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DNA & RNA Research
The latest news and information about DNA- and RNA-related research
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Designer Genes: Integrated DNA Technologies Offer Made-to-Order DNA Oligos

Designer Genes: Integrated DNA Technologies Offer Made-to-Order DNA Oligos | DNA & RNA Research | Scoop.it

Consumers have grown quite accustomed to having the ability to customize the products they buy, from clothing to cell phone cases, to interior lighting and more. This made-to-order trend is not limited to the consumer space, however. Even biotech research organizations are utilizing highly custom synthetic genetic material to advance discovery. This type of research represents the upper echelons of scientific progress in the pharmaceutical, agricultural, academic, and other life science markets. Genetic study analyzes the basic elements of life, allowing scientists to understand biological processes and make discoveries that protect our world.

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Women’s immune system genes operate differently from men’s

Women’s immune system genes operate differently from men’s | DNA & RNA Research | Scoop.it

A new technology reveals that immune system genes switch on and off differently in women and men, and the source of that variation is not primarily in the DNA.

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Heating and cooling with light leads to ultrafast DNA diagnostics

Heating and cooling with light leads to ultrafast DNA diagnostics | DNA & RNA Research | Scoop.it

The innovation greatly expands the potential field applications for PCR test used in forensics, medical diagnostics, biological research and more.

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Out of the lamplight

Out of the lamplight | DNA & RNA Research | Scoop.it

The human body is governed by complex biochemical circuits. Chemical inputs spur chain reactions that generate new outputs. Understanding how these circuits work—how their components interact to enable life—is critical both to advancing basic biology and to identifying new treatments to disease, which arises when these circuits misfire. But getting to that understanding is no trivial task.

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Strange Circular DNA May Offer New Way to Detect Cancers

Strange Circular DNA May Offer New Way to Detect Cancers | DNA & RNA Research | Scoop.it

Strange rings of DNA that exist outside chromosomes are distinct to the cell types that mistakenly produced them, researchers have discovered. The finding raises the possibility that the rings could be used as an indicator of different types of cancer.

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Hacked molecular machine could pump out custom proteins

Hacked molecular machine could pump out custom proteins | DNA & RNA Research | Scoop.it

Engineered ribosomes pave way for designer enzymes and synthetic cells.

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Scientists identify gene vital for rebuilding intestine after cancer treatment

Scientists identify gene vital for rebuilding intestine after cancer treatment | DNA & RNA Research | Scoop.it

Protecting the gastrointestinal system during chemotherapy or radiation could allow patients to tolerate more aggressive treatments to attack tumors.

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In CRISPR Advance, Scientists Successfully Edit Human T Cells

In CRISPR Advance, Scientists Successfully Edit Human T Cells | DNA & RNA Research | Scoop.it

In a project spearheaded by investigators at UC San Francisco, scientists have devised a new strategy to precisely modify human T cells using the genome-editing system known as CRISPR/Cas9. Because these immune-system cells play important roles in a wide range of diseases, from diabetes to AIDS to cancer, the achievement provides a versatile new tool for research on T cell function, as well as a path toward CRISPR/Cas9-based therapies for many serious health problems.

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Genomes Tell Story of Native American Biological Origins

Genomes Tell Story of Native American Biological Origins | DNA & RNA Research | Scoop.it

The first human inhabitants of the Americas lived in a time thousands of years before the first written records, and the story of their transcontinental migration is the subject of ongoing debate and active research.  A study by multi-institutional, international collaboration of researchers, published this week in Science (DOI: 10.1126/science.aab3884) presents strong evidence, gleaned from ancient and modern DNA samples, that the ancestry of all Native Americans can be traced back to a single migration event, with subsequent gene flow between some groups and populations that are currently located in East Asia and Australia.

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Using CRISPR to investigate pancreatic cancer

Using CRISPR to investigate pancreatic cancer | DNA & RNA Research | Scoop.it

Writing about pancreatic cancer always gives me a pang. My grandmother died from the disease over 30 years ago, but I still remember the anguish of her diagnosis and the years of chemotherapy and surgery she endured before her death. This disease is much more personal to me than many I cover. 

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Journeying back in time with ancient DNA

Journeying back in time with ancient DNA | DNA & RNA Research | Scoop.it

Some aspects of DNA research are decidedly modern: think genetic engineering or genetic testing. Another breed of DNA researchers, though, aim to blend new and old. By harnessing the power of modern sequencing and analytical techniques, they are working to uncover the genetic secrets hidden in the DNA of ancient specimens collected during archaeological expeditions or curated in museums. These ancient DNA researchers are analyzing preserved DNA from ancient hominids, plants, and animals to learn about their evolutionary histories, offering a level of detail that inferences based on modern DNA simply cannot match.

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DNA evidence proves climate change killed off prehistoric megafauna

DNA evidence proves climate change killed off prehistoric megafauna | DNA & RNA Research | Scoop.it

Imagine a world populated by woolly mammoths, giant sloths and car-sized armadillos – 50,000 years ago more than 150 types of these mysterious large-bodied mammals roamed our planet. But by 10,000 years ago, two-thirds of them had disappeared.

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Moffitt Cancer Center Researchers Develop First Genetic Test to Predict Tumor Sensitivity to Radiation Therapy

Recent advances in the understanding of cancer have led to more personalized therapies, such as drugs that target particular proteins and tests that analyze gene expression patterns in tumors to predict a patient’s response to therapy. Moffitt Cancer Center researchers have contributed to these advances by developing the first test that analyzes the sensitivity of tumors to radiation therapy. They discovered that colon cancer metastases have varying sensitivity to radiation therapy based on their anatomic location. 

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Oral rinses could help monitor patients with HPV-linked throat cancer

Oral rinses could help monitor patients with HPV-linked throat cancer | DNA & RNA Research | Scoop.it

Traces of DNA from the human papillomavirus found in oral rinses could lead to a way to track how throat cancer responds to treatment.

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Using DNA to Fight Dog Owners’ Discourtesy in Brooklyn

Using DNA to Fight Dog Owners’ Discourtesy in Brooklyn | DNA & RNA Research | Scoop.it

Appeals to decency have failed, so the operators of a condominium in Brooklyn Heights turned to science to combat dog waste in the halls and elevators.

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Newly identified mechanism of p53-induced cell death could aid cancer therapy

Newly identified mechanism of p53-induced cell death could aid cancer therapy | DNA & RNA Research | Scoop.it

St. Jude scientists have discovered how the p53 protein works outside the cell nucleus to trigger cell death. The results could aid cancer therapy.

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Remote Control Biology

Remote Control Biology | DNA & RNA Research | Scoop.it

Here at Lux we are approached on a weekly basis by PhDs looking to leave academia and enter industry. The first question I ask them is “How much time do you have left before graduating?” What I’m really asking is “How much time do you have left to network the hell out of industry?” There’s a lot of downtime in science, and that downtime is invaluable if your mind is made up that professorship is not for you.

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Scientists decipher the molecular basis of an as yet incurable leukemia in children

Acute lymphoblastic leukemia (ALL) is the most common type of cancer in children. It can occur in various forms, differing by specific changes in the genetic material of the leukemia cells, but also by their response to therapies. An international team of scientists from Berlin, Düsseldorf, Hannover, Heidelberg, Kiel, and Zurich has succeeded in decoding the molecular characteristics of an as yet incurable subtype of leukemia, paving the way for new therapeutic approaches. Their results have been published in the current issue of the journal Nature Genetics (27 July).

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At Tiny Scales, a Giant Burst on Tree of Life

At Tiny Scales, a Giant Burst on Tree of Life | DNA & RNA Research | Scoop.it

A new technique for finding and characterizing microbes has boosted the number of known bacteria by almost 50 percent, revealing a hidden world all around us.

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Cleaning Up Ancient Human DNA

Cleaning Up Ancient Human DNA | DNA & RNA Research | Scoop.it

With the genomes of Ötzi, the 5300-year-old iceman, and even Neandertals pouring out of DNA sequencing labs lately, you might think that it’s now a piece of cake to glean the entire genetic code of an ancient human. But it turns out that those studies used exceptionally pure samples of DNA taken from human bone, tooth, hair, or other tissue typically preserved in frozen soil, ice, or a chilly cave. More often, human remains found by scientists have been sitting in soil warm enough to harbor bacteria, which swamp out the human DNA with their genes and make it too costly to analyze. A clever new method for purifying ancient human DNA samples—reported here last week at the annual meeting of the American Society of Human Genetics—could change that, however.

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University of Wisconsin study shows how a kernel got naked and corn became king

University of Wisconsin study shows how a kernel got naked and corn became king | DNA & RNA Research | Scoop.it

Ten thousand years ago, a golden grain got naked, brought people together and grew to become one of the top agricultural commodities on the planet.

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Studying cancer from the inside out: What the epigenetic code can tell doctors about disease

Studying cancer from the inside out: What the epigenetic code can tell doctors about disease | DNA & RNA Research | Scoop.it

Receiving a cancer diagnosis can feel like losing control of everything. In the wake of such a diagnosis, patients, family and friends often yearn for more information. Is it aggressive? What treatments are offered? Will those treatments work? Will it spread? Sometimes doctors can offer answers, but in other cases they are elusive. Without information, the patient may decide to treat a benign tumor with harsh drugs or risky surgery or may take a wait-and-see approach with an aggressive tumor-neither of which are ideal. 

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3D ‘printouts’ at the nanoscale using self-assembling DNA structures

3D ‘printouts’ at the nanoscale using self-assembling DNA structures | DNA & RNA Research | Scoop.it

A novel way of making 3D nanostructures from DNA is described in a study published in the renowned journal Nature . The study was led by researchers at Sweden’s Karolinska Institutet who collaborated with a group at Finland's Aalto University. The new technique makes it possible to synthesize 3D DNA origami structures that are also able to tolerate the low salt concentrations inside the body, which opens the way for completely new biological applications of DNA nanotechnology. The design process is also highly automated, which enables the creation of synthetic DNA nanostructures of remarkable complexity.

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High-performance computing helps chemists sort through cellular statistics

High-performance computing helps chemists sort through cellular statistics | DNA & RNA Research | Scoop.it

DNA is often referred to as “the blueprint of life.” But it’s more than just a blueprint—it’s also a kind of operations manual for the workings of the cell, telling it what proteins to manufacture and when. 

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Simple technology makes CRISPR gene editing cheaper

Simple technology makes CRISPR gene editing cheaper | DNA & RNA Research | Scoop.it

University of California, Berkeley, researchers have discovered a much cheaper and easier way to target a hot new gene editing tool, CRISPR-Cas9, to cut or label DNA.

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