DNA and RNA Research
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DNA and RNA Research
The latest news and information about DNA- and RNA-related research
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Tips for effective use of BLAST and other NCBI tools

The National Center for Biotechnology Information (NCBI) provides one of the most extensive sets of web-based tools for biological research. The tools are indispensable when planning genomics experiments, including for qPCR, NGS, and CRISPR. In this presentation, Dr Matt McNeill takes a practical look at getting started with the wealth of NCBI tools, and shares some relevant tips to help you sift through the tools and options that we regularly use. In particular, he focuses on commonly adjusted parameters that will allow you to more effectively use the powerful Basic Local Alignment Algorithm Tool (BLAST) to identify off-target hybridization/annealing events. Dr McNeill also covers practical examples using NCBI tools to design assays.

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Biologists unlock 51.7m-year-old genetic secret to Darwin theory 

Biologists unlock 51.7m-year-old genetic secret to Darwin theory  | DNA and RNA Research | Scoop.it

Scientists have identified the cluster of genes responsible for reproductive traits in the Primula flower, first noted as important by Charles Darwin more than 150 years ago.

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Expanding the DNA alphabet to understand cancer

Expanding the DNA alphabet to understand cancer | DNA and RNA Research | Scoop.it

The base components of DNA - adenine, thymine, cytosine and guanine (commonly referred to as ATCG) are so fundamental to the study of genetics that they are probably familiar to anyone who has taken a high school biology class.

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Genome analysis reveals germ cell cancer’s distinct roots 

Genome analysis reveals germ cell cancer’s distinct roots  | DNA and RNA Research | Scoop.it

Primed for self-destruction, testicular cancer cells become drug-resistant as they lose pluripotency factors

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Biologists Watch Speciation in a Laboratory Flask

Biologists Watch Speciation in a Laboratory Flask | DNA and RNA Research | Scoop.it

Biologists have discovered that the evolution of a new species can occur rapidly enough for them to observe the process in a simple laboratory flask.

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Programmable Disorder 

Programmable Disorder  | DNA and RNA Research | Scoop.it

Researchers have developed a molecular programming language to create DNA tiles that exploit randomness to carry out nanofabrication tasks by self-assembly.

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An apple a day keeps your genetic risk at bay

An apple a day keeps your genetic risk at bay | DNA and RNA Research | Scoop.it

Genetics can predict some of your risk for heart disease, but lifestyle is important, too. A new study of 55,000 people found that favorable lifestyle habits can offset some of a person's genetic risk, reducing coronary events by half among those at high genetic risk.

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Crop Yield Gets Boost with Modified Genes in Photosynthesis 

Crop Yield Gets Boost with Modified Genes in Photosynthesis  | DNA and RNA Research | Scoop.it

Berkeley and Illinois researchers have bumped up crop productivity by increasing the expression of genes that result in more efficient use of light in photosynthesis. Their work could potentially be used to help address the world’s future food needs.

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New mechanism for cancer gene activation 

New mechanism for cancer gene activation  | DNA and RNA Research | Scoop.it

A team of EMBL scientists has identified a new molecular mechanism for cancer gene activation using publicly available data sets

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Around 600,000 in UK living with faulty gene that could lead to heart failure

Around 600,000 in UK living with faulty gene that could lead to heart failure | DNA and RNA Research | Scoop.it

A new study from scientists at Imperial College London suggests a gene variant can trigger heart failure when the organ is under stress.

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A step toward mitochondrial gene therapy 

A step toward mitochondrial gene therapy  | DNA and RNA Research | Scoop.it
A self-assembling, peptide-based gene delivery system might one day correct mitochondrial DNA mutations that underlie disease

 

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5000-year-old cobs reveal corn domestication in the act

5000-year-old cobs reveal corn domestication in the act | DNA and RNA Research | Scoop.it

Genome sequencing shows what genes ancient farmers first selected for in maize

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Multi-institutional collaboration uncovers how molecular machines assemble 

Multi-institutional collaboration uncovers how molecular machines assemble  | DNA and RNA Research | Scoop.it

New imaging method takes on molecular mixtures

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Study: Enhancing cancer response to radiation

Study: Enhancing cancer response to radiation | DNA and RNA Research | Scoop.it

Research in a mouse model shows microRNAs have the potential to one day influence cancer treatment

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Divining Tumor Markers from DNA 

Divining Tumor Markers from DNA  | DNA and RNA Research | Scoop.it

Researchers at UConn Health will team up with the Parker Institute for Cancer Immunotherapy, the Cancer Research Institute, and 30 other organizations in a hunt for the telltale marks of cancerous cells, the group announced today. The search for neoantigens, as these unique cancer markers are called, has become a robust area of research, as scientists believe they may hold the key to developing a new generation of personalized, targeted cancer immunotherapies.

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Study reveals key role of mRNA's 'fifth nucleotide' in determining sex in fruit flies

Study reveals key role of mRNA's 'fifth nucleotide' in determining sex in fruit flies | DNA and RNA Research | Scoop.it

A team of scientists led by the University of Birmingham has shown how a common mRNA modification, N6-methyladenosine (m6A), regulates gene expression to determine the sex of fruit flies.

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Mitochondrial DNA Helps Explain Autism

Mitochondrial DNA Helps Explain Autism | DNA and RNA Research | Scoop.it

By focusing on mitochondrial DNA instead of nuclear DNA, computational biologists shed light on how mutations contribute to autism.

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Sampling species' DNA trails is leading to better environmental monitoring

Sampling species' DNA trails is leading to better environmental monitoring | DNA and RNA Research | Scoop.it

Using a technique that can tell if a species has passed by from just a sample of water, scientists are developing new ways to assess ecosystems.

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Small RNA identified that offers clues for quieting the “voices” of schizophrenia

Small RNA identified that offers clues for quieting the “voices” of schizophrenia | DNA and RNA Research | Scoop.it

Researchers identify a microRNA that may be key to restoring normal functioning of a brain circuit and quieting the “voices” of schizophrenia

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Genes, Early Environment Sculpt the Gut Microbiome 

Genes, Early Environment Sculpt the Gut Microbiome  | DNA and RNA Research | Scoop.it

A new study has found that genes and early environment play big roles in shaping the gut microbiome. The microbes retained a clear “signature” formed where the mice were first raised, and the characteristics carried over to the next generation. The findings could potentially be used to develop designer diets optimized to an individual’s microbiome.

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By hacking cells’ DNA, virus traces brain activity patterns

By hacking cells’ DNA, virus traces brain activity patterns | DNA and RNA Research | Scoop.it

A mutant virus that infiltrates neurons and delivers genes to the nucleus can illuminate brain connections.

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Cancer cells 'talk' to their environment, and it talks back 

Cancer cells 'talk' to their environment, and it talks back  | DNA and RNA Research | Scoop.it

Interactions between an animal cell and its environment, a fibrous network called the extracellular matrix, play a critical role in cell function, including growth and migration. But less understood is the mechanical force that governs those interactions.

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Turning Back the Aging Clock 

Turning Back the Aging Clock  | DNA and RNA Research | Scoop.it

By boosting genes that destroy defective mitochondrial DNA, researchers can slow down and potentially reverse an important part of the aging process.

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Biomarker could help guide cancer therapy, avoid drug resistance

Biomarker could help guide cancer therapy, avoid drug resistance | DNA and RNA Research | Scoop.it

MIT biologists have identified a new biomarker — a protein called Mena — that can reveal whether patients with an aggressive type of breast cancer will be helped by the chemotherapy drug paclitaxel. They also showed that combining paclitaxel with another drug that interferes with Mena’s effects can kill the cells much more effectively than paclitaxel alone.

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Bad hair day? ‘Uncombable hair syndrome’ traced to gene mutations

Bad hair day? ‘Uncombable hair syndrome’ traced to gene mutations | DNA and RNA Research | Scoop.it

The matted and mussed hair of the famously bizarre German children’s book character Struwwelpeter was meant to serve as a warning about bad hygiene. But for kids that bear a striking resemblance to the straw-haired mischiefmaker (above), tangled hair is no fault of their own: It’s due to a rare genetic mutation.

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