Learn how the Högberg Lab designed a simplified DNA scaffolding method, including software that quickly determines the “oligonucleotide staples” required to fold a ssDNA sequence into any desired shape.
Fraternal twins tend to run in families, and scientists think they've identified genetic variations at play. Understanding that might someday help predict who is more likely to have a risky pregnancy, and might also help treat fertility problems.
We introduce a portable biochemical analysis platform for rapid field deployment of nucleic acid-based diagnostics using consumer-class quadcopter drones. This approach exploits the ability to isothermally perform the polymerase chain reaction (PCR) with a single heater, enabling the system to be operated using standard 5 V USB sources that power mobile devices (via battery, solar, or hand crank action). Time-resolved fluorescence detection and quantification is achieved using a smartphone camera and integrated image analysis app. Standard sample preparation is enabled by leveraging the drone’s motors as centrifuges via 3D printed snap-on attachments. These advancements make it possible to build a complete DNA/RNA analysis system at a cost of ∼$50 ($US). Our instrument is rugged and versatile, enabling pinpoint deployment of sophisticated diagnostics to distributed field sites. This capability is demonstrated by successful in-flight replication of Staphylococcus aureus and λ-phage DNA targets in under 20 min. The ability to perform rapid in-flight assays with smartphone connectivity eliminates delays between sample collection and analysis so that test results can be delivered in minutes, suggesting new possibilities for drone-based systems to function in broader and more sophisticated roles beyond cargo transport and imaging.
Biologists around the world routinely perform gene expression analysis to better understand living systems. Gene expression analysis examines the types and amounts of molecules produced by genes in living cells, telling us which genes are active and which are inactive at a given point in time. This reveals valuable information about the highly dynamic internal states of cells in living systems. NASA’s WetLab-2 hardware system is bringing to the International Space Station the technology to measure gene expression of biological specimens in space, and to transmit the results to researchers on Earth at the speed of light.
Scientists at the John Innes Centre (JIC) and The Sainsbury Laboratory (TSL) have pioneered a new gene-detecting technology which, if deployed correctly could lead to the creation of a new elite variety of wheat with durable resistance to disease.
Today, 23rd April, at the South Beach in Varna, 4000 people managed to break the Guinness World Record for the Largest Human DNA Helix. Organizer of the spectacular event is Medical University "Prof. Dr. Paraskev Stoyanov "- Varna. The event was carried out under the motto "Be a Part of the Future", through which the organizers united people of all ages.
Researchers are one step closer to understanding the genetic and biological basis of diseases like cancer, diabetes, Alzheimer’s and rheumatoid arthritis – and identifying new drug targets and therapies – thanks to work by three computational biology research teams from the University of Arizona Health Sciences, University of Pennsylvania and Vanderbilt University.
Metastasis. The very word evokes fear. Defined as the spread of cancer cells from one part of the body to another, metastasis is the cause of approximately 90 percent of deaths among cancer patients. How does metastasis come about? And can we stop it?
Scientists from Princeton University and Uppsala University in Sweden have identified a specific gene that within a year helped spur a permanent physical change in a finch species in response to a drought-induced food shortage. The findings provide a genetic basis for natural selection that, when combined with observational data, could serve as a comprehensive model of evolution.
In rare instances, DNA is known to have jumped from one species to another. If a parasite’s DNA jumps to its host’s genome, it could leave evidence of that parasitic interaction that could be found millions of years later – a DNA ‘fossil’ of sorts. An international research team led from Uppsala University has discovered a new type of so-called transposable element that occurred in the genomes of certain birds and nematodes.
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