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DNA & RNA Research
The latest news and information about DNA- and RNA-related research
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DECODED 4.2—Special qPCR Issue

DECODED 4.2—Special qPCR Issue | DNA & RNA Research | Scoop.it

Sign up to receive a print version of the special qPCR issue of DECODED.


Topics include:

  • Background and experimental design 
  • Primer and probe design
  • Handling primer and probe oligonucleotides 
  • qPCR using intercalating dyes 
  • Probe-based (5' nuclease) qPCR 
  • Multiplex qPCR 
  • Special applications
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Quality assurance for genome editing

Quality assurance for genome editing | DNA & RNA Research | Scoop.it

Labs the world over are jumping onto the gene editing bandwagon (and into the inevitable patent arguments). And it’s hard to blame them. As these technologies have evolved over the last two decades starting with the zinc finger nucleases (ZFNs), followed by transcription activator-like effector nucleases (TALENs) and CRISPR—they’ve become ever more powerful and easier to use.

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McGovern Institute Researchers Seek a Better Understanding of Mental Illness

McGovern Institute Researchers Seek a Better Understanding of Mental Illness | DNA & RNA Research | Scoop.it

Robert Desimone, head of MIT’s McGovern Institute for Brain Research, thinks ­breakthroughs in understanding mental illness are just around the corner.

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Biologists’ Clever Way to Detect Animals They Can’t Find

Biologists’ Clever Way to Detect Animals They Can’t Find | DNA & RNA Research | Scoop.it


Wildlife doesn’t get much weirder than the hellbender, a frilly, crayfish-gobbling salamander, about the length of a baby alligator, whose bizarre aliases include “snot otter,” “devil dog,” and “grampus.” The giant amphibian stalks rocky streambeds throughout the eastern United States—or at least it did, until agriculture, deforestation, and dams ruined water quality and habitats throughout much of its range. These days, scientists aren’t certain where snot otters still roam.

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Tracking Malaria’s Emerging Drug-Resistance

Tracking Malaria’s Emerging Drug-Resistance | DNA & RNA Research | Scoop.it

A microarray analysis of Southeast Asian malaria patients has revealed the factors driving the growing resistance to the drug Artemisin. 

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How Exercise Changes Our DNA

How Exercise Changes Our DNA | DNA & RNA Research | Scoop.it

We all know that exercise can make us fitter and reduce our risk for illnesses such as diabetes and heart disease. But just how, from start to finish, a run or a bike ride might translate into a healthier life has remained baffling.

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Big-data analysis reveals gene sharing in mice

Big-data analysis reveals gene sharing in mice | DNA & RNA Research | Scoop.it

Rice University scientists find evidence of genes shared by two mouse species across Europe, Africa 

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UCLA engineers first to detect and measure individual DNA molecules using smartphone microscope

UCLA engineers first to detect and measure individual DNA molecules using smartphone microscope | DNA & RNA Research | Scoop.it
Lightweight, compact device converts an ordinary smartphone into an advanced fluorescence microscope
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Algorithm identifies networks of genetic changes across cancers

Algorithm identifies networks of genetic changes across cancers | DNA & RNA Research | Scoop.it

Cancers often involve far more than a genetic mutation acting alone. Multiple mutations, many of which are rare, may occur in different networks of multiple genes. HotNet2 is a powerful algorithm that analyzes genes at the network level and can help cancer researchers search for genetic associations and likely sources of disease across almost unimaginable genetic complexities.

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Molecular link discovered between prostate and breast cancer, suggesting new treatment approach for men's tumor

Molecular link discovered between prostate and breast cancer, suggesting new treatment approach for men's tumor | DNA & RNA Research | Scoop.it

Prostate cancer can be driven by the same estrogen receptor responsible for the most common form of breast cancer, Weill Cornell Medical College researchers report.

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Proteins drive cancer cells to change states

Proteins drive cancer cells to change states | DNA & RNA Research | Scoop.it

When RNA-binding proteins are turned on, cancer cells get locked in a proliferative state.

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Ebola Virus May Replicate in an Exotic Way

Ebola Virus May Replicate in an Exotic Way | DNA & RNA Research | Scoop.it

University of Utah researchers ran biochemical analysis and computer simulations of a livestock virus to discover a likely and exotic mechanism to explain the replication of related viruses such as Ebola, measles and rabies. The mechanism may be a possible target for new treatments within a decade.

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How Two Startups Hope to Turn Cancer Into (Just) a Chronic Disease

How Two Startups Hope to Turn Cancer Into (Just) a Chronic Disease | DNA & RNA Research | Scoop.it

Blueprint and Foundation Medicine are leveraging increasingly powerful genomics tools to improve cancer diagnosis or treatments.

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A clear, molecular view of the evolution of human color vision

A clear, molecular view of the evolution of human color vision | DNA & RNA Research | Scoop.it

Many genetic mutations in visual pigments, spread over millions of years, were required for humans to evolve from a primitive mammal with a dim, shadowy view of the world into a greater ape able to see all the colors in a rainbow.

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Quest to unravel mysteries of our gene network

Quest to unravel mysteries of our gene network | DNA & RNA Research | Scoop.it

There are roughly 27,000 genes in the human body, all but a relative few of them connected through an intricate and complex network that plays a dominant role in shaping our physiological structure and functions.

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Behind The Scenes At The Lab That Fingerprints Microbiomes

Behind The Scenes At The Lab That Fingerprints Microbiomes | DNA & RNA Research | Scoop.it

The gut microbiome may soon reveal important answers to questions about our health. But those answers aren't yet easy to spot or quick to obtain.

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Amount of Mitochondrial DNA Predicts Frailty and Mortality

Amount of Mitochondrial DNA Predicts Frailty and Mortality | DNA & RNA Research | Scoop.it

Study could lead to mitochondrial DNA blood tests to foretell risk

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It's Not Just For Your Brain: Meditating Can Actually Change Your DNA

It's Not Just For Your Brain: Meditating Can Actually Change Your DNA | DNA & RNA Research | Scoop.it

Meditation is good for you. We don't need to tell you that. The chorus of voices extolling the virtues of mindfulness is never-ending: It decreases stress. It helps you focus. It can even rewire your mental circuitry. But it's not just your synapses that see the benefits: As it turns out, meditating can physically change your DNA.

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New method identifies genome-wide off-target cleavage sites of CRISPR-Cas nucleases

Massachusetts General Hospital (MGH) investigators have developed a method of detecting, across the entire genome of human cells, unwanted DNA breaks induced by use of the popular gene-editing tools called CRISPR-Cas RNA-guided nucleases (RGNs).  Members of the same team that first described these off-target effects in human cells describe their new platform, called Genome-wide Unbiased Indentification of DSBs Evaluated by Sequencing (GUIDE-seq), in a report being published online in Nature Biotechnology

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DNA Sheds Light on Why Largest Lemurs Disappeared

DNA Sheds Light on Why Largest Lemurs Disappeared | DNA & RNA Research | Scoop.it

Ancient DNA extracted from the bones and teeth of giant lemurs that lived thousands of years ago in Madagascar may help explain why the giant lemurs went extinct. It also explains what factors make some surviving species more at risk today, says a study in the Journal of Human Evolution.

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Genes for speciation

Genes for speciation | DNA & RNA Research | Scoop.it
Regions in the genome cause infertility in some hybrids of house mouse subspecies
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‘Radiogenetics’ seeks to remotely control cells and genes

‘Radiogenetics’ seeks to remotely control cells and genes | DNA & RNA Research | Scoop.it

It’s the most basic of ways to find out what something does, whether it’s an unmarked circuit breaker or an unidentified gene — flip its switch and see what happens. New remote-control technology may offer biologists a powerful way to do this with cells and genes. A team at Rockefeller University and Rensselaer Polytechnic Institute is developing a system that would make it possible to remotely control biological targets in living animals — rapidly, without wires, implants or drugs.

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'Genome editing' could correct genetic mutations for future generations

'Genome editing' could correct genetic mutations for future generations | DNA & RNA Research | Scoop.it

Scientists at Indiana University and colleagues at Stanford and the University of Texas have demonstrated a technique for “editing” the genome in sperm-producing adult stem cells, a result with powerful potential for basic research and for gene therapy.

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Researchers Reveal Key Step in Synthesis of DNA at Chromosome Ends

Researchers Reveal Key Step in Synthesis of DNA at Chromosome Ends | DNA & RNA Research | Scoop.it

Researchers have developed a clearer understanding of how telomeres, the protective caps at the tips of our chromosomes, are produced. Understanding this process, part of which is clarified by Weill Cornell Medical College scientists in a new study, helps to shed light on how it could be disrupted in the case of cancer cells, which require adequate telomeres for uncontrolled proliferation.

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Study sheds new light on relationship between personality and health

Study sheds new light on relationship between personality and health | DNA & RNA Research | Scoop.it

Researchers have found new evidence that explains how some aspects of our personality may affect our health and wellbeing, supporting long-observed associations between aspects of human character, physical health and longevity.

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