The era of Big Data has begun. Computer scientists, physicists, economists, mathematicians, political scientists, bio-informaticists, sociologists, and many others are clamoring for access to the massive quantities of information produced by and about people, things, and their interactions. Diverse groups argue about the potential benefits and costs of analyzing information from Twitter, Google, Verizon, 23andMe, Facebook, Wikipedia, and every space where large groups of people leave digital traces and deposit data. This essay offers six provocations that we hope can spark conversations about the issues of Big Data. Given the rise of Big Data as both a phenomenon and a methodological persuasion, we believe that it is time to start critically interrogating this phenomenon, its assumptions, and its biases.