DNA and RNA Research
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DNA and RNA Research
The latest news and information about DNA- and RNA-related research
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Tips for effective use of BLAST and other NCBI tools

The National Center for Biotechnology Information (NCBI) provides one of the most extensive sets of web-based tools for biological research. The tools are indispensable when planning genomics experiments, including for qPCR, NGS, and CRISPR. In this presentation, Dr Matt McNeill takes a practical look at getting started with the wealth of NCBI tools, and shares some relevant tips to help you sift through the tools and options that we regularly use. In particular, he focuses on commonly adjusted parameters that will allow you to more effectively use the powerful Basic Local Alignment Algorithm Tool (BLAST) to identify off-target hybridization/annealing events. Dr McNeill also covers practical examples using NCBI tools to design assays.

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Human Antisense RNA Can Boost Protein Expression, Not Only Repress It

Human Antisense RNA Can Boost Protein Expression, Not Only Repress It | DNA and RNA Research | Scoop.it

Researchers from RIKEN have shown for the first time that human RNA sequences can not only inhibit protein expression, but also boost it.

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Researchers modify yeast to show how plants respond to a key hormone 

Researchers modify yeast to show how plants respond to a key hormone  | DNA and RNA Research | Scoop.it

Researchers at the University of Washington have developed a novel toolkit based on modified yeast cells to tease out how plant genes and proteins respond to auxin, the most ubiquitous plant hormone. Their system, described in a paperpublished Sept. 19 in the Proceedings of the National Academy of Sciences, allowed them to decode auxin’s basic effects on the diverse family of genes that plants utilize to detect and interpret auxin-driven messages.

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New Research Provides Insights into Sage Grouse DNA

New Research Provides Insights into Sage Grouse DNA | DNA and RNA Research | Scoop.it

The greater sage grouse is an iconic bird that lives in the American West’s sagebrush landscape. It’s also a species at the center of a nationwide debate focused on how best to manage its habitat to balance multiple uses and ensure the bird’s long-term survival.

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Non-coding portions of genome are found to play role in cancer 

Non-coding portions of genome are found to play role in cancer  | DNA and RNA Research | Scoop.it

CSHL scientists test an antisense method of targeting long noncoding RNAs overexpressed in breast cancers

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Just add water: Biomolecular manufacturing ‘on-the-go’ 

Just add water: Biomolecular manufacturing ‘on-the-go’  | DNA and RNA Research | Scoop.it

Wyss Institute team unveils a low-cost, portable method to manufacture biomolecules for a wide range of vaccines, other therapies as well as diagnostics



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It Takes 2: RNA–DNA Mashup May Have Kick-Started Life on Earth

It Takes 2: RNA–DNA Mashup May Have Kick-Started Life on Earth | DNA and RNA Research | Scoop.it

New research shows each molecule needed the other one

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Essential Mouse Genes Could Guide Human Precision Medicine

Essential Mouse Genes Could Guide Human Precision Medicine | DNA and RNA Research | Scoop.it

About one-third of 1751 genes studied in the first comprehensive survey of the mouse genome are essential to life, according to research by an international collaboration including the UC Davis Mouse Biology Program. Mutations of these genes cause death at the embryo stage. Many of them have counterparts in the human genome, so understanding why these genes are so vital could help prioritize human genes for study.

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Nucleic acid instability challenges RNA world hypothesis

Nucleic acid instability challenges RNA world hypothesis | DNA and RNA Research | Scoop.it

Early life may have contained both RNA and DNA, rather than just RNA

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A Single Migration From Africa Populated the World, Studies Find

A Single Migration From Africa Populated the World, Studies Find | DNA and RNA Research | Scoop.it

Unprecedented DNA analyses of people in indigenous populations suggest that almost all non-Africans trace their roots to one migration from the continent.

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Youthful DNA in old age 

Youthful DNA in old age  | DNA and RNA Research | Scoop.it

The DNA of young people is regulated to express the right genes at the right time. With the passing of years, the regulation of the DNA gradually gets disrupted, which is an important cause of ageing. A study of over 3,000 people shows that this is not true for everyone: there are people whose DNA appears youthful despite their advanced years. These are the findings of 34 researchers from six collaborating institutes led by Dr Bas Heijmans from the Leiden University Medical Center (the Netherlands), reported in Genome Biology. 

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Fighting Plant Pathogens with RNA

Fighting Plant Pathogens with RNA | DNA and RNA Research | Scoop.it

Researchers develop strategy that could lead to environmentally friendly fungicide to fight pathogens that cause billions of dollars in crop loss

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New insights into “plant memories”

New insights into “plant memories” | DNA and RNA Research | Scoop.it

A special stretch of ribonucleic acid (RNA) called COOLAIR is revealing its inner structure and function to scientists, displaying a striking resemblance to an RNA molecular machine.

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Nanocarrier design 

Nanocarrier design  | DNA and RNA Research | Scoop.it

The University of Delaware's Emily Day is identifying the design rules for miRNA nanocarriers that will provide the best response for improved disease intervention.

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New software helps to find out why “jumping genes” are activated

New software helps to find out why “jumping genes” are activated | DNA and RNA Research | Scoop.it

Jumping genes, so-called transposons, reproduce as parasites in the genome. This selfish behaviour can be an evolutionary advantage for the organism or harm it. There is still a debate about the factors controlling the activity of transposons. Comparisons between populations could shed an answer on this but have been biased due to technical problems so far. The software PoPoolationTE2 developed by the Institute of Population Genetics at the University of Veterinary Medicine, Vienna enables an unbiased analysis for the first time and determines the frequency of transposons. This might also be useful for cancer research and neurology. The software was presented in the renowned journals Molecular Biology and Evolution.

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How our cells use mother’s and father’s genes

How our cells use mother’s and father’s genes | DNA and RNA Research | Scoop.it

Researchers at Karolinska Institutet and Ludwig Institute for Cancer Research have characterized how and to what degree our cells utilize the gene copies inherited from our mother and father differently. At a basic level this helps to explain why identical twins can appear rather different, even though they share identical genetic makeup. With this knowledge we will better understand the variation in outcomes of genetic disorders.

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UBC researchers discover how cancer’s ‘invisibility cloak’ works

UBC researchers discover how cancer’s ‘invisibility cloak’ works | DNA and RNA Research | Scoop.it

UBC researchers have discovered how cancer cells become invisible to the body’s immune system, a crucial step that allows tumours to metastasize and spread throughout the body.

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Regulatory RNA essential to DNA damage response

Regulatory RNA essential to DNA damage response | DNA and RNA Research | Scoop.it

Stanford researchers have found that a tumor suppressor known as p53 is stabilized by a regulatory RNA molecule called DINO. The interaction helps a cell respond to DNA damage and may play a role in cancer development and premature aging.

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“Out of Africa” Theory Gets the Genomic Treatment

“Out of Africa” Theory Gets the Genomic Treatment | DNA and RNA Research | Scoop.it

A trio of genetic studies on seldom-studied indigenous populations points to a single wave of migration as humanity wandered from its evolutionary homeland into the rest of the world.

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RNA Editing Gone Awry Could Indicate Gastric Cancer

RNA Editing Gone Awry Could Indicate Gastric Cancer | DNA and RNA Research | Scoop.it

Proteins involved in RNA editing could potentially be used as biomarkers to detect gastric cancer at an early stage, a study finds.

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New genetic links for heart disease risk factors identified 

New genetic links for heart disease risk factors identified  | DNA and RNA Research | Scoop.it

17 rare genetic variants found

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GUIDE-seq: A DNA Duct Tape to mark the DNA Damage

GUIDE-seq: A DNA Duct Tape to mark the DNA Damage | DNA and RNA Research | Scoop.it

Double-stranded breaks in DNA can be detected with several technologies. Doing so in plants is exceptionally difficult, but GUIDE-Seq shows promise in new studies. 

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Fralin researcher finds gene that reduces female mosquitoes

Fralin researcher finds gene that reduces female mosquitoes | DNA and RNA Research | Scoop.it

Virginia Tech researchers have found a gene that can reduce female mosquitoes over many generations.

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Send secret messages hidden in the DNA of bacterial spores

Send secret messages hidden in the DNA of bacterial spores | DNA and RNA Research | Scoop.it

Bacterial DNA could provide a good long-term solution for storing digital information thanks to new encryption techniques that protect it from hackers

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Smoking leaves historical ‘footprint’ in DNA

Smoking leaves historical ‘footprint’ in DNA | DNA and RNA Research | Scoop.it

Smoking leaves its “footprint” in your DNA, according to research released Tuesday. The new findings suggest that DNA methylation — a process by which cells control gene activity — could reveal a person’s smoking history and provide researchers with potential targets for new therapies.

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World’s hardiest animal has evolved radiation shield for its DNA

World’s hardiest animal has evolved radiation shield for its DNA | DNA and RNA Research | Scoop.it

Tough ‘water bears’ defy intense radiation by apparently wrapping their genetic material in a bizarre protein that can also protect human cells

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