Multiple Contacts Are Key to Synapse Formation | Expertpatient |

Team of Scientists from Freiburg and Jülich Find Explanation for Formation of Connections between Nerve Cells

Multiple synaptic contacts between nerve cells facilitate the creation of a new contact, as neuroscientists from the Bernstein Center Freiburg and the Forschungszentrum Jülich report in the latest issue of the journal PLoS Computational Biology. An integral mechanism of memory foundation is the formation of additional contacts between neurons in the brain. However, until now it was not known what conditions lead to the development of such synapses and how they are stabilized once created. By studying mathematical models, the scientists found a simple explanation for how and when synapses form – or disappear – in the brain. (...) - Bernstein Center Freiburg

Original publication (open access):

Deger M, Helias M, Rotter S, Diesmann M (2012) Spike-Timing Dependence of Structural Plasticity Explains Cooperative Synapse Formation in the Neocortex. PLoS Comput Biol 8(9): e1002689. doi:10.1371/journal.pcbi.1002689

Via Julien Hering, PhD