Engineering The Cure
54
Finding the cure for sufferings of the world. Following transhumanist technologies that could enable our techno-utopian future.
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A synthetic post-transcriptional controller to explore the modular design of gene circuits - ACS Synthetic Biology (ACS Publications)

A synthetic post-transcriptional controller to explore the modular design of gene circuits - ACS Synthetic Biology (ACS Publications) | Engineering The Cure | Scoop.it
From pubs.acs.org - May 4, 2012 12:13 AM

by
Francesca Ceroni, Simone Furini, Alessandra Stefan, Alejandro Hochkoeppler, and Emanuele Giordano
"The assembly from modular parts is an efficient approach for creating new devices in Synthetic Biology. In the Bottom-up designing strategy, modular parts are characterized in advance, and then mathematical modelling is used to predict the outcome of the final device. A prerequisite for Bottom-up design is that the biological parts behave in modular way when assembled together. We designed a new synthetic device for post-transcriptional regulation of gene expression, and tested if the outcome of the device can be described from the features of its components. Modular parts showed unpredictable behaviour when assembled in different complex circuits. This prevented a modular description of the device that was possible only under specific conditions. Our findings shed doubts into the feasibility of a pure Bottom-up approach in Synthetic Biology, highlighting the urgency for new strategies for the rational design of synthetic devices."

http://bit.ly/IEFUWE


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Printable bionic ear sends hearing to the dogs

Printable bionic ear sends hearing to the dogs | Engineering The Cure | Scoop.it
From news.cnet.com - May 4, 2:20 AM
Scientists have created a 3D-printed cartilage ear with an antenna that extends hearing far beyond the normal human range. Read this article by Michelle Starr on CNET.

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Nanoparticles loaded with bee venom kill HIV

Nanoparticles loaded with bee venom kill HIV | Engineering The Cure | Scoop.it
From medicalxpress.com - March 8, 10:55 PM
(Medical Xpress)—Nanoparticles carrying a toxin found in bee venom can destroy human immunodeficiency virus (HIV) while leaving surrounding cells unharmed, researchers at Washington University School of Medicine in St.
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Scientists Enhance Intelligence of Mice with Human Brain Cells

Scientists Enhance Intelligence of Mice with Human Brain Cells | Engineering The Cure | Scoop.it
From io9.com - March 8, 5:03 AM
It's not quite Rise of the Planet of the Apes, but it may not be too far off, either. By grafting human glial cells into the brains of mice, neuroscientists were able to "sharply enhance" their cognitive capacities.
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Facebook, Google tech gurus to design cancer research game

Facebook, Google tech gurus to design cancer research game | Engineering The Cure | Scoop.it
From www.reuters.com - February 28, 8:00 PM
LONDON (Reuters) - Scientists from a British cancer charity are teaming up with technology gurus from the likes of Amazon, Facebook and Google to design and develop a mobile game aimed at speeding the...
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How Google Retooled Android With Help From Your Brain | Wired Enterprise | Wired.com

How Google Retooled Android With Help From Your Brain | Wired Enterprise | Wired.com | Engineering The Cure | Scoop.it
From www.wired.com - February 18, 9:22 PM
When Google built the latest version of its Android mobile operating system, the web giant made some big changes to the way the OS interprets your voice commands.
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Roots of language in human and bird biology

Roots of language in human and bird biology | Engineering The Cure | Scoop.it
From phys.org - February 16, 9:01 PM
The genes activated for human speech are similar to the ones used by singing songbirds, new experiments suggest.

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Becoming biohackers: Learning the game

Becoming biohackers: Learning the game | Engineering The Cure | Scoop.it
From www.bbc.com - February 16, 8:50 PM
More and more amateur biologists are carrying out genetic experiments in homes and garages worldwide. How easy is it to do? Three writers tried to find out.
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iExaminer connects your iPhone and ophthalmoscope, has telemedicine potential

iExaminer connects your iPhone and ophthalmoscope, has telemedicine potential | Engineering The Cure | Scoop.it
From www.imedicalapps.com - February 13, 7:55 AM

Welch Allyn’s iExaminer is the next step in ophthalmoscopes for your practice.


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Philosophical Disquisitions: Is human enhancement disenchanting? (Part One)

Philosophical Disquisitions: Is human enhancement disenchanting? (Part One) | Engineering The Cure | Scoop.it
From philosophicaldisquisitions.blogspot.com - February 9, 5:59 AM
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20 New Biotech Breakthroughs that Will Change Medicine

20 New Biotech Breakthroughs that Will Change Medicine | Engineering The Cure | Scoop.it
From www.popularmechanics.com - February 5, 4:49 AM
From a spit test for cancer to a shot that helps your body re-grow nerves along your spinal cord, these new advances in the world of medicine blur the line between biology and technology—to help restore, improve and extend our lives.

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Primo Post-Human: Trans-humanist Culture

Primo Post-Human: Trans-humanist Culture | Engineering The Cure | Scoop.it
From archimorph.com - January 24, 5:30 AM
The transhumanist Culture Natasha Vita-More Cultural movements, from the Graeco-Romans, Romanesque culture, Humanism, the Renaissance, Romanticism, Modernism, and Postmodernisms to transhumanism, c...
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Quant junkies: The future is now

Quant junkies: The future is now | Engineering The Cure | Scoop.it
From tech.fortune.cnn.com - January 18, 1:35 AM
Socrates Logos's curator insight, January 17, 9:49 AM

By JP Mangalindan

"Want to keep track of every piece of personal data in your life? There's probably a tool for you.

If you want something done, do it yourself, the old saying goes. It's a philosophy that fuels the "quantified self," a growing movement toward tracking one's life with the help of technology. It extends far beyond Nike's (NKE) groundbreaking Nike+ running app: Devotees can dutifully track fitness routines, eating habits, even medical conditions. And companies are developing tools for nearly every scenario imaginable. Here are just a few.FitnessRunKeeper employs a phone's GPS to track activities like running and cycling, and through its Health Graph lets users compare performance. Devices like the Fitbit apply a data-tracking method called actigraphy to gauge movements during sleep.MedicineThe Spiroscout sensor, an inhaler attachment, uses satellite data to show asthmatics locations that may worsen their condition. The Boozerlyzer, built to measure blood alcohol levels, can be doctored to track drug intake and side effects.LifestyleWith GreenGoose's sticker-size sensors, everyday items  -- toothbrushes, toys, even pets -- transmit data back to an egg-shaped base station. Users can keep track of information such as how often they've brushed their teeth or if someone walked the dog...."


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This Google patent application had us at 'laser keyboard'

This Google patent application had us at 'laser keyboard' | Engineering The Cure | Scoop.it
From news.cnet.com - January 18, 1:29 AM
Google applies for a patent that could let Project Glass project a keyboard onto your arm. Read this article by Casey Newton on CNET News.
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Could Life Be Older Than Earth Itself? : DNews

Could Life Be Older Than Earth Itself? : DNews | Engineering The Cure | Scoop.it
From news.discovery.com - May 4, 2:18 AM
Applying a maxim from computer science to biology raises the intriguing possibility that life existed before Earth did.
AUNG THIHA's insight:

Could Life Be Older Than Earth Itself?

Two geneticists have applied Moore’s Law to the rate at which life on Earth grows in complexity — and the results suggest organic life first came into existence long before Earth itself.

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Why The Human Body Will Be The Next Computer Interface

Why The Human Body Will Be The Next Computer Interface | Engineering The Cure | Scoop.it
From www.fastcodesign.com - March 8, 6:12 AM
By now you’ve probably heard a lot about wearables, living services, the Internet of Things, and smart materials.
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Building Better Minds - and What to Do with Them | World Future Society

Building Better Minds - and What to Do with Them | World Future Society | Engineering The Cure | Scoop.it
From www.wfs.org - February 28, 9:33 PM
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Why Synthetic Biology Is the Field of the Future

Why Synthetic Biology Is the Field of the Future | Engineering The Cure | Scoop.it
From www.pbs.org - February 28, 7:59 PM
Socrates Logos's curator insight, February 28, 6:48 PM

by
Jay Keasling

"Most Americans may not be familiar with synthetic biology, but they may come to appreciate its advances someday soon. Synthetic biology focuses on creating technologies for designing and building biological organisms. A multidisciplinary effort, it calls biologists, engineers, software developers, and others to collaborate on finding ways to understand how genetic parts work together, and then to combine them to produce useful applications.

 Synthetic biology is a relatively young field, begun only about ten years ago. But in that time, we have made some astonishing progress. This is due, in part, to the enormous improvements in our ability to synthesize and sequence DNA. But we’ve also gained a much greater understanding of how the various parts of the genome interact. We now can reliably combine various genetic pieces to produce a range of consumer products, from biofuels to cosmetics....."

http://to.pbs.org/Z0UEAQ
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A sensational breakthrough: the first bionic hand that can feel

A sensational breakthrough: the first bionic hand that can feel | Engineering The Cure | Scoop.it
From www.independent.co.uk - February 18, 5:48 AM
The first bionic hand that allows an amputee to feel what they are touching will be transplanted later this year in a pioneering operation that could introduce a new generation of artificial limbs with sensory perception.
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Network Theory - Marc Samet

Network Theory - Marc Samet | Engineering The Cure | Scoop.it
From ed.ted.com - February 16, 9:00 PM
From social media to massive financial institutions, we live within a web of networks. But how do they work? How does Googling a single word provide millions of results?

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Ken Morrison's curator insight, January 27, 7:16 AM

A nice #TedEd annimation on network theory.
Ken Morrison's comment, January 27, 7:17 AM
I appreciate the helpful animation and clear explanation. Thanks for sharing
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The bionic man, and what he tells us about the future of being human

From www.youtube.com - February 13, 7:57 AM
Rex, as he's called, has been put together by an expert team for a forthcoming Channel 4 documentary 'How to Build a Bionic Man' - in an effort to show just ...
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Cell circuits remember their history

Cell circuits remember their history | Engineering The Cure | Scoop.it
From web.mit.edu - February 11, 7:22 AM
Socrates Logos's curator insight, February 10, 5:54 PM


by
Anne Trafton

"MIT engineers have created genetic circuits in bacterial cells that not only perform logic functions, but also remember the results, which are encoded in the cell’s DNA and passed on for dozens of generations.

 The circuits, described in the Feb. 10 online edition of Nature Biotechnology, could be used as long-term environmental sensors, efficient controls for biomanufacturing, or to program stem cells to differentiate into other cell types. “Almost all of the previous work in synthetic biology that we’re aware of has either focused on logic components or on memory modules that just encode memory. We think complex computation will involve combining both logic and memory, and that’s why we built this particular framework to do so,” says Timothy Lu, an MIT assistant professor of electrical engineering and computer science and biological engineering and senior author of the Nature Biotechnology paper. Lead author of the paper is MIT postdoc Piro Siuti. Undergraduate John Yazbek is also an author.  More than logic Synthetic biologists use interchangeable genetic parts to design circuits that perform a specific function, such as detecting a chemical in the environment. In that type of circuit, the target chemical would generate a specific response, such as production of green fluorescent protein (GFP).   Circuits can also be designed for any type of Boolean logic function, such as AND gates and OR gates. Using those kinds of gates, circuits can detect multiple inputs. In most of the previously engineered cellular logic circuits, the end product is generated only as long as the original stimuli are present: Once they disappear, the circuit shuts off until another stimulus comes along.  Lu and his colleagues set out to design a circuit that would be irreversibly altered by the original stimulus, creating a permanent memory of the event. To do this, they drew on memory circuits that Lu and colleagues designed in 2009. Those circuits depend on enzymes known as recombinases, which can cut out stretches of DNA, flip them, or insert them. Sequential activation of those enzymes allows the circuits to count events happening inside a cell. Lu designed the new circuits so that the memory function is built into the logic gate itself. With a typical cellular AND gate, the two necessary inputs activate proteins that together turn on expression of an output gene. However, in the new circuits, the inputs stably alter regions of DNA that control GFP production. These regions, known as promoters, recruit the cellular proteins responsible for transcribing the GFP gene into messenger RNA, which then directs protein assembly. For example, in one circuit described in the paper, two DNA sequences called terminators are interposed between the promoter and the output gene (GFP, in this case). Each of these terminators inhibits the transcription of the output gene and can be flipped by a different recombinase enzyme, making the terminator inactive.  Each of the circuit’s two inputs turns on production of one of the recombinase enzymes needed to flip a terminator. In the absence of either input, GFP production is blocked. If both are present, both terminators are flipped, resulting in their inactivation and subsequent production of GFP.  Once the DNA terminator sequences are flipped, they can’t return to their original state — the memory of the logic gate activation is permanently stored in the DNA sequence. The sequence also gets passed on for at least 90 generations. Scientists wanting to read the cell’s history can either measure its GFP output, which will stay on continuously, or if the cell has died, they can retrieve the memory by sequencing its DNA. Using this design strategy, the researchers can create all two-input logic gates and implement sequential logic systems. “It’s really easy to swap things in and out,” says Lu, who is also a member of MIT’s Synthetic Biology Center. “If you start off with a standard parts library, you can use a one-step reaction to assemble any kind of function that you want.” Long-term memory Such circuits could also be used to create a type of circuit known as a digital-to-analog converter. This kind of circuit takes digital inputs — for example, the presence or absence of single chemicals — and converts them to an analog output, which can be a range of values, such as continuous levels of gene expression.  For example, if the cell has two circuits, each of which expresses GFP at different levels when they are activated by their specific input, those inputs can produce four different analog output levels. Moreover, by measuring how much GFP is produced, the researchers can figure out which of the inputs were present. That type of circuit could offer better control over the production of cells that generate biofuels, drugs or other useful compounds. Instead of creating circuits that are always on, or using promoters that need continuous inputs to control their output levels, scientists could transiently program the circuit to produce at a certain level. The cells and their progeny would always remember that level, without needing any more information.  Used as environmental sensors, such circuits could also provide very precise long-term memory. “You could have different digital signals you wanted to sense, and just have one analog output that summarizes everything that was happening inside,” Lu says. This platform could also allow scientists to more accurately control the fate of stem cells as they develop into other cell types. Lu is now working on engineering cells to follow sequential development steps, depending on what kinds of inputs they receive from the environment.  Michael Jewett, an assistant professor of chemical and biological engineering at Northwestern University, says the new design represents a “huge advancement in DNA-encoded memory storage.” “I anticipate that the innovations reported here will help to inspire larger synthetic biology efforts that push the limits of engineered biological systems,” says Jewett, who was not involved in the research."http://bit.ly/Y3KzUJ


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https://plus.google.com/u/0/106140549977596536572/posts/Ae1bKTr1Bqz
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Probing The Matrix: Is our universe simulated, and if so… by who? | ExtremeTech

Probing The Matrix: Is our universe simulated, and if so… by who? | ExtremeTech | Engineering The Cure | Scoop.it
- February 5, 5:10 AM
Interpreting the universe as a computer simulation is perhaps the inevitable byproduct of living in the computer age.
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Rescooped by AUNG THIHA from "#Social World, Internet, Gadgets, Computers, CellPhones, Future, Space"
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meta AR glasses to offer gesture control of 3D virtual objects

meta AR glasses to offer gesture control of 3D virtual objects | Engineering The Cure | Scoop.it
From www.gizmag.com - February 5, 4:42 AM
A new start-up called meta has partnered with Epson to develop augmented reality glasses that will allow virtual objects to be controlled in 3D space using ...

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Programming Nature

Programming Nature | Engineering The Cure | Scoop.it
From www.vlab.org - January 22, 2:49 PM
Socrates Logos's curator insight, January 22, 2:11 PM

Entrepreneurs are transforming synthetic biology into real dollars

 When: Tuesday,  January 22, 2013 6:00 - 7:00pm  Networking and Refreshments 7:00 - 8:30pm  Panel Discussion and Q&A WhereCemex Auditorium at Knight Management Center (Parking and Directions) Event Description: Synthetic biology was once-upon-a-time reserved for big pharma and the multimillion dollar chemical manufacturing industry. But today, startups and hackers in their garages and basements are using cloud based services and low cost labs, tools, and equipment to manipulate organisms to produce materials and products of economic value. Startups like Lygos are altering the DNA of yeast and e-coli to produce nylon, polyester, and polypropylene for clothing. RefactoredMaterials is transforming proteins to create materials that mimic spider silk. All of this is possible because cloud-based services and low cost tools are enabling these companies to quickly and cheaply build and iterate through multiple DNA blueprints to discover the right formula to produce these materials. Come to our event on January 22, 2013 at the Stanford Graduate School of Business to learn: What are the tools and cloud services that enable synthetic biology for startups?What are the keys to low cost innovation that will democratize synthetic biology and create profitable ventures?How do movements like Biohacking and Biocurious help shape this new movement?Can backyard biologists have the same impact that the homebrew computer clubs did in the 1980s?Is there a Moore's law equivalent for this space and what do investors see as the next big opportunities?Join us to Learn More. Moderator:  Megan Palmer, Deputy Director,  Stanford University, Synthetic Biology Engineering Research Center (SynBERC) Panelists:  Dan Widmaier, CEO, Refactored Materials  Nathan J. Hillson, Founder and Chief Scientific Officer, Teselagen Warren Hogarth, Partner, Sequoia Capital   Sasha Kamb, Senior Vice President, Amgen      http://bit.ly/141eoKs ;
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Ben Goertzel interviews Natasha Vita-More

Ben Goertzel interviews Natasha Vita-More | Engineering The Cure | Scoop.it
From hplusmagazine.com - January 18, 1:35 AM
h+ Magazine is a new publication that covers technological, scientific, and cultural trends that are changing human beings in fundamental ways.
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