Scientists from Simon Fraser University (British Columbia, Canada) use guppies as a model to study the evolution of female mate preferences for male coloration. Read more about their field study using PrimeTime® qPCR Assays, ZEN™ Quencher Probes, and gBlocks® Gene Fragments.
For some, Iceland conjures thoughts of geothermal spas like the Blue Lagoon, moonlike landscapes and literary sagas peopled with Huldufólk, elfin creatures. Most people do not, however, think of large-scale genomic studies.
The new experimental assay can help scientists find the precise locations of repair of DNA damage caused by UV radiation and common chemotherapies. The invention could lead to better cancer drugs or improvements in the potency of existing ones.
DNA can be damaged by different environmental insults, such as ultraviolet light, ionizing radiation, oxidative stress or certain drugs. If the DNA is not repaired, cells may begin growing uncontrollably, leading to the development of cancer. Therefore, cells must maintain an intricate regulatory network to ensure that their DNA remains intact. Moffitt Cancer Center researchers have discovered a novel mechanism that controls a cell’s response to DNA damage.
Neurons may modify their DNA on a regular basis to adjust their level of activity, a new study reports. The cells change the pattern of methyl groups on their DNA to strengthen and weaken the connections—or synapses—they make with their neighbors.
Weill Cornell Medical College researchers have shown for the first time that a gene previously implicated in blood vessel formation during embryonic development and tumor growth also induces immune suppression during tumor development. This finding, published April 29 in Nature Communications, opens the door for new therapeutic approaches and vaccine development in treating patients with melanoma and other advanced-staged cancers.
Already the world’s leader in custom nucleic acid synthesis,Integrated DNA Technologies (IDT) is capitalizing on its expertise to deliver a broader range of validated molecular biology products. Research and development for these products will now be performed in a newly built facility in Redwood City, California. The 8,000 square foot building houses state-of-the-art labs that will allow IDT scientists to maximize the company’s world-class custom oligonucleotide manufacturing capability. For an advance look, view a video of IDT’s new Redwood City R&D facility.
People with Werner syndrome—a rare disease with symptoms that mimic premature aging—usually go gray in their 20s, develop cataracts and osteoporosis in their 30s, and die before 60. Now, researchers have for the first time created a key class of versatile stem cells that carry the genetic defect that causes the condition. Their analysis suggests that loosely wrapped DNA underlies the accelerated physical decline of Werner syndrome and promotes aging in the rest of the population.
Almost the entire human genome is transcribed into RNA, but only a fraction of this is actually used to produce protein. The function of the majority of the RNA, the so-called "non-coding transcriptome" remains an enigma. Some non-coding RNA families have been recognised through their shared structural features. Amongst these is the group of long non-coding RNAs (lncRNAs). Researchers at the Helmholtz Zentrum München now report the discovery of a very unexpected role for one such lncRNA, which they call PARTICLE, in regulating the response of cells to ionizing radiation.
Researchers at The University of Texas Health Science Center at Houston (UTHealth) are helping to make precision medicine a reality by sequencing entire exomes of people to assess chronic disease risk and drug efficacy. The results of a study on this topic were published in Nature Genetics on Monday.
Using a mouse’s own tumor DNA, researchers created personalized vaccines that cause the immune system to destroy the tumor. Human cancer patients in a new clinical trial are already receiving vaccines.
The IDT gel electrophoresis group runs preparatory polyacrylamide gels to purify certain oligonucleotides and can run up to 500 gels a day based on demand. Running that many gels means that this group has had a lot of experience with refining electrophoresis techniques and resolving gel issues. The following guide, provided by our gel electrophoresis team, contains troubleshooting tips for many of the gel issues they have come across during their work.
Researchers have found a way to deliver gene-activating molecules called transcription factors into specific tissues of a living animal for the first time. The approach, which many have written off as too technically challenging, prevented a form of liver damage in mice—though it has many more technical hurdles to clear before it can be used in other tissues, or in people.
Researchers at Caltech have discovered how an abundant class of RNA genes, called long non-coding RNAs (lncRNAs, pronounced link RNAs) can regulate key genes. By studying an important lncRNA, called Xist, the scientists identified how this RNA gathers a group of proteins and ultimately prevents women from having an extra functional X-chromosome—a condition in female embryos that leads to death in early development. These findings mark the first time that researchers have uncovered the detailed mechanism of action for lncRNA genes.
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