Drug discovery and drug safety
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Drug discovery and drug safety
Information related to drug discovery and drug safety
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When Exercise Is Unhealthy: Study Sheds New Light on Sudden Cardiac Death

When Exercise Is Unhealthy: Study Sheds New Light on Sudden Cardiac Death | Drug discovery and drug safety | Scoop.it
Researchers have discovered new aspects, involving a mutated protein, of a not-well-understood mechanism that underlies how sudden heart failure can occur during endurance exercise in patients with arrhythmogenic ventricular cardiomyopathy, which ...
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Near-Death Experiences: What Happens in the Brain Before Dying

Near-Death Experiences: What Happens in the Brain Before Dying | Drug discovery and drug safety | Scoop.it
In the moments before death, conventional wisdom says that as the heart stops beating and blood stops flowing, the rest of the body slowly shuts down. But a new study suggests this view may in fact be wrong.
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Improving computer modelling of cardiac properties by ditching the one-size-fits-all approach | NC3Rs

Improving computer modelling of cardiac properties by ditching the one-size-fits-all approach | NC3Rs | Drug discovery and drug safety | Scoop.it
For the first time since the prize was launched in 2005, the highest accolade has gone to a PhD student, Mr Oliver Britton, working with Professor Blanca Rodriguez, at the University of Oxford.
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Cell Death and Disease - Role of ion channels in regulating Ca2+ homeostasis during the interplay between immune and cancer cells

Cell Death and Disease - Role of ion channels in regulating Ca2+ homeostasis during the interplay between immune and cancer cells | Drug discovery and drug safety | Scoop.it
Brought to you by the editorial team of Cell Death and Differentiation, Cell Death and Disease is a peer-reviewed author-pays online journal in the field of translational cell death.
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Protein clue to sudden cardiac death | University of Oxford

Protein clue to sudden cardiac death | University of Oxford | Drug discovery and drug safety | Scoop.it
A protein has been shown to have a surprising role in regulating the 'glue' that holds heart cells together, a finding that may explain how a gene defect could cause sudden cardiac death.
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Medtronic Insertable Cardiac Monitors Detect Atrial Fibrillation in Stroke ... - Nasdaq

Medtronic Insertable Cardiac Monitors Detect Atrial Fibrillation in Stroke ... - Nasdaq | Drug discovery and drug safety | Scoop.it
Medtronic Insertable Cardiac Monitors Detect Atrial Fibrillation in Stroke Patients in 'Real-World' Study Findings Reinforce Patient Benefit of.
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Stem cell therapy for heart failure: first implant of cardiac cells derived from human embryonic stem cells

Stem cell therapy for heart failure: first implant of cardiac cells derived from human embryonic stem cells | Drug discovery and drug safety | Scoop.it
On the 21 October 2014, Professor Philippe Menasché and his team from the cardiovascular surgery service of the Georges Pompidou European Hospital, AP-HP, carried out a transplant of cardiac cells derived from human embryonic stem cells...

Via Gilbert C FAURE
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Leaky channels could contribute to unusual heart arrhythmias - Medical Xpress

Leaky channels could contribute to unusual heart arrhythmias - Medical Xpress | Drug discovery and drug safety | Scoop.it
Leaks are not just problems for plumbers and politicians; researchers in Canada reveal how leaky transmembrane channels could cause disruptions in normal heart function.
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Cytokinetics and Astellas Expand Development Collaboration Of Skeletal ... - SMA News Today

Cytokinetics and Astellas Expand Development Collaboration Of Skeletal ... - SMA News Today | Drug discovery and drug safety | Scoop.it
Read About How Cytokinetics and Astellas Expand Development Collaboration Of Skeletal Muscle Activators To Treat Muscular Atrophy, Other Neuromuscular Indications.
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FDA approves anti-clotting drug Savaysa - FDA.gov

The U.S. Food and Drug Administration today approved the anti-clotting drug Savaysa (edoxaban tablets) to reduce the risk of stroke and dangerous blood clots (systemic embolism) in patients with atrial fibrillation that is not caused by a heart...
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Epilepsy Is a Risk Factor for Sudden Cardiac Arrest in the General Population

Epilepsy Is a Risk Factor for Sudden Cardiac Arrest in the General Population | Drug discovery and drug safety | Scoop.it
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.

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Drug safety warnings - DigitalJournal.com

Drug safety warnings - DigitalJournal.com | Drug discovery and drug safety | Scoop.it
DigitalJournal.com
Drug safety warnings
DigitalJournal.com
Based on clinical trial data, the drug has a link to cardiac disorders, including cardiac failure, left ventricular failure, and tachycardia.
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Scientist develops new way using samples of beating heart tissue to test ... - News-Medical.net

Scientist develops new way using samples of beating heart tissue to test ...
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Medtronic says second study confirms gene linked to sudden cardiac death - Minneapolis Star Tribune

Medtronic says second study confirms gene linked to sudden cardiac death - Minneapolis Star Tribune | Drug discovery and drug safety | Scoop.it
Researchers have confirmed the finding of a long-running Medtronic study linking a specific genetic mutation to a higher risk of sudden cardiac death.
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Bladder Drug Re-Grows Myelin, Could Help Ease Multiple Sclerosis Symptoms

Bladder Drug Re-Grows Myelin, Could Help Ease Multiple Sclerosis Symptoms | Drug discovery and drug safety | Scoop.it
An unlikely drug, already marketed to treat overactive bladder, has triggered the regrowth of myelin in mice.

Via Krishan Maggon
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Krishan Maggon 's curator insight, March 10, 2015 6:25 AM

Vesicare (solifenacin) is marketed by Astellas, Teva, GSK for overactive bladder.


It is only a rodent study but since the same receptor blocks myelin regrowth, it may work in the clinic as well.

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Bioengineers put human hearts on a chip to aid drug screening

Bioengineers put human hearts on a chip to aid drug screening | Drug discovery and drug safety | Scoop.it
Researchers have created a 'heart-on-a-chip' that effectively uses human cardiac muscle cells derived from adult stem cells to model how a human heart reacts to cardiovascular medications.

Via #BBBundyBlog #NOMORELIES Tom Woods #Activist Award #Scoopiteer >20,000 Sources >250K Connections http://goo.gl/ruHO3Q
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Acid-sensing ion channels in pain and disease

Acid-sensing ion channels in pain and disease | Drug discovery and drug safety | Scoop.it
RT @WildernessEMC: Acid sensing #ion channels in pain and disease ,2013 .
I find this totally fascinating ! http://t.co/mG34Qo312U
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Anti-ageing pill – is the holy grail of long life already here? - BizNews

Anti-ageing pill – is the holy grail of long life already here? - BizNews | Drug discovery and drug safety | Scoop.it
Rapamycin is here and it's looking good as an anti-ageing pill to extend life span and treat or prevent chronic disease.
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Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation

BDNF enhances myocardial contractility/relaxation [Physiology] http://t.co/4iGvMctjBL
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Overtreatment for Heart Disease May Increase Risk of Alzheimer's - Alzheimer's News Today

Overtreatment for Heart Disease May Increase Risk of Alzheimer's - Alzheimer's News Today | Drug discovery and drug safety | Scoop.it
Read about a study that demonstrated how prolonged overtreatment for heart disease increases the risk of developing Alzheimer's disease.
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Safety concerns cloud early promise of powerful new cancer drugs - Fox News

Safety concerns cloud early promise of powerful new cancer drugs - Fox News | Drug discovery and drug safety | Scoop.it
A new wave of experimental cancer drugs that directly recruit the immune system's powerful T cells are proving to be immensely effective weapons against tumors, potentially transforming the $100 billion global market for drugs that fight the disease.
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Control of Cardiac Repolarization by Phosphoinositide 3-Kinase Signaling to Ion Channels

Control of Cardiac Repolarization by Phosphoinositide 3-Kinase Signaling to Ion Channels | Drug discovery and drug safety | Scoop.it
Review: Control of Cardiac Repolarization by Phosphoinositide 3-Kinase Signaling to Ion Channels http://t.co/a7PSXoXrdz
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Tetragenetics Collaborates with MedImmune on Multi-Target Ion Channel Drug ... - Business Wire (press release)

Tetragenetics Collaborates with MedImmune on Multi-Target Ion Channel Drug ... - Business Wire (press release) | Drug discovery and drug safety | Scoop.it
Tetragenetics Collaborates with MedImmune on Multi-Target Ion Channel Drug Discovery Program
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Heart Attacks Strike Young Women Harder Than Men - LiveScience.com

Heart Attacks Strike Young Women Harder Than Men - LiveScience.com | Drug discovery and drug safety | Scoop.it
Heart Attacks Strike Young Women Harder Than Men LiveScience.com Women make up one-quarter of heart attack patients among people who are relatively young, but fare worse afterward than their male counterparts — women have longer hospital stays on...
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New technique uses 'simulated' human heart to screen drugs - ECNmag.com

New technique uses 'simulated' human heart to screen drugs - ECNmag.com | Drug discovery and drug safety | Scoop.it
Nature World News New technique uses 'simulated' human heart to screen drugs ECNmag.com The breakthrough is the work of Dr Helen Maddock – an expert in cardiovascular physiology and pharmacology from the University's Centre for Applied Biological...
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