines made to protect against other viruses in the H7 family have shown the vaccines don't induce much of an immune response, even when people are given what would be considered very large doses."


This is a little worrying - and possibly a spur to making universal vaccines!

Rescooped by Mel Melendrez-Vallard from Virology News
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Medicago successfully produces VLP vaccine candidate for H7N9 virus

Medicago successfully produces VLP vaccine candidate for H7N9 virus | Influenza | Scoop.it

Medicago Inc. (TSX: MDG; OTCQX: MDCGF), a biopharmaceutical company focused on developing highly effective and competitive vaccines based on proprietary manufacturing technologies and Virus-Like Particles (VLPs), today announced that it has successfully produced a new VLP vaccine candidate  for the H7N9 virus that is responsible for the current influenza outbreak in China.

 

Influenza in birds graphic from Russell Kightley Media


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Ed Rybicki's curator insight, May 10, 2013 6:34 AM

I keep saying, you gotta go green...and Medicago do, and have for H7N9.

 

Quicker than anyone else, evidently.  Truly impressive for plant production technology!

Rescooped by Mel Melendrez-Vallard from Virology News
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A Brief History of Influenza

A Brief History of Influenza | Influenza | Scoop.it
I am TRYING to write an eBook on influenza, which stubbornly refuses to be finished - as part of a sabbatical project, which finished in December 2010.  So, like my History of Virology, I am triall...

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Ed Rybicki's curator insight, April 5, 2013 5:15 AM

I will reprise this post, given a considerable recent spike in interest in it as the new H7N9 Shanghai bird flu starts.  Hopefully to fizzle out, but you never know....

 

Incidentally, I have an almost-finished iBook (for iPad) on influenza: the first five respondents to this post can trial it for free!

Chris Upton + helpers's comment, April 8, 2013 2:39 PM
cool... and I have iPad