Scientists at the University of Chicago have created the first genetically modified animals containing reconstructed ancient genes, which they used to test the evolutionary effects of past genetic changes on the animals’ biology and fitness.
A team of scientists led by prof. Adrian Liston (VIB–KU Leuven) and prof. Isabelle Meyts (UZ Leuven – KU Leuven) were able to characterize a new genetic immunodeficiency resulting from a mutation in a gene named STAT2. This mutation causes patients to be extremely vulnerable to normally mild childhood illnesses such as rotavirus and enterovirus. Prof. Liston’s comprehensive analysis of the genetic defect allows clinicians to provide children with the proper therapies before illnesses prove fatal. The findings of the research have been published in the Journal of Allergy and Clinical Immunology.
Researchers at the Department of Energy’s Oak Ridge National Laboratory (ORNL) have released the largest-ever single nucleotide polymorphism (SNP) dataset of genetic variations in poplar trees, information useful to plant scientists as well as researchers in the fields of biofuels, materials science, and secondary plant metabolism.
Researchers have developed a new technique which allows them to examine huge amounts of information from a single cell or zoom out and see data patterns among thousands upon thousands of cells — all in a single experiment. The method could help researchers dive deep into the ecosystem of cancer.
Over millions of years retroviruses have been incorporated into our human DNA, where they today make up almost 10 per cent of the total genome. A research group at Lund University in Sweden has now discovered a mechanism through which these retroviruses may have an impact on gene expression. This means that they may have played a significant role in the development of the human brain as well as in various neurological diseases.
In cells, DNA is transcribed into RNAs that provide the molecular recipe for cells to make proteins. Most of the genome is transcribed into RNA, but only a small proportion of RNAs are actually from the protein-coding regions of the genome.
Molecular biologists at UT Southwestern Medical Center were able to uncover a new mechanism that choreographs a complex molecular dance by applying the latest in gene editing technology combined with a traditional method of making a microRNA target produce a fluorescent green protein.
Messenger RNAs bearing the genetic information for the synthesis of proteins are delivered to defined sites in the cell cytoplasm by molecular motors. LMU researchers have elucidated how the motors recognize their mRNA freight.
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