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DNA & RNA Research
The latest news and information about DNA- and RNA-related research
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Planning and Executing siRNA Experiments

Functional analysis by mRNA knockdown using siRNAs is now routine in many molecular biology labs. However, many RNAi experiments fail due to diversion from simple, good practices. This webinar will review the steps leading to successful siRNA experiments, including: 

-Understanding the target transcript
-siRNA selection
-Choosing the cell type
-Validating the assay
-Including appropriate biological controls

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CRISPR-Cas9: Engineering a revolution in gene editing

CRISPR-Cas9: Engineering a revolution in gene editing | DNA & RNA Research | Scoop.it

The CRISPR-Cas9 system is revolutionizing genomic engineering and equipping scientists with the ability to precisely modify the DNA of essentially any organism. Just how powerful is this technique? The ability for precision genome engineering comes with the potential to enhance food production, medicinal discoveries, and energy solutions, to name a few. In this booklet, we invite you to explore a selection of Science articles that highlight how this technique has grown into one of the most powerful genomic engineering tools to date.

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High-speed drug screen

High-speed drug screen | DNA & RNA Research | Scoop.it

MIT engineers have devised a way to rapidly test hundreds of different drug-delivery vehicles in living animals, making it easier to discover promising new ways to deliver a class of drugs called biologics, which includes antibodies, peptides, RNA, and DNA, to human patients.

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What happens when good genes get lost?

What happens when good genes get lost? | DNA & RNA Research | Scoop.it

Scientifically speaking, there is no bad DNA, though we like to blame it for unruly hair, klutziness or poor gardening skills. There is, however, junk DNA.

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Though It May Taste Divine, Coffee DNA Tells A Darwinian Tale

Though It May Taste Divine, Coffee DNA Tells A Darwinian Tale | DNA & RNA Research | Scoop.it

Charles Darwin did a fine job of showing why his theory of evolution explained the living world better than any creationist ideas could, and evidence has piled up ever since, but a swatch of the American public remain unconvinced. Therefore, it’s always good to come across new scenarios to show how evolution works and debunk some of the misconceptions spread by proponents of “intelligent design” and other versions of creationist mythology.

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Investigating the Genomic Origins of the 2014 Ebola Outbreak

Investigating the Genomic Origins of the 2014 Ebola Outbreak | DNA & RNA Research | Scoop.it

Since March of this year, the Ebola virus in West Africa has infected and killed thousands of people in the region and gripped the world's attention. Despite treatment and containment efforts, the epidemic persists with a fatality rate of a staggering 52 percent, according to the World Health Organization.

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Carnegie Mellon Research Shows Viral DNA Infects Cells by Changing from Solid to Fluid-Like State

Carnegie Mellon Research Shows Viral DNA Infects Cells by Changing from Solid to Fluid-Like State | DNA & RNA Research | Scoop.it

Many double-stranded DNA viruses infect cells by ejecting their genetic information into a host cell. But how does the usually rigid DNA packaged inside a virus' shell flow from the virus to the cell?

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Ancient human genome from southern Africa throws light on our origins

Ancient human genome from southern Africa throws light on our origins | DNA & RNA Research | Scoop.it

The skeleton of a man who lived 2,330 years ago in the southernmost tip of Africa tells us about ourselves as humans, and throws some light on our earliest common genetic ancestry.

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UTSA microbiologists discover regulatory thermometer that controls cholera

UTSA microbiologists discover regulatory thermometer that controls cholera | DNA & RNA Research | Scoop.it

Karl Klose, professor of biology and a researcher in UTSA's South Texas Center for Emerging Infectious Diseases, has teamed up with researchers at Ruhr University in Bochum, Germany, to understand how humans get infected with cholera. Their findings were released this week in an article published by the Proceedings of the National Academy of Sciences.

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Metabolic shift may train immune cells

Metabolic shift may train immune cells | DNA & RNA Research | Scoop.it

Over the past 3 years, new evidence has indicated that white blood cells called monocytes have memory, even though they are part of the innate immune system. Exposure to certain pathogens can boost the cells' ability to fight off future infections. As part of a large European project, called BLUEPRINT, to survey the epigenetics of various healthy and diseased blood cells at different stages of development, researchers have found chemical modifications to histone proteins surrounding DNA in trained immune cells. Those clues led them to discover that training to become better defenders involves activating an energy-producing process called glycolysis. Without glycolysis, training does not occur. The finding has implications for modifying the immune system to fight disease.

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Craig Venter, Scientist - DNA: The Software of Life

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New mushroom species discovered in London grocery store

New mushroom species discovered in London grocery store | DNA & RNA Research | Scoop.it

DNA barcoding tests 15 pieces in a package of porcini mushrooms

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Researchers Must Study Risks of Gene-Editing Drugs

Researchers Must Study Risks of Gene-Editing Drugs | DNA & RNA Research | Scoop.it

One of the inventors of gene editing says scientists should proceed cautiously before testing it in people.

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Sticky fingers ground jumping genes

Sticky fingers ground jumping genes | DNA & RNA Research | Scoop.it

Our DNA is locked in a constant battle with itself. It’s fighting to control mobile bits of genetic material that copy themselves and spread through the genome—so-called jumping genes. But that's a molecular game of Whac-A-Mole: For every bit it manages to suppress, another finds a way to break free. A new study has pinned down genes that have evolved to thwart these molecular intruders. The work paints a picture of the ongoing evolutionary struggle being waged within our genome.

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The symbol of life should be a loop, not a helix

The symbol of life should be a loop, not a helix | DNA & RNA Research | Scoop.it

The DNA helix gave 20th-century biology its symbol. But the more we learn, the more life loops back to an older image

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Ebola diagnosis could be easier after breakthrough by team at Victor Chang Cardiac Research Institute

Ebola diagnosis could be easier after breakthrough by team at Victor Chang Cardiac Research Institute | DNA & RNA Research | Scoop.it

The terrifying spread of the Ebola virus through west Africa has been exacerbated by the slow and painful process of diagnosis.

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Viruses melt ‘glassy’ DNA

Viruses melt ‘glassy’ DNA | DNA & RNA Research | Scoop.it

Researchers have shown how viruses liquefy their own DNA ready to inject into host cells

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In stickleback fish, dads influence offspring behavior and gene expression

In stickleback fish, dads influence offspring behavior and gene expression | DNA & RNA Research | Scoop.it

Researchers report that some stickleback fish fathers can have long-term effects on the behavior of their offspring: The most attentive fish dads cause their offspring to behave in a way that makes them less susceptible to predators. These behavioral changes are accompanied by changes in gene expression, the researchers report.

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New genetic indicators could help solve malaria puzzle

New genetic indicators could help solve malaria puzzle | DNA & RNA Research | Scoop.it

Five genes that have a role in either protecting or making people more susceptible to severe malaria have been identified in a new international study.

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Human genome was shaped by an evolutionary arms race with itself

Human genome was shaped by an evolutionary arms race with itself | DNA & RNA Research | Scoop.it

New study of primate genomes reveals an ongoing battle to control "jumping genes," driving the evolution of greater genomic complexity

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DNA signature found in ice storm babies

DNA signature found in ice storm babies | DNA & RNA Research | Scoop.it

Prenatal maternal stress exposure to natural disasters predicts epigenetic profile of offspring

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A Tiny Emissary From the Ancient Past

A Tiny Emissary From the Ancient Past | DNA & RNA Research | Scoop.it

Viroids, naked loops of RNA, attack crops and other plants today, but new research suggests they existed at the earliest stages of life on Earth.

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Hacking the Cancer Genome

Hacking the Cancer Genome | DNA & RNA Research | Scoop.it

These days, cancer is as much a target for researchers with number-crunching skills and their data-mining tools as it is for scientists in biomedical research labs. And one potentially powerful big-data approach to conquering cancer—which involves discovering clever genetic tricks to make cancer cells kill themselves—has moved in a promising new direction this month.

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Researchers engineer new mouse model to study disease

Researchers engineer new mouse model to study disease | DNA & RNA Research | Scoop.it

Time-saving tool takes advantage of CRISPR gene-editing technology

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New approach aims to silence cancer ‘survival genes’

New approach aims to silence cancer ‘survival genes’ | DNA & RNA Research | Scoop.it

Scientists at the University of York are working on a promising new approach for tackling colorectal cancer, the second most common cause of cancer-related death.

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