CRISPR gene drives allow scientists to change sequences of DNA and guarantee that the resulting edited genetic trait is inherited by future generations, opening up the possibility of altering entire species forever. More than anything, the technology has led to questions: How will this new power affect humanity? What are we going to use it to change? Are we gods now? Join journalist Jennifer Kahn as she ponders these questions and shares a potentially powerful application of gene drives: the development of disease-resistant mosquitoes that could knock out malaria and Zika.
A group of 21 youth climate activists scored a major victory in the courts on Friday: The plaintiffs, aged 8 to 19, allege unconstitutional discrimination by a federal government more interested in burning fossil fuels than protecting the rights to life, liberty, and property of young people. The Oregon federal judge hearing the case, Thomas Coffin, said they have a point.
Denying the federal government’s motion to dismiss the “relatively unprecedented lawsuit,” Judge Coffin wrote:
The court must accept the allegations as true and those allegations plausibly allege harm, though widespread, that is concrete. … the intractability of the debates before Congress and state legislatures and the alleged valuing of short term economic interest despite the cost to human life, necessitates a need for the courts to evaluate the constitutional parameters of the action or inaction taken by the government.
In other words, given the ultra-polarized political stalemate on climate change, a bunch of kids suing the government over decades of unnecessarily slow action may be the best shot humanity has left at addressing the problem before dangerous changes are locked in. The suit is a radical challenge to the status quo in an era of radical environmental change.
“The future of our generation is at stake,” said 16-year-old plaintiff Victoria Barrett in a statement. “People label our generation as dreamers, but hope is not the only tool we have.”
We often think of consciousness as binary: you’re either fully aware of something, or you’re not. Yet according to a team of cognitive neuroscientists at the University of California, Santa... read more
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Northwestern University scientists created a prosthetic ovary using a 3D printer – an implant that allowed mice that had their ovaries surgically removed to bear live young. The results will be presented Saturday, April 2, at the Endocrine Society’s annual meeting, ENDO 2016, in Boston. Researchers hope to use the technology to develop an ovary bioprosthesis that could be implanted in women to restore fertility. One group that could benefit is survivors of childhood cancers, who have an increased risk of infertility as adults. An estimated 1 in 250 adults has survived childhood cancer.
“One of the biggest concerns for patients diagnosed with cancer is how the treatment may affect their fertility and hormone health,” said lead study author Monica M. Laronda, PhD, a postdoctoral research fellow at Northwestern University’s Feinberg School of Medicine. “We are developing new ways to restore their quality of life by engineering ovary bioprosthesis implants.”
The researchers used a 3D printer to create a scaffold to support hormone-producing cells and immature egg cells, called oocytes. The structure was made out of gelatin – a biological material derived from the animal protein collagen. The scientists applied biological principles to manufacture the scaffold, which needed to be rigid enough to be handled during surgery and to provide enough space for oocyte growth, blood vessel formation and ovulation.
Using human cell cultures, the researchers determined the optimal scaffold design should have crisscrossing struts that allowed the cells to anchor at multiple points. The scaffolds were seeded with ovarian follicles – the spherical unit that contains a centralized oocyte with surrounding supportive, hormone-producing cells – to create the bioprosthesis.
To test the implant, researchers removed the ovaries of mice and replaced them with the ovary bioprosthesis. Following the procedure, the mice ovulated, gave birth to healthy pups and were able to nurse.
Implanting the prosthetic ovary in mice also restored the estrous, or female hormone cycle. Researchers theorize a similar implant could help maintain hormone cycling in women who were born with or have undergone disease treatments that have reduced ovarian function. These women often experience decreased production of reproductive hormones that can cause issues with the onset of puberty as well as bone and vascular health problems later in life.
“We developed this implant with downstream human applications in mind, as it is made through a scalable 3D printing method, using a material already used in humans,” Laronda said. “We hope to one day restore fertility and hormone function in women who suffer from the side effects of cancer treatments or who were born with reduced ovarian function.”
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