DNA and RNA Research
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DNA and RNA Research
The latest news and information about DNA- and RNA-related research
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ESI mass spectrometry—why we use it for oligonucleotide quality control

ESI mass spectrometry—why we use it for oligonucleotide quality control | DNA and RNA Research | Scoop.it

How (and why) ESI is used in oligonucleotide synthesis

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Engineering Undergraduates Use DNA Origami to Target Cancer

Engineering Undergraduates Use DNA Origami to Target Cancer | DNA and RNA Research | Scoop.it

A team of engineering students has a cancer-fighting idea up its sleeve—and the sleeve is nanoscale.

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Biologists propose to sequence the DNA of all life on Earth

Biologists propose to sequence the DNA of all life on Earth | DNA and RNA Research | Scoop.it

Still-unfunded plan would start with all plants, animals, and other eukaryotes—some 1.5 million species—for the cost of the original human genome project

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Electrons Use DNA Like a Wire for Signaling DNA Replication 

Electrons Use DNA Like a Wire for Signaling DNA Replication  | DNA and RNA Research | Scoop.it

A Caltech-led study has shown that the electrical wire-like behavior of DNA is involved in the molecule's replication.

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Computing with Biochemical Circuits Made Easy 

Computing with Biochemical Circuits Made Easy  | DNA and RNA Research | Scoop.it

A software tool and a systematic wet-lab procedure proven in practice are an advance in the design and construction of circuits made of DNA.

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The RNA code comes into focus 

The RNA code comes into focus  | DNA and RNA Research | Scoop.it

As researchers open up to the reality of RNA modification, an expanded epitranscriptomics toolbox takes shape.

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'Junk DNA' could play an important role in diabetes

'Junk DNA' could play an important role in diabetes | DNA and RNA Research | Scoop.it

Researchers at Imperial College London have found that so-called 'junk DNA' could play a role in diabetes.

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An Aging-Related Effect on the Circadian Clock

An Aging-Related Effect on the Circadian Clock | DNA and RNA Research | Scoop.it

Stress-related genes may be preferentially and rhythmically expressed as part of the circadian rhythms of older fruit flies, researchers report.  

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Gene Variants Affect Height in Surprising Ways

Gene Variants Affect Height in Surprising Ways | DNA and RNA Research | Scoop.it

Low-frequency genetic variants significantly affect human height and could pave the way for precision medicine targets.

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An epigenetics gold rush: new controls for gene expression

An epigenetics gold rush: new controls for gene expression | DNA and RNA Research | Scoop.it

How rediscovered chemical tags on DNA and RNA are shaking up the field.

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What happens to gene transcription during DNA damage? 

What happens to gene transcription during DNA damage?  | DNA and RNA Research | Scoop.it

For the first time, scientists at the Francis Crick Institute have described what happens at the molecular level when gene transcription slows down in response to DNA damage in a cell.

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The race to map the human body — one cell at a time

The race to map the human body — one cell at a time | DNA and RNA Research | Scoop.it

A host of detailed cell atlases could revolutionize understanding of cancer and other diseases.

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Why Is Cancer More Common in Men?

Why Is Cancer More Common in Men? | DNA and RNA Research | Scoop.it

Oncologists know that men are more prone to cancer than women; one in two men will develop some form of the disease in a lifetime, compared with one in three women.

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Shedding Light on Cancer Diversity and Resistance

Shedding Light on Cancer Diversity and Resistance | DNA and RNA Research | Scoop.it

A paradigm-changing study by cancer researchers and computer scientists at the University of California San Diego and other institutions found that short fragments of circular DNA that encode cancer genes are far more common in cancer cells than previously believed. Published online in the journal Nature, the study* also concluded that the circular DNA probably plays a central role in generating the cellular diversity that makes advanced cancers so difficult to treat. The new findings are likely to change the way tumor evolution is understood by scientists and could ultimately lead to new ways to prevent and treat many malignancies.

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New Type of Genetic Mutation Identified in Cancer 

New Type of Genetic Mutation Identified in Cancer  | DNA and RNA Research | Scoop.it

A newly discovered type of genetic mutation that occurs frequently in cancer cells may provide clues about the disease’s origins and offer new therapeutic targets, according to new research from Weill Cornell Medicine and the New York Genome Center

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A Novel DNA Vaccine Design Improves Chances of Inducing Anti-Tumor Immunity 

Scientists at The Wistar Institute and Inovio Pharmaceuticals, Inc. have devised a novel DNA vaccine approach through molecular design to improve the immune responses elicited against one of the most important cancer antigen targets. Study results were published in the journal Molecular Therapy.

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DNA patterns can unlock how glucose metabolism drives cancer, study finds

DNA patterns can unlock how glucose metabolism drives cancer, study finds | DNA and RNA Research | Scoop.it

UCLA-led study of DNA patterns in tumor cells suggests that the abundance of aberrant genetic signatures common in more aggressive cancers is not random.

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Anti-Aging Gene Identified as a Novel Promising Therapeutic Target for Older Melanoma Patients 

Anti-Aging Gene Identified as a Novel Promising Therapeutic Target for Older Melanoma Patients  | DNA and RNA Research | Scoop.it

Scientists at The Wistar Institute have shown that an anti-diabetic drug can inhibit the growth of melanoma in older patients by activating an anti-aging gene that in turn inhibits a protein involved in metastatic progression and resistance to targeted therapies for the disease. The study was published online in Clinical Cancer Research.

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Trading in the Scalpel for a Sharper Blade

Trading in the Scalpel for a Sharper Blade | DNA and RNA Research | Scoop.it

Losing a breast or a lung to cancer leaves a scar, both physical and emotional. But even a biopsy to determine if a tumor is cancerous, or to track a tumor’s response to drugs, brings short-term pain and can miss signs of metastasis. So, the possibility of a scalpel-free biopsy has been something of a holy grail — a way to relieve trauma, speed diagnosis and shrink medical bills.

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RNAi Used To Treat Eye Inflammation

RNAi Used To Treat Eye Inflammation | DNA and RNA Research | Scoop.it

Researchers have successfully used proline-modified short hairpin RNA targeting (pro)renin to treat eye inflammation in mice.

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‘Smart’ bacteria remodel their genes to infect our intestines

‘Smart’ bacteria remodel their genes to infect our intestines | DNA and RNA Research | Scoop.it

Infectious diarrhea, a common disease of children, is responsible for over 2 million infant deaths annually in developing counties alone. A primary cause of this and other devastating conditions is enteropathogenic bacteria, which attack the intestinal tract when contaminated food is consumed.The infection process involves hundreds of genes and proteins, both in the infectious bacteria and the human host. However, the processes by which the pathogens establish themselves in our gut are poorly understood.

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Many people with harmful genetic variants show no ill effects

Many people with harmful genetic variants show no ill effects | DNA and RNA Research | Scoop.it

Most adults with genetic variants tied to certain conditions, such as heart disease or cancer, go undiagnosed.

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‘Start Codons’ in DNA and RNA May Be More Numerous Than Previously Thought

‘Start Codons’ in DNA and RNA May Be More Numerous Than Previously Thought | DNA and RNA Research | Scoop.it

For decades, scientists working with genetic material have labored with a few basic rules in mind. To start, DNA is transcribed into messenger RNA (mRNA), and mRNA is translated into proteins, which are essential for almost all biological functions. A central principle regarding translation has long held that only a small number of three-letter sequences in mRNA, known as start codons, could trigger the production of proteins. But researchers might need to revisit and possibly rewrite this rule, after recent measurements from a team including scientists from the National Institute of Standards and Technology (NIST).

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DNA computer brings ‘intelligent drugs’ a step closer

DNA computer brings ‘intelligent drugs’ a step closer | DNA and RNA Research | Scoop.it

A new method that should enable controlled drug delivery into the bloodstream using DNA computers is an important step towards 'intelligent' medicine.

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Researchers are first to see DNA ‘blink’ 

Researchers are first to see DNA ‘blink’  | DNA and RNA Research | Scoop.it

A powerful Northwestern University imaging tool is the first to measure the structure of isolated chromosomes without the use of fluorescent labels.

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Switched-on DNA

Switched-on DNA | DNA and RNA Research | Scoop.it

DNA, the stuff of life, may very well also pack quite the jolt for engineers trying to advance the development of tiny, low-cost electronic devices. Much like flipping your light switch at home---only on a scale 1,000 times smaller than a human hair---an ASU-led team has now developed the first controllable DNA switch to regulate the flow of electricity within a single, atomic-sized molecule.

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